RU2507203C1 - Соединение, некоторые его новые формы, фармацевтические композиции на его основе и способы получения и применения - Google Patents
Соединение, некоторые его новые формы, фармацевтические композиции на его основе и способы получения и применения Download PDFInfo
- Publication number
- RU2507203C1 RU2507203C1 RU2012126112/04A RU2012126112A RU2507203C1 RU 2507203 C1 RU2507203 C1 RU 2507203C1 RU 2012126112/04 A RU2012126112/04 A RU 2012126112/04A RU 2012126112 A RU2012126112 A RU 2012126112A RU 2507203 C1 RU2507203 C1 RU 2507203C1
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- Prior art keywords
- ethyl
- methyl
- oxy
- dimethylamino
- phenyl
- Prior art date
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
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| CN2009101992592A CN102070618B (zh) | 2009-11-23 | 2009-11-23 | 一种化合物及其晶体 |
| CN200910199259.2 | 2009-11-23 | ||
| PCT/CN2010/078997 WO2011060746A1 (en) | 2009-11-23 | 2010-11-23 | Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use |
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| RU2012126112A RU2012126112A (ru) | 2013-12-27 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102070618B (zh) | 2009-11-23 | 2013-08-21 | 和记黄埔医药（上海）有限公司 | 一种化合物及其晶体 |
| ES2723969T3 (es) | 2014-06-19 | 2019-09-04 | Merial Inc | Composiciones parasiticidas que comprenden derivados de indol, procedimientos y usos de las mismas |
| CN105985326B (zh) * | 2015-02-16 | 2020-04-14 | 上海宣创生物科技有限公司 | 嘧啶衍生物晶型ⅲ及其制备方法和用途 |
| WO2016187767A1 (en) * | 2015-05-25 | 2016-12-01 | Hutchison Medipharma Limited | Pharmaceutical compositions and use thereof |
| US20190276439A1 (en) * | 2016-11-18 | 2019-09-12 | Hutchison Medipharma Limited | Method of treating solid tumors |
| JP2020164434A (ja) * | 2019-03-28 | 2020-10-08 | 上野製薬株式会社 | ２，６−ナフタレンビス（２−オキサゾリン）の製造方法 |
| CN118593700A (zh) * | 2020-03-09 | 2024-09-06 | 和记黄埔医药（上海）有限公司 | 抗pd-1抗体和多受体酪氨酸激酶抑制剂的药物组合及其使用方法 |
| CN117136185A (zh) * | 2021-04-12 | 2023-11-28 | 水疗免疫疗法有限公司 | 5-[（1,1-二氧化-4-硫代吗啉基）甲基]-2-苯基-n-（四氢-2h-吡喃-4-基）-1h-吲哚-7-胺的新晶型 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080255172A1 (en) * | 2007-04-16 | 2008-10-16 | Hutchison Medipharma Enterprises Limeted | Pyrimidine derivatives |
| CN101289444A (zh) * | 2007-04-16 | 2008-10-22 | 和记黄埔医药（上海）有限公司 | 一种嘧啶衍生物及其医药用途 |
| RU2373197C2 (ru) * | 2004-03-30 | 2009-11-20 | Тайсо Фармасьютикал Ко., Лтд. | Пиримидиновые производные, обладающие активностью в отношении мсн |
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| US20090149467A1 (en) | 2005-09-15 | 2009-06-11 | Merck & Co., Inc. | Tyrosine Kinase Inhibitors |
| TW201008933A (en) | 2008-08-29 | 2010-03-01 | Hutchison Medipharma Entpr Ltd | Pyrimidine compounds |
| CN102070618B (zh) | 2009-11-23 | 2013-08-21 | 和记黄埔医药（上海）有限公司 | 一种化合物及其晶体 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2373197C2 (ru) * | 2004-03-30 | 2009-11-20 | Тайсо Фармасьютикал Ко., Лтд. | Пиримидиновые производные, обладающие активностью в отношении мсн |
| US20080255172A1 (en) * | 2007-04-16 | 2008-10-16 | Hutchison Medipharma Enterprises Limeted | Pyrimidine derivatives |
| CN101289444A (zh) * | 2007-04-16 | 2008-10-22 | 和记黄埔医药（上海）有限公司 | 一种嘧啶衍生物及其医药用途 |
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