RU2680246C1 - Схема приема для селективного по альфа-изоформе ингибитора фосфатидилинозитол-3-киназы - Google Patents

Схема приема для селективного по альфа-изоформе ингибитора фосфатидилинозитол-3-киназы Download PDF

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RU2680246C1
RU2680246C1 RU2016126716A RU2016126716A RU2680246C1 RU 2680246 C1 RU2680246 C1 RU 2680246C1 RU 2016126716 A RU2016126716 A RU 2016126716A RU 2016126716 A RU2016126716 A RU 2016126716A RU 2680246 C1 RU2680246 C1 RU 2680246C1
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compound
pharmaceutically acceptable
acceptable salt
patient
days
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RU2016126716A
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Russian (ru)
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ТОМАЗО Эмманюэлль ДИ
Мари-Карелин ЖЕРМА
Кристиан МАССАЧЕЗИ
Кристин Фритч
Кристиан Рене ШНЕЛЛЬ
Ранджана ТЭЙВОРЕТ
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Новартис Аг
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2016126716A 2013-12-06 2014-12-03 Схема приема для селективного по альфа-изоформе ингибитора фосфатидилинозитол-3-киназы RU2680246C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13306679.5 2013-12-06
EP13306679 2013-12-06
PCT/IB2014/066558 WO2015083101A1 (en) 2013-12-06 2014-12-03 Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor

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RU2680246C1 true RU2680246C1 (ru) 2019-02-19

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US (4) US20170000778A1 (enExample)
EP (2) EP3076969B1 (enExample)
JP (1) JP2016539149A (enExample)
KR (1) KR20160095035A (enExample)
CN (1) CN105979947A (enExample)
AU (2) AU2014358773A1 (enExample)
BR (1) BR112016011811A2 (enExample)
CA (1) CA2930359C (enExample)
CL (1) CL2016001361A1 (enExample)
DK (1) DK3076969T3 (enExample)
ES (1) ES2899167T3 (enExample)
HU (1) HUE057092T2 (enExample)
IL (1) IL245709B (enExample)
MX (1) MX378409B (enExample)
PH (1) PH12016501026A1 (enExample)
PL (1) PL3076969T3 (enExample)
PT (1) PT3076969T (enExample)
RU (1) RU2680246C1 (enExample)
SI (1) SI3076969T1 (enExample)
TN (1) TN2016000179A1 (enExample)
TW (1) TWI666019B (enExample)
WO (1) WO2015083101A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108472289A (zh) * 2015-11-02 2018-08-31 诺华股份有限公司 磷脂酰肌醇3-激酶抑制剂的给药方案
WO2018060833A1 (en) * 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

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TWI666019B (zh) 2019-07-21
CL2016001361A1 (es) 2017-02-10
CA2930359A1 (en) 2015-06-11
MX2016007376A (es) 2017-05-11
AU2014358773A1 (en) 2016-06-02
MX378409B (es) 2025-03-10
PT3076969T (pt) 2021-11-23
IL245709B (en) 2021-03-25
HUE057092T2 (hu) 2022-04-28
TN2016000179A1 (en) 2017-10-06
AU2017245292B2 (en) 2018-09-27
DK3076969T3 (da) 2021-11-22
EP4000619A1 (en) 2022-05-25
US20200069670A1 (en) 2020-03-05
EP3076969B1 (en) 2021-09-01
KR20160095035A (ko) 2016-08-10
HK1223549A1 (zh) 2017-08-04
TW201609096A (zh) 2016-03-16
JP2016539149A (ja) 2016-12-15
BR112016011811A2 (pt) 2017-08-08
CN105979947A (zh) 2016-09-28
WO2015083101A1 (en) 2015-06-11
US20210196696A1 (en) 2021-07-01
SI3076969T1 (sl) 2021-12-31
PH12016501026A1 (en) 2016-07-04
US20180078540A1 (en) 2018-03-22
AU2017245292A1 (en) 2017-11-02
US20170000778A1 (en) 2017-01-05
IL245709A0 (en) 2016-07-31
PL3076969T3 (pl) 2022-01-17
US10434092B2 (en) 2019-10-08
EP3076969A1 (en) 2016-10-12
CA2930359C (en) 2022-03-01
ES2899167T3 (es) 2022-03-10

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