RU2681213C2 - Ингибиторы метастазирования - Google Patents

Ингибиторы метастазирования Download PDF

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Publication number
RU2681213C2
RU2681213C2 RU2015146997A RU2015146997A RU2681213C2 RU 2681213 C2 RU2681213 C2 RU 2681213C2 RU 2015146997 A RU2015146997 A RU 2015146997A RU 2015146997 A RU2015146997 A RU 2015146997A RU 2681213 C2 RU2681213 C2 RU 2681213C2
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RU
Russia
Prior art keywords
peptide
seq
mans
group
cancer
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RU2015146997A
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English (en)
Russian (ru)
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RU2015146997A (ru
RU2015146997A3 (https=
Inventor
Инду ПАРИХ
Кеннет Б. АДЛЕР
Original Assignee
Байомарк Фармасьютикалз, Лтд.
Норт Каролина Стейт Юниверсити
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Publication of RU2015146997A publication Critical patent/RU2015146997A/ru
Publication of RU2015146997A3 publication Critical patent/RU2015146997A3/ru
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Virology (AREA)
RU2015146997A 2013-04-05 2014-04-07 Ингибиторы метастазирования RU2681213C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361808966P 2013-04-05 2013-04-05
US61/808,966 2013-04-05
PCT/US2014/033206 WO2014165853A1 (en) 2013-04-05 2014-04-07 Inhibitors of metastasis

Publications (3)

Publication Number Publication Date
RU2015146997A RU2015146997A (ru) 2017-05-15
RU2015146997A3 RU2015146997A3 (https=) 2018-03-13
RU2681213C2 true RU2681213C2 (ru) 2019-03-05

Family

ID=51654619

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015146997A RU2681213C2 (ru) 2013-04-05 2014-04-07 Ингибиторы метастазирования

Country Status (19)

Country Link
US (4) US9408886B2 (https=)
EP (1) EP2981279B1 (https=)
JP (1) JP6449849B2 (https=)
KR (1) KR102191695B1 (https=)
CN (1) CN105517562B (https=)
AU (1) AU2014247979B2 (https=)
BR (1) BR112015025398A2 (https=)
CA (1) CA2908832C (https=)
DK (1) DK2981279T3 (https=)
ES (1) ES2714863T3 (https=)
HU (1) HUE043971T2 (https=)
IL (1) IL241937B (https=)
MX (1) MX363077B (https=)
PL (1) PL2981279T3 (https=)
PT (1) PT2981279T (https=)
RU (1) RU2681213C2 (https=)
SG (2) SG11201508249WA (https=)
WO (1) WO2014165853A1 (https=)
ZA (1) ZA201508010B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE043971T2 (hu) * 2013-04-05 2019-09-30 Biomarck Pharmaceuticals Ltd Egy fûtõrendszer mûködtetési eljárása, fûtõrendszer és felhasználásai
CN108686220A (zh) * 2018-07-13 2018-10-23 刘慧荣 一种针对甲状腺癌的抗肿瘤剂
EP4475866A4 (en) * 2022-02-07 2026-02-25 Park Strategic Ventures Llc Peptides and their methods of use in the treatment of eye disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090203620A1 (en) * 2006-07-26 2009-08-13 Indu Parikh Methods for attenuating release of inflammatory mediators and peptides useful therein
WO2011079015A1 (en) * 2009-12-21 2011-06-30 The Regents Of The University Of California Rgd-containing cyclic peptides

Family Cites Families (14)

* Cited by examiner, † Cited by third party
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US8501911B2 (en) 1999-02-24 2013-08-06 Biomarck Pharmaceuticals, Ltd Methods of reducing inflammation and mucus hypersecretion
US7544772B2 (en) * 2001-06-26 2009-06-09 Biomarck Pharmaceuticals, Ltd. Methods for regulating inflammatory mediators and peptides useful therein
US7265088B1 (en) 2000-02-24 2007-09-04 North Carolina State University Method and compositions for altering mucus secretion
AU2002322475B2 (en) 2001-06-26 2008-02-21 North Carolina State University Blocking peptide for inflammatory cell secretion
WO2003030827A2 (en) 2001-10-05 2003-04-17 The Trustees Of The University Of Pennsylvania Compositions for and methods of treating and preventing sirs/sepsis
DE60308251T2 (de) 2002-04-17 2007-08-30 Canon K.K. Vorrichtung zur Bereitstellung von öffentlichen Schlüsselzertifikaten
EP2399599A3 (en) 2005-01-20 2012-04-18 Biomarck Pharmaceuticals, Ltd. Mucin hypersecretion inhibitors and methods of use
WO2006086681A2 (en) 2005-02-09 2006-08-17 Beth Israel Deaconess Medical Center, Inc. Methods of inhibiting smooth muscle cell migration and proliferation
WO2008127355A2 (en) * 2006-10-06 2008-10-23 Celtaxsys, Inc. Chemorepulsion of cells
JP2010508512A (ja) 2006-10-27 2010-03-18 ジョージ メイソン インテレクチュアル プロパティーズ,インコーポレイテッド オブ フェアファックス,バージニア 転移性結腸直腸癌のアッセイ
WO2009062128A2 (en) 2007-11-08 2009-05-14 Indiana University Research And Technology Corporation Combination drug therapy for the treatment of cancer
EP2105511A1 (en) * 2008-03-28 2009-09-30 Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. Medicament compositions and substances for treatment and identifying adenocarcinoma of the lung
JP6225104B2 (ja) * 2011-04-08 2017-11-01 タフツ メディカル センター インコーポレイテッドTufts Medical Center,Inc. ペプデューシンの設計および使用
HUE043971T2 (hu) * 2013-04-05 2019-09-30 Biomarck Pharmaceuticals Ltd Egy fûtõrendszer mûködtetési eljárása, fûtõrendszer és felhasználásai

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090203620A1 (en) * 2006-07-26 2009-08-13 Indu Parikh Methods for attenuating release of inflammatory mediators and peptides useful therein
WO2011079015A1 (en) * 2009-12-21 2011-06-30 The Regents Of The University Of California Rgd-containing cyclic peptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN X et al., PhosphoMARCKS drives motility of mouse melanoma cells, Cell Signal., 2010 Jul;22(7):1097-103. -. *
TECHASEN A. et al, Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway, Cancer science, 2009, vol. 101, no. 3, pages 658 - 665- . *
TECHASEN A. et al, Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway, Cancer science, 2009, vol. 101, no. 3, pages 658 - 665- реферат. CHEN X et al., PhosphoMARCKS drives motility of mouse melanoma cells, Cell Signal., 2010 Jul;22(7):1097-103. -реферат. *

Also Published As

Publication number Publication date
DK2981279T3 (en) 2019-03-25
CA2908832A1 (en) 2014-10-09
AU2014247979A1 (en) 2015-10-29
EP2981279B1 (en) 2018-12-19
SG11201508249WA (en) 2015-11-27
NZ712955A (en) 2021-03-26
SG10201708125PA (en) 2017-11-29
MX2015014036A (es) 2016-02-25
PL2981279T3 (pl) 2019-09-30
ES2714863T3 (es) 2019-05-30
RU2015146997A (ru) 2017-05-15
JP2016516756A (ja) 2016-06-09
BR112015025398A2 (pt) 2017-10-10
AU2014247979B2 (en) 2018-06-28
ZA201508010B (en) 2017-01-25
JP6449849B2 (ja) 2019-01-09
KR102191695B1 (ko) 2020-12-16
US9408886B2 (en) 2016-08-09
CA2908832C (en) 2023-01-24
HUE043971T2 (hu) 2019-09-30
US10683328B2 (en) 2020-06-16
PT2981279T (pt) 2019-03-14
US20170121369A1 (en) 2017-05-04
HK1221159A1 (en) 2017-05-26
CN105517562A (zh) 2016-04-20
US10011636B2 (en) 2018-07-03
US20190119320A1 (en) 2019-04-25
KR20150140736A (ko) 2015-12-16
EP2981279A1 (en) 2016-02-10
CN105517562B (zh) 2018-12-28
US20210130403A1 (en) 2021-05-06
WO2014165853A1 (en) 2014-10-09
US11466054B2 (en) 2022-10-11
US20140302057A1 (en) 2014-10-09
IL241937B (en) 2019-03-31
RU2015146997A3 (https=) 2018-03-13
MX363077B (es) 2019-03-07
EP2981279A4 (en) 2016-11-09

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