JP6761410B2 - グルココルチコイドおよびミネラル・コルチコイドレセプターアンタゴニストを使用する脂肪肝疾患の処置 - Google Patents

グルココルチコイドおよびミネラル・コルチコイドレセプターアンタゴニストを使用する脂肪肝疾患の処置 Download PDF

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JP6761410B2
JP6761410B2 JP2017520388A JP2017520388A JP6761410B2 JP 6761410 B2 JP6761410 B2 JP 6761410B2 JP 2017520388 A JP2017520388 A JP 2017520388A JP 2017520388 A JP2017520388 A JP 2017520388A JP 6761410 B2 JP6761410 B2 JP 6761410B2
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acid
compounds
liver disease
liver
compound
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JP2017531013A (ja
JP2017531013A5 (enExample
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ジョセフ ケー． ベラノフ，
ジョセフ ケー． ベラノフ，
ヘイゼル ハント，
ヘイゼル ハント，
オノ セー． メイヤ，
オノ セー． メイヤ，
デン ヘフェル， ホセ ファン
デン ヘフェル， ホセ ファン
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コーセプト セラピューティクス， インコーポレイテッド
コーセプト セラピューティクス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017520388A 2014-10-15 2015-10-14 グルココルチコイドおよびミネラル・コルチコイドレセプターアンタゴニストを使用する脂肪肝疾患の処置 Active JP6761410B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462064358P 2014-10-15 2014-10-15
US62/064,358 2014-10-15
US201462092041P 2014-12-15 2014-12-15
US62/092,041 2014-12-15
PCT/US2015/055487 WO2016061195A1 (en) 2014-10-15 2015-10-14 Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists

Publications (3)

Publication Number Publication Date
JP2017531013A JP2017531013A (ja) 2017-10-19
JP2017531013A5 JP2017531013A5 (enExample) 2018-11-22
JP6761410B2 true JP6761410B2 (ja) 2020-09-23

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JP2017520388A Active JP6761410B2 (ja) 2014-10-15 2015-10-14 グルココルチコイドおよびミネラル・コルチコイドレセプターアンタゴニストを使用する脂肪肝疾患の処置

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US (5) US10238659B2 (enExample)
EP (2) EP4353310A3 (enExample)
JP (1) JP6761410B2 (enExample)
KR (1) KR102435956B1 (enExample)
CN (2) CN111557942B (enExample)
AU (1) AU2015333645B2 (enExample)
BR (1) BR112017007860B1 (enExample)
CA (1) CA2964625C (enExample)
DK (1) DK3206692T3 (enExample)
ES (1) ES2978871T3 (enExample)
FI (1) FI3206692T3 (enExample)
IL (1) IL251729B (enExample)
MX (1) MX2017004943A (enExample)
NZ (1) NZ731060A (enExample)
PH (1) PH12017500710B1 (enExample)
PL (1) PL3206692T3 (enExample)
PT (1) PT3206692T (enExample)
RU (1) RU2718921C2 (enExample)
SG (1) SG11201703024VA (enExample)
UA (1) UA123537C2 (enExample)
WO (1) WO2016061195A1 (enExample)
ZA (1) ZA201702813B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12017500710B1 (en) 2014-10-15 2024-01-17 Corcept Therapeutics Inc Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists
KR102589213B1 (ko) * 2018-06-04 2023-10-12 코어셉트 쎄라퓨틱스 인코포레이티드 피리미딘 사이클로헥세닐 글루코코르티코이드 수용체 조절제
US20220288091A1 (en) 2019-03-18 2022-09-15 Lynnette K. NIEMAN Method for Improving Insulin Sensitivity
BR112022022473A2 (pt) * 2020-05-06 2022-12-13 Corcept Therapeutics Inc Formulações de moduladores de receptor de glucocorticoide ciclo-hexil pirimidina
US11548856B2 (en) 2020-05-06 2023-01-10 Corcept Therapeutics Incorporated Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
KR102481705B1 (ko) * 2020-08-04 2022-12-27 연세대학교 산학협력단 트리아졸 유도체를 유효성분으로 포함하는 간 섬유증의 예방 또는 치료용 조성물
IL303881A (en) * 2020-12-21 2023-08-01 Corcept Therapeutics Inc Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators
EP4333848A4 (en) * 2021-05-05 2025-03-19 Corcept Therapeutics Incorporated Methods for reducing liver fat and treating fatty liver disease
WO2025174745A1 (en) * 2024-02-12 2025-08-21 Corcept Therapeutics Incorporated MIRICORILANT TREATMENT FOR FATTY LIVER DISEASES and its EFFECTS on LIVER FAT CONTENT, FATTY ACIDS, ACYLGLYCEROLS, and SECONDARY BILE ACIDS

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US2153546A (en) 1936-07-29 1939-04-11 Universal Draft Gear Attachmen Hand brake actuating mechanism
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
GB0213745D0 (en) * 2002-06-14 2002-07-24 Univ Edinburgh Enzyme
EP1534273A4 (en) 2002-07-18 2007-08-22 Bristol Myers Squibb Co MODULATORS OF THE GLUCOCORTICOID RECEPTOR AND METHOD
AU2006247537B2 (en) 2005-05-18 2011-01-06 Merck Sharp & Dohme Corp. D-homoandrosta-17-yl-carbamate derivatives as selective glucocorticoid receptor ligands
US8389472B2 (en) * 2005-08-19 2013-03-05 Amylin Pharmaceuticals, Llc Exendin-4 to treat nonalcoholic steatohepatitis and nonalcoholic fatty liver disease
KR20080065617A (ko) * 2005-09-19 2008-07-14 존슨 앤드 존슨 파머슈티컬 리서치 앤드 디벨로프먼트 엘엘씨 글루코코티코이드 수용체 발현의 조절
GB0601092D0 (en) * 2006-01-19 2006-03-01 Daniolabs Ltd The Prevention Of Systemic Side-Effects Of Glucocorticoids
EP2032134B1 (en) 2006-05-09 2015-06-24 Genzyme Corporation Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
WO2008127591A2 (en) * 2007-04-13 2008-10-23 Schering Corporation Pyrimidinedione derivatives and use thereof
US8003689B2 (en) 2008-06-20 2011-08-23 Gtx, Inc. Metabolites of selective androgen receptor modulators and methods of use thereof
JP5511942B2 (ja) 2009-04-03 2014-06-04 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 組成物及びその使用
EP2685827B1 (en) 2011-03-18 2016-02-03 Corcept Therapeutics, Inc. Pyrimidine cyclohexyl glucocorticoid receptor modulators
PH12017500710B1 (en) 2014-10-15 2024-01-17 Corcept Therapeutics Inc Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists

Also Published As

Publication number Publication date
BR112017007860B1 (pt) 2023-03-07
FI3206692T3 (fi) 2024-05-06
EP4353310A2 (en) 2024-04-17
JP2017531013A (ja) 2017-10-19
PH12017500710B1 (en) 2024-01-17
CN111557942A (zh) 2020-08-21
US10238659B2 (en) 2019-03-26
AU2015333645A1 (en) 2017-05-04
RU2017114596A3 (enExample) 2019-05-08
US20210085682A1 (en) 2021-03-25
WO2016061195A1 (en) 2016-04-21
SG11201703024VA (en) 2017-05-30
ES2978871T3 (es) 2024-09-23
CA2964625A1 (en) 2016-04-21
BR112017007860A2 (pt) 2018-01-16
EP3206692A1 (en) 2017-08-23
EP3206692A4 (en) 2018-05-30
RU2017114596A (ru) 2018-11-15
US11590135B2 (en) 2023-02-28
US12226417B2 (en) 2025-02-18
PL3206692T3 (pl) 2024-07-22
PH12017500710A1 (en) 2017-10-09
ZA201702813B (en) 2019-05-29
KR102435956B1 (ko) 2022-08-23
PT3206692T (pt) 2024-04-30
IL251729A0 (en) 2017-06-29
US20190151318A1 (en) 2019-05-23
CN111557942B (zh) 2023-10-03
AU2015333645B2 (en) 2020-01-30
KR20170066646A (ko) 2017-06-14
IL251729B (en) 2020-03-31
DK3206692T3 (da) 2024-04-29
UA123537C2 (uk) 2021-04-21
CN107106562B (zh) 2020-08-18
RU2718921C2 (ru) 2020-04-15
EP4353310A3 (en) 2024-06-19
US10881660B2 (en) 2021-01-05
US20250221995A1 (en) 2025-07-10
US20230218621A1 (en) 2023-07-13
MX2017004943A (es) 2017-07-19
CN107106562A (zh) 2017-08-29
NZ731060A (en) 2023-07-28
CA2964625C (en) 2023-03-07
US20160106749A1 (en) 2016-04-21
EP3206692B1 (en) 2024-04-03

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