RU2756313C2 - Модифицированная РНК, кодирующая полипептиды VEGF-A, составы, содержащие ее, и пути их применения - Google Patents

Модифицированная РНК, кодирующая полипептиды VEGF-A, составы, содержащие ее, и пути их применения Download PDF

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RU2756313C2
RU2756313C2 RU2018147229A RU2018147229A RU2756313C2 RU 2756313 C2 RU2756313 C2 RU 2756313C2 RU 2018147229 A RU2018147229 A RU 2018147229A RU 2018147229 A RU2018147229 A RU 2018147229A RU 2756313 C2 RU2756313 C2 RU 2756313C2
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vegf
rna
modified
composition
citrate
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RU2018147229A
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RU2018147229A (ru
RU2018147229A3 (enExample
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Лиф Карлссон ПАРИНДЕР
ДАНИЕЛЬСОН Регина Десирэ ФРИТШЕ
Кенни Микаэль ХАНССОН
Ли Мин ГАНЬ
Джонатан КЛАРК
Энн-Шарлотт Эва ЭГНЕЛЛЬ
Кеннет Рэндалл ЧЕЙН
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Модернатикс, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
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    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
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RU2018147229A 2016-06-07 2017-06-06 Модифицированная РНК, кодирующая полипептиды VEGF-A, составы, содержащие ее, и пути их применения RU2756313C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662346979P 2016-06-07 2016-06-07
US62/346,979 2016-06-07
US201662411091P 2016-10-21 2016-10-21
US62/411,091 2016-10-21
US201662432005P 2016-12-09 2016-12-09
US62/432,005 2016-12-09
PCT/US2017/036188 WO2017214175A1 (en) 2016-06-07 2017-06-06 Modified rna encoding vegf-a polypeptides, formulations, and uses relating thereto

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RU2018147229A RU2018147229A (ru) 2020-07-10
RU2018147229A3 RU2018147229A3 (enExample) 2020-09-23
RU2756313C2 true RU2756313C2 (ru) 2021-09-29

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JP7345888B2 (ja) * 2021-06-17 2023-09-19 株式会社ニューギン 遊技機
WO2023061985A2 (en) * 2021-10-12 2023-04-20 Modernatx, Inc. Compositions comprising modified rna encoding vegf-a and methods of use
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KR20220038819A (ko) 2022-03-29
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EP3464338B1 (en) 2021-07-21
EP3971204A1 (en) 2022-03-23
RU2018147229A (ru) 2020-07-10
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MA45172A (fr) 2019-04-10
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