RU2688919C1 - Изоксазолиновые композиции и их применение в провилактике или лечении паразитарных инвазий животных - Google Patents

Изоксазолиновые композиции и их применение в провилактике или лечении паразитарных инвазий животных Download PDF

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Publication number
RU2688919C1
RU2688919C1 RU2016129474A RU2016129474A RU2688919C1 RU 2688919 C1 RU2688919 C1 RU 2688919C1 RU 2016129474 A RU2016129474 A RU 2016129474A RU 2016129474 A RU2016129474 A RU 2016129474A RU 2688919 C1 RU2688919 C1 RU 2688919C1
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Prior art keywords
drinking water
polysorbate
polysorbate surfactant
surfactant
fluralaner
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RU2016129474A
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English (en)
Russian (ru)
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RU2016129474A (ru
Inventor
Анн ЛЕЭ
Анни ФЛОШЛЕ-СИГОНЬО
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Интервет Интернэшнл Б.В.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2016129474A 2013-12-20 2014-12-19 Изоксазолиновые композиции и их применение в провилактике или лечении паразитарных инвазий животных RU2688919C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13199006.1 2013-12-20
EP13199006 2013-12-20
PCT/EP2014/078634 WO2015091898A1 (en) 2013-12-20 2014-12-19 Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2019114223A Division RU2791637C2 (ru) 2013-12-20 2014-12-19 Изоксазолиновые композиции и их применение в профилактике или лечении паразитарных инвазий животных

Publications (2)

Publication Number Publication Date
RU2016129474A RU2016129474A (ru) 2018-01-25
RU2688919C1 true RU2688919C1 (ru) 2019-05-23

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Family Applications (1)

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RU2016129474A RU2688919C1 (ru) 2013-12-20 2014-12-19 Изоксазолиновые композиции и их применение в провилактике или лечении паразитарных инвазий животных

Country Status (11)

Country Link
US (4) US10456358B2 (enExample)
EP (2) EP3082867B1 (enExample)
JP (1) JP6581586B2 (enExample)
CN (2) CN105813651B (enExample)
ES (2) ES3036365T3 (enExample)
HU (2) HUE072822T2 (enExample)
MX (1) MX373872B (enExample)
PL (2) PL4306168T3 (enExample)
PT (1) PT4306168T (enExample)
RU (1) RU2688919C1 (enExample)
WO (1) WO2015091898A1 (enExample)

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MX383746B (es) 2015-06-23 2025-03-14 Intervet Int Bv Solución de isoxazolina que contiene vitamina e para usarse con agua potable desinfectada.
WO2018039508A1 (en) * 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
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CA3081653A1 (en) * 2017-11-07 2019-05-16 Intervet International B.V. Process for preparing large size isoxazoline particles
EP4316522A3 (en) * 2017-11-07 2024-04-03 Intervet International B.V. Injectable isoxazoline pharmaceutical compositions and their use against parasite infestation
AU2018385766B2 (en) 2017-12-15 2022-12-01 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations and methods for treating blepharitis
US11533893B2 (en) 2017-12-20 2022-12-27 Intervet Inc. Method and system for external fish parasite monitoring in aquaculture
CN111526716B (zh) 2017-12-20 2023-04-04 英特维特国际股份有限公司 用于水产养殖中的鱼外部寄生虫监测的方法和系统
CN111511201A (zh) * 2017-12-20 2020-08-07 英特维特国际股份有限公司 用于水产养殖中的鱼外部寄生虫监测的系统
CN111511202A (zh) * 2017-12-20 2020-08-07 英特维特国际股份有限公司 用于水产养殖中的鱼外部寄生虫监测的系统
CN111491508B (zh) * 2017-12-20 2022-05-24 英特维特国际股份有限公司 用于水产养殖中的鱼外部寄生虫监测的系统
KR102142916B1 (ko) * 2018-08-17 2020-08-10 부산대학교 산학협력단 상향식 방법을 통한 난용성 약물을 포함하는 나노현탁액의 제조방법 및 이로 제조된 나노현탁액
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
JP2022537389A (ja) * 2019-06-19 2022-08-25 ターサス ファーマシューティカルズ， インコーポレイテッド 眼瞼炎を治療するためのイソキサゾリン寄生虫駆除剤の処方及び方法
US20220249445A1 (en) * 2019-06-19 2022-08-11 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations and methods for treating blepharitis
BR112022012269A2 (pt) 2019-12-18 2022-08-30 Elanco Tiergesundheit Ag Derivados de isoxazolina como pesticidas
CN116194450A (zh) 2020-07-24 2023-05-30 礼蓝美国公司 用于制备异噁唑啉化合物及其中间体的工艺
CA3211576A1 (en) * 2021-03-11 2022-09-15 In The Bowl Animal Health, Inc. Oral canine feed and methods for controlling tick infestations in a canine
CN114306231B (zh) * 2021-12-29 2023-03-24 天津市中升挑战生物科技有限公司 一种氟雷拉纳杀虫剂及其制备方法和应用
CN117064851A (zh) * 2023-09-20 2023-11-17 中国农业大学 一种异噁唑啉类驱虫药制剂的制备方法

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WO2009024541A2 (en) * 2007-08-17 2009-02-26 Intervet International B.V. Isoxazoline compositions and their use as antiparasitics
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US20130065846A1 (en) * 2011-09-12 2013-03-14 Mark D. Soll Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof

Also Published As

Publication number Publication date
EP3082867A1 (en) 2016-10-26
ES2971061T3 (es) 2024-06-03
US10456358B2 (en) 2019-10-29
WO2015091898A1 (en) 2015-06-25
JP2016540809A (ja) 2016-12-28
PT4306168T (pt) 2025-07-24
US20240122849A1 (en) 2024-04-18
US20200000720A1 (en) 2020-01-02
US20210353537A1 (en) 2021-11-18
EP4306168A3 (en) 2024-03-13
US20160317439A1 (en) 2016-11-03
PL3082867T3 (pl) 2024-05-13
MX2016008118A (es) 2016-09-16
CN110327468A (zh) 2019-10-15
ES3036365T3 (en) 2025-09-18
MX373872B (es) 2020-03-26
EP3082867B1 (en) 2024-01-17
HUE066811T2 (hu) 2024-09-28
CN110327468B (zh) 2023-04-28
RU2016129474A (ru) 2018-01-25
RU2019114223A (ru) 2019-06-28
PL4306168T3 (pl) 2025-11-17
CN105813651A (zh) 2016-07-27
US11883530B2 (en) 2024-01-30
JP6581586B2 (ja) 2019-09-25
EP4306168A2 (en) 2024-01-17
HUE072822T2 (hu) 2025-12-28
CN105813651B (zh) 2021-11-23
EP4306168B1 (en) 2025-06-25

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