RU2750035C2 - Способы и наборы диагностики и стратификации риска пациентов с ишемией - Google Patents

Способы и наборы диагностики и стратификации риска пациентов с ишемией Download PDF

Info

Publication number
RU2750035C2
RU2750035C2 RU2018139780A RU2018139780A RU2750035C2 RU 2750035 C2 RU2750035 C2 RU 2750035C2 RU 2018139780 A RU2018139780 A RU 2018139780A RU 2018139780 A RU2018139780 A RU 2018139780A RU 2750035 C2 RU2750035 C2 RU 2750035C2
Authority
RU
Russia
Prior art keywords
apo
glcnac
levels
glycosylated
acetylglucosamine
Prior art date
Application number
RU2018139780A
Other languages
English (en)
Russian (ru)
Other versions
RU2018139780A (ru
RU2018139780A3 (enExample
Inventor
МАЭСТРО Лина БАДИМОН
РАФОЛС Худит КУБЕДО
КАПМАНИ Тереза ПАДРО
Original Assignee
Консехо Супериор Де Инвестигасионес Сьентификас
Фундасио Институт Де Ресерка Де Л'Оспиталь Де Ла Санта Креу И Сант Пау
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Консехо Супериор Де Инвестигасионес Сьентификас, Фундасио Институт Де Ресерка Де Л'Оспиталь Де Ла Санта Креу И Сант Пау filed Critical Консехо Супериор Де Инвестигасионес Сьентификас
Publication of RU2018139780A publication Critical patent/RU2018139780A/ru
Publication of RU2018139780A3 publication Critical patent/RU2018139780A3/ru
Application granted granted Critical
Publication of RU2750035C2 publication Critical patent/RU2750035C2/ru

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775Apolipopeptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/38Post-translational modifications [PTMs] in chemical analysis of biological material addition of carbohydrates, e.g. glycosylation, glycation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2871Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/324Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/56Staging of a disease; Further complications associated with the disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2018139780A 2016-04-12 2017-04-12 Способы и наборы диагностики и стратификации риска пациентов с ишемией RU2750035C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16382167.1 2016-04-12
EP16382167.1A EP3232200A1 (en) 2016-04-12 2016-04-12 Methods and kits for the diagnosis and risk stratification of patients with ischemia
PCT/EP2017/058768 WO2017178521A1 (en) 2016-04-12 2017-04-12 Methods and kits for the diagnosis and risk stratification of patients with ischemia

Publications (3)

Publication Number Publication Date
RU2018139780A RU2018139780A (ru) 2020-05-12
RU2018139780A3 RU2018139780A3 (enExample) 2020-07-24
RU2750035C2 true RU2750035C2 (ru) 2021-06-21

Family

ID=56008566

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018139780A RU2750035C2 (ru) 2016-04-12 2017-04-12 Способы и наборы диагностики и стратификации риска пациентов с ишемией

Country Status (15)

Country Link
US (1) US11486884B2 (enExample)
EP (2) EP3232200A1 (enExample)
JP (1) JP7075894B2 (enExample)
KR (1) KR102344344B1 (enExample)
CN (1) CN109154620B (enExample)
AU (1) AU2017251355A1 (enExample)
BR (1) BR112018070971A2 (enExample)
CA (1) CA3020666A1 (enExample)
ES (1) ES2979390T3 (enExample)
IL (1) IL262245B (enExample)
MA (1) MA44658A (enExample)
MX (1) MX2018012580A (enExample)
RU (1) RU2750035C2 (enExample)
SG (1) SG11201808820QA (enExample)
WO (1) WO2017178521A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022506108A (ja) * 2018-10-23 2022-01-17 グリカルディアル ダイアグノスティクス エセ. エレ. グリコシル化ApoJに特異的な抗体およびその使用
WO2020115095A2 (en) * 2018-12-05 2020-06-11 Glycardial Diagnostics, S.L. Methods and compositions for the prevention and/or treatment of ischemia and of ischemia/reperfusion injury
KR102158726B1 (ko) 2019-04-17 2020-09-22 한림대학교 산학협력단 Itpr3 유전자 업스트림의 유전자간 영역을 포함하는 지연성 허혈 진단용 dna 메틸화 마커 조성물
KR102281657B1 (ko) 2019-12-23 2021-07-26 한림대학교 산학협력단 지연성 허혈 진단을 위한 cdhr5 유전자 과메틸화 마커
KR102281644B1 (ko) 2019-12-23 2021-07-23 한림대학교 산학협력단 지연성 허혈 진단을 위한 insr 유전자 과메틸화 마커
KR102312534B1 (ko) 2019-12-31 2021-10-13 한림대학교 산학협력단 뇌척수액 유래 미토콘드리아 마커를 이용한 지연성 허혈 진단 방법
KR102318236B1 (ko) 2020-02-18 2021-10-26 한림대학교 산학협력단 혈중 코펩틴의 농도를 이용한 지연성 뇌허혈 진단 방법
KR102336507B1 (ko) 2020-02-21 2021-12-06 한림대학교 산학협력단 국소뇌산소포화도를 이용한 지연성 뇌허혈 진단 방법
KR102369155B1 (ko) 2020-07-07 2022-02-28 한림대학교 산학협력단 근적외선 분광분석법을 이용한 지연성 뇌허혈 진단 방법
KR102473349B1 (ko) 2020-09-11 2022-12-05 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 kifap3 유전자 과메틸화 마커
KR102473350B1 (ko) 2020-09-11 2022-12-05 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 racgap1 유전자 과메틸화 마커
KR102496589B1 (ko) 2020-09-11 2023-02-03 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 vhl 유전자 과메틸화 마커
KR102473348B1 (ko) 2020-09-11 2022-12-05 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 kif3a 유전자 과메틸화 마커
KR102477500B1 (ko) 2020-09-15 2022-12-14 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 oprm1 유전자 과메틸화 마커
KR102477501B1 (ko) 2020-09-15 2022-12-14 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 alb 유전자 저메틸화 마커
KR102477502B1 (ko) 2020-09-15 2022-12-14 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 il5 유전자 저메틸화 마커
KR102466956B1 (ko) 2020-11-05 2022-11-11 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 dapk1 바이오마커
KR102470789B1 (ko) 2020-11-05 2022-11-25 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 pink1 바이오마커
KR102398533B1 (ko) 2020-11-05 2022-05-13 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 뇌척수액 마이토파지 마커
KR102398534B1 (ko) 2020-11-05 2022-05-13 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 bnip3l 바이오마커
CN113462744B (zh) * 2021-05-24 2023-06-23 中国药科大学 N-乙酰葡萄糖胺作为标志物在制备诊断缺血性脑中风试剂中的应用
KR102865129B1 (ko) 2021-08-06 2025-09-26 에이치앤비지노믹스 주식회사 지능형 오믹스 기반 개인별 맞춤형 복잡질환 발병 위험도 정보 제공 방법 및 장치

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011098645A1 (es) * 2010-02-09 2011-08-18 Consejo Superior De Investigaciones Científicas (Csic) Uso de las isoformas de apo j como biomarcadores de lesión tisular
US20130123137A1 (en) * 2010-06-22 2013-05-16 CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOMATERIALS (CIC biomaGUNE) Method for the characterization of intermolecular interactions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
CA2301634A1 (en) * 1997-07-15 1999-01-28 Pradeep Ghosh Determining alcohol intake using sialic acid/apo j
US6197599B1 (en) 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins
EP1746902A4 (en) * 2004-05-05 2007-06-13 Univ Northeastern MULTI-LECTIN AFFINITY CHROMATOGRAPHY AND USES THEREOF
JP6028960B2 (ja) * 2009-07-14 2016-11-24 国立研究開発法人産業技術総合研究所 肝疾患病態指標糖鎖マーカー
JP2012107932A (ja) 2010-11-16 2012-06-07 Mitsubishi Chemicals Corp Clusterin蛋白質による脳梗塞の検査方法
DK3289363T3 (da) 2015-04-30 2022-02-28 Idexx Lab Inc Specifik påvisning af clusterin isoformer
CN107957498A (zh) * 2016-10-18 2018-04-24 厦门德馨尚品医疗科技有限公司 一种含有载脂蛋白j的试剂盒及其在临床诊断中的应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011098645A1 (es) * 2010-02-09 2011-08-18 Consejo Superior De Investigaciones Científicas (Csic) Uso de las isoformas de apo j como biomarcadores de lesión tisular
US20130123137A1 (en) * 2010-06-22 2013-05-16 CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOMATERIALS (CIC biomaGUNE) Method for the characterization of intermolecular interactions

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHARLWOOD J. et al. Use of Proteomic Methodology for the Characterization of Human Milk Fat Globular Membrane Proteins // Analytical Biochemistry. - 2002. - Vol. 301. - No. 2. - P. 314-324. *
CHARLWOOD J. et al. Use of Proteomic Methodology for the Characterization of Human Milk Fat Globular Membrane Proteins // Analytical Biochemistry. - 2002. - Vol. 301. - No. 2. - P. 314-324. GBORMITTAH F. O. et al. Clusterin glycopeptide variant characterization reveals significant site-specific glycan changes in the plasma of clear cell renal cell carcinoma // Journal of proteome research. - 2015. - V. 14. - No. 6. - P. 2425-2436. *
COMUNALE M. A. et al. Novel changes in glycosylation of serum Apo-J in patients with hepatocellular carcinoma // Cancer Epidemiology and Prevention Biomarkers. - 2011. - Vol. 20. - No. 6. - P. 1222-1229. *
CUBEDO J. et al. Proteomic signature of Apolipoprotein J in the early phase of new-onset myocardial infarction // Journal of proteome research. - 2011. - Vol. 10. - No. 1. - P. 211-220. *
CUBEDO J. et al. Proteomic signature of Apolipoprotein J in the early phase of new-onset myocardial infarction // Journal of proteome research. - 2011. - Vol. 10. - No. 1. - P. 211-220. COMUNALE M. A. et al. Novel changes in glycosylation of serum Apo-J in patients with hepatocellular carcinoma // Cancer Epidemiology and Prevention Biomarkers. - 2011. - Vol. 20. - No. 6. - P. 1222-1229. *
GBORMITTAH F. O. et al. Clusterin glycopeptide variant characterization reveals significant site-specific glycan changes in the plasma of clear cell renal cell carcinoma // Journal of proteome research. - 2015. - V. 14. - No. 6. - P. 2425-2436. *

Also Published As

Publication number Publication date
SG11201808820QA (en) 2018-11-29
RU2018139780A (ru) 2020-05-12
IL262245A (en) 2018-11-29
KR102344344B1 (ko) 2021-12-28
EP3443353A1 (en) 2019-02-20
JP7075894B2 (ja) 2022-05-26
CN109154620A (zh) 2019-01-04
EP3232200A1 (en) 2017-10-18
US20190128900A1 (en) 2019-05-02
KR20190008216A (ko) 2019-01-23
ES2979390T3 (es) 2024-09-25
CN109154620B (zh) 2022-03-08
RU2018139780A3 (enExample) 2020-07-24
EP3443353B1 (en) 2024-03-13
BR112018070971A2 (pt) 2019-01-29
JP2019516966A (ja) 2019-06-20
US11486884B2 (en) 2022-11-01
AU2017251355A1 (en) 2018-11-08
MX2018012580A (es) 2019-02-25
MA44658A (fr) 2019-02-20
CA3020666A1 (en) 2017-10-19
IL262245B (en) 2021-03-25
WO2017178521A1 (en) 2017-10-19

Similar Documents

Publication Publication Date Title
RU2750035C2 (ru) Способы и наборы диагностики и стратификации риска пациентов с ишемией
US9733261B2 (en) Methods and compositions for diagnosis and prognosis of stroke or other cerebral injury
EP3255434B1 (en) Novel biomarkers for cognitive impairment and methods for detecting cognitive impairment using such biomarkers
US11726099B2 (en) Biomarker for mental disorders including cognitive disorders, and method using said biomarker to detect mental disorders including cognitive disorders
ES2944613T3 (es) proADM y/o histonas como marcadores indicadores de un acontecimiento adverso
US8999658B2 (en) Methods and kits for diagnosing obstructive sleep apnea
JP2023522066A (ja) 大血管閉塞により引き起こされる卒中についてのバイオマーカーとしてのd-ダイマー、グリア線維酸性タンパク質(gfap)、オステオプロテジェリン(opg)及びオステオポンチン(opn)
JP2023527087A (ja) 敗血症状態の予測
Badimón Maestro et al. Methods and kits for the diagnosis and risk stratification of patients with ischemia
CN111065922A (zh) 肾上腺髓质素原作为危重病患者的肾脏替代治疗的指标
HK40003205B (en) Methods and kits for the diagnosis and risk stratification of patients with ischemia
HK40003205A (en) Methods and kits for the diagnosis and risk stratification of patients with ischemia
JP2012037349A (ja) 認知機能障害疾患のバイオマーカーおよび該バイオマーカーを用いた認知機能障害疾患の検出方法
JPWO2002037105A1 (ja) 精神分裂病の診断薬キット
CN120787361A (zh) 轻度认知障碍和阿尔茨海默氏病的蛋白标志物
HK40029189A (en) Proadrenomedullin as indicator for renal replacement therapy in critically ill patients
JP2015017923A (ja) 糖尿病の病態進展を評価するためのバイオマーカー