CN106459217A - 多特异性抗体构建体 - Google Patents
多特异性抗体构建体 Download PDFInfo
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- CN106459217A CN106459217A CN201580034555.0A CN201580034555A CN106459217A CN 106459217 A CN106459217 A CN 106459217A CN 201580034555 A CN201580034555 A CN 201580034555A CN 106459217 A CN106459217 A CN 106459217A
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
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- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
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| GB1411420.1 | 2014-06-26 | ||
| PCT/EP2015/064450 WO2015197789A1 (en) | 2014-06-26 | 2015-06-25 | Multi-specific antibody constructs |
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|---|---|
| CN106459217A true CN106459217A (zh) | 2017-02-22 |
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| US (1) | US20170198062A1 (enExample) |
| EP (1) | EP3161008B1 (enExample) |
| JP (1) | JP2017528117A (enExample) |
| CN (1) | CN106459217A (enExample) |
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| GB (1) | GB201411420D0 (enExample) |
| RU (1) | RU2710730C2 (enExample) |
| WO (1) | WO2015197789A1 (enExample) |
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| PT2758432T (pt) * | 2011-09-16 | 2019-06-14 | Ucb Biopharma Sprl | Anticorpos neutralizantes contra as exotoxinas principais tcda e tcdb de clostridium difficile |
| GB201409558D0 (en) | 2014-05-29 | 2014-07-16 | Ucb Biopharma Sprl | Method |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| GB201412659D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
| GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
| GB201601075D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies molecules |
| GB201521391D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521393D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521389D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Method |
| GB201521383D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl And Ucb Celltech | Method |
| GB201521382D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| KR20240165484A (ko) | 2017-04-11 | 2024-11-22 | 인히브릭스 바이오사이언스, 인크. | 제한된 cd3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 이를 이용한 방법 |
| CN109970856B (zh) | 2017-12-27 | 2022-08-23 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| CN111836832A (zh) * | 2018-01-08 | 2020-10-27 | 南京传奇生物科技有限公司 | 多特异性抗原结合蛋白及其使用方法 |
| EP3773913A1 (en) | 2018-04-11 | 2021-02-17 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| US12195533B2 (en) | 2018-07-24 | 2025-01-14 | Inhibrx Biosciences, Inc. | Multispecific polypeptide constructs containing a constrained CD3 binding domain and a receptor binding region and methods of using the same |
| TW202028245A (zh) | 2018-10-11 | 2020-08-01 | 美商英伊布里克斯公司 | Dll3單域抗體及其治療性組合物 |
| GB201919061D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Multi-specific antibody |
| GB201919058D0 (en) * | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Multi-specific antibodies |
| GB201919062D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Antibody |
| GB202001447D0 (en) | 2020-02-03 | 2020-03-18 | Ucb Biopharma Sprl | Antibodies |
| CN119143877A (zh) * | 2020-03-03 | 2024-12-17 | 成都百利多特生物药业有限责任公司 | 抗cd19抗体及其使用和制备方法 |
| BR112022019047A2 (pt) | 2020-03-27 | 2022-11-01 | UCB Biopharma SRL | Peptídeos de domínio knob autônomos |
| PE20231953A1 (es) | 2020-12-07 | 2023-12-06 | UCB Biopharma SRL | Anticuerpos multiespecificos y combinaciones de anticuerpos |
| GB202111905D0 (en) | 2021-08-19 | 2021-10-06 | UCB Biopharma SRL | Antibodies |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100081796A1 (en) * | 2008-09-26 | 2010-04-01 | Ulrich Brinkmann | Bispecific anti-egfr/anti-igf-1r antibodies |
| WO2012025530A1 (en) * | 2010-08-24 | 2012-03-01 | F. Hoffmann-La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
| EP2535349A1 (en) * | 2007-09-26 | 2012-12-19 | UCB Pharma S.A. | Dual specificity antibody fusions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2246538C2 (ru) * | 1998-05-20 | 2005-02-20 | Чугаи Сейяку Кабусики Кайся | Способ и набор для выявления гена, кодирующего мембраносвязанный белок, вектор (варианты) |
| TW200732350A (en) * | 2005-10-21 | 2007-09-01 | Amgen Inc | Methods for generating monovalent IgG |
| WO2010027981A1 (en) * | 2008-09-03 | 2010-03-11 | Genentech, Inc. | Multispecific antibodies |
| ES2536996T3 (es) * | 2009-07-06 | 2015-06-01 | F. Hoffmann-La Roche Ag | Anticuerpos biespecíficos de unión a digoxigenina |
| EP2543680A1 (en) * | 2011-07-07 | 2013-01-09 | Centre National de la Recherche Scientifique | Multispecific mutated antibody Fab fragments |
| CA2867020C (en) * | 2012-03-13 | 2022-11-15 | Novimmune S.A. | Readily isolated bispecific antibodies with native immunoglobulin format |
-
2014
- 2014-06-26 GB GBGB1411420.1A patent/GB201411420D0/en not_active Ceased
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2015
- 2015-06-25 CA CA2953638A patent/CA2953638A1/en not_active Abandoned
- 2015-06-25 EP EP15733415.2A patent/EP3161008B1/en active Active
- 2015-06-25 RU RU2017102312A patent/RU2710730C2/ru active
- 2015-06-25 ES ES15733415T patent/ES2763525T3/es active Active
- 2015-06-25 CN CN201580034555.0A patent/CN106459217A/zh active Pending
- 2015-06-25 WO PCT/EP2015/064450 patent/WO2015197789A1/en not_active Ceased
- 2015-06-25 JP JP2016575026A patent/JP2017528117A/ja active Pending
- 2015-06-25 BR BR112016030424A patent/BR112016030424A2/pt not_active Application Discontinuation
- 2015-06-25 US US15/321,061 patent/US20170198062A1/en not_active Abandoned
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2535349A1 (en) * | 2007-09-26 | 2012-12-19 | UCB Pharma S.A. | Dual specificity antibody fusions |
| US20100081796A1 (en) * | 2008-09-26 | 2010-04-01 | Ulrich Brinkmann | Bispecific anti-egfr/anti-igf-1r antibodies |
| WO2012025530A1 (en) * | 2010-08-24 | 2012-03-01 | F. Hoffmann-La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
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| REBECCA CROASDALE等: "Development of tetravalent IgG1 dual targeting IGF-1R-EGFR antibodies with potent tumor inhibition", 《ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS》 * |
| S.METZ等: "Bispecific antibody derivates with restricted binding functionalities that are activated by proteolytic processing", 《PROTEIN ENGINEERING DESIGN AND SELECTION》 * |
| SCHANZER J等: "Dvelopment of Tetravalent,Bispecific CCR5 Antibodies with Acivity against CCR5 Monoclonal Antibody-Resistant HIV-1 Strains", 《ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,AMERICAN SOCIETY FOR MICROBIOLOGY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017102312A (ru) | 2018-07-26 |
| EP3161008B1 (en) | 2019-09-25 |
| CA2953638A1 (en) | 2015-12-30 |
| RU2017102312A3 (enExample) | 2019-02-15 |
| ES2763525T3 (es) | 2020-05-29 |
| WO2015197789A1 (en) | 2015-12-30 |
| US20170198062A1 (en) | 2017-07-13 |
| EP3161008A1 (en) | 2017-05-03 |
| RU2710730C2 (ru) | 2020-01-10 |
| GB201411420D0 (en) | 2014-08-13 |
| JP2017528117A (ja) | 2017-09-28 |
| BR112016030424A2 (pt) | 2017-10-24 |
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