RU2745997C1 - Biologically active composition with adaptogenic and anti-stress activity - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to the field of pharmaceutics and medicine and constitutes a biologically active composition with adaptogenic and anti-stress activity, characterized by being comprised of a substance of drone brood homogenate and dry extracts of licorice roots, rootstock with roots of safflower leuzea, grass of astragalus glycyphyllos and fruit bodies of inonotus obliquus in the following ratios, % wt.: dry extract of dried root of safflower leuzea - 37.5; dry extract of dried grass of astragalus glycyphyllos - 25.0; dry extract of dried root of licorice - 15.0; dry extract of dried fruit bodies of inonotus obliquus - 10.0; freeze-dried drone brood homogenate - 12.5.

EFFECT: composition allows increasing adaptogenic and anti-stress activity by synergetic activity of the constituent ingredients thereof.

1 cl, 1 tbl, 2 ex

Description

The invention relates to the field of pharmacy and medicine. The composition, which has an adaptogenic and anti-stress effect, contains a homogenate of drone brood, as well as dry extracts of licorice roots, rhizomes with roots of safflower leuzea, astragalus grass and fruit bodies of inonotus mowed.

Known tablets "Apilar" (Patent RU 2233666 C1, publ. 10.08.2004 Bull. No. 22) on the basis of a homogenate of drone brood, proposed for use as a general tonic, anabolic agent, and also as an aid in pediatric and geriatric practice.

The disadvantage of this method is an undesirable increase in nervous excitability.

Known Medicinal product "Phytobalm-Fabacerone" based on medicinal plants of the legume family, which has a sedative effect. (Patent RU 2197257 C2, publ. 27.01.2003 Bull. No. 3).

The disadvantage of this tool is the use of alcohol in the composition, which affects the patient's ability to drive vehicles.

Known biologically active food additive "Ecdysterone P" to increase the adaptive capacity of the body, which includes a drone homogenate, Leuzea extract (Unified Register of State Registration Certificates: certificate No. RU.77.99.88.003.E.002339.05.17.

Known biologically active food additive "Leveton-Forte" (Unified register of certificates of state registration: certificate No. RU.77.99.29.003.Е.003287.02.15. Composition: pollen (pollen), roots with rhizomes of safflower leuzea, drone homogenate with vitamin B6, vitamin C, E, milk sugar, calcium stearate, hypromellose, tween-80, titanium dioxide.

For the prototype of the proposed invention, a biologically active additive (Patent RU 2390270 C1, publ. 05/27/2010 Bull. No. 15) based on a homogenate of drone brood and leuzea was chosen, aimed at increasing physical performance, adaptive forces of the body and optimizing the processes of acclimatization of an athlete.

The disadvantage of the above biologically active additives is the low adaptogenic activity.

The purpose of the invention is to create a biologically active composition that provides an increase in adaptogenic and anti-stress action, achieved through the synergistic action of its constituent components.

This goal is achieved as follows:

Raw material drone brood homogenate obtained by mechanical pressing is freeze-dried. The substance of drone brood homogenate prepared in this way is mixed with dry extracts of licorice roots, rhizomes with roots of Safflower Leuzea (maral root), herb of astragalus sweet-leaved and fruit bodies of inonotus mowed (chaga (tinder fungus (dried mushroom)) in the following proportions ( :

Leuzea safflower root dried extract dry 37.5%

astragalus sweet-leaved herb dried extract dry 25.0%

dried licorice root extract dry 15.0%

inonotus of mown fruit bodies dried dry extract 10.0%

freeze-dried drone brood homogenate 12.5%,

The resulting composition, hereinafter referred to as "FitAp", is encapsulated on a ProFiller 3800 capsule filling machine.

Drone brood is a source of fats, proteins, rich in essential amino acids and carbohydrates, micro- and macroelements, as well as testosterone, progesterone and estradiol. Proteins are mainly represented by free amino acids and easily assimilated transport oligopeptides. This substance contributes to the accelerated restoration of the biochemical and massometric characteristics of the testes and the prostate gland, acting as a stimulator of the central mechanisms of regulation of the intensity of androgen formation. Drone brood homogenate is actively used in folk medicine. According to the manufacturers, this substance has a tonic effect on the body, improves appetite, improves the activity of the endocrine system, increases libido, physical performance and increases tolerance to high physical and emotional stress.

The adaptogenic effect of licorice naked is associated with the corticoid-like effect of glycyrrhizic acid, which is part of it, the biological effects of which include suppression of lymphoid organs, stimulation of the synthesis of carbohydrates from proteins and an increase in the body's resistance to stress.

Safflower Leuzea increases physical performance, has a tonic, tonic and anabolic effect, promotes accelerated recovery after stress and injuries, has a positive effect on metabolism and immunity, has a wound healing and antiseptic effect.

The use of astragalus promotes the expansion of the vessels of the brain, peripheral vessels, thereby improving blood circulation and oxygen saturation, which makes its use effective for physical and mental stress.

Inonotus beveled contains a large amount of antioxidants that prevent damage to body cells by reactive oxygen species under increased stress.

To assess the effect of the composition "FitAp" on physical performance, a forced swimming test with a load was carried out on laboratory animals (female Wistar rats). The high-level limit swimming test allows you to study mixed (aerobic-anaerobic) physical performance, and is also used in drug testing for the benefit of elite sports. The forced swimming test was carried out as follows: the animal was taken out of the cage, weighed, and a lead weight weighing 10% of the animal's body weight was fixed on its body in the abdominal region. At the beginning of the study, the animal was immersed in the pool water without sudden movements, and the stopwatch was turned on during the first swimming movements of the animal.

The criterion for stopping the measurement was the animal's inability to active swimming movements (staying at the bottom of the pool without swimming movements for 10-15 seconds, the appearance of rotational movements or agonal cramps of the trunk). At this point, the animal was quickly removed from the water and dried with a dry towel, after which it was returned to the cage.

The criterion for physical performance was the swimming time in seconds.

The assessment of the orienting motor response and locomotor activity was carried out in the psychoemotional ethological test "open field". The rat was placed in the corner of a large rectangular chamber (60 × 60 cm) with walls 40 cm high. The floor was a polystyrene sheet on which a grating was applied with black paint, dividing the field into 25 (5 × 5) equal squares. Lighting was provided by a lamp placed 150 cm above the field. Animals placed in an open field were observed for 2.5 minutes. As soon as the animal entered the new square with both forepaws, this moment was recorded. The number of visits to the 16 peripheral squares (adjacent to the walls) was recorded separately from the number of visits to the 9 inner squares.

The criterion for increased psycho-emotional stability was an increase in research activity, expressed in the number of squares visited.

As a result of the study, it was found that the use of the biologically active composition "FitAp" leads to a significant increase in both physical performance and psychoemotional stability of the studied animals. The results of the study are presented in Table 1.

Claims (6)

Biologically active composition with adaptogenic and anti-stress action, characterized in that it contains the substance of drone brood homogenate and dry extracts of licorice roots, rhizomes with roots of safflower leuzea, astragalus grass and fruit bodies of inonotus mowed in the following ratios, wt%: Leuzea safflower root dried extract dry - 37.5; astragalus sweet-leaved herb dried dry extract - 25.0; dried licorice root extract dry - 15.0; inonotus of beveled fruit bodies of dried dry extract - 10.0; freeze-dried drone brood homogenate - 12.5.