RU2737291C2 - Фармацевтические составы пегилированных липосом и факторов свертывания крови - Google Patents
Фармацевтические составы пегилированных липосом и факторов свертывания крови Download PDFInfo
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| WO2007002886A2 (en) * | 2005-06-29 | 2007-01-04 | The Research Foundation Of State University Of New York | Compositions and methods for less immunogenic pr0tein-lip1d complexes |
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| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US6326353B1 (en) | 1993-03-23 | 2001-12-04 | Sequus Pharmaceuticals, Inc. | Enhanced circulation effector composition and method |
| DE69418334T2 (de) | 1993-08-06 | 2000-01-27 | Opperbas Holding B.V., Amsterdam | Verfahren zur hohen beladung von vesikeln mit biopolymeren substanzen |
| IL113010A (en) * | 1994-03-31 | 1999-10-28 | Pharmacia & Upjohn Ab | Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| US6156337A (en) * | 1994-07-08 | 2000-12-05 | Opperbas Holding B.V. | Method for high loading of vesicles with biopolymeric substances |
| US6310183B1 (en) * | 1997-09-10 | 2001-10-30 | Novo Nordisk A/S | Coagulation factor VIIa composition |
| MXPA00010241A (es) * | 1998-04-27 | 2004-09-06 | Opperbas Holding Bv | Composicion farmaceutica que comprende el factor viii y liposomas neutrales.. |
| RU2250911C2 (ru) * | 1999-07-14 | 2005-04-27 | Элзэ Копэрейшн | Липосомальная композиция, нейтральный липополимер и способ увеличения времени циркуляции липосомы |
| AU2001256148A1 (en) * | 2000-05-03 | 2001-11-12 | Novo-Nordisk A/S | Subcutaneous administration of coagulation factor vii |
| US20030232075A1 (en) | 2002-05-06 | 2003-12-18 | University Of Minnesota, A Minnesota Corporation | Compositions for producing factor Xa |
| EP2099475B1 (en) * | 2007-01-03 | 2016-08-24 | Novo Nordisk Health Care AG | Subcutaneous administration of coagulation factor viia-related polypeptides |
| CA2701884A1 (en) | 2007-10-15 | 2009-04-23 | Wake Forest University Health Sciences | Methods and compositions for printing biologically compatible nanotube composites of autologous tissue |
| AU2010255391C1 (en) | 2009-06-03 | 2016-10-27 | Sequessome Technology Holdings Limited | Formulations for the treatment of deep tissue pain |
| MX336482B (es) | 2009-08-21 | 2016-01-21 | Henk-Andre Kroon | Formulaciones vesiculares. |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| GB201007357D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| TW201240664A (en) * | 2010-09-01 | 2012-10-16 | Portola Pharm Inc | Methods and formulations of treating thrombosis with betrixaban and a P-glycoprotein inhibitor |
| EP2838566A2 (en) * | 2012-04-16 | 2015-02-25 | Cantab Biopharmaceuticals Patents Limited | Optimised subcutaneous therapeutic agents |
| GB201417589D0 (en) * | 2014-10-06 | 2014-11-19 | Cantab Biopharmaceuticals Patents Ltd | Pharmaceutical Formulations |
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Patent Citations (2)
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| WO2004091723A1 (en) * | 2003-04-15 | 2004-10-28 | Opperbas Holding B.V. | Pharmaceutical composition comprising proteins and/or polypeptides and colloidal particles |
| WO2007002886A2 (en) * | 2005-06-29 | 2007-01-04 | The Research Foundation Of State University Of New York | Compositions and methods for less immunogenic pr0tein-lip1d complexes |
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| BARU M. ET AL., Factor VIII efficient and specific non-covalent binding to PEGylated liposomes enables prolongation of its circulation time and haemostatic efficacy, Thrombosis and haemostasis, schattauer gmbh, (20050601), vol. 93, N6, pages 1061-1068. PENG A. ET AL., PEGylation of a Factor VIII-Phosphatidylinositol Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice, AAPS Journal, American association of pharmaceutical scientists, (20111216), vol. 14, N1, doi:10.1208/S12248-011-9309-2, pages 35-42. * |
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