RU2437653C1 - Method of treatment and prevention of gastrointestinal diseases in newborn calves - Google Patents

Abstract

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: method of treatment and prevention of gastrointestinal diseases in newborn calves includes administration of bacteriostatic, rehydration and symptomatic medications. As antimicrobial, bacteriostatic and rehydration medication applied is medication, containing wt %: norsulphasol -1.624, glucose - 1.169, sodium chloride - 6.23, potassium chloride - 0.649, calcium chloride - 0.2. Medication is applied orally, preliminarily dissolving 500 g of medication in 8 l of hot water, 2 times per day during three days in dose 0.7-1.5 l per one animal, portion of colostrum being reduced on the first day by 50-100%, on the second day - by 25%. 40 minutes before each introduction of medication calves are given decoction of oak bark in amount 15 g and 1 time per day and 20% solution of sodium caffeine-benzoate is introduced subcutaneously in dose 3 ml. ^ EFFECT: method possesses high therapeutic-preventive efficiency in treatment of gastrointestinal diseases of newborn calves. ^ 2 tbl, 2 ex

Description

The invention relates to veterinary medicine, in particular for the treatment and prevention of gastrointestinal diseases of newborn calves.

The development of gastrointestinal diseases of newborn calves is based on the inability of the gastrointestinal tract to properly digest colostrum. As a result, diarrhea occurs, increasing metabolic disorders, causing dehydration, loss of appetite and severe illness. Depending on the severity of the disease, the animal’s body experiences exogenous and endogenous nutritional deficiencies, assimilation is weakened, and dissimilation predominates. The volume of water lost with feces in sick calves is more than 28 times higher than in healthy calves, the loss of sodium ions is 27, potassium 17, chlorine 37, calcium 24 and magnesium 40 times. Comprehensive therapeutic measures for this disease should be aimed at regulating feeding, as well as maintaining water, electrolyte, acid-base balance in the body, preventing putrefactive processes in the intestine.

Known therapeutic agents for the treatment of gastrointestinal diseases of calves - Ringer-Lock solution, saline for the treatment of calves, Kalinata.

The composition of the Ringer-Lock solution includes sodium chloride, sodium bicarbonate, calcium chloride and potassium chloride, glucose, water for injection [1].

The saline solution for treating calves contains sodium chloride, sodium phosphate disubstituted 12-water, monosubstituted alkali metal phosphate, glucose and water (USSR Author's Certificate 1246448, 1983).

Kalinat contains sodium chloride, potassium chloride and glucose. The drug is used orally in the form of a 2.5% aqueous solution in doses of 0.5-1.5 liters per 1 dose [2].

However, these funds are aimed only at restoring water-salt and carbohydrate metabolism.

Known drugs whose actions are also aimed at replenishing the body of animals with micro and macro elements, vitamins. A preparation for treating acute gastrointestinal diseases of newborn calves and a method for treating acute gastrointestinal diseases of newborn calves, which include sodium chloride, potassium chloride, glucose, calcium chloride, magnesium chloride, ascorbic acid, thiamine bromide (RF Patent 2010566, 1992 ) A preparation for the treatment of acute gastrointestinal diseases of newborn calves and a method for its use contains sodium chloride, potassium chloride, glucose, calcium acetic acid or lactic acid, ascorbic or acetylsalicylic acid, sodium bicarbonate, furacilin (RF Patent 2080110, 1993).

There is a method of treating gastrointestinal diseases of newborn calves with signs of diarrhea, containing a mixture of antibacterial, antitoxic and rehydration agents - furazolidone, chloramphenicol, enthony, glucose, sodium chloride, calcium chloride, potassium chloride, sodium bicarbonate (USSR Author's Certificate 1727836, 1990, USSR certificate 1727836 )

The purpose of the invention is the expansion of the arsenal of highly effective agents for the treatment and prevention of gastrointestinal diseases of newborn calves.

This goal is achieved by using the proposed method for the treatment and prevention of gastrointestinal diseases of newborn calves. The method is based on the use of bacteriostatic, rehydration and symptomatic agents, characterized in that in order to increase the effectiveness of the method, a drug containing norsulfazole, glucose, sodium chloride, potassium chloride, calcium chloride is administered inside the calves as an antimicrobial bacteriostatic and rehydration agent , wt.%:

Norsulfazole - 1,624

Glucose - 1,169

Sodium chloride - 6.23

Potassium chloride - 0.649

Calcium chloride - 0.2.

Norsulfazole is a white or yellowish crystalline, odorless, slightly soluble substance in water. Antimicrobial bacteriostatic agent, sulfonamide. It is active against gram-positive and gram-negative cocci, Escherichia coli, Shigella spp., Klebsiella spp., Vibrio cholerae, etc. [1].

Glucose - is a colorless crystal or odorless white crystalline powder, soluble in water. It is a source of easily digestible energy material by the body, which increases the body's resistance and improves its function [3].

Sodium chloride - is a cubic crystal or a white crystalline powder, odorless, salty taste, soluble in water.

Potassium chloride - colorless crystals or a white crystalline powder without an odor, salty to the taste, soluble in water. Sodium and potassium chlorides normalize the water-salt balance [3].

Calcium chloride is a colorless, crystalline substance, of bitter taste, soluble in water. Calcium chloride manifests itself as an anti-inflammatory agent, increases the function of the reticuloendothelial system and the phagocytic activity of leukocytes [1].

The finished product consists of two packages. Package No. 1 contains glucose, potassium chloride, sodium chloride, calcium chloride. Package No. 2 contains norsulfazole. A tool for the treatment and prevention of gastrointestinal diseases of newborn calves is obtained by mixing the calculated amounts of the components to a homogeneous state, subsequently packaged in package No. 1. Norsulfazole is packaged in package No. 2.

The drug is used as follows. The contents of bags No. 1 and No. 2 are dissolved in 8 liters of hot (70-80 ° C) drinking water, filtered through two layers of gauze in a glass dish. The treatment solution is prepared before use and immediately used or stored in the refrigerator for no more than 6 days. The solution is administered orally at a dose of 0.7-1.5 L per animal 2 times a day for three days. During the use of the drug, the portion of colostrum during the first application is reduced by 50% or completely removed, with repeated use it is reduced by 25%. The drug is used against the background of conventional treatment: a decoction of oak bark is prescribed 15 g 2 times a day, a 20% solution of caffeine-sodium benzoate subcutaneously 3 ml 1 time per day.

The invention is illustrated by examples.

Example 1. The effectiveness of the treatment of gastrointestinal diseases in calves

A study of the effectiveness of the treatment of gastrointestinal diseases in calves was carried out in ZapSibHleb-Iset OJSC of Iset district of the Tyumen region on calves 1-10 days old (120 animals) in 2009.

For the treatment of calves of the experimental group, a preparation was used for the treatment and prevention of gastrointestinal diseases of newborn calves in the following ratio of components, wt.%:

Norsulfazole - 1,624

Glucose - 1,169

Sodium chloride - 6.23

Potassium chloride - 0.649

Calcium chloride - 0.2.

Before use, the preparation (contents of packages No. 1 and No. 2) was dissolved in hot (70-80 ° C) drinking water at the rate of 500 g of the drug per 8 liters of water, filtered through two layers of gauze in a glass dish. The drug was given orally at a dose of 0.7-1.5 L per animal 2 times a day for three days. On the first day, a portion of colostrum was reduced by 50% in calves with a weak clinical picture (n-76) or removed from the diet in calves with a pronounced clinical picture (n-44), on the second day, a portion of colostrum was reduced by 25%. The dose of the drug depends on the amount of colostrum missing in the calf's diet. 40 minutes before the drug was administered, the calves were given a decoction of oak bark at the rate of 15 g per calf 2 times a day, a 20% sodium caffeine-benzoate solution was injected subcutaneously at a dose of 3 ml per calf 1 time per day for three days.

For the treatment of calves in the control group (50 goals), preparations used in the household — Kalinat, intromycin according to the instructions for use — were prescribed for 5 days. The results of the experiment are presented in table 1.

Table 1. Therapeutic efficacy of the proposed method for the treatment of gastrointestinal diseases of newborn calves Indicators Group of animals Experienced Control Number of animals, goal. 120 fifty Recovered Goal. 120 47 % one hundred 94 Fell Goal. - one % - 2 Duration of recovery, days 2.25 3.36

As studies have shown, the proposed method has high therapeutic efficacy in the treatment of gastrointestinal diseases in newborn calves. In calves of the experimental group, in comparison with the control group, the recovery time and death of the animals decreased.

Example 2. Prophylactic efficacy in gastrointestinal diseases of newborn calves

The study of the prophylactic effectiveness of the proposed method for gastrointestinal diseases in calves was carried out in JSC ZapSibHleb-Iset, Iset district of the Tyumen region on 60 calves 1-10 days of age.

For the prevention of gastrointestinal diseases in calves of the experimental group, the drug was used in the following ratio of components, wt.%:

Norsulfazole - 1,624

Glucose - 1,169

Sodium chloride - 6.23

Potassium chloride - 0.649

Calcium chloride - 0.2.

Before use, the preparation (contents of packages No. 1 and No. 2) was dissolved in hot (70-80 ° C) drinking water at the rate of 500 g of the drug per 8 liters of water, filtered through two layers of gauze in a glass dish. The drug was given orally at a dose of 0.7-1.5 L per animal 2 times a day for three days. On the first day, a portion of colostrum was reduced by 50%, on the second day, a portion of colostrum was reduced by 25%. The dose of the drug depends on the amount of colostrum missing in the calf's diet. Calves of the control group (40 goals) were prescribed Kalinat for 5 days. The research results are presented in table 2.

As can be seen from table 2, the proposed method for the treatment and prevention of gastrointestinal diseases in calves has prophylactic effectiveness and increases prophylactic efficiency by 9.2% compared with the existing treatment method. The lysozyme and β-lysine activity of blood serum in calves of the experimental group by the end of the experiment increased by 13.7% and 28.2% of the baseline.

Table 2. Therapeutic efficacy of the proposed method for gastrointestinal diseases of calves Indicators Group of animals Experienced Control Number of animals, goal. 60 40 Dose, l per animal Got sick Goal. 2 5 % 3.3 12.5 Preventive efficacy,% 96.7 87.5 Lysozyme activity, units / l before the course of prevention 0.204 0,200 after a course of prevention 0.232 0.206 β-lysine activity,% before the course of prevention 13.1 13.6 after a course of prevention 16.8 13.9

Thus, the results of industrial tests in the economy allowed to recommend the proposed method for the treatment and prevention of gastrointestinal diseases of newborn calves as a highly effective method of treatment and prevention of gastrointestinal diseases.

Information sources

1. Subbotin V.M., Aleksandrov I.D. Veterinary pharmacology. - M .: KolosS, 2004 .-- S.311, 445-446, 599-600.

2. Guidance on the use of Kalinata for the treatment of newborn calves in gastrointestinal diseases. Approved GUV Ministry of Agriculture of the USSR June 19, 1985

3. Mashkovsky M.D. Medicines Part 2. - 12th ed. reslave. and add. - M .: Medicine, 1994. - P.131, 219-220.

4. Copyright certificate of the USSR 1246448, 13.06.83.

5. RF patent 2010566, 03.02.92.

6. RF patent 2080110, 06.21.93.

7. Copyright certificate of the USSR 1727836, 16.01.90.

Claims (1)

A method for the treatment and prevention of gastrointestinal diseases of newborn calves by the appointment of bacteriostatic, rehydration and symptomatic agents, characterized in that a drug containing norsulfazole, glucose, sodium chloride, potassium chloride, calcium chloride is used as an antimicrobial, bacteriostatic and rehydration agent the ratio of components, wt.%:
Norsulfazole 1,624 Glucose 1,169 Sodium chloride 6.23 Potassium chloride 0.649 Calcium chloride 0.2
the drug is administered orally, after dissolving 500 g of the drug in 8 l of hot water, 2 times a day for three days at a dose of 0.7-1.5 l per animal and reduce the portion of colostrum on the first day by 50-100%, on the second day - 25%, while 40 minutes before each administration of the drug, the calves are given a decoction of oak bark at the rate of 15 g and a 20% solution of caffeine-sodium benzoate in a dose of 3 ml is subcutaneously injected once a day.