RU2456992C1 - Agent for oestrus control in male cats and dogs - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to veterinary science. The agent oestrus control of male cats and dogs contains, wt %: α- Acetoxy -3β-butanoyloxy-6- methylpregna -4_,6-dien-20-one 0.500, ethinylestradiol 0.020, lactose 62.000 potatoe -35.980, tropaeolin O 0.5, calcium stearate 1.00.

EFFECT: declared agent shows high efficacy in oestrus control of male cats and dogs.

2 ex

Description

The invention relates to veterinary medicine and is intended to regulate sexual hunting in cats and dogs.

The proposed tool is intended to suppress satyriasis in males during sexual hunting.

The problem of correcting the sexual function of domestic animals, in particular cats and dogs, remains extremely important in veterinary medicine. First of all, it is dictated by the need to eliminate the clinical manifestations of one of the periods (libido) of the stage of the sexual cycle in animals, indicating their readiness for mating and causing a lot of trouble to their owners. During this period, animals become aggressive, eat poorly, break into the street, emit piercing screams, often run away from home. Contact sexual diseases also cause a lot of trouble. Two solutions are fundamentally possible to eliminate these problems: a hormonal correction or sterilization with castration. Both methods affect the metabolic processes of the animal organism. However, the advantage of hormonal effects is its reversibility, while castration and sterilization are irreversible, lead to an irreversible loss of reproductive function and exert constant pressure on the metabolic processes of the animal for the rest of its life.

In world veterinary practice, synthetic derivatives of 17α-hydroxyprogesterone, such as its capronate, megestrol acetate, medroxyprogesterone acetate, proligestone, are widely used to regulate the reproductive function of animals (Karpov V.A. Obstetrics and gynecology of small domestic animals. M., 1990, p. .268-270).

The disadvantages of using these drugs is the increased dose of these synthetic analogues of hormones during monotherapy.

Also known is a means for regulating the sexual hunting of cats and bitches (RF patent 2295345, 03/20/2007) containing gestagen hormone from a number of pregnan alcohol esters, such as 3β-butyroxy-17α-acetoxy-6-methylpregna-4,6-diene-20 -one or 3β-acetoxy-17α-acetoxy-6-methylpregn-4,6-dien-20-one and estrogen hormone, in particular 17α-ethynyl-estratriene-1,3,5 (10) -diol-3,17β as well as gelatin, glycerin, parahydroxybenzoic acid methyl ester and refined vegetable oil, D, L-α-tocopherol and 3-methyl-6-isopropyl-cyclohexanol, and as the ester of pregnane alcohol it contains lives in the following ratio of components, wt.%:

3β-butyroxy-17α-acetoxy-6-methylpregna-4,6-dien-20-one or 3β-acetoxy-17a-acetoxy-6-methylpregn-4,6-dien-20-one 0.5 17α-ethynyl-estratriene-1,3,5 (10) -diol-3,17β 0.01 Gelatin 14.0 Glycerol 5,0 Parahydroxybenzoic acid methyl ester 0.1 D, L-α-tocopherol 0.005 3-methyl-6-isopropyl-cyclohexanol 0.01 Refined vegetable oil Up to 100.0

The main disadvantage of the proposed tool is the selectivity of its action. The product is intended for a complex effect on both bitches and males, therefore its concentration in the composition of the product is excessive for females. On the other hand, this complex tool does not take into account the ratio of hormones in each sex, and therefore the ratio of synthetic hormone analogues in the known bihormonal system is overestimated, for example, for cats and dogs, which affects the safety of the drug. In addition, the preparative form of the known funds are drops, which limits the scope of its application.

We made an attempt to develop a specialized tool for cats and dogs, taking into account their gender characteristics. In particular, a tablet form of a tool for regulating the sexual hunting of cats and dogs was developed, containing 17α-acetoxy-3β-butanoyloxy-6-methylpregn-4,6-dien-20-one and ethinyl estradiol, while the product additionally contains milk sugar, potato starch , tropeolin O, calcium stearic acid in the following recommended ratio of components, wt.%:

17α-acetoxy-3β-butanoyloxy-6-methylpregna-4,6-dien-20-one 0,500 ethinyl estradiol 0,020 milk sugar 62,000 potato starch 35,980 tropeolin Oh 0.5 calcium stearic acid 1.00

The technical result of the invention is the specificity of the action, increasing the effectiveness of the drug.

The distinguishing feature of this invention (namely, the dose and ratio of components) is found empirically.

The following are examples of the preparation of the proposed tool and an example of testing the proposed tool:

Example 1. Preparation of the drug in the form of tablets

Raw material preparation

Auxiliary raw materials (milk sugar, starch, calcium stearate) were sieved through a No. 32 sieve. Then, to increase the degree of solubility of the drug and the absorption area, the micronization of the active substances was carried out: 17α-acetoxy-3β-butanoyloxy-6-methylpregn-4,6-dien-20-one and ethinyl estradiol (17α-ethynyl estratriene-1,3,5 (10) -diol-3.17β.

Preparation of starch paste

The components of the paste were taken in the following proportions: purified water - 0.5 kg; starch - 0.27 kg; hot water (90-95) ° C - 5.6 kg. The components were mixed and the starch paste was stained by adding tropeoline O - 2.5 g to the paste, dissolved in purified water - 0.05 kg.

Trituration Preparation:

Lactose - 0.5 kg

Ethinyl estradiol - 0.20 g

17α-acetoxy-3β-butanoyloxy-6-methylpregn-4,6-dien-20-one - 5 g

Rubbing and mixing the powder for up to 20 min.

Loading in a granulator dryer is carried out in layers:

Lactose - 6.0 kg

Starch - 3.7 kg

Trituration mixture 0.54 kg

Lactose 6.0 kg

Dry mixing is carried out for 10 minutes, then starch paste is sprayed and wet granulated.

Drying at a temperature of 40-50 ° C to a residual moisture content of 1.6-2.2%

Dry granulation includes dusting with calcium stearate - 0.145 g. Then tableting is carried out.

Example 2. The study of the action of the drug on dogs (dogs) and cats

Observations were carried out on 15 cats and 20 males, both in vivarium conditions and at home. Experiments took animals that have reached puberty. Sexual arousal in males was manifested by excitement (in dogs barking), anxiety, disobedience, aggressiveness, and a decrease in appetite.

The drug was administered orally to cats during sexual arousal, 1 tablet each. In most (75%) animals, inhibition occurred when prescribing the drug at the rate of 1 tablet per day for 3 days. Animals calmed down, some became drowsy, ceased to be aggressive and anxious. The inhibitory effect of the drug on sexual arousal lasted for 3-5 weeks. A inhibitory effect on sexual behavior was noted both in cats in the vivarium and at home.

The results of observations of the males showed that the remedy had a calming effect on animals in an excited state, provided that they administered 1 tablet per 5 kg of body weight once a day for 3-4 days. The calming effect of the drug was observed for 2-3 weeks.

Comparative tests conducted on cats and cats showed that with an equal ratio of the drug administered, the onset of the effect was observed in cats faster than in cats, which confirms the presence of more specific properties of the claimed drug.

Observations of animals for several months after completing the course of taking the claimed drug showed that side effects that could be associated with taking the drugs were not detected. The reproductive function of animals was fully restored after 2-3 months after cessation of treatment.

Claims (1)

Means for regulating sexual hunting of cats and dogs containing 17α-acetoxy-3β-butanoyloxy-6-methylpregna-4,6-dien-20-one and ethinyl estradiol, the product additionally containing milk sugar, potato starch, tropeolin O, calcium stearic acid in the following recommended ratio of components, wt.%:
17α-acetoxy-3β-butanoyloxy-6-methylpregna-4,6-dien-20-one 0,500 ethinyl estradiol 0,020 milk sugar 62,000 potato starch 35,980 tropeolin Oh 0.5 calcium stearic acid 1.00