RU2696497C2 - Композиция с факторами роста для применения в интраназальном лечении нейродегенеративного заболевания или других заболеваний центральной нервной системы и способ ее получения - Google Patents
Композиция с факторами роста для применения в интраназальном лечении нейродегенеративного заболевания или других заболеваний центральной нервной системы и способ ее получения Download PDFInfo
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- RU2696497C2 RU2696497C2 RU2015104076A RU2015104076A RU2696497C2 RU 2696497 C2 RU2696497 C2 RU 2696497C2 RU 2015104076 A RU2015104076 A RU 2015104076A RU 2015104076 A RU2015104076 A RU 2015104076A RU 2696497 C2 RU2696497 C2 RU 2696497C2
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| ES201200810A ES2442242B1 (es) | 2012-08-09 | 2012-08-09 | Composición con factores de crecimiento destinada al tratamiento intranasal de una enfermedad neurodegenerativa u otra patología del sistema nervioso central, y su método de fabricación. |
| ESP201200810 | 2012-08-09 | ||
| PCT/ES2013/000176 WO2014023860A1 (es) | 2012-08-09 | 2013-07-19 | Composición con factores de crecimiento obtenidos a partir del plasma sanguíneo destinada al tratamiento de enfermedades neurodegenerativas |
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| RU2015104076A RU2015104076A (ru) | 2016-09-27 |
| RU2696497C2 true RU2696497C2 (ru) | 2019-08-02 |
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| RU2015104076A RU2696497C2 (ru) | 2012-08-09 | 2013-07-19 | Композиция с факторами роста для применения в интраназальном лечении нейродегенеративного заболевания или других заболеваний центральной нервной системы и способ ее получения |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2784952C2 (ru) * | 2020-12-24 | 2022-12-01 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр травматологии и ортопедии имени Н.Н. Приорова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТО им. Н.Н. Приорова" Минздрава России) | In vivo биореактор для восстановления целостности проводящих путей спинного мозга после анатомического перерыва и стимуляции нейрорегенерации при травматической болезни спинного мозга |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CL2016003282A1 (es) | 2016-12-21 | 2017-08-18 | Univ Chile | Virus aav/igf2, método de tratamiento genético y su uso en enfermedades relacionadas con mal plegamiento de proteínas tal como la enfermedad de huntington |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1066838A1 (en) * | 1999-01-26 | 2001-01-10 | Eduardo Anitua Aldecoa | Bone tissue regenerating composition |
| ES2369945A1 (es) * | 2011-07-29 | 2011-12-09 | Eduardo Anitua Aldecoa | Procedimiento de obtención de una composición que contiene factores de crecimiento a partir de un compuesto sanguíneo, y composición obtenible por dicho procedimiento. |
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| ES2252993T3 (es) * | 1998-12-09 | 2006-05-16 | Chiron Corporation | Administracion de agentes neurotroficos al sistema nervioso central. |
| US7608258B2 (en) * | 2002-04-13 | 2009-10-27 | Allan Mishra | Method for treatment of tendinosis using platelet rich plasma |
| US6811777B2 (en) * | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
| ES2221770B2 (es) | 2002-04-19 | 2006-07-16 | Eduardo Anitua Aldecoa | Metodo de preparacion de un compuesto para la regeneracion de tejidos. |
| US20060004189A1 (en) * | 2004-07-02 | 2006-01-05 | James Gandy | Compositions for treating wounds and processes for their preparation |
| WO2007025249A2 (en) * | 2005-08-26 | 2007-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treatment of headaches by administration of oxytocin |
| JP2011504163A (ja) * | 2007-06-08 | 2011-02-03 | ヘルスパートナーズ リサーチ ファウンデーション | 中枢神経系への治療化合物の標的化を高めるための薬学的組成物および方法 |
| ES2333498B1 (es) * | 2007-08-02 | 2011-01-10 | Biotechnology Institute, I Mas D, S.L. | Metodo y compuesto para el tratamiento de enfermedades o dolencias articulares o para el tratamiento de la piel con fines esteticos u otros, y el metodo de preparacion del compuesto. |
| BRPI0816784A8 (pt) * | 2007-09-14 | 2016-01-19 | Scil Tech Gmbh | Fatores neuro-endócrinos para o tratamento de doenças degenerativas |
| PE20120317A1 (es) * | 2009-05-14 | 2012-04-16 | Biotechnology Inst I Mas D Sl | Metodo para la preparacion de al menos un compuesto a partir de sangre |
| KR101114712B1 (ko) * | 2009-10-23 | 2012-02-29 | 세원셀론텍(주) | 염화칼슘용액과 제1형 콜라겐으로 혈소판풍부혈장(ｐｒｐ)을 활성화하여 조직재생을 유도하는 조성물의 제조방법 |
-
2012
- 2012-08-09 ES ES201200810A patent/ES2442242B1/es not_active Expired - Fee Related
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2013
- 2013-07-19 TW TW102125858A patent/TWI649084B/zh not_active IP Right Cessation
- 2013-07-19 CN CN201380041280.4A patent/CN104519961A/zh active Pending
- 2013-07-19 BR BR112015002760A patent/BR112015002760A2/pt not_active Application Discontinuation
- 2013-07-19 EP EP13756518.0A patent/EP2883569B1/en not_active Not-in-force
- 2013-07-19 PE PE2015000116A patent/PE20150616A1/es not_active Application Discontinuation
- 2013-07-19 CA CA2881075A patent/CA2881075A1/en not_active Abandoned
- 2013-07-19 RU RU2015104076A patent/RU2696497C2/ru active
- 2013-07-19 JP JP2015525915A patent/JP6339568B2/ja not_active Expired - Fee Related
- 2013-07-19 KR KR1020157001551A patent/KR102149162B1/ko not_active Expired - Fee Related
- 2013-07-19 WO PCT/ES2013/000176 patent/WO2014023860A1/es not_active Ceased
- 2013-07-19 ES ES13756518.0T patent/ES2662385T3/es active Active
- 2013-07-19 MX MX2015001677A patent/MX357828B/es active IP Right Grant
- 2013-08-08 AR ARP130102835A patent/AR092086A1/es unknown
- 2013-08-08 US US13/962,340 patent/US20140044795A1/en not_active Abandoned
-
2014
- 2014-12-23 CL CL2014003510A patent/CL2014003510A1/es unknown
- 2014-12-31 IN IN2675MUN2014 patent/IN2014MN02675A/en unknown
-
2015
- 2015-01-20 CO CO15010369A patent/CO7170177A2/es unknown
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1066838A1 (en) * | 1999-01-26 | 2001-01-10 | Eduardo Anitua Aldecoa | Bone tissue regenerating composition |
| ES2369945A1 (es) * | 2011-07-29 | 2011-12-09 | Eduardo Anitua Aldecoa | Procedimiento de obtención de una composición que contiene factores de crecimiento a partir de un compuesto sanguíneo, y composición obtenible por dicho procedimiento. |
Non-Patent Citations (3)
| Title |
|---|
| DE ROSA R., et al., Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc Natl Acad Sci US A. 2005 Mar 8;102(10):3811-6. Epub 200 * |
| HARGUINDEY S., et al., Growth and trophic factors, pH and the Na+/H+ exchanger in Alzheimer's disease, other neurodegenerative diseases and cancer: new therapeutic possibilities and potential dangers. Curr Alzheimer Res. 2007 Feb;4(1):53-65. 5 Feb 23. * |
| HARGUINDEY S., et al., Growth and trophic factors, pH and the Na+/H+ exchanger in Alzheimer's disease, other neurodegenerative diseases and cancer: new therapeutic possibilities and potential dangers. Curr Alzheimer Res. 2007 Feb;4(1):53-65. DE ROSA R., et al., Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc Natl Acad Sci US A. 2005 Mar 8;102(10):3811-6. Epub 2005 Feb 23. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2784952C2 (ru) * | 2020-12-24 | 2022-12-01 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр травматологии и ортопедии имени Н.Н. Приорова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТО им. Н.Н. Приорова" Минздрава России) | In vivo биореактор для восстановления целостности проводящих путей спинного мозга после анатомического перерыва и стимуляции нейрорегенерации при травматической болезни спинного мозга |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201408310A (zh) | 2014-03-01 |
| MX2015001677A (es) | 2015-04-10 |
| KR102149162B1 (ko) | 2020-08-31 |
| WO2014023860A1 (es) | 2014-02-13 |
| ES2662385T3 (es) | 2018-04-06 |
| ES2442242A1 (es) | 2014-02-10 |
| JP6339568B2 (ja) | 2018-06-06 |
| US20160184360A1 (en) | 2016-06-30 |
| IN2014MN02675A (enExample) | 2015-08-28 |
| AR092086A1 (es) | 2015-03-25 |
| CO7170177A2 (es) | 2015-01-28 |
| KR20150040860A (ko) | 2015-04-15 |
| ES2442242B1 (es) | 2014-11-25 |
| EP2883569B1 (en) | 2017-12-20 |
| CL2014003510A1 (es) | 2015-05-04 |
| TWI649084B (zh) | 2019-02-01 |
| RU2015104076A (ru) | 2016-09-27 |
| MX357828B (es) | 2018-07-25 |
| JP2015524464A (ja) | 2015-08-24 |
| CN104519961A (zh) | 2015-04-15 |
| EP2883569A1 (en) | 2015-06-17 |
| US20140044795A1 (en) | 2014-02-13 |
| CA2881075A1 (en) | 2014-02-13 |
| BR112015002760A2 (pt) | 2020-04-22 |
| PE20150616A1 (es) | 2015-05-25 |
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