RU2638802C2 - Применение антагонистов cxcr4 - Google Patents
Применение антагонистов cxcr4 Download PDFInfo
- Publication number
- RU2638802C2 RU2638802C2 RU2013155601A RU2013155601A RU2638802C2 RU 2638802 C2 RU2638802 C2 RU 2638802C2 RU 2013155601 A RU2013155601 A RU 2013155601A RU 2013155601 A RU2013155601 A RU 2013155601A RU 2638802 C2 RU2638802 C2 RU 2638802C2
- Authority
- RU
- Russia
- Prior art keywords
- bis
- methylene
- cxcr4
- tetraazacyclotetradecane
- cxcr4 antagonist
- Prior art date
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| US9375406B2 (en) * | 2014-09-30 | 2016-06-28 | Taigen Biotechnology Co., Ltd. | Substituted pyrimidines for mobilizing cells expressing a type 4 CXC chemokine receptor |
| WO2017106332A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| CN109069426B (zh) | 2015-12-14 | 2021-10-29 | X4 制药有限公司 | 治疗癌症的方法 |
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| WO2017223243A1 (en) * | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| CN109640988A (zh) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
| CN110536966A (zh) * | 2016-09-08 | 2019-12-03 | 能源环境和技术研究中心O.A.,M.P. | 用于范可尼贫血患者的基因疗法 |
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| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
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| CN113662937B (zh) * | 2021-10-09 | 2022-08-23 | 江苏省人民医院（南京医科大学第一附属医院） | Plerixafor在上调EFTUD2表达和抑制HBV药物中的用途 |
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| US6365583B1 (en) * | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
| US20080234294A1 (en) * | 2005-08-18 | 2008-09-25 | Novartis Ag | Cxcr4 Binding Molecules |
| US20090221683A1 (en) * | 2005-10-18 | 2009-09-03 | Caritas St.Elizabeth Medical Center Of Boston, Inc | Combination of CXCR4 Antagonist and Morphogen to Increase Angiogenesis |
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| US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
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| US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
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| GB9400411D0 (en) | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
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| US5606053A (en) | 1995-05-02 | 1997-02-25 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
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| GB9511357D0 (en) | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
| WO1999047158A2 (en) | 1998-03-13 | 1999-09-23 | The University Of British Columbia | Therapeutic chemokine receptor antagonists |
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| DE60103052T2 (de) | 2000-05-09 | 2005-03-03 | The University Of British Columbia, Vancouver | Verwendung von cxcr4 antagonisten zur behandlung von krebs und autoimmunkrankheiten |
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2012
- 2012-05-15 RU RU2013155601A patent/RU2638802C2/ru active
- 2012-05-15 BR BR112013029482A patent/BR112013029482A2/pt not_active IP Right Cessation
- 2012-05-15 PL PL12786739T patent/PL2709991T3/pl unknown
- 2012-05-15 JP JP2014511460A patent/JP2014513727A/ja not_active Withdrawn
- 2012-05-15 WO PCT/US2012/037970 patent/WO2012158707A1/en not_active Ceased
- 2012-05-15 EP EP12786739.8A patent/EP2709991B1/en active Active
- 2012-05-15 ES ES12786739T patent/ES2831049T3/es active Active
- 2012-05-15 CN CN201280024014.6A patent/CN103596935A/zh active Pending
- 2012-05-15 KR KR1020137033309A patent/KR20140045411A/ko not_active Ceased
- 2012-05-15 KR KR1020207003632A patent/KR20200016407A/ko not_active Ceased
- 2012-05-15 US US14/118,144 patent/US20150030561A1/en not_active Abandoned
- 2012-05-15 KR KR1020217023153A patent/KR20210094672A/ko not_active Ceased
- 2012-05-15 MX MX2013013308A patent/MX365242B/es active IP Right Grant
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2020
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2709991A4 (en) | 2014-10-01 |
| PL2709991T3 (pl) | 2021-04-06 |
| ES2831049T3 (es) | 2021-06-07 |
| RU2013155601A (ru) | 2015-06-27 |
| KR20140045411A (ko) | 2014-04-16 |
| MX365242B (es) | 2019-05-28 |
| BR112013029482A2 (pt) | 2016-08-09 |
| US20210161859A1 (en) | 2021-06-03 |
| EP2709991B1 (en) | 2020-09-02 |
| JP2014513727A (ja) | 2014-06-05 |
| US20150030561A1 (en) | 2015-01-29 |
| CN103596935A (zh) | 2014-02-19 |
| KR20200016407A (ko) | 2020-02-14 |
| KR20210094672A (ko) | 2021-07-29 |
| MX2013013308A (es) | 2014-02-27 |
| EP2709991A1 (en) | 2014-03-26 |
| WO2012158707A1 (en) | 2012-11-22 |
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