RU2516969C1 - Preparation for prevention and treatment of gastrointestinal diseases of newborn calves, which proceeds with signs of diarrhea - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: preparation comprises glucose, sodium chloride, sodium carbonate and potassium chloride, calcium acetate or calcium lactate, ascorbic acid, iron sulfate, chloromycetin and phtalazol with the following ratio of the components, g/l aqueous solution: glucose - 30.0; sodium chloride - 9.0; sodium carbonate - 5.0; potassium chloride - 0.2; calcium acetate or calcium lactate - 1.0; ascorbic acid - 0.5; iron sulfate - 0.2; chloromycetin - 1.0; phtalazol - 1.0.

EFFECT: preparation has high therapeutic and prophylactic efficacy in case of gastrointestinal diseases of newborn calves.

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Description

The invention relates to veterinary medicine and can be used for the prevention and treatment of gastrointestinal diseases of newborn calves, accompanied by diarrhea.

Comprehensive therapeutic and preventive measures for gastrointestinal diseases of newborn calves should be aimed at regulating feeding, as well as maintaining water, electrolyte, acid-base balance in the body, and prevention of putrefactive processes in the intestines.

In veterinary practice, for the treatment and prevention of gastrointestinal disorders accompanied by diarrhea, many drugs of various compositions are used.

Known methods for the prevention and treatment of gastrointestinal diseases of newborn calves using traditional antibiotics, sulfonamides and nitrofurans [1]. However, the known methods have low therapeutic efficacy due to the wide circulation of microorganisms with multiple drug resistance.

Also known therapeutic and prophylactic agents for the treatment of gastrointestinal diseases of calves - Ringer-Locke solution [2], saline for the treatment of calves [3] and Kalinat [4].

As a preferred analogue, a drug called Vetglucosalan is considered - a combined glucose-electrolyte mixture, which includes sodium chloride, sodium bicarbonate, potassium chloride and glucose or granulated sugar [5]. Vetglucosalan restores water-electrolyte balance disturbed by dehydration of animals.

However, all of the above funds are used only to restore water-salt and carbohydrate metabolism in the body of sick calves and have low therapeutic and prophylactic efficacy due to the lack of bactericidal activity of drugs, which eliminates the possibility of eliminating the microbial factor.

Summarizing the available information about the treatment and prevention of gastrointestinal diseases of young animals accompanied by diarrhea, it can be stated that combined preparations of antibiotics and sulfonamides are more effective than drugs separately. Preferred in this regard from antibiotics chloramphenicol, from sulfonamides - phthalazole.

The aim of the invention is the creation of a drug for the prevention and treatment of gastrointestinal diseases of calves, which has high therapeutic and prophylactic effectiveness and does not violate the biocenosis of the body.

The proposed drug containing glucose, sodium chloride, sodium bicarbonate and potassium chloride, characterized in that in order to increase the efficiency additionally contains calcium acetic acid or lactic acid, ascorbic acid, iron sulfate, chloramphenicol and phthalazole in the following ratio of components, g / l aqueous solution :

Glucose - 30.0

Sodium chloride - 9.0

Sodium bicarbonate - 5.0

Potassium chloride - 0.2

Calcium Acetic Acid or Lactic Acid - 1.0

Ascorbic acid - 0.5

Iron Sulfate - 0.2

Chloramphenicol - 1.0

Phthalazole 1.0

Glucose, which is part of the complex preparation, reduces dehydration, alleviates energy deficiency, slows intestinal motility, enhances the enzymatic activity of the digestive glands, and helps to eliminate toxins from the body and inactivate them in the liver.

Sodium and potassium chlorides normalize the water-salt balance.

Sodium bicarbonate restores acid-base balance, increases the overall resistance of the body.

Calcium acetate or lactic acid fills the deficit of calcium ions in the body.

Ascorbic acid normalizes carbohydrate and protein metabolism, increases the overall resistance of the body.

Iron sulfate stimulates erythropoiesis and improves metabolism.

Chloramphenicol has a bacteriostatic effect, inhibits the growth of various bacteria and metabolic disorders in the microbial cell.

The drug phthalazole is slowly absorbed, and therefore a high concentration is created in the gastrointestinal tract, providing an antimicrobial effect against enteropathogenic strains of E. coli, salmonella and many other bacteria.

The drug is a homogeneous powder, soluble in water, sweetish-salty taste. Its components do not enter into chemical reactions between themselves and do not change their pharmacological properties.

The drug is used as follows. It is dissolved in one liter of warm water and given to the calves inside in the form of a solution. For prophylactic purposes, in the first four binges after birth, 300-400 ml of the drug solution is added to each single serving of colostrum for two days and is drunk from the nipple drinker.

For therapeutic purposes, in the next two or three drinkings, sick calves are given 800-1000 ml of the drug solution instead of milk. Then, in each subsequent portion of milk, 300-400 ml of the drug solution are added. The drug is given until complete clinical recovery of the animal.

The invention is illustrated by examples.

Example 1. The effectiveness of the drug for the treatment of gastrointestinal diseases of calves.

The study of the effectiveness of the drug for the treatment of gastrointestinal diseases of calves was carried out in LLC “Molochnik” - Kizlyarsky and SEC “Khizroeva” - Khunzakhsky regions of the Republic of Dagestan, on calves 1-10 days old (240 animals) in 2012.

The drug was used when the first signs of the disease appeared. In the next two or three drinks, sick calves were given 800-1000 ml of the drug instead of milk. Then, in each subsequent portion of milk, 300-400 ml of the drug was added. The drug was given until complete clinical recovery of the animal.

For the treatment of calves in the control group (140 goals), the drugs used on the farm — chlortetracycline, Vetglyukosalan — were prescribed for 3-4 days according to the instructions for use. The effectiveness of the drug was evaluated by the following indicators: the duration of the disease, the percentage of recovery and mortality. The results of the experiment are presented in table 1.

Table 1 Therapeutic efficacy of the proposed drug for the treatment of gastrointestinal diseases of newborn calves Indicators Group of animals experienced control Number of animals, goals 240 140 Recovered goals 238 128 % 99,2 91.4 Fell goals 2 12 % 0.8 8.6 Duration of recovery, days 2,30 3.40

As studies have shown, the proposed drug has high therapeutic efficacy in the treatment of gastrointestinal diseases of newborn calves. In calves of the experimental group, in comparison with the control group, the recovery time and death of the animals decreased.

Example 2. Preventive efficacy of the drug in gastrointestinal diseases of newborn calves.

The study of the prophylactic efficacy of the claimed drug in gastrointestinal diseases of calves was carried out in MUL them. Kirov Tarumovskogo area on 84 calves 1-10 days of age.

For the prevention of gastrointestinal diseases in calves of the experimental group, the proposed preparation was used orally in the form of a solution. In the first four drinkers after birth, 300-400 ml of the drug solution was added to each single serving of colostrum within two days and was evaporated from the nipple drinker. The calves of the control group (62 heads) were prescribed Vetglucosalan for 3-4 days. The research results are presented in table 2.

table 2 Prophylactic effectiveness of the proposed drug for the treatment of gastrointestinal diseases of newborn calves Indicators Group of animals experienced control Number of animals, goals 84 62 Got sick Goals 2 eleven % 2,4 17.7 Preventive efficacy,% 97.6 82.3 Bactericidal activity of blood serum,% before the course of prevention 28.1 ± 1.1 28.4 ± 1.3 after a course of prevention 39.8 ± 1.2 32.7 ± 0.9 Lysozyme activity of blood serum,% before the course of prevention 2.0 ± 0.4 2.0 ± 0.3 after a course of prevention 3.6 ± 0.2 2.3 ± 0.5 B-lysine activity of blood serum,% before the course of prevention 13.2 ± 0.3 13.9 ± 0.4 after a course of prevention 17.8 ± 0.7 14.6 ± 0.1

As can be seen from table 2, the proposed drug has a higher (15.3%) prophylactic efficacy compared to the analogue. The bactericidal activity of blood serum in calves of the experimental group by the end of the experiment increased by 11.7%, lysozyme and B-lysine activity, respectively, 1.6 and 4.6% of the baseline. All this indicates the activation of metabolic processes in the animal body.

Thus, the test results on the farm allowed to recommend the proposed drug as a highly effective tool for the treatment and prevention of gastrointestinal diseases of calves. The proposed drug is well tolerated by calves and in recommended doses is non-toxic.

Information sources

1. RF patent 2105548 dated 02.27.1998.

2. Instructions for use of the Ringer-Locke solution.

3. Copyright certificate of the USSR No. 1246448 dated 06/13/1983.

4. Guidance on the use of Kalinata for the treatment of newborn calves in gastrointestinal diseases. Approved GUV Ministry of Agriculture of the USSR June 19, 1985.

5. TU 10-07-090-89.

Claims (1)

A preparation for the prevention and treatment of acute gastrointestinal diseases of newborn calves with signs of diarrhea, containing glucose, sodium chloride, sodium bicarbonate and potassium chloride, characterized in that it additionally contains calcium acetic or lactic acid, ascorbic acid, iron sulfate, chloramphenicol and phthalazole , in the following ratio of constituent components, g / l aqueous solution:
Glucose 30,0 Sodium chloride 9.0 Sodium bicarbonate 5,0 Potassium chloride 0.2 Calcium Acetic Acid or Lactic Acid 1,0 Vitamin C 0.5 Iron sulfate 0.2 Chloramphenicol 1,0 Phthalazole 1,0