RU2464261C2 - Новые индольные производные, способ их получения и их применение в качестве антибактериальных средств - Google Patents
Новые индольные производные, способ их получения и их применение в качестве антибактериальных средств Download PDFInfo
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- RU2464261C2 RU2464261C2 RU2009132657/04A RU2009132657A RU2464261C2 RU 2464261 C2 RU2464261 C2 RU 2464261C2 RU 2009132657/04 A RU2009132657/04 A RU 2009132657/04A RU 2009132657 A RU2009132657 A RU 2009132657A RU 2464261 C2 RU2464261 C2 RU 2464261C2
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- 229940054051 antipsychotic indole derivative Drugs 0.000 title description 10
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- 238000000034 method Methods 0.000 claims abstract description 72
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 123
- 125000004432 carbon atom Chemical group C* 0.000 claims description 106
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- 125000000217 alkyl group Chemical group 0.000 claims description 66
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 44
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- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 20
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- LPSLGTZFBDZNEK-UHFFFAOYSA-N tert-butyl 5-methoxyindole-1-carboxylate Chemical compound COC1=CC=C2N(C(=O)OC(C)(C)C)C=CC2=C1 LPSLGTZFBDZNEK-UHFFFAOYSA-N 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0700717 | 2007-02-01 | ||
| FR0700717A FR2912133B1 (fr) | 2007-02-01 | 2007-02-01 | Nouveaux derives indoliques,leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009132657A RU2009132657A (ru) | 2011-03-10 |
| RU2464261C2 true RU2464261C2 (ru) | 2012-10-20 |
Family
ID=38476052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009132657/04A RU2464261C2 (ru) | 2007-02-01 | 2008-01-31 | Новые индольные производные, способ их получения и их применение в качестве антибактериальных средств |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8343964B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2121601B8 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5368317B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101652346B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008224776B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2677146C (cg-RX-API-DMAC7.html) |
| FR (1) | FR2912133B1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2464261C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008110690A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011060976A1 (en) | 2009-11-20 | 2011-05-26 | Universite De Liege | Tryptamine-derived compounds as antibacterial agents |
| FR2969150B1 (fr) * | 2010-12-20 | 2013-07-26 | Centre Nat Rech Scient | Nouvelles molecules indoliques demontrant des activites antibacteriennes dans une variete de bacteries a gram-negatif et positif dont des bacteries multidrogues-resistantes |
| ES2464598T3 (es) | 2011-07-22 | 2014-06-03 | Université Joseph Fourier | Nuevos derivados bis-indólicos, procedimiento para su preparación, y sus utilizaciones como fármaco |
| ES2461997T3 (es) | 2011-07-22 | 2014-05-22 | Université Joseph Fourier | Derivados bis-indólicos nuevos, sus usos, en particular como antibacterianos |
| EP2639220A1 (en) * | 2012-03-15 | 2013-09-18 | Omnia Molecular, S. L. | Indole derivatives and their use as antibiotics |
| CN103664733B (zh) * | 2013-12-10 | 2016-04-20 | 邯郸惠达化工有限公司 | 一种吲哚啉的制备方法 |
| CN105669519B (zh) * | 2016-01-04 | 2018-01-05 | 北方民族大学 | 吲哚类化合物、制备方法及其作为抗耐药菌药物的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2125986C1 (ru) * | 1992-08-13 | 1999-02-10 | Американ Цианамид Компани | 7-(замещенные)-9-(замещенные-глицил)амидо-6-деметил-6-дезокситетрациклины, промежуточные соединения, способы их получения, способ лечения и композиция |
| WO2003088897A2 (en) * | 2001-04-06 | 2003-10-30 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4492694A (en) * | 1983-04-12 | 1985-01-08 | Eli Lilly And Company | Indolylglycyl cephalosporin derivatives |
| JP4880448B2 (ja) | 2003-03-17 | 2012-02-22 | アフィナム ファーマシューティカルズ，インコーポレーテッド | 複数の抗生物質を含む組成物、及びそれを用いる方法 |
| DE10320453A1 (de) * | 2003-05-08 | 2004-11-25 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Bioisostere von Actinonin |
-
2007
- 2007-02-01 FR FR0700717A patent/FR2912133B1/fr not_active Expired - Fee Related
-
2008
- 2008-01-31 US US12/525,503 patent/US8343964B2/en not_active Expired - Fee Related
- 2008-01-31 CA CA2677146A patent/CA2677146C/fr not_active Expired - Fee Related
- 2008-01-31 RU RU2009132657/04A patent/RU2464261C2/ru not_active IP Right Cessation
- 2008-01-31 JP JP2009547728A patent/JP5368317B2/ja not_active Expired - Fee Related
- 2008-01-31 CN CN2008800097669A patent/CN101652346B/zh not_active Expired - Fee Related
- 2008-01-31 WO PCT/FR2008/000118 patent/WO2008110690A2/fr not_active Ceased
- 2008-01-31 EP EP08761826.0A patent/EP2121601B8/fr not_active Not-in-force
- 2008-01-31 AU AU2008224776A patent/AU2008224776B2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2125986C1 (ru) * | 1992-08-13 | 1999-02-10 | Американ Цианамид Компани | 7-(замещенные)-9-(замещенные-глицил)амидо-6-деметил-6-дезокситетрациклины, промежуточные соединения, способы их получения, способ лечения и композиция |
| WO2003088897A2 (en) * | 2001-04-06 | 2003-10-30 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2677146A1 (fr) | 2008-09-18 |
| JP5368317B2 (ja) | 2013-12-18 |
| FR2912133B1 (fr) | 2009-04-24 |
| WO2008110690A2 (fr) | 2008-09-18 |
| RU2009132657A (ru) | 2011-03-10 |
| WO2008110690A3 (fr) | 2009-03-19 |
| CN101652346B (zh) | 2013-10-30 |
| AU2008224776A1 (en) | 2008-09-18 |
| CN101652346A (zh) | 2010-02-17 |
| US20100144726A1 (en) | 2010-06-10 |
| US8343964B2 (en) | 2013-01-01 |
| CA2677146C (fr) | 2016-11-15 |
| FR2912133A1 (fr) | 2008-08-08 |
| EP2121601A2 (fr) | 2009-11-25 |
| AU2008224776B2 (en) | 2012-09-06 |
| JP2010517983A (ja) | 2010-05-27 |
| EP2121601B8 (fr) | 2016-12-07 |
| EP2121601B1 (fr) | 2016-06-15 |
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Legal Events
| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20190201 |