RU2461630C2 - Применение комбинации вируса миксомы и рапамицина для терапевтического лечения - Google Patents

Применение комбинации вируса миксомы и рапамицина для терапевтического лечения Download PDF

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RU2461630C2
RU2461630C2 RU2007137008/10A RU2007137008A RU2461630C2 RU 2461630 C2 RU2461630 C2 RU 2461630C2 RU 2007137008/10 A RU2007137008/10 A RU 2007137008/10A RU 2007137008 A RU2007137008 A RU 2007137008A RU 2461630 C2 RU2461630 C2 RU 2461630C2
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cancer
cell
myxoma virus
virus
cells
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RU2007137008/10A
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RU2007137008A (ru
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Грант МАКФЭДДЕН (CA)
Грант МАКФЭДДЕН
Джон БАРРЕТТ (CA)
Джон Барретт
Мэрианн СТАНФОРД (CA)
Мэрианн СТАНФОРД
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Робартс Рисерч Инститьют
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2007137008/10A 2005-03-07 2006-03-06 Применение комбинации вируса миксомы и рапамицина для терапевтического лечения RU2461630C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65881605P 2005-03-07 2005-03-07
US60/658,816 2005-03-07

Publications (2)

Publication Number Publication Date
RU2007137008A RU2007137008A (ru) 2009-04-20
RU2461630C2 true RU2461630C2 (ru) 2012-09-20

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RU2007137008/10A RU2461630C2 (ru) 2005-03-07 2006-03-06 Применение комбинации вируса миксомы и рапамицина для терапевтического лечения

Country Status (14)

Country Link
US (5) US20090035276A1 (https=)
EP (2) EP2388315B1 (https=)
JP (2) JP2008531739A (https=)
KR (1) KR101479093B1 (https=)
CN (2) CN102357104B (https=)
AU (1) AU2006222500B2 (https=)
CA (1) CA2600675C (https=)
DK (1) DK2388315T3 (https=)
IL (2) IL185376A0 (https=)
MX (1) MX2007010962A (https=)
NZ (2) NZ577283A (https=)
RU (1) RU2461630C2 (https=)
UA (1) UA96412C2 (https=)
WO (1) WO2006094385A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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RU2695136C1 (ru) * 2018-06-19 2019-07-22 Общество с ограниченной ответственностью Биотехнология (ООО Биотехнология) Онколитический способ терапии рака молочной железы.

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US20090035276A1 (en) 2005-03-07 2009-02-05 Robarts Research Institute Use of a combination of myxoma virus and rapamycin for therapeutic treatment
WO2007143548A2 (en) 2006-06-01 2007-12-13 Robarts Research Institute Myxoma virus mutants for cancer treatment
JP5748656B2 (ja) * 2008-05-22 2015-07-15 ジェ イル ファーマシューティカル カンパニー リミテッド 過剰増殖細胞の腫瘍抑制因子に基づいた腫瘍崩壊ウイルスに対する感受性を判定する方法
US20120100109A1 (en) * 2010-10-26 2012-04-26 Xiaoliu Zhang Method for increasing the replication of oncolytic HSVs in highly resistant tumor cells using mTOR pathway and PI3K inhibitors
WO2012171007A2 (en) 2011-06-09 2012-12-13 University Of Florida Research Foundation, Inc. Methods for treating or preventing graft versus host disease
EP3833367A4 (en) 2018-08-08 2022-05-11 Arizona Board of Regents on behalf of Arizona State University Method for improved poxvirus yields
CA3112788A1 (en) * 2018-09-05 2020-03-12 Arizona Board Of Regents On Behalf Of Arizona State University Oncolytic virus platform to treat hematological cancer
JP2022546985A (ja) * 2019-09-02 2022-11-10 アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・アリゾナ・ステイト・ユニバーシティー 非許容性の癌に対する腫瘍溶解性ウイルスの感染を改善する方法および組成物
EP4041266A1 (en) * 2019-10-10 2022-08-17 Arizona Board of Regents on behalf of Arizona State University Oncolytic virus comprising immunomodulatory transgenes and uses thereof
AU2020361622A1 (en) * 2019-10-10 2022-04-28 Arizona Board Of Regents On Behalf Of Arizona State University Oncolytic viruses that express multi-specific immune cell engagers
WO2022139440A1 (ko) * 2020-12-22 2022-06-30 바이로큐어 주식회사 신규한 재조합 믹소마바이러스 및 이의 용도

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2695136C1 (ru) * 2018-06-19 2019-07-22 Общество с ограниченной ответственностью Биотехнология (ООО Биотехнология) Онколитический способ терапии рака молочной железы.

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Publication number Publication date
JP5674210B2 (ja) 2015-02-25
WO2006094385A1 (en) 2006-09-14
US9987315B2 (en) 2018-06-05
CN102357104A (zh) 2012-02-22
EP2388315B1 (en) 2014-05-21
CA2600675A1 (en) 2006-09-14
NZ560840A (en) 2009-07-31
CA2600675C (en) 2015-12-15
IL185376A0 (en) 2008-02-09
AU2006222500A1 (en) 2006-09-14
JP2008531739A (ja) 2008-08-14
EP2388315A3 (en) 2012-05-02
EP1863906A4 (en) 2009-06-03
CN101137748B (zh) 2011-12-14
NZ577283A (en) 2010-11-26
CN101137748A (zh) 2008-03-05
CN102357104B (zh) 2016-01-27
US20130171106A1 (en) 2013-07-04
KR20070110423A (ko) 2007-11-16
UA96412C2 (ru) 2011-11-10
US20140134134A1 (en) 2014-05-15
HK1163175A1 (en) 2012-09-07
US20180256656A1 (en) 2018-09-13
JP2012236860A (ja) 2012-12-06
EP1863906A1 (en) 2007-12-12
US20110195050A1 (en) 2011-08-11
US20090035276A1 (en) 2009-02-05
DK2388315T3 (da) 2014-08-25
IL208070A (en) 2015-06-30
EP2388315A2 (en) 2011-11-23
AU2006222500B2 (en) 2011-09-01
MX2007010962A (es) 2008-03-10
KR101479093B1 (ko) 2015-01-26
IL208070A0 (en) 2010-12-30
RU2007137008A (ru) 2009-04-20

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Effective date: 20130307