RU2635482C2 - Ингибитор альфа1-протеиназы для задержки начала или прогрессирования легочных обострений - Google Patents

Ингибитор альфа1-протеиназы для задержки начала или прогрессирования легочных обострений Download PDF

Info

Publication number
RU2635482C2
RU2635482C2 RU2014106758A RU2014106758A RU2635482C2 RU 2635482 C2 RU2635482 C2 RU 2635482C2 RU 2014106758 A RU2014106758 A RU 2014106758A RU 2014106758 A RU2014106758 A RU 2014106758A RU 2635482 C2 RU2635482 C2 RU 2635482C2
Authority
RU
Russia
Prior art keywords
a1pi
pulmonary
exacerbations
subject
increased
Prior art date
Application number
RU2014106758A
Other languages
English (en)
Russian (ru)
Other versions
RU2014106758A (ru
Inventor
Марк ФОРШАГ
Ройс УОЛТРИП
Лес ГАРЛИНГХАУС
Уилльям БАРНЕТТ
Original Assignee
Грайфолз, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Грайфолз, С.А. filed Critical Грайфолз, С.А.
Publication of RU2014106758A publication Critical patent/RU2014106758A/ru
Application granted granted Critical
Publication of RU2635482C2 publication Critical patent/RU2635482C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2014106758A 2011-12-30 2012-11-22 Ингибитор альфа1-протеиназы для задержки начала или прогрессирования легочных обострений RU2635482C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161581708P 2011-12-30 2011-12-30
US61/581,708 2011-12-30
PCT/IB2012/056616 WO2013098672A2 (en) 2011-12-30 2012-11-22 Alpha1-proteinase inhibitor for delaying the onset or progression of pulmonary exacerbations

Publications (2)

Publication Number Publication Date
RU2014106758A RU2014106758A (ru) 2015-08-27
RU2635482C2 true RU2635482C2 (ru) 2017-11-13

Family

ID=47470050

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014106758A RU2635482C2 (ru) 2011-12-30 2012-11-22 Ингибитор альфа1-протеиназы для задержки начала или прогрессирования легочных обострений

Country Status (18)

Country Link
US (1) US9421248B2 (enExample)
EP (1) EP2758065B1 (enExample)
JP (4) JP2015504051A (enExample)
KR (1) KR20140108516A (enExample)
CN (2) CN107596359A (enExample)
AR (2) AR088971A1 (enExample)
AU (1) AU2012337241B2 (enExample)
BR (1) BR112014007127A2 (enExample)
CA (1) CA2844878C (enExample)
CL (1) CL2014000722A1 (enExample)
ES (1) ES2887358T3 (enExample)
IL (1) IL231109B (enExample)
MX (1) MX351189B (enExample)
MY (1) MY166314A (enExample)
RU (1) RU2635482C2 (enExample)
SG (2) SG2014012066A (enExample)
UY (1) UY34465A (enExample)
WO (1) WO2013098672A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105592854A (zh) * 2013-08-05 2016-05-18 杰拉德·沃尔曼 使吸烟的不利作用减少的新方法
EP3236772A4 (en) * 2014-12-22 2018-10-17 Alexion Pharmaceuticals, Inc. Methods of purifying recombinant proteins
EP3253406B1 (en) 2015-02-05 2023-11-01 Canem Holdings, LLC Compositions for treating granulomatosis with polyangiitis
CA3054267A1 (en) * 2017-02-21 2018-08-30 Kamada Ltd. Methods and uses of alpha 1-antitrypsin for early intervention in pulmonary diseases
US10663434B2 (en) * 2017-03-31 2020-05-26 Sonix, Inc. Wafer chuck
WO2020014326A1 (en) * 2018-07-10 2020-01-16 Ciancone Christopher V Breath measurement device
WO2021028927A1 (en) * 2019-08-15 2021-02-18 Kamada Ltd Combination of alpha-1-antitrypsin and steroids and uses therefor
CA3151997A1 (en) * 2019-08-23 2021-03-04 Ph Pharma Co., Ltd. Use of a neutrophil elastase inhibitor in lung disease
EP4142775B1 (en) * 2020-05-01 2026-03-25 Ageronix SA Treatment and/or prevention of a disease or a syndrome related to a virus infection

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005048985A2 (en) * 2003-11-14 2005-06-02 Baxter International Inc. Alpha 1-antitrypsin compositions and treatment methods using such compositions
US20050201951A1 (en) * 2004-03-09 2005-09-15 Barr Philip J. Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor
US20090131305A1 (en) * 2006-02-09 2009-05-21 Shabtai Bauer Alpha-1 antitrypsin for treating exacerbation episodes of pulmonary diseases
WO2011056793A2 (en) * 2009-11-03 2011-05-12 Talecris Biotherapeutics, Inc. Composition, method, and kit for alpha-1 proteinase inhibitor

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE395611B (sv) 1975-12-12 1977-08-22 Draco Ab Aerosolinhalationsanordning avsedd for inhalering genom ett inhaleringsmunstycke av farmakologiskt aktiva substanser
SE411705B (sv) 1976-11-09 1980-02-04 Draco Ab Anordning for generering av en avskermad, vesentligen drivmedelsfri aerosol
EP0069715B1 (en) 1981-07-08 1986-11-05 Aktiebolaget Draco Powder inhalator
US5218091A (en) 1982-08-13 1993-06-08 Zymogenetics, Inc. Glycolytic promoters for regulated protein expression: protease inhibitor
US4667688A (en) 1983-11-28 1987-05-26 Francisco Roig Mini pack of cigarettes
US4711848A (en) 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
US4931373A (en) 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
US4732973A (en) 1984-06-14 1988-03-22 Chiron Corporation Active site modified protease α-1-antitrypsin inhibitors
JP2599585B2 (ja) 1984-06-19 1997-04-09 トランスジ−ン ソシエテ アノニム ヒトα▲下１▼−アンチトリプシン誘導体及びその製造法
US4697003A (en) 1985-11-01 1987-09-29 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US5366894A (en) 1986-06-30 1994-11-22 Pharmaceutical Proteins Limited Peptide production
US5093316A (en) 1986-12-24 1992-03-03 John Lezdey Treatment of inflammation
JP2656944B2 (ja) 1987-04-30 1997-09-24 クーパー ラボラトリーズ タンパク質性治療剤のエアロゾール化
US5079336A (en) 1989-06-23 1992-01-07 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production
US5134119A (en) 1990-10-16 1992-07-28 Lezdey John Treatment of inflammation using 358 substituted alpha-antitrypsin
US5915378A (en) 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US5709202A (en) 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
DE69535897D1 (de) 1994-03-07 2009-01-22 Nektar Therapeutics Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin
AU696387B2 (en) 1994-05-18 1998-09-10 Inhale Therapeutic Systems, Inc. Methods and compositions for the dry powder formulation of interferons
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
EP1736483A3 (en) 1995-09-07 2008-07-30 Pharming Intellectual Property BV Purification of alpha-1 proteinase inhibitor
US5780440A (en) 1996-06-17 1998-07-14 Protease Sciences Inc. Treatment of pulmonary disease with protease inhibitors
AT407114B (de) 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung
GEP20043260B (en) 1998-03-16 2004-06-25 Nectar Therapeutics Aerosolized Active Agent Delivery and Device for Realization Thereof
US6093804A (en) 1998-09-24 2000-07-25 American National Red Cross Method for purification of alpha-1 proteinase inhibitor
US6397838B1 (en) 1998-12-23 2002-06-04 Battelle Pulmonary Therapeutics, Inc. Pulmonary aerosol delivery device and method
DE19953317C1 (de) * 1999-11-05 2001-02-01 Pari Gmbh Inhalationsvernebler
US6462180B1 (en) 1999-11-24 2002-10-08 Bayer Corporation Method of preparing α-1 proteinase inhibitor
JP4426179B2 (ja) 2000-12-18 2010-03-03 アライバ ファーマシューティカルズ，インコーポレイティド 多機能性プロテアーゼインヒビターおよびそれらの疾患治療における使用
DK1664123T4 (da) 2003-09-22 2012-03-05 Kamada Ltd Storskalafremstilling af alfa-1-proteinaseinhibitor og anvendelse deraf
US20080078382A1 (en) 2006-09-20 2008-04-03 Lemahieu Edward Methods and Systems of Delivering Medication Via Inhalation
EP1927373B1 (en) 2006-11-30 2012-08-22 PARI Pharma GmbH Inhalation nebulizer
NZ590257A (en) * 2008-07-18 2012-08-31 Grifols Therapeutics Inc Method of preparing alpha-1 proteinase inhibitor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005048985A2 (en) * 2003-11-14 2005-06-02 Baxter International Inc. Alpha 1-antitrypsin compositions and treatment methods using such compositions
US20050201951A1 (en) * 2004-03-09 2005-09-15 Barr Philip J. Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor
US20090131305A1 (en) * 2006-02-09 2009-05-21 Shabtai Bauer Alpha-1 antitrypsin for treating exacerbation episodes of pulmonary diseases
RU2433841C2 (ru) * 2006-02-09 2011-11-20 Пари Фарма Гмбх Доставка в легкие альфа-1-ингибитора протеиназ
WO2011056793A2 (en) * 2009-11-03 2011-05-12 Talecris Biotherapeutics, Inc. Composition, method, and kit for alpha-1 proteinase inhibitor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Глобальная стратегия диагностики, лечения и профилактики хронической обструктивной болезни легких", пересмотр 2007 года, перевод с английского, М., изд. дом. "Атмосфера", 2008. *
"Глобальная стратегия диагностики, лечения и профилактики хронической обструктивной болезни легких", пересмотр 2007 года, перевод с английского, М., изд. дом. "Атмосфера", 2008. TONELLI AR et al. "Alpha-1-antitrypsin augmentation therapy in deficient individuals enrolled in the Alpha-1 Foundation DNA and Tissue Bank". Int J Chron Obstruct Pulmon Dis. 2009;4:443-52, реферат, найдено 18.08.2017 из PubMed PMID: 20054436. *
TONELLI AR et al. "Alpha-1-antitrypsin augmentation therapy in deficient individuals enrolled in the Alpha-1 Foundation DNA and Tissue Bank". Int J Chron Obstruct Pulmon Dis. 2009;4:443-52, , найдено 18.08.2017 из PubMed PMID: 20054436. *

Also Published As

Publication number Publication date
SG10201610913PA (en) 2017-02-27
UY34465A (es) 2013-07-31
RU2014106758A (ru) 2015-08-27
MX2014001764A (es) 2014-04-30
WO2013098672A2 (en) 2013-07-04
JP2018104439A (ja) 2018-07-05
US9421248B2 (en) 2016-08-23
JP2017039745A (ja) 2017-02-23
IL231109B (en) 2018-02-28
AU2012337241A1 (en) 2013-07-18
MY166314A (en) 2018-06-25
MX351189B (es) 2017-10-04
CL2014000722A1 (es) 2014-10-10
US20150011460A1 (en) 2015-01-08
NZ621596A (en) 2016-08-26
WO2013098672A3 (en) 2013-10-24
KR20140108516A (ko) 2014-09-11
AR116887A2 (es) 2021-06-23
JP2019135243A (ja) 2019-08-15
JP2015504051A (ja) 2015-02-05
CA2844878C (en) 2017-11-28
AU2012337241B2 (en) 2016-10-13
SG2014012066A (en) 2014-09-26
HK1198918A1 (en) 2015-06-19
CN103889436A (zh) 2014-06-25
CA2844878A1 (en) 2013-07-04
EP2758065B1 (en) 2021-06-23
BR112014007127A2 (pt) 2017-04-04
ES2887358T3 (es) 2021-12-22
EP2758065A2 (en) 2014-07-30
CN107596359A (zh) 2018-01-19
IL231109A0 (en) 2014-04-30
AR088971A1 (es) 2014-07-23

Similar Documents

Publication Publication Date Title
US9421248B2 (en) Alpha 1-proteinase inhibitor for delaying the onset or progression of pulmonary exacerbations
CA2641875C (en) Pulmonary delivery of alpha-1 proteinase inhibitor
CN115427576B (zh) 包括透明质酸和蛋白聚糖连接蛋白1的用于预防或治疗肺部疾病的组合物
JP2006510657A5 (enExample)
US10960062B2 (en) Methods and uses of alpha 1-antitrypsin for early intervention in pulmonary diseases
EP3723790B1 (en) Methods of inducing immune tolerance and reducing anti-drug antibody response
NZ621596B2 (en) Alpha1-proteinase inhibitor for delaying the onset or progression of pulmonary exacerbations
HK1198918B (en) Alpha1-proteinase inhibitor for use in delaying the onset or progression of pulmonary exacerbations
CN115811969A (zh) 用于预防和治疗纤维化和炎性病症的组合物和方法