RU2671089C2 - Би- или полиспецифические полипептиды, связывающие поверхностные антигены иммунных эффекторных клеток и антигены hbv для лечения инфекций bv и ассоциированных с ними состояний - Google Patents

Би- или полиспецифические полипептиды, связывающие поверхностные антигены иммунных эффекторных клеток и антигены hbv для лечения инфекций bv и ассоциированных с ними состояний Download PDF

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RU2671089C2
RU2671089C2 RU2016114504A RU2016114504A RU2671089C2 RU 2671089 C2 RU2671089 C2 RU 2671089C2 RU 2016114504 A RU2016114504 A RU 2016114504A RU 2016114504 A RU2016114504 A RU 2016114504A RU 2671089 C2 RU2671089 C2 RU 2671089C2
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hbv
cells
antigen
polypeptide
polypeptides
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RU2016114504A
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RU2016114504A3 (enExample
RU2016114504A (ru
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Ульрике ПРОТЦЕР
Феликс БОНЕ
Франк МОМБУРГ
Герхард МОЛЬДЕНХАУЭР
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Хельмхольтц Центрум Мюнхен - Дойчес Форшунгсцентрум Фюр Гезундхайт Унд Умвельт (Гмбх)
Дойчес Кребсфоршунгсцентрум
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • C07K16/081—DNA viruses
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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RU2016114504A 2013-09-16 2014-09-16 Би- или полиспецифические полипептиды, связывающие поверхностные антигены иммунных эффекторных клеток и антигены hbv для лечения инфекций bv и ассоциированных с ними состояний RU2671089C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13184635 2013-09-16
EP13184635.4 2013-09-16
PCT/EP2014/069675 WO2015036606A1 (en) 2013-09-16 2014-09-16 Bi- or multispecific polypeptides binding immune effector cell surface antigens and hbv antigens for treating hbv infections and associated conditions

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Publication Number Publication Date
RU2016114504A RU2016114504A (ru) 2017-10-23
RU2016114504A3 RU2016114504A3 (enExample) 2018-04-25
RU2671089C2 true RU2671089C2 (ru) 2018-10-29

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US (2) US10059767B2 (enExample)
EP (1) EP3046938B1 (enExample)
JP (1) JP6599338B2 (enExample)
CN (2) CN111606998B (enExample)
CA (1) CA2924252C (enExample)
ES (1) ES2773306T3 (enExample)
RU (1) RU2671089C2 (enExample)
WO (1) WO2015036606A1 (enExample)

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WO2016146702A1 (en) * 2015-03-16 2016-09-22 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Trispecific binding molecules for treating hbv infection and associated conditions
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SG11202007579TA (en) 2018-02-08 2020-09-29 Dragonfly Therapeutics Inc Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells
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JP7353576B2 (ja) 2018-02-20 2023-10-02 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
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CN109265559B (zh) * 2018-09-25 2021-12-07 山东兴瑞生物科技有限公司 嵌合抗原受体、其制备方法、利用其修饰的nk细胞及治疗hbv感染的应用
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