JP6859369B2 - Vegf−aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用 - Google Patents

Vegf−aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用 Download PDF

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JP6859369B2
JP6859369B2 JP2018564389A JP2018564389A JP6859369B2 JP 6859369 B2 JP6859369 B2 JP 6859369B2 JP 2018564389 A JP2018564389 A JP 2018564389A JP 2018564389 A JP2018564389 A JP 2018564389A JP 6859369 B2 JP6859369 B2 JP 6859369B2
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vegf
modified rna
formulation
composition
citrate
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JP2019521976A5 (enExample
JP2019521976A (ja
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パリンダー,ライフ・カールソン
フリッチェ・ダニエルソン,レジーナ・デジレ
ハンソン,ケニー・ミカエル
ガン,リー・ミーン
クラーク,ヨナタン
エグネル,アン−シャーロット・エヴァ
チエン,ケネス・ランドール
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ModernaTx Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61K38/18Growth factors; Growth regulators
    • A61K38/1858Platelet-derived growth factor [PDGF]
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    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • C07K14/475Growth factors; Growth regulators
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons

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  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
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  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2018564389A 2016-06-07 2017-06-06 Vegf−aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用 Active JP6859369B2 (ja)

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Application Number Priority Date Filing Date Title
JP2021049671A JP7167226B2 (ja) 2016-06-07 2021-03-24 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用
JP2022171389A JP2023011733A (ja) 2016-06-07 2022-10-26 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662346979P 2016-06-07 2016-06-07
US62/346,979 2016-06-07
US201662411091P 2016-10-21 2016-10-21
US62/411,091 2016-10-21
US201662432005P 2016-12-09 2016-12-09
US62/432,005 2016-12-09
PCT/US2017/036188 WO2017214175A1 (en) 2016-06-07 2017-06-06 Modified rna encoding vegf-a polypeptides, formulations, and uses relating thereto

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JP2021049671A Division JP7167226B2 (ja) 2016-06-07 2021-03-24 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用

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JP2019521976A JP2019521976A (ja) 2019-08-08
JP2019521976A5 JP2019521976A5 (enExample) 2020-10-01
JP6859369B2 true JP6859369B2 (ja) 2021-04-14

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JP2018564389A Active JP6859369B2 (ja) 2016-06-07 2017-06-06 Vegf−aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用
JP2021049671A Active JP7167226B2 (ja) 2016-06-07 2021-03-24 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用
JP2022171389A Pending JP2023011733A (ja) 2016-06-07 2022-10-26 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用

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JP2021049671A Active JP7167226B2 (ja) 2016-06-07 2021-03-24 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用
JP2022171389A Pending JP2023011733A (ja) 2016-06-07 2022-10-26 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用

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LT3464338T (lt) 2016-06-07 2022-01-10 Modernatx, Inc. Modifikuota rnr, koduojanti vegf-a polipeptidus, vaisto formos, ir su jomis susiję panaudojimo būdai
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PL3703658T3 (pl) 2017-10-31 2022-08-22 Astrazeneca Ab Nanocząstki lipidowe do dostarczania zmodyfikowanego rna kodującego polipeptyd vegf-a
US20220226243A1 (en) * 2019-05-08 2022-07-21 Astrazeneca Ab Methods of using lipid nanoparticles for delivering modified rna encoding a vegf-a polypeptide and pharmaceutical compositions comprising the same
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WO2023061985A2 (en) * 2021-10-12 2023-04-20 Modernatx, Inc. Compositions comprising modified rna encoding vegf-a and methods of use
WO2023084013A1 (en) * 2021-11-12 2023-05-19 Modernatx, Inc. Compositions comprising modified rna encoding vegf-a and methods of use

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HRP20211569T1 (hr) 2022-01-21
CA3026500A1 (en) 2017-12-14
SMT202100586T1 (it) 2021-11-12
KR20230107891A (ko) 2023-07-18
US20200407411A1 (en) 2020-12-31
CY1124667T1 (el) 2022-07-22
TWI818375B (zh) 2023-10-11
TW201808325A (zh) 2018-03-16
MX2018015110A (es) 2019-09-06
KR102552543B1 (ko) 2023-07-06
RU2018147229A (ru) 2020-07-10
IL263370A (en) 2018-12-31
SI3464338T1 (sl) 2022-02-28
AU2017277277B2 (en) 2023-05-04
JP2023011733A (ja) 2023-01-24
US11866475B2 (en) 2024-01-09
KR20220038819A (ko) 2022-03-29
EP3464338A1 (en) 2019-04-10
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AU2023208200A1 (en) 2023-08-17
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