RU2745604C2 - Лираглутид при сердечно-сосудистых состояниях - Google Patents

Лираглутид при сердечно-сосудистых состояниях Download PDF

Info

Publication number
RU2745604C2
RU2745604C2 RU2018134061A RU2018134061A RU2745604C2 RU 2745604 C2 RU2745604 C2 RU 2745604C2 RU 2018134061 A RU2018134061 A RU 2018134061A RU 2018134061 A RU2018134061 A RU 2018134061A RU 2745604 C2 RU2745604 C2 RU 2745604C2
Authority
RU
Russia
Prior art keywords
liraglutide
subject
paragraphs
placebo
mace
Prior art date
Application number
RU2018134061A
Other languages
English (en)
Russian (ru)
Other versions
RU2018134061A3 (enExample
RU2018134061A (ru
Inventor
Сёрен Расмуссен
Кайса КВИСТ
Original Assignee
Ново Нордиск А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59723004&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2745604(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ново Нордиск А/С filed Critical Ново Нордиск А/С
Publication of RU2018134061A publication Critical patent/RU2018134061A/ru
Publication of RU2018134061A3 publication Critical patent/RU2018134061A3/ru
Application granted granted Critical
Publication of RU2745604C2 publication Critical patent/RU2745604C2/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
RU2018134061A 2016-03-04 2017-03-03 Лираглутид при сердечно-сосудистых состояниях RU2745604C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP16158739 2016-03-04
EP16158739.9 2016-03-04
EP16173917.2 2016-06-10
EP16173917 2016-06-10
EP16001329.8 2016-06-13
EP16001329 2016-06-13
US15/401,651 US9968659B2 (en) 2016-03-04 2017-01-09 Liraglutide in cardiovascular conditions
US15/401,651 2017-01-09
PCT/EP2017/054990 WO2017149112A1 (en) 2016-03-04 2017-03-03 Liraglutide in cardiovascular conditions

Publications (3)

Publication Number Publication Date
RU2018134061A RU2018134061A (ru) 2020-04-06
RU2018134061A3 RU2018134061A3 (enExample) 2020-07-15
RU2745604C2 true RU2745604C2 (ru) 2021-03-29

Family

ID=59723004

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018134061A RU2745604C2 (ru) 2016-03-04 2017-03-03 Лираглутид при сердечно-сосудистых состояниях

Country Status (24)

Country Link
US (2) US9968659B2 (enExample)
EP (1) EP3423082B1 (enExample)
JP (1) JP6940512B2 (enExample)
KR (1) KR102417455B1 (enExample)
CN (2) CN108778317A (enExample)
AU (2) AU2017225841A1 (enExample)
BR (1) BR112018067344A2 (enExample)
CA (1) CA3013532C (enExample)
CL (1) CL2018002515A1 (enExample)
DK (1) DK3423082T5 (enExample)
ES (1) ES2893755T3 (enExample)
HR (1) HRP20211492T1 (enExample)
HU (1) HUE055844T2 (enExample)
IL (1) IL261169B (enExample)
MA (1) MA43704A (enExample)
MX (1) MX394179B (enExample)
MY (1) MY195657A (enExample)
PH (1) PH12018501844B1 (enExample)
PL (1) PL3423082T3 (enExample)
RS (1) RS62501B1 (enExample)
RU (1) RU2745604C2 (enExample)
SI (1) SI3423082T1 (enExample)
WO (1) WO2017149112A1 (enExample)
ZA (1) ZA201805538B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9968659B2 (en) 2016-03-04 2018-05-15 Novo Nordisk A/S Liraglutide in cardiovascular conditions
CA3177693A1 (en) 2019-04-05 2020-10-05 Eli Lilly And Company Therapeutic uses of dulaglutide
CN118987224A (zh) * 2020-12-16 2024-11-22 香港中文大学 一种治疗受试者的衰老相关脑功能障碍的组合物及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220255A1 (en) * 2002-04-04 2003-11-27 Knudsen Liselotte Bjerre GLP-1 agonist and cardiovascular complications

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808203A (en) 1997-05-12 1998-09-15 Medrad, Inc. Fluid pressure measurement devices
CN104826116A (zh) * 2003-11-20 2015-08-12 诺沃挪第克公司 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂
CN112618700A (zh) * 2004-11-12 2021-04-09 诺和诺德公司 促胰岛素肽的稳定制剂
WO2009030738A1 (en) * 2007-09-05 2009-03-12 Novo Nordisk A/S Glucagon-like peptide-1 derivatives and their pharmaceutical use
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
AR075204A1 (es) 2009-01-29 2011-03-16 Boehringer Ingelheim Int Inhibidores de dpp-4 y composiciones farmaceuticas que los comprenden, utiles para tratar enfermedades metabolicas en pacientes pediatricos, particularmente diabetes mellitus tipo 2
KR20110135411A (ko) 2009-03-27 2011-12-16 브리스톨-마이어스 스큅 컴퍼니 Dpp-iv 억제제로 주요 유해 심장혈관 이벤트를 예방하는 방법
WO2011140176A1 (en) 2010-05-04 2011-11-10 Glaxosmithkline Llc Methods for treating or preventing cardiovascular disorders and providing cardiovascular protection
KR20230051307A (ko) 2010-06-24 2023-04-17 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
US20130172244A1 (en) 2011-12-29 2013-07-04 Thomas Klein Subcutaneous therapeutic use of dpp-4 inhibitor
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
EP4151218A1 (en) 2012-05-14 2023-03-22 Boehringer Ingelheim International GmbH Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
JP6374862B2 (ja) 2012-05-24 2018-08-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 自己免疫性糖尿病、特に、ladaの治療に使用するためのdpp−4阻害剤としてのキサンチン誘導体
CN103893744B (zh) * 2012-12-24 2017-12-19 杭州九源基因工程有限公司 一种治疗糖尿病的药物制剂及其制备方法
JP2016510795A (ja) 2013-03-15 2016-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 心臓保護及び腎臓保護の抗糖尿病治療におけるリナグリプチンの使用
JP6507154B2 (ja) 2013-06-14 2019-04-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及びその合併症を治療するためのddp−4阻害薬
US8969371B1 (en) 2013-12-06 2015-03-03 Orexigen Therapeutics, Inc. Compositions and methods for weight loss in at risk patient populations
EP3110449B1 (en) 2014-02-28 2023-06-28 Boehringer Ingelheim International GmbH Medical use of a dpp-4 inhibitor
WO2016019587A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [7, 6]-fused bicyclic antidiabetic compounds
US9968659B2 (en) 2016-03-04 2018-05-15 Novo Nordisk A/S Liraglutide in cardiovascular conditions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220255A1 (en) * 2002-04-04 2003-11-27 Knudsen Liselotte Bjerre GLP-1 agonist and cardiovascular complications

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
LEE WC et al. Long-term clinical and economic outcomes associated with liraglutide versus sitagliptin therapy when added to metformin in the treatment of type 2 diabetes: a CORE Diabetes Model analysis. J Med Econ, 2012, 15 Suppl 2, р.28-37. *
MUNDIL DHANWANTEE et al. GLP-1 receptor agonists: A clinical perspective on cardiovascular effects. Diab Vasc Dis Res, 2012, 9(2), p.95-108. *
MUNDIL DHANWANTEE et al. GLP-1 receptor agonists: A clinical perspective on cardiovascular effects. Diab Vasc Dis Res, 2012, 9(2), p.95-108. ZAVATTARO MARCO et al. One-year treatment with liraglutide improved renal function in patients with type 2 diabetes: a pilot prospective study. Endocrine, 2015 Dec, 50(3), p.620-6. RIZZO M et al. Liraglutide Reduces Oxidative Stress And Restores Heme Oxygenase-1 and Ghrelin Levels in Patients with Type 2 Diabetes: A Prospective Pilot Study. J Clin Endocrinol Metab, 2015, 100(2), p.603-6. *
RIZZO M et al. Liraglutide Reduces Oxidative Stress And Restores Heme Oxygenase-1 and Ghrelin Levels in Patients with Type 2 Diabetes: A Prospective Pilot Study. J Clin Endocrinol Metab, 2015, 100(2), p.603-6. *
SCHEEL-THOMSEN J et al. Diabetes and stroke: liraglutide is associated with a decreased risk of stroke in type 2 diabetes mellitus. A nested case-control study. Journal of Neurology, 2014, vol. 21, no. Suppl.1, ISSN 1351-5101, p. 154. *
SCHEEL-THOMSEN J et al. Diabetes and stroke: liraglutide is associated with a decreased risk of stroke in type 2 diabetes mellitus. A nested case-control study. Journal of Neurology, 2014, vol. 21, no. Suppl.1, ISSN 1351-5101, p. 154. LEE WC et al. Long-term clinical and economic outcomes associated with liraglutide versus sitagliptin therapy when added to metformin in the treatment of type 2 diabetes: a CORE Diabetes Model analysis. J Med Econ, 2012, 15 Suppl 2, р.28-37. *
ZAVATTARO MARCO et al. One-year treatment with liraglutide improved renal function in patients with type 2 diabetes: a pilot prospective study. Endocrine, 2015 Dec, 50(3), p.620-6. *

Also Published As

Publication number Publication date
JP6940512B2 (ja) 2021-09-29
CA3013532A1 (en) 2017-09-08
ES2893755T3 (es) 2022-02-10
MX394179B (es) 2025-03-24
CN108778317A (zh) 2018-11-09
PH12018501844B1 (en) 2023-03-17
DK3423082T3 (da) 2021-10-11
AU2024201937A1 (en) 2024-04-11
EP3423082B1 (en) 2021-08-04
IL261169A (en) 2018-10-31
CN116327897A (zh) 2023-06-27
DK3423082T5 (da) 2023-02-06
CL2018002515A1 (es) 2018-11-09
WO2017149112A1 (en) 2017-09-08
US20180236038A1 (en) 2018-08-23
PH12018501844A1 (en) 2019-05-15
HRP20211492T1 (hr) 2021-12-24
MX2018010097A (es) 2018-11-09
US20170252408A1 (en) 2017-09-07
PL3423082T3 (pl) 2021-12-27
US9968659B2 (en) 2018-05-15
RU2018134061A3 (enExample) 2020-07-15
RU2018134061A (ru) 2020-04-06
KR102417455B1 (ko) 2022-07-06
MY195657A (en) 2023-02-03
IL261169B (en) 2019-11-28
JP2019507174A (ja) 2019-03-14
AU2017225841A1 (en) 2018-08-23
HUE055844T2 (hu) 2021-12-28
CA3013532C (en) 2019-07-23
EP3423082A1 (en) 2019-01-09
ZA201805538B (en) 2020-05-27
MA43704A (fr) 2021-04-14
BR112018067344A2 (pt) 2019-01-08
KR20180114168A (ko) 2018-10-17
SI3423082T1 (sl) 2021-10-29
RS62501B1 (sr) 2021-11-30

Similar Documents

Publication Publication Date Title
JP7221694B2 (ja) 心血管状態におけるセマグルチド
US12233114B2 (en) Method for treating diabetes
AU2024201937A1 (en) Liraglutide in cardiovascular conditions
JP2019535791A (ja) 血糖コントロールの改善並びに急性及び長期糖尿病合併症の低減のためのインスリンデグルデク
US20190091295A1 (en) Liraglutide in Renal Conditions
CN108883159A (zh) 用于糖尿病性足溃疡的利拉鲁肽
HK1259166A1 (en) Liraglutide in cardiovascular conditions
HK1259166B (en) Liraglutide in cardiovascular conditions
BR122025010585A2 (pt) Uso de semaglutida para reduzir o risco de um evento cardiovascular adverso maior (mace) em indivíduos com diabetes mellitus tipo 2 e alto risco cardiovascular