RU2720509C2 - Комбинированная терапия pac-1 - Google Patents
Комбинированная терапия pac-1 Download PDFInfo
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- RU2720509C2 RU2720509C2 RU2017146346A RU2017146346A RU2720509C2 RU 2720509 C2 RU2720509 C2 RU 2720509C2 RU 2017146346 A RU2017146346 A RU 2017146346A RU 2017146346 A RU2017146346 A RU 2017146346A RU 2720509 C2 RU2720509 C2 RU 2720509C2
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- vemurafenib
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| CN104507479B (zh) * | 2012-03-06 | 2017-08-18 | 伊利诺伊大学评议会 | 通过联合治疗的半胱天冬酶‑3酶原激活 |
| AU2016271527B2 (en) * | 2015-06-05 | 2021-09-02 | The Board Of Trustees Of The University Of Illinois | PAC-1 combination therapy |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| JP7349155B2 (ja) * | 2017-11-17 | 2023-09-22 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ | 二元的なｍｅｋシグナル伝達の低減によるがん治療 |
| WO2020072774A1 (en) * | 2018-10-05 | 2020-04-09 | The Board Of Trustees Of The University Of Illinois | Combination therapy for the treatment of uveal melanoma |
| EP3976062A4 (en) * | 2019-05-30 | 2023-06-14 | The Board Of Trustees Of The University Of Illinois | PROCASPASE-3 ACTIVATION AND IMMUNOTHERAPY FOR THE TREATMENT OF CANCER |
| WO2022006512A1 (en) * | 2020-07-02 | 2022-01-06 | The Board Of Regents Of The University Of Texas System | Methods of treatment for melanoma |
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| WO2010091383A2 (en) * | 2009-02-09 | 2010-08-12 | St. Jude Medical | Inflatable minimally invasive system for delivering and securing an annular implant |
| WO2010091382A1 (en) * | 2009-02-09 | 2010-08-12 | The Board Of Trustees Of The University Of Illinois | Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs |
| WO2013134398A1 (en) * | 2012-03-06 | 2013-09-12 | The Board Of Trustees Of The University Of Illinois | Procaspase combination therapy for glioblastoma |
| WO2013134307A1 (en) * | 2012-03-05 | 2013-09-12 | Ronald Mark Buck | Top mounting bottle container |
| WO2014072357A1 (en) * | 2012-11-06 | 2014-05-15 | Interna Technologies B.V. | Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway |
| WO2014138279A1 (en) * | 2013-03-05 | 2014-09-12 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
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| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| FR2757866B1 (fr) | 1996-12-30 | 2004-12-17 | Catalyse | Polymeres comportant des groupes ammoniums quaternaires, leur utilisation pour la fabrication d'un materiau a propretes antibacteriennes et leurs procedes de preparation |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US20070049602A1 (en) | 2005-05-26 | 2007-03-01 | The Board Of Trustees Of The University Of Illinois | Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3 |
| WO2008134474A2 (en) | 2007-04-27 | 2008-11-06 | The Board Of Trustees Of The University Of Illinois | Compositions and methods including cell death inducers and procaspase activation |
| US20140348819A1 (en) * | 2011-06-24 | 2014-11-27 | Dana-Farber Cancer Institute, Inc. | Methods of Treating Cancer |
| US8916705B2 (en) | 2011-10-14 | 2014-12-23 | The Board of Trustees of The University of Illilnois | Procaspase-activating compounds and compositions |
| AU2013225682B2 (en) | 2012-03-02 | 2016-04-14 | The Board Of Trustees Of The University Of Illinois | Potent anticancer activity via dual compound activation |
| CN104507479B (zh) * | 2012-03-06 | 2017-08-18 | 伊利诺伊大学评议会 | 通过联合治疗的半胱天冬酶‑3酶原激活 |
| US20150141470A1 (en) * | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| BR112015002357B1 (pt) | 2012-08-03 | 2022-03-15 | The Board Of Trustees Of The University Of Illinois | Compostos e composições ativadores de enzimas |
| EP3003316B1 (en) * | 2013-05-31 | 2020-07-22 | Merck Sharp & Dohme Corp. | Combination therapies for cancer |
| US11007174B2 (en) * | 2013-07-12 | 2021-05-18 | Piramal Enterprises Limited | Pharmaceutical combination for the treatment of melanoma |
| AU2016271527B2 (en) * | 2015-06-05 | 2021-09-02 | The Board Of Trustees Of The University Of Illinois | PAC-1 combination therapy |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010091383A2 (en) * | 2009-02-09 | 2010-08-12 | St. Jude Medical | Inflatable minimally invasive system for delivering and securing an annular implant |
| WO2010091382A1 (en) * | 2009-02-09 | 2010-08-12 | The Board Of Trustees Of The University Of Illinois | Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs |
| WO2013134307A1 (en) * | 2012-03-05 | 2013-09-12 | Ronald Mark Buck | Top mounting bottle container |
| WO2013134398A1 (en) * | 2012-03-06 | 2013-09-12 | The Board Of Trustees Of The University Of Illinois | Procaspase combination therapy for glioblastoma |
| WO2014072357A1 (en) * | 2012-11-06 | 2014-05-15 | Interna Technologies B.V. | Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway |
| WO2014138279A1 (en) * | 2013-03-05 | 2014-09-12 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
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