RU2684906C2 - Амидные соединения - Google Patents
Амидные соединения Download PDFInfo
- Publication number
- RU2684906C2 RU2684906C2 RU2016141650A RU2016141650A RU2684906C2 RU 2684906 C2 RU2684906 C2 RU 2684906C2 RU 2016141650 A RU2016141650 A RU 2016141650A RU 2016141650 A RU2016141650 A RU 2016141650A RU 2684906 C2 RU2684906 C2 RU 2684906C2
- Authority
- RU
- Russia
- Prior art keywords
- compound
- pharmaceutically acceptable
- receptor
- renal failure
- chronic renal
- Prior art date
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- 230000007935 neutral effect Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
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- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
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- 239000008188 pellet Substances 0.000 description 1
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- 229960001412 pentobarbital Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
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- 230000001766 physiological effect Effects 0.000 description 1
- 208000030761 polycystic kidney disease Diseases 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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- 239000002244 precipitate Substances 0.000 description 1
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014064590 | 2014-03-26 | ||
| JP2014-064590 | 2014-03-26 | ||
| PCT/JP2015/059026 WO2015147020A1 (ja) | 2014-03-26 | 2015-03-25 | アミド化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016141650A RU2016141650A (ru) | 2018-04-27 |
| RU2016141650A3 RU2016141650A3 (zh) | 2018-11-12 |
| RU2684906C2 true RU2684906C2 (ru) | 2019-04-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016141650A RU2684906C2 (ru) | 2014-03-26 | 2015-03-25 | Амидные соединения |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10106523B2 (zh) |
| EP (1) | EP3124480B1 (zh) |
| JP (1) | JP6428763B2 (zh) |
| KR (1) | KR20160138098A (zh) |
| CN (1) | CN106132945B (zh) |
| AR (1) | AR099833A1 (zh) |
| CA (1) | CA2943778A1 (zh) |
| ES (1) | ES2684334T3 (zh) |
| MX (1) | MX368098B (zh) |
| PL (1) | PL3124480T3 (zh) |
| PT (1) | PT3124480T (zh) |
| RU (1) | RU2684906C2 (zh) |
| TW (1) | TW201623277A (zh) |
| WO (1) | WO2015147020A1 (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| CA3063632A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as pge2 receptor modulators |
| ES2896476T3 (es) | 2017-05-18 | 2022-02-24 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina |
| EA201992677A1 (ru) | 2017-05-18 | 2020-04-23 | Идорсия Фармасьютиклз Лтд | Пиримидиновые производные в качестве модуляторов pge2 рецепторов |
| CA3063637A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | N-substituted indole derivatives |
| LT3625222T (lt) | 2017-05-18 | 2021-11-10 | Idorsia Pharmaceuticals Ltd | Fenilo dariniai, kaip pge2 receptoriaus moduliatoriai |
| EP4245301A1 (en) | 2020-11-13 | 2023-09-20 | ONO Pharmaceutical Co., Ltd. | Cancer treatment by combined use of ep4 antagonist and immune checkpoint inhibitor |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008017164A1 (en) * | 2006-08-11 | 2008-02-14 | Merck Frosst Canada Ltd. | Thiophenecarboxamide derivatives as ep4 receptor ligands |
| US20110028463A1 (en) * | 2007-07-03 | 2011-02-03 | Astellas Pharma Inc. | Amide compounds |
| WO2012039972A1 (en) * | 2010-09-21 | 2012-03-29 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition |
| WO2012103071A2 (en) * | 2011-01-25 | 2012-08-02 | Eisai R&D Management Co., Ltd. | Compounds and compositions |
| RU2479576C9 (ru) * | 2008-05-14 | 2014-03-10 | Астеллас Фарма Инк. | Амидное соединение |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006506327A (ja) * | 2002-05-23 | 2006-02-23 | セラテクノロジーズ インコーポレイティド | プロスタグランジンｅ２の受容体サブタイプｅｐ４のアンタゴニスト・ポリペプチド |
-
2015
- 2015-03-24 TW TW104109378A patent/TW201623277A/zh unknown
- 2015-03-25 WO PCT/JP2015/059026 patent/WO2015147020A1/ja active Application Filing
- 2015-03-25 MX MX2016012318A patent/MX368098B/es active IP Right Grant
- 2015-03-25 JP JP2016510404A patent/JP6428763B2/ja not_active Expired - Fee Related
- 2015-03-25 CN CN201580016273.8A patent/CN106132945B/zh active Active
- 2015-03-25 PT PT15770149T patent/PT3124480T/pt unknown
- 2015-03-25 US US15/127,574 patent/US10106523B2/en active Active
- 2015-03-25 PL PL15770149T patent/PL3124480T3/pl unknown
- 2015-03-25 CA CA2943778A patent/CA2943778A1/en not_active Abandoned
- 2015-03-25 AR ARP150100875A patent/AR099833A1/es unknown
- 2015-03-25 EP EP15770149.1A patent/EP3124480B1/en active Active
- 2015-03-25 RU RU2016141650A patent/RU2684906C2/ru active
- 2015-03-25 KR KR1020167027923A patent/KR20160138098A/ko active IP Right Grant
- 2015-03-25 ES ES15770149.1T patent/ES2684334T3/es active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008017164A1 (en) * | 2006-08-11 | 2008-02-14 | Merck Frosst Canada Ltd. | Thiophenecarboxamide derivatives as ep4 receptor ligands |
| US20110028463A1 (en) * | 2007-07-03 | 2011-02-03 | Astellas Pharma Inc. | Amide compounds |
| RU2479576C9 (ru) * | 2008-05-14 | 2014-03-10 | Астеллас Фарма Инк. | Амидное соединение |
| WO2012039972A1 (en) * | 2010-09-21 | 2012-03-29 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition |
| WO2012103071A2 (en) * | 2011-01-25 | 2012-08-02 | Eisai R&D Management Co., Ltd. | Compounds and compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3124480A4 (en) | 2017-11-22 |
| MX368098B (es) | 2019-09-19 |
| US10106523B2 (en) | 2018-10-23 |
| EP3124480B1 (en) | 2018-07-11 |
| US20180030030A1 (en) | 2018-02-01 |
| RU2016141650A (ru) | 2018-04-27 |
| CA2943778A1 (en) | 2015-10-01 |
| ES2684334T3 (es) | 2018-10-02 |
| WO2015147020A1 (ja) | 2015-10-01 |
| TW201623277A (zh) | 2016-07-01 |
| MX2016012318A (es) | 2017-02-23 |
| PT3124480T (pt) | 2018-10-04 |
| PL3124480T3 (pl) | 2018-10-31 |
| RU2016141650A3 (zh) | 2018-11-12 |
| JPWO2015147020A1 (ja) | 2017-04-13 |
| JP6428763B2 (ja) | 2018-11-28 |
| AR099833A1 (es) | 2016-08-24 |
| CN106132945B (zh) | 2019-04-26 |
| KR20160138098A (ko) | 2016-12-02 |
| EP3124480A1 (en) | 2017-02-01 |
| CN106132945A (zh) | 2016-11-16 |
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