CN102357104B - 粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用 - Google Patents

粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用 Download PDF

Info

Publication number
CN102357104B
CN102357104B CN201110306752.7A CN201110306752A CN102357104B CN 102357104 B CN102357104 B CN 102357104B CN 201110306752 A CN201110306752 A CN 201110306752A CN 102357104 B CN102357104 B CN 102357104B
Authority
CN
China
Prior art keywords
cells
virus
cell
myxoma virus
rapamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201110306752.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN102357104A (zh
Inventor
格兰特·麦克法登
约翰·巴雷特
玛丽安·斯坦福
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robarts Research Institute
Original Assignee
Robarts Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robarts Research Institute filed Critical Robarts Research Institute
Publication of CN102357104A publication Critical patent/CN102357104A/zh
Application granted granted Critical
Publication of CN102357104B publication Critical patent/CN102357104B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02Recovery or purification
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/768Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/275Poxviridae, e.g. avipoxvirus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24032Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201110306752.7A 2005-03-07 2006-03-06 粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用 Expired - Fee Related CN102357104B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65881605P 2005-03-07 2005-03-07
US60/658,816 2005-03-07
CN2006800075336A CN101137748B (zh) 2005-03-07 2006-03-06 粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2006800075336A Division CN101137748B (zh) 2005-03-07 2006-03-06 粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用

Publications (2)

Publication Number Publication Date
CN102357104A CN102357104A (zh) 2012-02-22
CN102357104B true CN102357104B (zh) 2016-01-27

Family

ID=36952904

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201110306752.7A Expired - Fee Related CN102357104B (zh) 2005-03-07 2006-03-06 粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用
CN2006800075336A Expired - Fee Related CN101137748B (zh) 2005-03-07 2006-03-06 粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2006800075336A Expired - Fee Related CN101137748B (zh) 2005-03-07 2006-03-06 粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用

Country Status (14)

Country Link
US (5) US20090035276A1 (https=)
EP (2) EP1863906A4 (https=)
JP (2) JP2008531739A (https=)
KR (1) KR101479093B1 (https=)
CN (2) CN102357104B (https=)
AU (1) AU2006222500B2 (https=)
CA (1) CA2600675C (https=)
DK (1) DK2388315T3 (https=)
IL (2) IL185376A0 (https=)
MX (1) MX2007010962A (https=)
NZ (2) NZ560840A (https=)
RU (1) RU2461630C2 (https=)
UA (1) UA96412C2 (https=)
WO (1) WO2006094385A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006222500B2 (en) 2005-03-07 2011-09-01 Robarts Research Institute Use of a combination of Myxoma virus and rapamycin for therapeutic treatment
MX2008015265A (es) * 2006-06-01 2008-12-12 Robarts Res Inst Mutates del virus de mixoma para tratamiento del cancer.
CN102124335B (zh) * 2008-05-22 2014-07-30 第一药品株式会社 基于肿瘤抑制因子的过度增生细胞对溶瘤病毒疗法的敏感性
US20120100109A1 (en) * 2010-10-26 2012-04-26 Xiaoliu Zhang Method for increasing the replication of oncolytic HSVs in highly resistant tumor cells using mTOR pathway and PI3K inhibitors
CN104039333B (zh) 2011-06-09 2018-11-16 佛罗里达大学研究基金会有限公司 移植物抗宿主疾病的治疗或预防方法
RU2695136C1 (ru) * 2018-06-19 2019-07-22 Общество с ограниченной ответственностью Биотехнология (ООО Биотехнология) Онколитический способ терапии рака молочной железы.
KR20210042135A (ko) 2018-08-08 2021-04-16 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 개선된 폭스바이러스 수율을 위한 방법
WO2020051248A1 (en) * 2018-09-05 2020-03-12 Arizona Board Of Regents On Behalf Of Arizona State University Oncolytic virus platform to treat hematological cancer
US20220296660A1 (en) * 2019-09-02 2022-09-22 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for improving oncolytic virus infection for nonpermissive cancers
EP4041256A4 (en) * 2019-10-10 2023-11-08 Arizona Board of Regents on behalf of Arizona State University Oncolytic viruses that express multi-specific immune cell engagers
US20240091284A1 (en) * 2019-10-10 2024-03-21 Arizona Board Of Regents On Behalf Of Arizona State University Oncolytic virus comprising immunomodulatory transgenes and uses thereof
WO2022139440A1 (ko) * 2020-12-22 2022-06-30 바이로큐어 주식회사 신규한 재조합 믹소마바이러스 및 이의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001004318A2 (en) * 1999-07-12 2001-01-18 Viron Therapeutics, Inc. Myxoma virus genes for immune modulation
US6596268B1 (en) * 1999-11-12 2003-07-22 Oncolytics Biotech Inc. Viruses for the treatment of cellular proliferative disorders
WO2004078206A1 (en) * 2003-03-07 2004-09-16 Robarts Research Institute Use of myxoma virus for the therapeutic treatment of cancer and chronic viral infection

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401653A (en) * 1981-03-09 1983-08-30 Ayerst, Mckenna & Harrison Inc. Combination of rapamycin and picibanil for the treatment of tumors
US4806347A (en) 1985-12-11 1989-02-21 Schering Corporation Interferon combinations
GB9415320D0 (en) 1994-07-29 1994-09-21 Medical Res Council Cancer treatment
DE69722608T2 (de) 1996-01-25 2004-04-29 The University Court Of The University Of Glasgow, Glasgow Hsv-mutant-1716 zur behandlung von mesotheliomen
JP2001510053A (ja) 1997-07-18 2001-07-31 カイロン コーポレイション レンチウイルスベクター
US7041654B2 (en) * 1997-10-03 2006-05-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for inducing tumor-specific cytotoxicity
IL135507A0 (en) 1997-10-09 2001-05-20 Pro Virus Inc Treatment of neoplasms with viruses
US6264940B1 (en) * 1998-08-05 2001-07-24 The Research Foundation Of State University Of New York Recombinant poliovirus for the treatment of cancer
WO2001087324A1 (en) * 2000-05-17 2001-11-22 Viron Therapeutics, Inc. Compositions and methods for promoting immunosuppression
PL409579A1 (pl) * 2001-02-19 2015-03-02 Novartis Ag Leczenie raka
UA77200C2 (en) * 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
EP2269619A1 (en) * 2002-08-12 2011-01-05 Jennerex Biotherapeutics ULC Methods and compositions concerning poxviruses and cancer
ATE352301T1 (de) * 2003-04-22 2007-02-15 Wyeth Corp Antineoplastische zusammensetzungen
WO2005002607A2 (en) * 2003-07-07 2005-01-13 Oncolytics Biotech Inc. Oncolytic reoviruses for the treatment of neoplasms having activated pp2a or rac
NZ550430A (en) * 2004-04-27 2009-06-26 Wellstat Biologics Corp Cancer treatment using viruses and camptothecins
AU2006222500B2 (en) 2005-03-07 2011-09-01 Robarts Research Institute Use of a combination of Myxoma virus and rapamycin for therapeutic treatment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001004318A2 (en) * 1999-07-12 2001-01-18 Viron Therapeutics, Inc. Myxoma virus genes for immune modulation
US6596268B1 (en) * 1999-11-12 2003-07-22 Oncolytics Biotech Inc. Viruses for the treatment of cellular proliferative disorders
WO2004078206A1 (en) * 2003-03-07 2004-09-16 Robarts Research Institute Use of myxoma virus for the therapeutic treatment of cancer and chronic viral infection

Also Published As

Publication number Publication date
JP5674210B2 (ja) 2015-02-25
CN101137748B (zh) 2011-12-14
US20110195050A1 (en) 2011-08-11
US9987315B2 (en) 2018-06-05
NZ560840A (en) 2009-07-31
EP2388315B1 (en) 2014-05-21
EP1863906A1 (en) 2007-12-12
JP2008531739A (ja) 2008-08-14
AU2006222500B2 (en) 2011-09-01
UA96412C2 (ru) 2011-11-10
HK1163175A1 (en) 2012-09-07
EP1863906A4 (en) 2009-06-03
WO2006094385A1 (en) 2006-09-14
US20090035276A1 (en) 2009-02-05
RU2007137008A (ru) 2009-04-20
EP2388315A3 (en) 2012-05-02
US20140134134A1 (en) 2014-05-15
CN102357104A (zh) 2012-02-22
AU2006222500A1 (en) 2006-09-14
CN101137748A (zh) 2008-03-05
CA2600675A1 (en) 2006-09-14
JP2012236860A (ja) 2012-12-06
RU2461630C2 (ru) 2012-09-20
IL185376A0 (en) 2008-02-09
CA2600675C (en) 2015-12-15
NZ577283A (en) 2010-11-26
US20130171106A1 (en) 2013-07-04
IL208070A0 (en) 2010-12-30
KR101479093B1 (ko) 2015-01-26
KR20070110423A (ko) 2007-11-16
US20180256656A1 (en) 2018-09-13
DK2388315T3 (da) 2014-08-25
MX2007010962A (es) 2008-03-10
EP2388315A2 (en) 2011-11-23
IL208070A (en) 2015-06-30

Similar Documents

Publication Publication Date Title
US9987315B2 (en) Use of a combination of Myxoma virus and rapamycin for therapeutic treatment
US8227440B2 (en) Use of Myxoma virus for the therapeutic treatment of cancer and chronic viral infection
CN100379453C (zh) 粘液瘤病毒在治疗癌症和慢性病毒感染中的用途
HK1163175B (en) Use of a myxoma virus that does not express functional m135r for therapeutic treatment
HK1081099B (en) Use of myxoma virus for therapeutic treatment of cancer and chronic viral infection

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160127

Termination date: 20210306

CF01 Termination of patent right due to non-payment of annual fee