TWI752036B - 編碼vegf-a多肽的經修飾rna、配製物及關於它們之用途 - Google Patents

編碼vegf-a多肽的經修飾rna、配製物及關於它們之用途 Download PDF

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TWI752036B
TWI752036B TW106118838A TW106118838A TWI752036B TW I752036 B TWI752036 B TW I752036B TW 106118838 A TW106118838 A TW 106118838A TW 106118838 A TW106118838 A TW 106118838A TW I752036 B TWI752036 B TW I752036B
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vegf
modified rna
formulation
composition
saline buffer
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TW106118838A
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Chinese (zh)
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TW201808325A (zh
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萊夫 K. 帕林德
蕾吉娜 D. 弗里切丹尼爾森
肯尼 M. 漢森
黎明 甘
強納森 克拉克
安夏洛特 E. 艾格尼爾
肯尼斯 R. 簡
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美商瑪德那特克斯股份有限公司
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
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    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW106118838A 2016-06-07 2017-06-07 編碼vegf-a多肽的經修飾rna、配製物及關於它們之用途 TWI752036B (zh)

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US201662346979P 2016-06-07 2016-06-07
US62/346,979 2016-06-07
US201662411091P 2016-10-21 2016-10-21
US62/411,091 2016-10-21
US201662432005P 2016-12-09 2016-12-09
US62/432,005 2016-12-09

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PT3464338T (pt) 2016-06-07 2021-10-19 Modernatx Inc Arn modificado que codifica polipéptidos vegf-a, formulações e respetivos usos
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MA50522B1 (fr) * 2017-10-31 2022-09-30 Astrazeneca Ab 151 85 Soedertaelje Nanoparticules lipidiques pour l'administration d'un arn modifié codant pour un polypeptide vegf-a
CN114173826A (zh) * 2019-05-08 2022-03-11 阿斯利康(瑞典)有限公司 使用脂质纳米颗粒用于递送编码vegf-a多肽的经修饰的rna的方法和包含其的药物组合物
JP7345888B2 (ja) * 2021-06-17 2023-09-19 株式会社ニューギン 遊技機
WO2023061985A2 (en) * 2021-10-12 2023-04-20 Modernatx, Inc. Compositions comprising modified rna encoding vegf-a and methods of use
WO2023084013A1 (en) * 2021-11-12 2023-05-19 Modernatx, Inc. Compositions comprising modified rna encoding vegf-a and methods of use

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WO2012138453A1 (en) * 2011-04-03 2012-10-11 The General Hospital Corporation Efficient protein expression in vivo using modified rna (mod-rna)

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AU2017277277B2 (en) 2023-05-04
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RU2756313C2 (ru) 2021-09-29
MX2018015110A (es) 2019-09-06
MA45172B1 (fr) 2021-11-30
JP2021100961A (ja) 2021-07-08
AU2017277277A1 (en) 2019-01-03
DK3464338T3 (da) 2021-10-18
CN109790207B (zh) 2023-06-20
KR20220038819A (ko) 2022-03-29
KR102376245B1 (ko) 2022-03-21
EP3464338B1 (en) 2021-07-21
EP3971204A1 (en) 2022-03-23
RU2018147229A (ru) 2020-07-10
SI3464338T1 (sl) 2022-02-28
RU2018147229A3 (enExample) 2020-09-23
MA45172A (fr) 2019-04-10
JP2019521976A (ja) 2019-08-08
TWI818375B (zh) 2023-10-11
CY1124667T1 (el) 2022-07-22
LT3464338T (lt) 2022-01-10
WO2017214175A1 (en) 2017-12-14
KR20230107891A (ko) 2023-07-18
PL3464338T3 (pl) 2021-12-27
EP3464338A1 (en) 2019-04-10
TW202218670A (zh) 2022-05-16
CN116606861A (zh) 2023-08-18
KR102552543B1 (ko) 2023-07-06
CA3026500A1 (en) 2017-12-14
RS62556B1 (sr) 2021-12-31
ES2895421T3 (es) 2022-02-21
JP6859369B2 (ja) 2021-04-14
HUE056055T2 (hu) 2022-01-28
JP7167226B2 (ja) 2022-11-08
PT3464338T (pt) 2021-10-19
US20200407411A1 (en) 2020-12-31
KR20230019505A (ko) 2023-02-08
HRP20211569T1 (hr) 2022-01-21
US11866475B2 (en) 2024-01-09
AU2023208200A1 (en) 2023-08-17
IL263370A (en) 2018-12-31
SMT202100586T1 (it) 2021-11-12
CN109790207A (zh) 2019-05-21
KR20190039066A (ko) 2019-04-10
JP2023011733A (ja) 2023-01-24
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