RU2710730C2 - Конструкции мультиспецифичных антител - Google Patents

Конструкции мультиспецифичных антител Download PDF

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Publication number
RU2710730C2
RU2710730C2 RU2017102312A RU2017102312A RU2710730C2 RU 2710730 C2 RU2710730 C2 RU 2710730C2 RU 2017102312 A RU2017102312 A RU 2017102312A RU 2017102312 A RU2017102312 A RU 2017102312A RU 2710730 C2 RU2710730 C2 RU 2710730C2
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RU
Russia
Prior art keywords
domain
antibody
igg
dsfv
dsscfv
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RU2017102312A
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English (en)
Russian (ru)
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RU2017102312A3 (enExample
RU2017102312A (ru
Inventor
Паллави Бхатта
Эмма ДЕЙВ
Сэм Филип Хейвуд
Дэвид Пол Хамфриз
Original Assignee
Юсб Биофарма Спрл
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Application filed by Юсб Биофарма Спрл filed Critical Юсб Биофарма Спрл
Publication of RU2017102312A publication Critical patent/RU2017102312A/ru
Publication of RU2017102312A3 publication Critical patent/RU2017102312A3/ru
Application granted granted Critical
Publication of RU2710730C2 publication Critical patent/RU2710730C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2017102312A 2014-06-26 2015-06-25 Конструкции мультиспецифичных антител RU2710730C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1411420.1 2014-06-26
GBGB1411420.1A GB201411420D0 (en) 2014-06-26 2014-06-26 Antibody constructs
PCT/EP2015/064450 WO2015197789A1 (en) 2014-06-26 2015-06-25 Multi-specific antibody constructs

Publications (3)

Publication Number Publication Date
RU2017102312A RU2017102312A (ru) 2018-07-26
RU2017102312A3 RU2017102312A3 (enExample) 2019-02-15
RU2710730C2 true RU2710730C2 (ru) 2020-01-10

Family

ID=51410201

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017102312A RU2710730C2 (ru) 2014-06-26 2015-06-25 Конструкции мультиспецифичных антител

Country Status (10)

Country Link
US (1) US20170198062A1 (enExample)
EP (1) EP3161008B1 (enExample)
JP (1) JP2017528117A (enExample)
CN (1) CN106459217A (enExample)
BR (1) BR112016030424A2 (enExample)
CA (1) CA2953638A1 (enExample)
ES (1) ES2763525T3 (enExample)
GB (1) GB201411420D0 (enExample)
RU (1) RU2710730C2 (enExample)
WO (1) WO2015197789A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014006175B1 (pt) * 2011-09-16 2020-02-11 Ucb Pharma S.A. Anticorpos capazes de neutralisar as exotoxinas principais tcda e tcdb de clostridium difficile
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201412659D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201601075D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies molecules
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
GB201601077D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
GB201521383D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl And Ucb Celltech Method
GB201521391D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
GB201521382D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521393D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
WO2018191438A1 (en) 2017-04-11 2018-10-18 Inhibrx, Inc. Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same
CN109970856B (zh) 2017-12-27 2022-08-23 信达生物制药(苏州)有限公司 抗lag-3抗体及其用途
TW201930349A (zh) * 2018-01-08 2019-08-01 大陸商南京傳奇生物科技有限公司 多重特異性抗原結合蛋白及其使用方法
IL277863B2 (en) 2018-04-11 2026-02-01 Inhibrx Inc Multispecific polypeptide constructs with forced CD3 binding and related methods and uses
CA3105891A1 (en) 2018-07-24 2020-01-30 Inhibrx, Inc. Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same
EP3864045A2 (en) 2018-10-11 2021-08-18 Inhibrx, Inc. Dll3 single domain antibodies and therapeutic compositions thereof
CN113518647A (zh) 2018-10-11 2021-10-19 印希比股份有限公司 5t4单域抗体及其治疗性组合物
GB201919061D0 (en) 2019-12-20 2020-02-05 Ucb Biopharma Sprl Multi-specific antibody
GB201919058D0 (en) 2019-12-20 2020-02-05 Ucb Biopharma Sprl Multi-specific antibodies
GB201919062D0 (en) 2019-12-20 2020-02-05 Ucb Biopharma Sprl Antibody
GB202001447D0 (en) 2020-02-03 2020-03-18 Ucb Biopharma Sprl Antibodies
JP7641292B2 (ja) * 2020-03-03 2025-03-06 システィミューン， インク． 抗ｃｄ１９抗体、その使用方法及び製造方法
EP4126936A1 (en) 2020-03-27 2023-02-08 UCB Biopharma SRL Autonomous knob domain peptides
KR20230117588A (ko) 2020-12-07 2023-08-08 유씨비 바이오파마 에스알엘 다중특이적 항체 및 항체 조합
GB202111905D0 (en) 2021-08-19 2021-10-06 UCB Biopharma SRL Antibodies

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2246538C2 (ru) * 1998-05-20 2005-02-20 Чугаи Сейяку Кабусики Кайся Способ и набор для выявления гена, кодирующего мембраносвязанный белок, вектор (варианты)
US20100081796A1 (en) * 2008-09-26 2010-04-01 Ulrich Brinkmann Bispecific anti-egfr/anti-igf-1r antibodies
US8193321B2 (en) * 2008-09-03 2012-06-05 Genentech, Inc. Multispecific antibodies
EP2543680A1 (en) * 2011-07-07 2013-01-09 Centre National de la Recherche Scientifique Multispecific mutated antibody Fab fragments
US20140051833A1 (en) * 2012-03-13 2014-02-20 Novlmmune S.A. Readily Isolated Bispecific Antibodies with Native Immunoglobulin Format

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200732350A (en) * 2005-10-21 2007-09-01 Amgen Inc Methods for generating monovalent IgG
US8629246B2 (en) * 2007-09-26 2014-01-14 Ucb Pharma S.A. Dual specificity antibody fusions
SG177560A1 (en) * 2009-07-06 2012-03-29 Hoffmann La Roche Bi-specific digoxigenin binding antibodies
RU2013110875A (ru) * 2010-08-24 2014-09-27 Ф.Хоффманн-Ля Рош Аг БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЙ ДИСУЛЬФИДОМ ФРАГМЕНТ Fv

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2246538C2 (ru) * 1998-05-20 2005-02-20 Чугаи Сейяку Кабусики Кайся Способ и набор для выявления гена, кодирующего мембраносвязанный белок, вектор (варианты)
US8193321B2 (en) * 2008-09-03 2012-06-05 Genentech, Inc. Multispecific antibodies
US20100081796A1 (en) * 2008-09-26 2010-04-01 Ulrich Brinkmann Bispecific anti-egfr/anti-igf-1r antibodies
EP2543680A1 (en) * 2011-07-07 2013-01-09 Centre National de la Recherche Scientifique Multispecific mutated antibody Fab fragments
US20140051833A1 (en) * 2012-03-13 2014-02-20 Novlmmune S.A. Readily Isolated Bispecific Antibodies with Native Immunoglobulin Format

Also Published As

Publication number Publication date
ES2763525T3 (es) 2020-05-29
CN106459217A (zh) 2017-02-22
US20170198062A1 (en) 2017-07-13
RU2017102312A3 (enExample) 2019-02-15
EP3161008B1 (en) 2019-09-25
EP3161008A1 (en) 2017-05-03
BR112016030424A2 (pt) 2017-10-24
GB201411420D0 (en) 2014-08-13
WO2015197789A1 (en) 2015-12-30
JP2017528117A (ja) 2017-09-28
CA2953638A1 (en) 2015-12-30
RU2017102312A (ru) 2018-07-26

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