CA2953638A1 - Multi-specific antibody constructs - Google Patents
Multi-specific antibody constructs Download PDFInfo
- Publication number
- CA2953638A1 CA2953638A1 CA2953638A CA2953638A CA2953638A1 CA 2953638 A1 CA2953638 A1 CA 2953638A1 CA 2953638 A CA2953638 A CA 2953638A CA 2953638 A CA2953638 A CA 2953638A CA 2953638 A1 CA2953638 A1 CA 2953638A1
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- Prior art keywords
- specific antibody
- antibody molecule
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- antibody
- igg
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
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- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
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| PCT/EP2015/064450 WO2015197789A1 (en) | 2014-06-26 | 2015-06-25 | Multi-specific antibody constructs |
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| CA2953638A1 true CA2953638A1 (en) | 2015-12-30 |
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| EP3619235A1 (en) | 2017-04-11 | 2020-03-11 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same |
| CN109970856B (zh) | 2017-12-27 | 2022-08-23 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| AU2019205406A1 (en) * | 2018-01-08 | 2020-08-27 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| SG11202009804RA (en) * | 2018-04-11 | 2020-11-27 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| TW202035451A (zh) | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
| CA3115089A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
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2015
- 2015-06-25 ES ES15733415T patent/ES2763525T3/es active Active
- 2015-06-25 US US15/321,061 patent/US20170198062A1/en not_active Abandoned
- 2015-06-25 EP EP15733415.2A patent/EP3161008B1/en active Active
- 2015-06-25 RU RU2017102312A patent/RU2710730C2/ru active
- 2015-06-25 JP JP2016575026A patent/JP2017528117A/ja active Pending
- 2015-06-25 CN CN201580034555.0A patent/CN106459217A/zh active Pending
- 2015-06-25 WO PCT/EP2015/064450 patent/WO2015197789A1/en not_active Ceased
- 2015-06-25 CA CA2953638A patent/CA2953638A1/en not_active Abandoned
- 2015-06-25 BR BR112016030424A patent/BR112016030424A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016030424A2 (pt) | 2017-10-24 |
| RU2017102312A3 (enExample) | 2019-02-15 |
| RU2710730C2 (ru) | 2020-01-10 |
| EP3161008B1 (en) | 2019-09-25 |
| GB201411420D0 (en) | 2014-08-13 |
| US20170198062A1 (en) | 2017-07-13 |
| WO2015197789A1 (en) | 2015-12-30 |
| RU2017102312A (ru) | 2018-07-26 |
| ES2763525T3 (es) | 2020-05-29 |
| JP2017528117A (ja) | 2017-09-28 |
| CN106459217A (zh) | 2017-02-22 |
| EP3161008A1 (en) | 2017-05-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20211123 |
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| FZDE | Discontinued |
Effective date: 20211123 |