RU2756318C2 - Мутеины липокалина 2 человека с аффинностью в отношении глипикана-3 (gpc3) - Google Patents

Мутеины липокалина 2 человека с аффинностью в отношении глипикана-3 (gpc3) Download PDF

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RU2756318C2
RU2756318C2 RU2017135605A RU2017135605A RU2756318C2 RU 2756318 C2 RU2756318 C2 RU 2756318C2 RU 2017135605 A RU2017135605 A RU 2017135605A RU 2017135605 A RU2017135605 A RU 2017135605A RU 2756318 C2 RU2756318 C2 RU 2756318C2
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Марлон Хиннер
Андреа Аллерсдорфер
Рачида Сихам Бел Айба
Михаэла АЛЁ
Александер Виденман
Габриеле МАЧИНЕР
Мартин Хюльсмейер
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ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/102—Mutagenizing nucleic acids
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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RU2017135605A 2015-05-18 2016-05-18 Мутеины липокалина 2 человека с аффинностью в отношении глипикана-3 (gpc3) RU2756318C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15167922 2015-05-18
EP15167922.2 2015-05-18
PCT/EP2016/061058 WO2016184875A1 (en) 2015-05-18 2016-05-18 Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3)

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RU2017135605A RU2017135605A (ru) 2019-06-18
RU2017135605A3 RU2017135605A3 (enExample) 2019-11-13
RU2756318C2 true RU2756318C2 (ru) 2021-09-29

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US (2) US10273275B2 (enExample)
EP (1) EP3298029A1 (enExample)
JP (2) JP6942060B2 (enExample)
KR (1) KR20180008649A (enExample)
CN (2) CN114456252A (enExample)
AU (1) AU2016262838B2 (enExample)
BR (1) BR112017020961A2 (enExample)
CA (1) CA2982034A1 (enExample)
MX (1) MX2017014730A (enExample)
RU (1) RU2756318C2 (enExample)
SG (1) SG11201707872WA (enExample)
WO (1) WO2016184875A1 (enExample)
ZA (1) ZA201706605B (enExample)

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RU2564125C2 (ru) 2009-12-07 2015-09-27 Пирис Аг Мутеины липокалина 2 человека (lcn2, hngal) с аффинностью для определенной мишени
CA2891557A1 (en) 2013-03-26 2014-05-22 Pieris Ag Novel specific-binding polypeptides and uses thereof
SG10201912019WA (en) 2014-05-22 2020-02-27 Pieris Pharmaceuticals Gmbh Novel specific-binding polypeptides and uses thereof
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EP3292148B1 (en) 2015-05-04 2024-01-24 Pieris Pharmaceuticals GmbH Anti-cancer fusion polypeptide
EP4177262A1 (en) 2015-05-04 2023-05-10 Pieris Pharmaceuticals GmbH Proteins specific for cd137
RU2756318C2 (ru) 2015-05-18 2021-09-29 ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ Мутеины липокалина 2 человека с аффинностью в отношении глипикана-3 (gpc3)
JP6947642B2 (ja) 2015-05-18 2021-10-13 ピエリス ファーマシューティカルズ ゲーエムベーハー 抗がん性融合ポリペプチド
EP3115371A1 (en) 2015-07-07 2017-01-11 Sanofi Fusion molecules
SG10201911499TA (en) 2015-11-30 2020-01-30 Pieris Australia Pty Ltd Novel anti-angiogenic fusion polypeptides
TW201725212A (zh) 2015-12-10 2017-07-16 第一三共股份有限公司 特異性於降鈣素基因相關胜肽的新穎蛋白
EP3931209A1 (en) * 2019-02-26 2022-01-05 Pieris Pharmaceuticals GmbH Novel fusion proteins specific for cd137 and gpc3
CN113939307A (zh) 2019-03-29 2022-01-14 皮里斯制药有限公司 脂质运载蛋白突变蛋白的吸入施用
CA3177098A1 (en) 2020-06-05 2021-12-09 Pieris Pharmaceuticals Gmbh Multimeric immunomodulator targeting 4-1bb

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JP6942060B2 (ja) 2021-09-29
AU2016262838A1 (en) 2018-01-04
CA2982034A1 (en) 2016-11-24
US10787491B2 (en) 2020-09-29
US20190309037A1 (en) 2019-10-10
WO2016184875A1 (en) 2016-11-24
KR20180008649A (ko) 2018-01-24
CN107787327A (zh) 2018-03-09
BR112017020961A2 (pt) 2018-07-10
RU2017135605A3 (enExample) 2019-11-13
JP7217783B2 (ja) 2023-02-03
EP3298029A1 (en) 2018-03-28
JP2018519802A (ja) 2018-07-26
JP2021184725A (ja) 2021-12-09
CN114456252A (zh) 2022-05-10
SG11201707872WA (en) 2017-10-30
US20180141988A1 (en) 2018-05-24
US10273275B2 (en) 2019-04-30
RU2017135605A (ru) 2019-06-18
CN107787327B (zh) 2022-02-08
MX2017014730A (es) 2018-06-28
ZA201706605B (en) 2020-05-27
AU2016262838B2 (en) 2020-10-08

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