IL259429B - Macrocyclic broad spectrum antibiotics - Google Patents

Macrocyclic broad spectrum antibiotics

Info

Publication number
IL259429B
IL259429B IL259429A IL25942918A IL259429B IL 259429 B IL259429 B IL 259429B IL 259429 A IL259429 A IL 259429A IL 25942918 A IL25942918 A IL 25942918A IL 259429 B IL259429 B IL 259429B
Authority
IL
Israel
Prior art keywords
broad spectrum
macrocyclic antibiotic
macrocyclic
antibiotic
broad
Prior art date
Application number
IL259429A
Other languages
English (en)
Hebrew (he)
Other versions
IL259429A (en
Original Assignee
Rqx Pharmaceuticals Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rqx Pharmaceuticals Inc, Genentech Inc filed Critical Rqx Pharmaceuticals Inc
Publication of IL259429A publication Critical patent/IL259429A/en
Publication of IL259429B publication Critical patent/IL259429B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL259429A 2015-11-20 2018-05-16 Macrocyclic broad spectrum antibiotics IL259429B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/095165 2015-11-20
CNPCT/CN2016/105043 2016-11-08
PCT/CN2016/106597 WO2017084629A1 (en) 2015-11-20 2016-11-21 Macrocyclic broad spectrum antibiotics

Publications (2)

Publication Number Publication Date
IL259429A IL259429A (en) 2018-07-31
IL259429B true IL259429B (en) 2021-12-01

Family

ID=58231314

Family Applications (1)

Application Number Title Priority Date Filing Date
IL259429A IL259429B (en) 2015-11-20 2018-05-16 Macrocyclic broad spectrum antibiotics

Country Status (12)

Country Link
US (1) US11072635B2 (https=)
EP (1) EP3377474B1 (https=)
JP (1) JP6873993B2 (https=)
KR (1) KR20180109858A (https=)
CN (1) CN109219596B (https=)
AU (1) AU2016357926B2 (https=)
BR (1) BR112018010267A2 (https=)
CA (1) CA3005551A1 (https=)
IL (1) IL259429B (https=)
MX (1) MX387476B (https=)
RU (1) RU2761476C2 (https=)
WO (1) WO2017084629A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
WO2015179441A2 (en) 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
US11072635B2 (en) 2015-11-20 2021-07-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
AU2018222093B2 (en) * 2017-02-15 2022-03-31 Genentech, Inc. Macrocyclic broad spectrum antibiotics
CN111386283A (zh) * 2017-09-29 2020-07-07 基因泰克公司 肽抗菌复合物及其使用方法
JP7078807B2 (ja) 2019-05-28 2022-05-31 エフ．ホフマン－ラ ロシュ アーゲー 大環状広域スペクトル抗生物質

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014081886A1 (en) * 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics

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EP0862638A1 (en) 1995-11-03 1998-09-09 E.I. Du Pont De Nemours And Company Positive selection vector for bacillus sp.
KR100509388B1 (ko) 1996-10-18 2005-08-23 버텍스 파마슈티칼스 인코포레이티드 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제
EP0895999A1 (en) 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
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US6660832B1 (en) 1999-08-20 2003-12-09 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
US6951840B2 (en) 2001-08-31 2005-10-04 Eli Lilly And Company Lipoglycopeptide antibiotics
DE10226921A1 (de) 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
CN1839150A (zh) 2003-07-17 2006-09-27 麦根克斯有限公司 脂肽抗菌衍生物组合物及其应用方法
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014247A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
AU2011223790A1 (en) 2010-03-01 2012-08-30 Myrexis, Inc. Compounds and therapeutic uses thereof
CN102939095A (zh) 2010-03-09 2013-02-20 默沙东公司 增强β-内酰胺抗菌药物的活性的桥联脂糖肽类
WO2011120071A1 (en) 2010-04-01 2011-10-06 The University Of Queensland Oxytocin peptide analogues
BR112013006265A2 (pt) 2010-09-15 2016-06-07 Scripps Research Inst espectros antibióticos gerais análogos a arilomicina
TWI642684B (zh) 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
CN103159830B (zh) 2011-12-15 2017-06-20 上海来益生物药物研究开发中心有限责任公司 脂肽类化合物
FR2986154B1 (fr) 2012-01-31 2017-08-04 Pierre Fabre Dermo Cosmetique Nouveau systeme photoprotecteur
CA2867448A1 (en) 2012-03-14 2013-09-19 Floyd E. Romesberg Broad spectrum antibiotic arylomycin analogs
CN103788176A (zh) * 2012-10-31 2014-05-14 上海来益生物药物研究开发中心有限责任公司 一种arylomycin类化合物及其制备方法和应用
WO2015179441A2 (en) * 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
ITUB20154591A1 (it) 2015-10-12 2017-04-12 Crestoptics S R L Apparato di microscopia confocale e relativo procedimento di acquisizione ed elaborazione di immagini
US11072635B2 (en) 2015-11-20 2021-07-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
TWI725075B (zh) 2015-11-20 2021-04-21 美商Ｒｑｘ製藥公司 巨環廣效抗生素
AU2018222093B2 (en) 2017-02-15 2022-03-31 Genentech, Inc. Macrocyclic broad spectrum antibiotics
ES2892173T3 (es) 2017-03-27 2022-02-02 Hoffmann La Roche Procedimiento para fabricar análogos de anillo de arilomicina
CN111386283A (zh) 2017-09-29 2020-07-07 基因泰克公司 肽抗菌复合物及其使用方法
JP7078807B2 (ja) 2019-05-28 2022-05-31 エフ．ホフマン－ラ ロシュ アーゲー 大環状広域スペクトル抗生物質

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014081886A1 (en) * 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics

Also Published As

Publication number Publication date
JP6873993B2 (ja) 2021-05-19
US11072635B2 (en) 2021-07-27
US20200239519A1 (en) 2020-07-30
MX387476B (es) 2025-03-18
CN109219596A (zh) 2019-01-15
BR112018010267A2 (pt) 2018-11-27
CA3005551A1 (en) 2017-05-26
AU2016357926A1 (en) 2018-06-14
KR20180109858A (ko) 2018-10-08
AU2016357926B2 (en) 2021-05-27
RU2761476C2 (ru) 2021-12-08
CN109219596B (zh) 2022-04-19
WO2017084629A1 (en) 2017-05-26
EP3377474B1 (en) 2023-08-16
RU2018122498A (ru) 2019-12-26
JP2019501123A (ja) 2019-01-17
EP3377474A1 (en) 2018-09-26
MX2018006199A (es) 2019-01-10
RU2018122498A3 (https=) 2020-02-28
EP3377474C0 (en) 2023-08-16
IL259429A (en) 2018-07-31

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