RU2718921C2 - Лечение жировой болезни печени с применением антагонистов глюкокортикоидных и минералокортикоидных рецепторов - Google Patents

Лечение жировой болезни печени с применением антагонистов глюкокортикоидных и минералокортикоидных рецепторов Download PDF

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RU2718921C2
RU2718921C2 RU2017114596A RU2017114596A RU2718921C2 RU 2718921 C2 RU2718921 C2 RU 2718921C2 RU 2017114596 A RU2017114596 A RU 2017114596A RU 2017114596 A RU2017114596 A RU 2017114596A RU 2718921 C2 RU2718921 C2 RU 2718921C2
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liver disease
fatty liver
liver
receptor
alcoholic
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RU2017114596A
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Russian (ru)
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RU2017114596A3 (enExample
RU2017114596A (ru
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Джозеф К. БЕЛАНОФФ
Хэйзел ХАНТ
Онно К. МЕЙЕР
ДЕН ХЁВЕЛ Хосе ВАН
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Корсепт Терапьютикс, Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2017114596A 2014-10-15 2015-10-14 Лечение жировой болезни печени с применением антагонистов глюкокортикоидных и минералокортикоидных рецепторов RU2718921C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462064358P 2014-10-15 2014-10-15
US62/064,358 2014-10-15
US201462092041P 2014-12-15 2014-12-15
US62/092,041 2014-12-15
PCT/US2015/055487 WO2016061195A1 (en) 2014-10-15 2015-10-14 Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists

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RU2017114596A RU2017114596A (ru) 2018-11-15
RU2017114596A3 RU2017114596A3 (enExample) 2019-05-08
RU2718921C2 true RU2718921C2 (ru) 2020-04-15

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RU2017114596A RU2718921C2 (ru) 2014-10-15 2015-10-14 Лечение жировой болезни печени с применением антагонистов глюкокортикоидных и минералокортикоидных рецепторов

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CN (2) CN111557942B (enExample)
AU (1) AU2015333645B2 (enExample)
BR (1) BR112017007860B1 (enExample)
CA (1) CA2964625C (enExample)
DK (1) DK3206692T3 (enExample)
ES (1) ES2978871T3 (enExample)
FI (1) FI3206692T3 (enExample)
IL (1) IL251729B (enExample)
MX (1) MX2017004943A (enExample)
NZ (1) NZ731060A (enExample)
PH (1) PH12017500710B1 (enExample)
PL (1) PL3206692T3 (enExample)
PT (1) PT3206692T (enExample)
RU (1) RU2718921C2 (enExample)
SG (1) SG11201703024VA (enExample)
UA (1) UA123537C2 (enExample)
WO (1) WO2016061195A1 (enExample)
ZA (1) ZA201702813B (enExample)

Cited By (1)

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RU2849641C1 (ru) * 2020-08-19 2025-10-28 ЕА Фарма Ко., Лтд. Терапевтическое средство против жировой болезни печени

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PH12017500710B1 (en) 2014-10-15 2024-01-17 Corcept Therapeutics Inc Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists
KR102589213B1 (ko) * 2018-06-04 2023-10-12 코어셉트 쎄라퓨틱스 인코포레이티드 피리미딘 사이클로헥세닐 글루코코르티코이드 수용체 조절제
US20220288091A1 (en) 2019-03-18 2022-09-15 Lynnette K. NIEMAN Method for Improving Insulin Sensitivity
BR112022022473A2 (pt) * 2020-05-06 2022-12-13 Corcept Therapeutics Inc Formulações de moduladores de receptor de glucocorticoide ciclo-hexil pirimidina
US11548856B2 (en) 2020-05-06 2023-01-10 Corcept Therapeutics Incorporated Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
KR102481705B1 (ko) * 2020-08-04 2022-12-27 연세대학교 산학협력단 트리아졸 유도체를 유효성분으로 포함하는 간 섬유증의 예방 또는 치료용 조성물
IL303881A (en) * 2020-12-21 2023-08-01 Corcept Therapeutics Inc Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators
EP4333848A4 (en) * 2021-05-05 2025-03-19 Corcept Therapeutics Incorporated Methods for reducing liver fat and treating fatty liver disease
WO2025174745A1 (en) * 2024-02-12 2025-08-21 Corcept Therapeutics Incorporated MIRICORILANT TREATMENT FOR FATTY LIVER DISEASES and its EFFECTS on LIVER FAT CONTENT, FATTY ACIDS, ACYLGLYCEROLS, and SECONDARY BILE ACIDS

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BR112017007860B1 (pt) 2023-03-07
FI3206692T3 (fi) 2024-05-06
EP4353310A2 (en) 2024-04-17
JP2017531013A (ja) 2017-10-19
PH12017500710B1 (en) 2024-01-17
JP6761410B2 (ja) 2020-09-23
CN111557942A (zh) 2020-08-21
US10238659B2 (en) 2019-03-26
AU2015333645A1 (en) 2017-05-04
RU2017114596A3 (enExample) 2019-05-08
US20210085682A1 (en) 2021-03-25
WO2016061195A1 (en) 2016-04-21
SG11201703024VA (en) 2017-05-30
ES2978871T3 (es) 2024-09-23
CA2964625A1 (en) 2016-04-21
BR112017007860A2 (pt) 2018-01-16
EP3206692A1 (en) 2017-08-23
EP3206692A4 (en) 2018-05-30
RU2017114596A (ru) 2018-11-15
US11590135B2 (en) 2023-02-28
US12226417B2 (en) 2025-02-18
PL3206692T3 (pl) 2024-07-22
PH12017500710A1 (en) 2017-10-09
ZA201702813B (en) 2019-05-29
KR102435956B1 (ko) 2022-08-23
PT3206692T (pt) 2024-04-30
IL251729A0 (en) 2017-06-29
US20190151318A1 (en) 2019-05-23
CN111557942B (zh) 2023-10-03
AU2015333645B2 (en) 2020-01-30
KR20170066646A (ko) 2017-06-14
IL251729B (en) 2020-03-31
DK3206692T3 (da) 2024-04-29
UA123537C2 (uk) 2021-04-21
CN107106562B (zh) 2020-08-18
EP4353310A3 (en) 2024-06-19
US10881660B2 (en) 2021-01-05
US20250221995A1 (en) 2025-07-10
US20230218621A1 (en) 2023-07-13
MX2017004943A (es) 2017-07-19
CN107106562A (zh) 2017-08-29
NZ731060A (en) 2023-07-28
CA2964625C (en) 2023-03-07
US20160106749A1 (en) 2016-04-21
EP3206692B1 (en) 2024-04-03

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