RU2601624C1 - Agent possessing general strengthening and antioxidant action - Google Patents

Abstract

FIELD: pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to an agent possessing general tonic, antioxidant action. Agent contains apple pectin, source of biologically active substances (BAS), glutathione, amino acids, potassium sorbate, water with negative oxidation-reduction potential from -200 to -240 mV, taken in a certain amount. BAS source is selected from: extract of red wine, and/or extract of hawthorn fruits, and/or cranberry fruit extract, and/or rosehips extract with vitamin C, and/or extract of spinach, and/or extract of stems and pineapple fruits, and/or celery extract, and/or red bilberry extract, and/or extract of juniper, and/or melon extract, and/or orange extract, and/or oat extract, and/or extract of black currants, and/or sprouts extract broccoli, and/or ginger root extract, and/or mango extract, and/or walnut extract, and/or extract of berries, and/or extract of green tea, and/or Bilberry fruit extract, and/or raspberry extract and/or quercetin, and/or soya isoflavones. Amino acid selected from: alanine, and/or aspartic acid, and/or glutamine, and/or glutamic acid, and/or arginine, and/or leucine, and/or lysine, and/or proline.

EFFECT: agent described above possesses the pronounced general tonic, antioxidant action, increased storage life.

4 cl, 9 ex

Description

The invention relates to the chemical and pharmaceutical industry, in particular to the creation of an agent having a tonic and antioxidant effect, namely, a drug based on components of natural origin, acting on a number of physiological functions of the human body. In particular, the tool has a restorative and preventive effect on key vital processes of the human body for its restoration, rejuvenation and enhancement of its biological properties and vital signs, and also has a protective effect against free radicals.

Inside any organism, redox processes occur continuously. As a result of these processes, free radicals are formed. In the organic molecules that make up our body, the electrons on the outer electron shell are arranged in pairs. Free radicals are molecular particles that have one or more unpaired electrons on the outer electron shell, which makes them especially active and “aggressive”. Therefore, they are the cause of many serious diseases.

The prior art means with a tonic, antioxidant effect.

In the documents (RU 2162702 C1, 02.10.2001; RU 2171113 C1, 07.27.2001; RU 2176514 C2, 10.12.2001, RU 2390347 C2, 05.27.2010) compositions based on plant materials are disclosed that have a restorative, adaptogenic, tonic, antioxidant , tonic effect.

The disadvantages of the known drugs are low digestibility, the preservation of a significant amount of free radicals in the blood of the patient.

Known agent having antioxidant properties, representing a powder from squeezed apples, obtained by a method that provides a high content of pectin, protopectin, vitamin C and trace element selenium therein (RU 2371012 C1, 10.27.2009).

However, this tool also has insufficient antioxidant activity.

The present invention relates to a tool in which a unique combination of glutathione, sources of biologically active substances (selected from standardized plant extracts, quercetin and / or soy isoflavones), amino acids, water with a negative redox potential, gives a pronounced and long-lasting healing, restorative, antioxidant effect .

The present invention is aimed at achieving a technical result, which consists in creating a product based on components having a natural origin, which has an increased tonic and antioxidant effect, stable during long-term storage (from 1 to 1.5 years). This ensures a high biological activity of the components for the formation of a general strengthening effect and a regenerating effect on individual human organs by eliminating the destructive effect of free radicals.

The specified technical result is achieved by the fact that the proposed tool contains apple pectin, a source of biologically active substances (BAS), glutathione, amino acids, potassium sorbate, water with a negative redox potential from -200 to -240 mV, with the following components, in mass . %:

apple pectin 5-7 source of biologically active substances 0.4-8 glutathione 1,5-2 amino acids 2-3.8 potassium sorbate 0.08-0.09 redox negative water potential from -200 to -240 mV rest

the source of biologically active substances is selected from: extract of red wine and / or extract of hawthorn fruit, and / or extract of cranberry fruit, and / or extract of rose hips with vitamin C, and / or spinach extract, and / or extract of stems and pineapple fruits, and / or celery extract and / or lingonberry extract and / or juniper extract and / or melon extract and / or orange extract and / or oat extract and / or blackcurrant extract and / or broccoli sprout extract and / or ginger root extract and / or mango extract and / or walnut extract and / or grape berry extract, and / or green tea extract, and / or blueberry fruit extract, and / or raspberry and / or quercetin extract, and / or soy isoflavones,

amino acids are selected from: alanine and / or aspartic acid and / or glutamine and / or glutamic acid and / or arginine and / or leucine and / or lysine and / or proline.

The tool may additionally contain lecithin in an amount of 1.1-1.2 wt.%, As well as vitamins selected from the group of vitamin B1 and / or B6, and / or B9, and / or B12, and / or vitamins PP, and / or vitamin C, lipolic acid, glucosamine, in an effective amount.

Each component of the proposed tool in itself is an effective assistant to the body. Its original development is a precisely selected quantitative combination of these components, providing a unique strong impact on human health and a long shelf life.

These signs are essential to achieve a technical result.

An essential component of the proposed product is water. The authors conducted studies on the use of water with a low (negative) redox potential (ORP) to increase the effectiveness of drugs, homeopathic medicines and dietary supplements (dietary supplements), which use water or an aqueous solution as the basis. It has been established that homeopathic information recorded on any liquid medium (including gel forms) with negative AFP (less than 0 mV) allows one to improve the digestibility of the drug by the human body when applied.

The main processes that ensure vital activity are redox reactions. The energy released during these reactions is spent on the regeneration of body cells and maintaining homeostasis - the relative dynamic constancy of the composition and properties of the internal environment. In the course of redox reactions, the electric potential of substances changes: one substance gives off its electrons and oxidizes, acquiring a positive charge, the other accepts electrons and, being charged negatively, is restored. The difference in electrical potentials between them is the redox potential (ORP). ORP, which is also called the redox potential, characterizes the degree of electron activity in redox reactions. The greatest oxidizing ability is oxygen, and the reducing ability is hydrogen. Differences in the ORP of the internal environment of the human body and drinking water mean that the activity of electrons in the internal environment of the human body is much higher than the activity of electrons in drinking water. If the fluid entering the body has an ORP close to the value of the ORP of the internal environment of the human body, then the electrical energy of the cell membranes (the vital energy of the body) is not spent on correcting the activity of the electrons of this fluid, and it is immediately absorbed, since it has biological compatibility in this parameter. If the incoming liquid has an ORP more negative than the ORP of the internal environment of the body, then it feeds it with this energy, which is used by the cells as an energy reserve of the antioxidant defense of the body from the adverse effects of the external environment.

Studies have been conducted on the use of water with AFP with - 200 mV for disinfection and sterilization of instruments, rooms, equipment, care items, skin and mucous membranes, etc., as well as for the treatment of purulent wounds. Tests have shown that they, when exposed for 5-10 minutes to rinse the oral cavity, reduce the seeding by microorganisms of the oral cavity and pharynx by 25-100 times, which is confirmed by their successful use for rinsing with diseases of the pharynx (L.G. Bazhenov et al., 1999) . The use of wetted wipes allows you to completely clean the wound cavities with gunshot wounds, phlegmon, abscesses, trophic ulcers, mastitis, extensive purulent-necrotic lesions of the subcutaneous tissue in 3-5 days, and subsequent use within 5-7 days significantly accelerates the reparative processes. There is also evidence of the high therapeutic efficacy of electroactivated solutions for non-specific and candidal colpitis, endocervicitis, residual urethritis, cervical erosion, corneal ulcers, purulent keratitis, infected wounds of the eyelids, for the correction of dysbiosis and immune disorders, in the treatment of stomatitis, gingivitis, parade with diseases of the stomach; in the treatment of salmonellosis, dysentery, as well as in the treatment of diabetes mellitus, tonsillitis, purulent otitis media, oily and dry seborrhea of the face, hair loss, contact allergic dermatitis, wrinkle correction. A good effect was found when using water with AFP - 200 mV for gastritis, peptic ulcer, hemorrhoids, dermatomycosis, eczema, prostate adenoma and chronic prostatitis, tonsillitis, bronchitis, chronic pyelonephritis, chronic hepatitis, viral hepatitis, deforming arthrosis, etc. . (S.A. Alekhin, 1997 and others).

Using water with negative AFP, the authors have developed a functional tool that has a restorative and preventive effect on the key life processes of the human body for its restoration, rejuvenation and enhancement of its biological properties and vital signs.

One of the main components of the drug is glutathione, which determines the redox status of the intracellular environment and keeps it in a stable range. Glutathione - g-glutaminyl-cystsinyl-glycine, a tripeptide formed by the residues of three amino acids - glutamic acid, cysteine and glycine. The structural feature of glutathione is a peptide bond between cysteine and glutamic acid, in which its g-carboxyl group is involved. Glutathione is found in all living organisms and is important for redox reactions due to the ability of the sulfhydryl group (SH-) cysteine to enter a reversible reaction. Apparently, the functions of glutathione in metabolism also include the protection of SH groups of cytoplasmic proteins from oxidation. Thanks to glutathione, the ORP value in the agent is preserved (-200) - (- 240) millivolts (mV). Thus, glutathione creates an active, workable, favorable environment for each cell. Glutathione is a key element of antioxidant protection: it is able to restore other antioxidants. The main antioxidant role of glutathione is to protect immune cells, primarily lymphocytes. If glutathione is not enough, lymphocytes die and the functioning of the immune system is seriously impaired, which leads to a number of diseases. Glutathione contains sulfur-containing groups. Sulfur is a sticky substance, and all the “debris” contained in the body adheres to its molecules, including free radicals, toxins and heavy metals. Glutathione is a protein that is synthesized in every cell of the human body.

Glutathione needs to be replenished by everyone, even very healthy people, starting from the age of 20. Since it is from this age, the synthesis of glutathione in the body begins to decline (approximately 1% per year). The older a person becomes, the more his body loses its ability to produce enough glutathione. This makes a person susceptible to cell decay due to oxidative stress and the growth of free radicals, defenseless against infections and many immune diseases. Glutathione deficiency occurs in so many diseases. These include chronic fatigue syndrome, cardiovascular disease, cancer, chronic infections, autoimmune diseases, diabetes, autism, Alzheimer's disease, Parkinson's disease, arthritis, asthma, kidney and liver diseases, and many others.

Used sources of biologically active substances, as well as additional introduction of vitamins into the remedy, make up for the lack of biologically active compounds, contribute to the effective restoration and improvement of the body, enhance the antioxidant defense of the body.

Each of the used sources of biologically active substances contains vitamins necessary for healing, substances that help strengthen the body, antioxidant protection. It is important to note that all plant extracts that make up the proposed product are natural, which are carefully selected.

The medicinal extracts that make up the proposed product are standardized. This means that the recommended amount of the product contains an equal amount of active ingredients and thus guarantees the same quality and level of effectiveness in every dose.

Another important substance contained in the proposed tool is pectin. Pectin is a natural substance that is found in the cell walls and intercellular space of all plants. They are especially rich in fruits, berries and vegetables. Pectin is necessary to stabilize the metabolism, reduces cholesterol in the body, improves peripheral blood circulation, as well as intestinal motility. He has the ability to clean living organisms from harmful substances without disturbing the bacteriological balance of the body. Its enveloping and astringent properties favorably affect the condition of the mucous membrane of the gastrointestinal tract.

It is the combination of glutathione + a source of biologically active substances + amino acids, taken in a certain amount, against a background of negative ORP of water, that provides the maximum healing effect on the body and protection against the destructive effect of free radicals, as well as an increased shelf life.

The tool may additionally contain vitamins B1, B6, B12, PP, C, as well as lecithin, glucosamine, in an effective amount.

The tool is obtained by mixing the components in predetermined quantities.

The following are examples of agents that have a tonic, antioxidant effect, the composition of which is selected experimentally.

The compositions are not limited to the presented examples, the components can be in any proportions falling into the claimed ranges of their quantitative content in the proposed tool.

Example 1

A tool with a tonic, antioxidant effect, containing, in mass. %:

apple pectin 6 source of biologically active substances: extracts of red wine, hawthorn and cranberry 4-7 glutathione 1,5-2 amino acids: Alanine, Aspartic Acid, Glutamine, Arginine 2-3.8 vitamin b1 0.04 vitamin b6 0.05 vitamin b12 0.00015 potassium sorbate 0.08 redox negative water potential from -200 to -240 mV rest

The source of biologically active substances is a mixture of extracts of red wine, hawthorn and cranberries, the extracts can be used in various proportions, with their total content in the tool 4-7 wt.%.

To prepare the funds according to example 1, standardized extracts were used:

Red wine extract - BY.70.06.01.003.E.003438.10.12. from 10/23/2012

Cranberry fruit extract - RU.77.99.11.003.E.044745.08.11 from 08.26.2011

Hawthorn fruit extract - RU.77.99.11.003.E.040082.07.11 dated 07/22/2011

Alanine, aspartic acid, glutamine, arginine were used as amino acids. These amino acids can be used in any ratios with each other, with a total total content in the agent of 2-3.8 wt.%.

Red wine extract - contains quercetin, rutin, anthocyanins, catechins, resveratrol, micro and macro elements, essential amino acids, vitamins, organic acids. It helps to improve the condition of the aorta and lower cholesterol, widen the coronary vessels, lower blood pressure and lower blood viscosity. Prevents blood clots.

Hawthorn fruit extract is a source of flavonoids, the amount of which reaches 17, trace elements Cu, Fe, Zn, Mg, Ca. It has a vasodilating effect on the vessels of the heart, contribute to the absorption of oxygen by the heart muscle.

Cranberry fruit extract - contains bioflavonoids, catechins and phenolic acids, as well as betaine and important micro and macro elements: potassium, calcium and phosphorus. Strengthens the muscles of the heart, increases the strength of capillaries, prevents the formation of blood clots in blood vessels, and improves blood circulation in blood vessels and the brain.

B vitamins (B1, B6, B12 - thiamine hydrochloride, pyridoxine hydrochloride, cyanocobalamin) - help strengthen the cardiovascular and nervous system, improve blood formation, support the body with prolonged overload and stress.

Apple pectin - stabilizes metabolism, lowers cholesterol in the body, improves peripheral blood circulation. It cleanses the body of harmful substances without disturbing the bacteriological balance of the body.

The experiments were carried out on 45 kidney fragments of Wistar rats weighing 150-200 g. The studies were carried out by administering massive doses of catecholamines to the animals, which leads to an excessive stimulating effect of the heart muscle with a relative lack of blood and oxygen supply, which causes heart-like changes in the heart ECG changes and the appearance of arrhythmias. The use of the composition before introducing the stimulator confirmed the energy-saving effect of the composition, which was manifested in the inhibition of glycolysis, increasing the efficiency of oxidative phosphorylation in mitochondria. As a result of the action of the composition during hypoxia and ischemia, glycogen stores are not depleted, the activity of LDH, LDH decreases, the activity of NADH-DG is preserved.

The composition according to example 1 has a pronounced tonic, antioxidant effect. It is a source of polyphenolic compounds, glutathione. Vitamins B1, B6, B12.

The tool showed stability for 1 year and 2 months, while maintaining the properties of water with negative ORP within the stated range and maintaining the structure of the composition.

Example 2

A tool with a tonic, antioxidant effect, containing, in mass. %:

apple pectin 5.5 source of biologically active substances: rosehip extracts with vitamin C, spinach, lingonberries, junipers, cranberries, stalks and fruits of pineapple, celery 0.4-8 glutathione 1,5-2 amino acids: aspartic acid, glutamic acid 2-3.8 vitamin b6 0.04-0.06 lecithin 1.1-1.2 potassium sorbate 0.08 redox negative water potential from -200 to -240 mV rest

The source of biologically active substances is a mixture of extracts of rose hips with vitamin C, spinach, lingonberries, junipers, cranberries, stems and fruits of pineapple, celery, extracts can be used in various proportions, with their total content in the product of 0.4-8 wt.% .

To prepare the product according to example 2, standardized extracts were used:

Rosehip Extract with Vitamin C - SGR No. RU.77.99.11.003.E.044555.08.11. from 08/26/2011

Vegetable Spinach Extract - SGR No. RU.77.99.88.009.E.001696.03.13. March 6, 2013

Lingonberry extract - СГ No. RU.77.99.88.009.E.045694.11.11. from 11/07/2011

Juniper Extract - SGR No. RU.77.99.88.009.E.045687.11.11. from 11/07/2011

Cranberry fruit extract - SGR RU.77.99.11.003.E.044745.08.11 from 08.26.2011

Extract of stalks and fruits of pineapple - СГ No. RU.77.99.11.003.E.050058.10.11. from 10/14/2011

Celery extract - SGR No. RU.77.99.88.009.E.008111.05.12. from 05/18/2012

As amino acids, aspartic acid and glutamic acid were used. These amino acids can be used in any ratios with each other, with a total total content of 2-3.8 wt.% In the product.

Glutathione complex, glutamic, aspartic acid - determines the redox status of the intracellular environment, has a powerful antioxidant effect.

Rosehip extract with vitamin C - contains ascorbic acid, riboflavin, carotene, phylloquinone and bioflavonoids (vitamin P).

Soya lecithin - the body needs it as a building material for the renewal of damaged cells, prevention of stone formation, has a general strengthening effect.

Cranberry, lingonberry extracts - have diuretic and antimicrobial properties, relieve the condition with urolithiasis and inflammation of the urinary tract, and prevent the formation of kidney stones.

Juniper Extract - contains vitamins, sugars, pectin, organic acids. Provides anti-inflammatory, bactericidal and diuretic effects. Helps to remove pathogens from the body.

Pineapple extract - provides decongestant action.

Celery extract - contains zinc, potassium, calcium, phosphorus, iron, magnesium. Vitamins of groups B, PP, E, A. Prevents the appearance of kidney stones, helps to eliminate decay products, normalizes pressure.

Apple pectin - stabilizes metabolism, lowers cholesterol in the body, improves peripheral blood circulation. It cleanses the body of harmful substances without disturbing the bacteriological balance of the body.

The effect of the drug on the development of kidney explants. The experiments were performed on 45 kidney fragments of Wistar rats weighing 150-200 g. The composition was added to the nutrient medium at a concentration of 2 ml / 100 g. The biological index of activity was the area index (IP) - the ratio of the area of the entire explant along with the growth zone to the outgoing area of the kidney fragment. The IP values were expressed as a percentage, the control IP value was taken as 100%. It was established that after 2 days of cultivation, the explants spread on a collagen substrate and the proliferation of proliferating and migrating cells began on the periphery of the explant. On the 3rd day of cultivation, at a drug concentration, a significant increase in the explant PI by 28% was observed compared with the control PI values. Thus, in relation to kidney tissue, the drug exerted a tissue-specific effect, manifested in stimulating the growth of explants.

The composition according to example 2 has a pronounced tonic, antioxidant effect. It is a source of vitamins C, B6, glutathione.

The composition according to example 2 effectively increases the detoxification capabilities of the body, has a restorative effect. The skin condition is restored, excessive puffiness goes away, the manifestation of cellulite is reduced.

The tool showed stability for 1.5 years, while maintaining the properties of water with negative ORP within the stated range and maintaining the structure of the composition.

Example 3

A tool with a tonic, antioxidant effect, containing, in mass. %:

apple pectin 5 source of biologically active substances: extracts of green tea, celery, oats, blackcurrant, orange melon 0.4-8 glutathione 1,5-2 amino acids: aspartic acid, glutamic acid, leucine 2-3.8 vitamin b9 0.02-0.03 lipolic acid 0.4-0.5 lecithin 1.1-1.2 potassium sorbate 0.08 redox negative water potential from -200 to -240 mV rest

The source of biologically active substances is a mixture of extracts of green tea, celery, oats, blackcurrant, orange, melon, extracts can be used in various proportions, with a total total content of 0.4-8 wt.% In the product.

To prepare the product according to example 3, standardized extracts were used:

Green tea extract - SGR No. RU.77.99.11.003.E.016937.12.12. from 12/13/2012

Celery extract - SGR No. RU.77.99.88.009.E.008111.05.12. from 05/18/2012

Oat extract - SGR No. RU.77.99.11.003.E.050033.10.11. from 10.24.2011

Blackcurrant extract - СГ No. RU.77.99.11.003.E.051412.11.11. from 11/25/2011

Orange extract - SGR RU.77.99.11.003.E.009569.03.11 dated 03.16.2011

Melon extract - SGR No. RU.77.99.11.009.E.041147.07.11. from 07/20/2011

As amino acids, aspartic acid and glutamic acid were used. These amino acids can be used in any ratios with each other, with a total total content of 2-3.8 wt.% In the product.

The composition according to example No. 3 - helps to normalize the function of the liver, biliary tract and gastrointestinal tract. It helps to restore the functioning of the liver and biliary tract, increases the production of bile and prevents its stagnation with dyskinesia of the biliary tract, helps dissolve stones in the gall bladder. It has a hepatoprotective property, i.e. protects the liver cell from various lesions of toxins, from viruses, decay products, removes toxins from the body. It has anti-allergic, antiseptic anti-inflammatory properties, mild laxative properties. It normalizes bilirubin metabolism and the level of cholesterol in the body involved in the formation of prothrombin in the liver, which is necessary to maintain normal blood coagulation in the body.

The glutathione-amino acid complex determines the redox status of the intracellular environment, initiates the production of detoxification enzymes in the liver, protects the cells of the liver itself from damage, and promotes their regeneration.

Green tea extract - a source of catechins, vitamins C, B1, B2, PP, K, amino acids and trace elements, has a hepatoprotective effect, preventing structural changes in the tissues of organs, their growth.

Lipoic acid - protects the liver, restores the integrity of liver cells. It prevents fatty degeneration of the liver and removes excess fat from the liver. Reduces glutathione consumption

Oat extract - contains amino acids: tryptophan and lysine. As well as gum and vitamins: B1, B2, B6, vitamin K, carotene and acids (oxalic, erucic, molonic), magnesium and potassium, chromium and phosphorus, manganese, iron, nickel, iodine, fluorine and zinc, sulfur. Helps cleanse the liver. It has anti-allergic, antiseptic anti-inflammatory properties, mild laxative properties.

Blackcurrant extract - contains vitamins C, B1, B2, B6, B9, E, K, P, A, D. Pectins, carotenoids, salts of phosphorus, iron and potassium. It has an auxiliary, anti-inflammatory effect. Helps dissolve gallstones. Antitumor protection.

Melon extract - contains potassium, vitamins PP, B, C, carotene, phosphorus, copper, silicon, magnesium, calcium, organic acids, carbohydrates. Helps restore liver function, helps dissolve gallstones.

Celery extract - contains proteins, vitamins, amino acids and minerals. Ensures the stability of body cells and slows down the aging process. Reduces fat deposition in the liver.

Orange extract - has a choleretic effect.

Vitamin B9 - prevents liver obesity, restores liver tissue damaged by toxic drugs, viruses, alcohol and drugs.

Apple pectin - stabilizes metabolism, lowers cholesterol in the body, improves peripheral blood circulation. It cleanses the body of harmful substances without disturbing the bacteriological balance of the body.

The experiments were performed on liver fragments of Wistar rats weighing 150-200 g. Liver fragments were placed in this medium and cultured in Petri dishes in an incubator at a temperature of 36.7 ° C for 2 days. The peptide composition was added to the experimental medium at concentrations of 2 ml / 100 g. The area index (PI), the ratio of the area of the entire explant together with the growth zone to the outgoing area of the liver fragment, was used as a criterion of biological activity.

It was established that after 2 days of cultivation, the explants spread on a collagen substrate and the proliferation of proliferating and migrating cells began on the periphery of the explant. There was a significant increase in the explant PI by 40%, compared with the control PI values, which indicates a tissue-specific effect, manifested in stimulating the growth of explants.

The composition according to example 3 has a pronounced tonic, antioxidant effect. It is a source of catechins, lipolic acid, folic acid, glutathione.

The tool showed stability for 1.3 years, while maintaining the properties of water with negative ORP within the stated range and maintaining the structure of the composition.

Example 4

A tool with a tonic, antioxidant effect, containing, in mass. %:

apple pectin 7 source of biologically active substances: extracts of blackcurrant, mango, lingonberry, juniper, raspberries, oranges, ginger root 0.4-8 glutathione 1,5-2 amino acids: aspartic acid, glutamic acid, leucine, alanine 2-3.8 vitamin b6 0.04 vitamin b12 0.00015 potassium sorbate 0.09 redox negative water potential from -200 to -240 mV rest

The source of biologically active substances is a mixture of extracts of blackcurrant, mango, lingonberry, juniper, raspberry, orange, ginger root, extracts can be used in various proportions, with a total total content of 0.4-8 wt.% In the product.

To prepare the product according to example 4, standardized extracts were used:

Blackcurrant extract - СГ № RU.77.99.11.003.Е.051412.11.11. from 11/25/2011

Mango extract - SGR No. RU.77.99.11.003.E.050037.10.11. from 10.24.2011

Lingonberry extract - СГ No. RU.77.99.88.009.E.045694.11.11. from 11/07/2011

Juniper Extract - SGR No. RU.77.99.88.009.E.045687.11.11. from 11/07/2011

Raspberry extract - SGR No. RU.77.99.88.009.E.047881.11.11. from 11/23/2011

Orange extract - SGR RU.77.99.11.003.E.009569.03.11 dated 03.16.2011

Ginger Root Extract - SGR No. RU.77.99.11.003.E.039165.07.11. from 07/20/2011

As amino acids, aspartic acid, glutamic acid, leucine, alanine were used. These amino acids can be used in any ratios with each other, with a total total content of 2-3.8 wt.% In the product.

The composition according to example No. 4 - contributes to the normalization of respiratory function. The respiratory system consists of the nose, pharynx, trachea, bronchi and lungs. It has a bactericidal effect in infections of the upper respiratory tract. It has an expectorant, antitussive, anti-inflammatory, antifungal, antiviral effect. Helps to restore the function of the bronchopulmonary system, reduce inflammation in the bronchi, trachea, lungs, restoring the functional state of the mucosa. It has a resolving, healing, diaphoretic and antipyretic, tonic and stimulating effect. It has an immunomodulatory effect.

The glutathione complex, alanine, glutamine, aspartic acid, leucine determines the redox status of the intracellular environment, has a powerful antioxidant, healing and regenerating effect.

Blackcurrant extract is a powerful anti-inflammatory effect, as it is a source of natural antibiotics and phytoncides, which kill fungi, bacteria, viruses in the body, and a high content of ascorbic acid increases immunity.

Extracts of mango, ginger root, lingonberry - sources of vitamins: A, B1, B2, PP, B5, B6, B9, C, E. They contain minerals: potassium, calcium, phosphorus, magnesium, sodium, iron, copper, zinc, manganese, sulfur. Provide a pronounced anti-inflammatory effect, dilutes sputum and promotes its easy passage from the bronchi, increases immunity.

Juniper extract - contains many tannins, organic and ascorbic acids. Provides bactericidal effect. It removes phlegm. Helps to restore the functional state of the bronchial mucosa.

Extracts of raspberries, oranges - contain vitamins C, B1, B2, P, K, E, B9, carotene. It has a bactericidal effect in infections of the upper respiratory tract, as well as diaphoretic and antipyretic, tonic.

Vitamins P6 and B12 - increase oxygen consumption by cells, which helps to eliminate hypoxia that occurs in acute and chronic bronchitis, and also facilitates its course.

Apple pectin - stabilizes metabolism, lowers cholesterol in the body, improves peripheral blood circulation. It cleanses the body of harmful substances without disturbing the bacteriological balance of the body.

The tissue explants of lungs of mature Wistar rats were cultured in Petri dishes with a collagen-coated bottom. The test composition was added to the culture medium at a concentration of 2 ml / 100 g of culture medium. The same volume of 0.9% NaCl solution was added to the control group explants. After incubation for 3 days at a temperature of 37 ° C, an increase in the area of the explants was evaluated under a phase contrast microscope. The biological effect of the composition was evaluated by changing the area index (PI) of explants grown in a medium with a peptide, compared with the control. The results of the experiment showed that the composition significantly stimulates the growth of explants of organotypic culture of rat lungs of more than 50%.

The composition according to example 4 has a pronounced tonic, antioxidant effect. It is a source of anthocyanins, vitamins B6, B12, glutathione.

The tool showed stability for 1.5 years, while maintaining the properties of water with negative ORP within the stated range and maintaining the structure of the composition.

Example 5

A tool with a tonic, antioxidant effect, containing, in mass. %:

apple pectin 5-7 source of biologically active substances: extracts of blueberries, melons, green tea, oats, sprouts broccoli, cranberry, ginger root and soy isoflavones 0.4-8 glutathione 1,5-2 amino acids: aspartic acid, glutamic acid, glycine 2-3.8 vitamin b9 0.02-0.03 vitamin PP 0.4-0.6 potassium sorbate 0.09 redox negative water potential from -200 to -240 mV rest.

The source of biologically active substances is a mixture of extracts of blueberries, melon, green tea, oats, broccoli, cranberry, ginger root and soy isoflavones, soy extracts and isoflavones can be used in various proportions, with a total content of 0.4-8-8 mass%.

For the preparation of the product of example 5, standardized extracts were used:

Blueberry fruit extract - SGR No. RU.77.99.11.003.E.017131.12.12. December 12, 2012

Melon extract - SGR No. RU.77.99.11.009.E.041147.07.11. from 07/20/2011

Green Tea Extract - SGR No. RU.77.99.11.003.E.016937.12.12. from 12/13/2012

Oat extract - SGR No. RU.77.99.11.003.E.050033.10.11. from 10.24.2011

Broccoli sprout extract - SGR No. RU.77.99.11.003.E.044567.08.11. from 08/26/2011

Cranberry fruit extract - RU.77.99.11.003.E.044745.08.11 from 08.26.2011

Ginger Root Extract - SGR No. RU.77.99.11.003.E.039165.07.11. from 07/20/2011

Soy isoflavones - SGR No. RU.77.99.11.003.E.016698.12.12 of December 6, 2012.

As amino acids, aspartic acid, glutamic acid, glycine were used. These amino acids can be used in any ratios with each other, with a total total content of 2-3.8 wt.% In the product.

The composition according to example No. 5 contributes to the normalization of the digestive system. Digestive system: oral cavity, pharynx and esophagus, stomach, duodenum - the initial section of the intestine, small intestine, large intestine, digestive glands - liver, pancreas, salivary glands. Helps to normalize the functional state of the stomach, duodenum 12, liver, pancreas, small and large intestines. It improves the composition of the intestinal flora, reduces pain and inflammation, reduces secretion, normalizes intestinal motility and improves the absorption process. Helps to improve intestinal motor function. Eliminates the main symptoms of diseases of the digestive system, normalizing acute and chronic processes that turn into a stable remission.

The glutathione complex, glutamic acid, aspartic acid determines the redox status of the intracellular environment, has a powerful antioxidant, healing and regenerating effect.

Glycine - slows down the degeneration of muscle tissue, is necessary for the synthesis of nucleic acids (DNA and RNA). Useful for repairing damaged tissue.

Vitamin PP - promotes the breakdown of proteins, fats and carbohydrates, thereby helping the stomach easier to digest food.

Melon extracts - contains vitamins A, B1, B2, B3, B4, B5, B6, B9, C, E. Minerals: iron, potassium, calcium, magnesium, manganese, copper, sodium, selenium, phosphorus, fluorine, zinc. It normalizes intestinal function, helps restore intestinal motor function, and provides detoxification processes.

Green tea extract - contains tannin, catechins, antioxidants - helps to improve the digestive process, and normalizes the processes of the gastrointestinal tract. It has an antimicrobial effect, removes radioactive substances from the body.

Ginger root extracts are a source of vitamins: A, B1, B2, PP, B5, B6, B9, C, E. It contains minerals: potassium, calcium, phosphorus, magnesium, sodium, iron, copper, zinc, manganese, sulfur. Improves the composition of microflora. Promotes the digestion of heavy animal proteins, removes toxins and other harmful substances. Promotes weight loss.

Cranberry fruit extract - contains iron, iodine, calcium, magnesium, etc. Vitamins: B1, B2, K, PP, C, benzoic, malic, citric acids, antioxidants. Stimulates pancreatic function. Improves metabolism and immune defense, slows down the aging process.

Oat extract - contains vitamins A, B1, B2, B3, B6, K and F. Organic acids, essential amino acids, trace elements: potassium, magnesium, sulfur, chromium, iron, fluorine, iodine, manganese, zinc, nickel, phosphorus. It contributes to the normalization of acute and chronic processes in the stomach and pancreas, small and large intestines.

Broccoli sprout extract - contains ascorbic acid, vitamins A, E, vitamins of group B, PP, potassium, calcium, chromium, phosphorus, iron, magnesium, manganese, copper, iodine. Helps to eliminate belching, heartburn, nausea. Improves performance, helps cleanse the digestive system.

Soy isoflavones - contribute to the strengthening of anti-inflammatory, healing processes, normalization of the motor activity of the gastrointestinal tract, and have an immunostimulating effect.

Folic acid - has a beneficial effect on fat metabolism in the liver.

Apple pectin - stabilizes metabolism, lowers cholesterol in the body, improves peripheral blood circulation. It cleanses the body of harmful substances without disturbing the bacteriological balance of the body.

A study of the biological activity of the composition on the mitochondrial mechanisms of apoptosis in gastric epithelial cells induced by the Helicobacter pylori microbe was carried out on SGC7901 human gastric epithelial cells. Cells were passaged in culture medium for 5 days, after which they were taken for research. On the 5th day after the start of cell passage, the composition was introduced into the culture medium at a concentration of 2 ml / 100 g, and after 30 min of incubation, the cells were taken for examination. As a control, cells were considered without adding a composition. The condition of isolated mitochondria was assessed using immunofluorescence confocal laser microscopy. Under the action of the composition, the outlines and structure of mitochondria were preserved, the expression of mitochondrial GFP practically does not differ from the initial indicators (2.48 ± 0.17 cu in optical density; 3.84 ± 0.20% in expression area), which indicates the property of preventing mitochondrial apoptosis disorders, arising under the influence of Helicobacter pylori.

The composition according to example 5 has a pronounced tonic, antioxidant effect. It is a source of anthocyanins, vitamins PP, folic acid, glutathione.

The tool showed stability for 1.4 years, while maintaining the properties of water with negative ORP within the stated range and maintaining the structure of the composition.

Example 6

A tool with a tonic, antioxidant effect, containing, in mass. %:

apple pectin 6.3 quercetin 0.7-5 glutathione 1,5-2 amino acids: aspartic acid, glutamic acid, alanine 2-3.8 vitamin C 0,03 glucosamine 0.05 potassium sorbate 0.09 redox negative water potential from -200 to -240 mV rest

The source of biologically active substances is quercetin - SGR No. RU.77.99.11.009.E.016086.11.12. from 11/20/2012.

As amino acids, aspartic acid, glutamic acid, alanine were used. These amino acids can be used in any ratios with each other, with a total total content of 2-3.8 wt.% In the product.

The composition according to example No. 6 contributes to the recovery processes of the musculoskeletal system. Helps to restore joint function, increase mobility, range of motion in the joint, stop the sensation of crunching and swelling. It promotes the fixation of sulfur during the synthesis of chondroitin sulfuric acid, facilitates the normal deposition of Ca ²⁺ in bone tissue, inhibits the development of degenerative processes in the joints, restores their function, reducing joint pain. Restores the synthesis of the main proteins of connective tissue, in particular, bone and cartilage. Normalizes metabolic processes in them; helps prevent age-related, inflammatory and metabolic lesions of the joints. The permeability and fragility of capillary vessels decreases, improves the elastic state of the vessel wall, restoration of articular surfaces. It has a bactericidal effect in infections in various joints, has an anti-inflammatory effect. It has a diuretic effect, softens and removes salts from articular surfaces.

The complex glutathione, alanine, aspartic acid, glutamine - determines the redox status of the intracellular environment, has a powerful antioxidant, healing and regenerating effects.

Glucosamine - increases the permeability of the joint capsule, restores the enzymatic processes, processes in the cells of the synovial membrane and articular cartilage.

Vitamin C - is a coenzyme necessary for the synthesis of the main proteins of connective tissue, in particular, bone and cartilage. Normalizes metabolic processes in them; helps prevent age-related, inflammatory and metabolic lesions of the joints of the limbs and spine.

Apple pectin - stabilizes metabolism, lowers cholesterol in the body, improves peripheral blood circulation. It cleanses the body of harmful substances without disturbing the bacteriological balance of the body.

Evaluation of the anti-inflammatory activity of standard NSAID therapy, as well as in combination with the components of the pharmaceutical composition according to the level of pro-inflammatory cytokines.

To study anti-inflammatory activity from patients with rheumatoid arthritis. To characterize the course of the inflammatory reaction, we studied the expression of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), the concentration of which was measured using a traditional enzyme-linked immunosorbent assay.

Studies have shown that the level of pro-inflammatory cytokines is least pronounced in the synovial fluid of patients who received combination therapy, a combination of NSAIDs and Protetion 6 at a dosage of 2 ml per day.

This study distinguishes additional properties of the composition and demonstrates the benefits of achieving a more pronounced effect in the treatment of joint diseases.

The composition according to example 6 has a pronounced tonic, antioxidant effect. It is a source of vitamin C, quercetin, glutathione.

The tool showed stability for 1.4 years, while maintaining the properties of water with negative ORP within the stated range and maintaining the structure of the composition.

Example 7

A tool with a tonic, antioxidant effect, containing, in mass. %:

apple pectin 5-7 source of biologically active substances: extracts of red wine, melon, mango, walnut, stalks and pineapple fruit celery 0.4-8 glutathione 1,5-2 amino acids: aspartic acid, glutamic acid, lysine, proline 2-3.8 vitamin PP 0.43 potassium sorbate 0.09 redox negative water potential from -200 to -240 mV rest

The source of biologically active substances is a mixture of extracts of red wine, melon, mango, walnut, stalks and fruits of pineapple, celery, extracts can be used in various ratios, with a total total content of 0.4-8 wt.% In the product.

To prepare the product according to example 7, standardized extracts were used:

Red wine extract - SGR No. BY.70.06.01.003.E.003438.10.12. from 10/23/2012

Melon extract - SGR No. RU.77.99.11.009.E.041147.07.11. from 07/20/2011

Mango extract - SGR No. RU.77.99.11.003.E.050037.10.11. from 10.24.2011

Walnut extract - SGR No. RU.77.99.88.009.E.046483.11.11. from 11/11/2011

Extract of stalks and fruits of pineapple - СГ No. RU.77.99.11.003.E.050058.10.11. from 10/14/2011

Celery extract - SGR No. RU.77.99.88.009.E.008111.05.12. from 05/18/2012

As amino acids, aspartic acid, glutamic acid, lysine, and proline were used. These amino acids can be used in any ratios with each other, with a total total content of 2-3.8 wt.% In the product.

The composition according to example No. 7 regulates the work of the male reproductive system. Helps to restore fertilization processes, prevention and treatment of male infertility. Normalizes function and provides support for the prostate gland. Supports the normal functioning of the genitourinary and reproductive systems. It harmonizes the nervous and endocrine systems and improves vitality. It maintains the full reproductive function of men. Supports the normal functioning of the urinary system. It has an anti-inflammatory effect, pain and inflammation decrease, and restores potency in men.

The complex glutathione, lysine, glutamic acid, aspartic acid, proline - determines the redox status of the intracellular environment, has a powerful antioxidant, healing and regenerating effect.

Red wine extract - contains quercetin, rutin, anthocyanins, catechins, resveratrol, micro and macro elements, essential amino acids, vitamins, organic acids. It increases the production of testosterone in men by 2.7 times, promotes the harmonization of the nervous and endocrine systems, increases vitality, a powerful antioxidant defense.

Vitamin PP (nicotinic acid or vitamin B3) is extremely important for men's health.

Mango extract - contains vitamins A, C, B6.

Walnut extract - rich in vitamins A, B1, B2, B3, B12, C, K, E, PP. It contains minerals - phosphorus, potassium, magnesium, calcium, sulfur, iron, aluminum, manganese, zinc. Helps increase the synthesis of male sex hormone - testosterone, enhance the production of sex hormone, helps restore male potency.

Melon extract - contains potassium, calcium, sodium, iron, magnesium, phosphorus, vitamins B9, C, A, pectins. Promotes the normal functioning of the genitourinary and reproductive systems, normalization of the function of the prostate gland.

Celery extract - contains vitamin C, vitamins B, E, A, PP, K. Minerals of zinc, magnesium, calcium, as well as potassium, iron, phosphorus, male sex hormone - androsterone, which enhances the appearance of secondary sexual characteristics and increases potency, It is a prophylactic against prostatitis. Thanks to its diuretic properties, it helps to cope with infectious diseases of the genitourinary system and reproductive organs.

Pineapple stalk and fruit extract - contains vitamin A, C, PP, B vitamins, iron, calcium, copper, iodine, potassium, magnesium. It has anti-inflammatory effect, restores male power.

Apple pectin - stabilizes metabolism, lowers cholesterol in the body, improves peripheral blood circulation. It cleanses the body of harmful substances without disturbing the bacteriological balance of the body.

We studied the contractility of isolated preparations of the prostate gland of guinea pigs at a concentration of 2 ml / 100 g. It was shown that Protethion 7 significantly increased the response of the smooth muscle of the prostate to electrical stimulation, and caused a significant increase in the amplitude of phase-tonic contractions. This effect of the drug enhances microcirculation and improves the outflow of secretion from the prostate gland. Such an action seems to be very important for the correction of disorders accompanying any changes in blood circulation and trophism of the prostate gland (and, consequently, functionally and anatomically connected organs) caused by stagnation of blood in the pelvis, dysrhythmia of sexual life, hypothermia, trauma to soft tissues of the perineum, etc. d.

Complex No. 7 - the peptide complex has a healing effect on the reproductive female organs, as well as general support for the female body. Normalizes the functional state of the female reproductive system. Improves blood circulation of the pelvic organs and the state of healthy microflora. The condition of the pathological menopause is removed. Improves well-being, improves body tone. Helps to restore fertilization processes and reduces the risk of infertility, normalizes menstrual function. It normalizes the metabolism of female sex hormones - estrogens, blocks the carcinogenic effect of their metabolites, which cause the growth of tumor cells. It reduces the risk of diseases associated with changes in the hormonal background (overweight, osteoporosis, mastopathy, breast cancer, premenstrual and menopausal syndrome). Supports a woman’s health in menopause, reduces the severity of symptoms characteristic of the onset of menopause. It has a rejuvenating effect, actively inhibits the aging of the body, helps to relieve fatigue.

The composition according to example 7 has a pronounced tonic, antioxidant effect. It is a source of polyphenolic compounds, vitamin PP, glutathione.

The tool showed stability for 1.5 years, while maintaining the properties of water with negative ORP within the stated range and maintaining the structure of the composition.

Example 8

A tool with a tonic, antioxidant effect, containing, in mass. %:

apple pectin 5-7 source of biologically active substances: extracts of broccoli sprouts, cranberries, grapes, blackcurrant, mango and soy isoflavones 0.4-8 glutathione 1,5-2 amino acids: glutamine, lysine 2-3.8 vitamin PP 0.4 vitamin b1 0.04 vitamin b6 0.05 potassium sorbate 0.09 redox negative water potential from -200 to -240 mV rest

The source of biologically active substances is a mixture of extracts of broccoli, cranberry, grape, blackcurrant, mango and soy isoflavones, extracts can be used in various proportions, with a total content of 0.4-8 wt.% In the product.

To prepare the product of example 8, standardized extracts were used:

Broccoli sprout extract - SGR No. RU.77.99.11.003.E.044567.08.11. from 08/26/2011

Cranberry fruit extract - RU.77.99.11.003.E.044745.08.11 of 08.26.2011

Grape Berry Extract - SGR No. RU.77.99.11.003.E.004488.02.12. 02/15/2012

Blackcurrant extract - СГ № RU.77.99.11.003.Е.051412.11.11. from 11/25/2011

Mango extract - SGR No. RU.77.99.11.003.E.050037.10.11. from 10.24.2011

Soy isoflavones - SGR No. RU.77.99.11.003.E.016698.12.12 of December 6, 2012.

Glutamine and lysine were used as amino acids. These amino acids can be used in any ratios with each other, with a total total content of 2-3.8 wt.% In the product.

Glutamine - has a strong antioxidant effect due to vitamins (C, E, B - carotine) and selenium, which is part of glutathione peroxidase, which blocks the formation of free radicals. Provides acid-base balance.

Lysine is an indispensable amino acid that is part of almost any protein, it is necessary for the growth and restoration of tissues, the production of antibodies, hormones, enzymes.

Soy isoflavones - called "the secret of female attractiveness" or "plant estrogen." Recommended for any disturbances in estrogen balance in women. Contribute to the weakening of hot flashes during menopause, lowering cholesterol, lowering the risk of cardiovascular disease.

Broccoli Sprout Extract - contains the antioxidant sulforaphane. Helps to increase the body's production of enzymes that remove toxins and toxins. It is proved that the accumulation of residual metabolic products worsens complexion and skin condition.

Cranberry fruit extract - relieves inflammation of the female genitourinary system. Improves the overall tone of the body.

Grape berry extract is a source of vitamin A, C, P, B6. It contains trace elements - calcium, iron, phosphorus, potassium, magnesium, selenium. It has a tonic and firming effect.

Blackcurrant extract - restores metabolism, protects cell membranes from destruction by free radicals.

Mango extract is a source of vitamins A, B, C, D and E. It has the strongest antioxidant activity, removes toxins and salts of heavy metals from the body.

Thiamine hydrochloride (B1) - is involved in the regulation of estrogen hormone metabolism, the synthesis of acetylcholine.

Apple pectin - stabilizes metabolism, lowers cholesterol in the body, improves peripheral blood circulation. It cleanses the body of harmful substances without disturbing the bacteriological balance of the body.

The effect of the composition on lymphocyte subpopulations was evaluated using the indirect immunofluorescence reaction of monoclonal antibodies obtained against differentiating antigens of the cell surface. Lymphocytes were isolated from heparinized (25 units / ml) peripheral blood of 18 patients with purulent-inflammatory lung diseases and chronic purulent bronchitis, accompanied by secondary immunodeficiency conditions, centrifugation in a density gradient ficoll-urotrast. It was found that the action of the composition in all concentrations led to an increase in the initially reduced number of T-helpers, which indicates a pronounced immunobiological activity of the composition.

The composition according to example 8 has a pronounced tonic, antioxidant effect. It is a source of isoflavones, vitamin PP, B1, B6, glutathione.

The tool showed stability for 1.4 years, while maintaining the properties of water with negative ORP within the stated range and maintaining the structure of the composition.

The compositions with other combinations of components (sources of biologically active substances and amino acids) in the given quantitative ranges were also studied. Clinical trials have shown that all formulations are characterized by a pronounced tonic and powerful antioxidant effect, are stable during storage for up to 1.5 years.

Clinical studies have shown that the proposed tool is completely absorbed by the body due to the gel structure. The gel form allows the components of the drug to enter the blood and lymph, bypassing the digestive tract, which improves the digestibility of nutrients, maximizing their biological effects on the body. The product itself and its concentration allows you to keep in this gel the negative ORP of water (-200) - (- 240) for almost a year. No one in the world has ever invented such a thing. This invention provides the creation of drugs for the prevention and improvement of health, since each complex has a redox potential (ORP) more negative than the ORP of the internal environment of the body, this difference is used by cells as an energy reserve of antioxidant protection of the body from adverse environmental factors. A high concentration of the drug provides a daily rate of active compounds necessary for the active life of the body.

Studies have shown that the quantitative content of the components is optimal, provides stability during storage, as well as a more pronounced tonic and antioxidant effect.

So, with a shift in the quantitative ranges of the components to a smaller or larger side, the activity of the agent decreased. Also, storage stability decreased.

Example 9

A tool with a tonic, antioxidant effect, containing, in mass. %:

apple pectin 3-4 source of biologically active substances: extracts of broccoli sprouts, cranberries, grapes, blackcurrant, mango and soy isoflavones 0.4-8 glutathione 0.3-1.4 amino acids: glutamine, lysine 2-3.8 vitamin PP 0.4 vitamin b1 0.04 vitamin b6 0.05 potassium sorbate 0.05-0.07 redox negative water potential from -200 to -240 mV rest

The composition of example 9 had a less pronounced tonic and antioxidant effect compared to the composition of example 8. Also, the shelf life of the composition of example 9 was 5.5 months. With further storage of the redox potential increased, the structure of the product was stratified.

Similar results were obtained in the study of other compounds with a reduced or increased content of components, compared with the proposed tool.

Thus, the proposed invention has a pronounced tonic and antioxidant effect, as well as a long shelf life.

Claims (4)

1. A tool with a tonic, antioxidant effect, containing apple pectin, a source of biologically active substances (BAS), glutathione, amino acids, potassium sorbate, water with a negative redox potential of -200 to -240 mV, with the following components, in mass %:
apple pectin 5-7 source of biologically active substances 0.4-8 glutathione 1,5-2 amino acids 2-3.8 potassium sorbate 0.08-0.09 redox negative water potential from -200 to -240 mV rest
the source of biologically active substances is selected from: extract of red wine and / or extract of hawthorn fruit, and / or extract of cranberry fruit, and / or extract of rose hips with vitamin C, and / or spinach extract, and / or extract of stems and pineapple fruits, and / or celery extract and / or lingonberry extract and / or juniper extract and / or melon extract and / or orange extract and / or oat extract and / or blackcurrant extract and / or broccoli sprout extract and / or ginger root extract and / or mango extract and / or walnut extract and / or grape berry extract and / or green tea extract and / or blueberry fruit extract and / or raspberry and / or quercetin extract and / or soy isoflavones;
amino acids are selected from: alanine and / or aspartic acid and / or glutamine and / or glutamic acid and / or arginine and / or leucine and / or lysine and / or proline. 2. The tool according to p. 1, characterized in that it further comprises vitamins selected from the group of vitamin B1, and / or B6, and / or B9, and / or B12, and / or vitamin PP, and / or vitamin C, in effective amount. 3. The tool according to p. 1, characterized in that it further comprises lecithin in an amount of 1.1-1.2 mass. % 4. The tool according to p. 1, characterized in that it further comprises components selected from lipolic acid, glucosamine, in an effective amount.