RU2643326C2 - Ингибитор рецептора фрф для применения в лечении гипофосфатемических заболеваний - Google Patents
Ингибитор рецептора фрф для применения в лечении гипофосфатемических заболеваний Download PDFInfo
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- RU2643326C2 RU2643326C2 RU2014143517A RU2014143517A RU2643326C2 RU 2643326 C2 RU2643326 C2 RU 2643326C2 RU 2014143517 A RU2014143517 A RU 2014143517A RU 2014143517 A RU2014143517 A RU 2014143517A RU 2643326 C2 RU2643326 C2 RU 2643326C2
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- ethylpiperazin
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| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| PE20190736A1 (es) | 2012-06-13 | 2019-05-23 | Incyte Holdings Corp | Compuestos triciclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroblastos (fgfr) |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| KR102269032B1 (ko) | 2013-04-19 | 2021-06-24 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
| EA028614B1 (ru) * | 2014-05-22 | 2017-12-29 | Общество С Ограниченной Ответственностью "Русские Фармацевтические Технологии" | Селективные ингибиторы, нарушающие взаимодействие рецептора фактора роста фибробластов и frs2, для профилактики и лечения рака |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| ES2895769T3 (es) | 2015-02-20 | 2022-02-22 | Incyte Corp | Heterociclos bicíclicos como inhibidores de FGFR |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016189472A1 (en) * | 2015-05-28 | 2016-12-01 | Novartis Ag | Fgfr inhibitor for use in the treatment of the phosphaturic mesenchymal tumor |
| US10624897B2 (en) | 2015-07-20 | 2020-04-21 | Taipei Medical University | Chlorobenzene substituted azaaryl compounds |
| KR20180028524A (ko) * | 2015-07-24 | 2018-03-16 | 데비오팜 인터네셔날 에스 에이 | Fgfr 발현 및 fgfr 억제제에 대한 민감성 |
| CN110402143B (zh) * | 2017-01-06 | 2022-11-22 | 雷莫内克斯生物制药有限公司 | 预防或治疗转移性卵巢癌、子宫内膜癌或乳腺癌的组合物 |
| WO2018128510A1 (ko) * | 2017-01-06 | 2018-07-12 | 주식회사 레모넥스 | 전이성 난소암, 자궁내막암 또는 유방암의 예방 또는 치료용 조성물 |
| JP6387198B1 (ja) | 2017-04-14 | 2018-09-05 | 堺ディスプレイプロダクト株式会社 | 有機ｅｌ表示装置の製造方法及び製造装置 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| SG11202010882XA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Salts of an fgfr inhibitor |
| SI3788047T1 (sl) | 2018-05-04 | 2024-11-29 | Incyte Corporation | Trdne oblike inhibitorja fgfr in postopki priprave le-teh |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US11607416B2 (en) | 2019-10-14 | 2023-03-21 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021113462A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021119108A1 (en) * | 2019-12-09 | 2021-06-17 | Cedars-Sinai Medical Center | Use of fgfr inhibitors for treatment of idiopathic short stature |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| WO2022261159A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
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| RU2003123108A (ru) * | 2000-12-26 | 2005-02-27 | Чугаи Сейяку Кабусики Кайся (Jp) | Мутантные формы человеческого белка fgf23, снижающие содержание фосфора в крови |
| WO2009133101A1 (en) * | 2008-04-29 | 2009-11-05 | Novartis Ag | Methods of monitoring the modulation of the kinase activity of fibroblast growth factor receptor and uses of said methods |
| WO2011051425A1 (en) * | 2009-10-30 | 2011-05-05 | Novartis Ag | N-oxide of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea |
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| EP1882475A1 (en) * | 2006-07-26 | 2008-01-30 | Novartis AG | Method of treating disorders mediated by the fibroblast growth factor receptor |
| AR079257A1 (es) * | 2009-12-07 | 2012-01-04 | Novartis Ag | Formas cristalinas de 3-(2,6-dicloro-3-5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas |
| EP2512476A1 (en) * | 2009-12-18 | 2012-10-24 | Novartis AG | Method for treating haematological cancers |
| WO2013088191A1 (en) | 2011-12-12 | 2013-06-20 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Antagonist of the fibroblast growth factor receptor 3 (fgfr3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of fgfr3 |
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- 2013-03-29 AU AU2013241664A patent/AU2013241664B2/en active Active
- 2013-03-29 CN CN201380015597.0A patent/CN104321058A/zh active Pending
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2016
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| RU2003123108A (ru) * | 2000-12-26 | 2005-02-27 | Чугаи Сейяку Кабусики Кайся (Jp) | Мутантные формы человеческого белка fgf23, снижающие содержание фосфора в крови |
| WO2009133101A1 (en) * | 2008-04-29 | 2009-11-05 | Novartis Ag | Methods of monitoring the modulation of the kinase activity of fibroblast growth factor receptor and uses of said methods |
| WO2011051425A1 (en) * | 2009-10-30 | 2011-05-05 | Novartis Ag | N-oxide of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea |
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| MARSELL R. et al. "Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men". Osteoporos.Int. 2009 Jul;20(7):1167-73, , найдено 05.07.2017 из PubMed PMID:18974917. * |
| MOSEKILDE L. "Primery hyperparathyroidism and the skeleton". Clin Endocrinol(Oxf) 2008 Jul;69(1):1-19, , найдено 05.07.2017 из PubMed PMID:18167138. * |
| MOSEKILDE L. "Primery hyperparathyroidism and the skeleton". Clin Endocrinol(Oxf) 2008 Jul;69(1):1-19, реферат, найдено 05.07.2017 из PubMed PMID:18167138. MARSELL R. et al. "Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men". Osteoporos.Int. 2009 Jul;20(7):1167-73, реферат, найдено 05.07.2017 из PubMed PMID:18974917. * |
Also Published As
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| AU2013241664A1 (en) | 2014-10-02 |
| JP2015511621A (ja) | 2015-04-20 |
| AU2013241664B2 (en) | 2016-05-19 |
| EP2830626B1 (en) | 2019-01-02 |
| KR20140145133A (ko) | 2014-12-22 |
| US20170007606A1 (en) | 2017-01-12 |
| CN104321058A (zh) | 2015-01-28 |
| KR102126092B1 (ko) | 2020-06-24 |
| US10028955B2 (en) | 2018-07-24 |
| WO2013144339A1 (en) | 2013-10-03 |
| EP2830626A1 (en) | 2015-02-04 |
| IN2014DN08969A (enExample) | 2015-05-22 |
| JP6190871B2 (ja) | 2017-08-30 |
| CA2866229A1 (en) | 2013-10-03 |
| US20240398798A1 (en) | 2024-12-05 |
| US20150072019A1 (en) | 2015-03-12 |
| US20210308132A1 (en) | 2021-10-07 |
| RU2014143517A (ru) | 2016-05-27 |
| MX354783B (es) | 2018-03-21 |
| CN109718239A (zh) | 2019-05-07 |
| CN109718239B (zh) | 2024-09-10 |
| MX2014011841A (es) | 2015-02-10 |
| CA2866229C (en) | 2020-09-15 |
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