RU2677346C2 - Композиции и способы для лечения сильной боли - Google Patents
Композиции и способы для лечения сильной боли Download PDFInfo
- Publication number
- RU2677346C2 RU2677346C2 RU2015134136A RU2015134136A RU2677346C2 RU 2677346 C2 RU2677346 C2 RU 2677346C2 RU 2015134136 A RU2015134136 A RU 2015134136A RU 2015134136 A RU2015134136 A RU 2015134136A RU 2677346 C2 RU2677346 C2 RU 2677346C2
- Authority
- RU
- Russia
- Prior art keywords
- pain
- pharmaceutical composition
- peg
- weight
- headache
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361752356P | 2013-01-14 | 2013-01-14 | |
| US61/752,356 | 2013-01-14 | ||
| PCT/EP2014/050628 WO2014108569A1 (en) | 2013-01-14 | 2014-01-14 | Compositions and methods for treating severe pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015134136A RU2015134136A (ru) | 2017-02-20 |
| RU2677346C2 true RU2677346C2 (ru) | 2019-01-16 |
Family
ID=50064547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015134136A RU2677346C2 (ru) | 2013-01-14 | 2014-01-14 | Композиции и способы для лечения сильной боли |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP2943183A1 (enExample) |
| JP (1) | JP6474732B2 (enExample) |
| KR (1) | KR20150129665A (enExample) |
| CN (1) | CN104968330A (enExample) |
| AU (1) | AU2014204739B2 (enExample) |
| BR (1) | BR112015015864B1 (enExample) |
| CA (1) | CA2897874A1 (enExample) |
| HK (1) | HK1217650A1 (enExample) |
| IL (1) | IL239921A0 (enExample) |
| MX (1) | MX2015009045A (enExample) |
| RU (1) | RU2677346C2 (enExample) |
| SG (1) | SG11201505245XA (enExample) |
| WO (1) | WO2014108569A1 (enExample) |
| ZA (1) | ZA201505005B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US9271950B2 (en) | 2010-10-29 | 2016-03-01 | Infirst Healthcare Limited | Compositions for treating chronic inflammation and inflammatory diseases |
| US11730709B2 (en) | 2010-10-29 | 2023-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US10695431B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| US10695432B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| US8895537B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating cardiovascular diseases |
| US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
| US9308213B2 (en) | 2010-10-29 | 2016-04-12 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
| WO2018027001A1 (en) * | 2016-08-03 | 2018-02-08 | Temple University-Of The Commonwealth System Of Higher Education | Microencapsulation of active agents |
| JP7027786B2 (ja) * | 2017-10-12 | 2022-03-02 | ライオン株式会社 | 筋・筋膜性疼痛用の内服治療剤 |
| CA3212583A1 (en) | 2021-03-27 | 2022-10-06 | Daniel Gooding | Compositions having improved bioavailability of therapeutics |
| CN116660550B (zh) * | 2023-06-19 | 2024-08-13 | 南通大学 | 一种dgat2的抑制剂pf-06424439用于缓解疼痛的方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2202346C2 (ru) * | 1997-07-29 | 2003-04-20 | Фармация Энд Апджон Компани | Фармацевтическая композиция для кислотных липофильных соединений в форме самоэмульгирующейся композиции |
| EP1352638A1 (en) * | 2001-01-19 | 2003-10-15 | Shiseido Company, Ltd. | Cosmetics |
| WO2007138339A2 (en) * | 2006-06-01 | 2007-12-06 | Syntaxin Limited | Treatment of pain by use of a single chain polypeptide fusion protein |
| RU2397759C2 (ru) * | 2004-02-06 | 2010-08-27 | Новартис Аг | Микроэмульсионные композиции, включающие антагонисты вещества р |
| WO2012104655A2 (en) * | 2011-02-04 | 2012-08-09 | Biocopea Limited | Compostions and methods for treating chronic inflammation and inflammatory diseases |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143934A (en) * | 1990-11-21 | 1992-09-01 | A/S Dumex (Dumex Ltd.) | Method and composition for controlled delivery of biologically active agents |
| GB9613858D0 (en) * | 1996-07-02 | 1996-09-04 | Cortecs Ltd | Hydrophobic preparations |
| KR100509776B1 (ko) * | 1997-07-29 | 2005-08-24 | 파마시아 앤드 업존 캄파니 엘엘씨 | 친지성 화합물의 자가유화 제제 |
| GB2331458B (en) * | 1997-11-21 | 2002-07-31 | Gursharan Singh Moonga | Solubilising systems for difficult pharmaceutical actives for preparing concentrated stable solutions for encapsulation into soft gelatine |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| WO2000067728A2 (de) * | 1999-05-07 | 2000-11-16 | Pharmasol Gmbh | Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung |
| KR20020011985A (ko) * | 1999-05-07 | 2002-02-09 | 파르마솔 게엠베하 | 액상 및 고체상 지질 혼합물에 기초한 지질입자들 및 그의제조방법 |
| RU2246293C2 (ru) * | 1999-06-14 | 2005-02-20 | Космо С.П.А. | Фармацевтические композиции для перорального введения с регулируемым высвобождением активного ингредиента и маскируемым вкусом |
| US6455067B1 (en) * | 2000-05-24 | 2002-09-24 | Sang-A Pharmaceutical Co., Ltd. | Transdermal patch for nonsteroidal antiinflammatory drug(s) |
| US20070298099A1 (en) * | 2004-11-24 | 2007-12-27 | Peresypkin Andrey V | Liquid and Semi-Solid Pharmaceutical Formulations for Oral Administration of a Substituted Amide |
| JP2008539230A (ja) * | 2005-04-28 | 2008-11-13 | ガレニカ テクノロジー アンチエボラグ | 脂質相を含む薬学的投与形態 |
| GB0704846D0 (en) * | 2007-03-13 | 2007-04-18 | Futura Medical Dev Ltd | Topical pharmaceutical formulation |
| EP2310371B1 (fr) | 2008-05-26 | 2013-05-15 | Genfit | Composés agonistes ppar, préparation et utilisations pour le traitement du diabète et/ou des dyslipidémies |
| CN102048680B (zh) * | 2009-11-11 | 2013-05-01 | 河北奥星集团药业有限公司 | 一种含有扎托布洛芬的肠溶缓释制剂及其制备方法 |
| CN102579350B (zh) * | 2012-03-02 | 2013-04-24 | 海南灵康制药有限公司 | 右旋布洛芬脂质体固体制剂 |
-
2014
- 2014-01-14 EP EP14702759.3A patent/EP2943183A1/en not_active Withdrawn
- 2014-01-14 SG SG11201505245XA patent/SG11201505245XA/en unknown
- 2014-01-14 CN CN201480006249.1A patent/CN104968330A/zh active Pending
- 2014-01-14 KR KR1020157020599A patent/KR20150129665A/ko not_active Withdrawn
- 2014-01-14 HK HK16105731.5A patent/HK1217650A1/zh unknown
- 2014-01-14 WO PCT/EP2014/050628 patent/WO2014108569A1/en not_active Ceased
- 2014-01-14 MX MX2015009045A patent/MX2015009045A/es unknown
- 2014-01-14 RU RU2015134136A patent/RU2677346C2/ru active IP Right Revival
- 2014-01-14 JP JP2015552092A patent/JP6474732B2/ja active Active
- 2014-01-14 CA CA2897874A patent/CA2897874A1/en not_active Abandoned
- 2014-01-14 AU AU2014204739A patent/AU2014204739B2/en active Active
- 2014-01-14 BR BR112015015864-1A patent/BR112015015864B1/pt active IP Right Grant
-
2015
- 2015-07-13 ZA ZA2015/05005A patent/ZA201505005B/en unknown
- 2015-07-14 IL IL239921A patent/IL239921A0/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2202346C2 (ru) * | 1997-07-29 | 2003-04-20 | Фармация Энд Апджон Компани | Фармацевтическая композиция для кислотных липофильных соединений в форме самоэмульгирующейся композиции |
| EP1352638A1 (en) * | 2001-01-19 | 2003-10-15 | Shiseido Company, Ltd. | Cosmetics |
| RU2397759C2 (ru) * | 2004-02-06 | 2010-08-27 | Новартис Аг | Микроэмульсионные композиции, включающие антагонисты вещества р |
| WO2007138339A2 (en) * | 2006-06-01 | 2007-12-06 | Syntaxin Limited | Treatment of pain by use of a single chain polypeptide fusion protein |
| WO2012104655A2 (en) * | 2011-02-04 | 2012-08-09 | Biocopea Limited | Compostions and methods for treating chronic inflammation and inflammatory diseases |
Non-Patent Citations (5)
| Title |
|---|
| Charbonnet G.H. et al. Thermal Properties of Fats and Oils // The Journal of the American Oil Chemists’ Society. - 1947. - P.140-142. Dijkstra A.J. et al. Trans Fatty Acids. - Blackwell Publishing Ltd: 2008. * |
| Dijkstra A.J. et al. Trans Fatty Acids. - Blackwell Publishing Ltd: 2008. * |
| Raymond C Rowe. Handbook of Pharmaceutical Excipients. 6th ed. Published by the Pharmaceutical Press, the American Pharmacists Association, 2009. * |
| Raymond C Rowe. Handbook of Pharmaceutical Excipients. 6th ed. Published by the Pharmaceutical Press, the American Pharmacists Association, 2009. Charbonnet G.H. et al. Thermal Properties of Fats and Oils // The Journal of the American Oil Chemists’ Society. - 1947. - P.140-142. * |
| Абрамзон А.А. Поверхностно-активные вещества: Свойства и применение, 2-е изд. - Л.: 1981. * |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1217650A1 (zh) | 2017-01-20 |
| KR20150129665A (ko) | 2015-11-20 |
| JP6474732B2 (ja) | 2019-02-27 |
| ZA201505005B (en) | 2016-10-26 |
| BR112015015864A2 (pt) | 2017-07-11 |
| IL239921A0 (en) | 2015-08-31 |
| BR112015015864B1 (pt) | 2022-08-23 |
| WO2014108569A1 (en) | 2014-07-17 |
| BR112015015864A8 (pt) | 2018-01-16 |
| EP2943183A1 (en) | 2015-11-18 |
| MX2015009045A (es) | 2015-12-17 |
| CN104968330A (zh) | 2015-10-07 |
| AU2014204739A1 (en) | 2015-07-16 |
| JP2016504401A (ja) | 2016-02-12 |
| SG11201505245XA (en) | 2015-08-28 |
| RU2015134136A (ru) | 2017-02-20 |
| CA2897874A1 (en) | 2014-07-17 |
| AU2014204739B2 (en) | 2016-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20200115 |
|
| NF4A | Reinstatement of patent |
Effective date: 20210304 |