RU2442566C2 - Means of preventive maintenance and treatment of the pustulous diseases caused by bacterial skin defeats (variants) - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: group of inventions refers namely to dermatology and can be used for prevention and treatment of the pustulous diseases caused by bacterial skin defeats. For this purpose the damaged skin amazed and adjoining areas are worked with the antiseptic of "Likvacid" received with the use of trinol by means of its preliminary dissolution in a dimethyl sulfoxide in the ratio 1 mas.h. to 0,9 mas.h., accordingly, at the temperature not below indoor temperature before dark blue coloring of a mix occurs, and mixture then with a filler based on alcohol with addition of glycerin and further filtration of the received mix, herewith using as a filler of a solution of acid in ethyl spirit with its initial concentration accepted that the end-product has not less than 70 %, and with a choice of all components in the following ratio, mas.: trinitrotoluene- 0,25-1,5, a dimethyl sulfoxide - 1,0-10,0, acid - 0,5-1,0, glycerin - 17,5-23,0, ethyl spirit - the rest. The skin is greased with a wadded tampon with frequency of 2-3 times a day. Thus duration of therapy is not less than 17 days and to epulosisof the damaged surface. Or in case of the second invention grease the damaged skin and adjoining areas are greased with a wadded tampon with frequency of 2-3 times a day. The therapy course is not less and in addition is accepted than 10 days by taking "Likvacid" per oral 2-3 times a day within no more than 10 days. Herewith adults people take 11-16 ml, young men to 18-year-old age - 5-10 ml.

EFFECT: the use of the given inventions allows carrying out effective preventive maintenance and treatment in case of optimum terms of therapy.

2 tbl, 1 dwg

Description

The invention relates to medicine and relates to the prevention and treatment of bacterial complications on the skin.

A known method for the prevention and treatment of pustular skin diseases using a drug in the form of an antiseptic obtained by dissolving trinitrotoluene (TNT) powder in ethanol with the addition of glycerin (Makeev V.D. Experience in using TNT in ethanol for the treatment of patients with eczema and neurodermatitis, Transactions of GIDUV, Bulletin of dermatology, t.21, 1960, ms. 146). The disadvantage of this method is the inability to achieve the desired concentration of TNT in the mixture for effective treatment.

There is also known a method for the prevention and treatment of skin diseases caused by bacterial complications, which include pustular skin diseases in the form of boils, acne on the face, microbial infection, etc., by the external use of the antiseptic drug "Likvatsid" obtained according to RU patent 2089185, published September 10, 1997, free from the above drawback - prototype. According to the technical solution according to the patent 2089185, an antiseptic agent called “Liquacid” is obtained using trinitotoluene by preliminary dissolving it in dimethyl sulfoxide in a ratio of 1 wt. part to 0.9 wt. parts, respectively, at a temperature not lower than room temperature until the dark blue color of the mixture appears and then mixes with an alcohol-based filler with the addition of glycerol and then filtering the resulting mixture, using a solution of an acid in ethanol as its filler with its initial concentration taken from the condition that in the final product it should be at least 70%, and with the choice of all ingredients in the following ratios, wt.: trinitrotoluene - 0.25-1.5, dimethyl sulfoxide - 1.0-10.0, acid - 0, 5-1.0, glycerol - 17.5-23.0, et silt alcohol - the rest.

However, the solution does not know the frequency of application of the drug to the affected areas of the skin and the duration of therapy, including the minimum treatment time. In addition, studies show that the use of the drug according to the mentioned solution only by external application does not provide sufficient efficiency in terms of reducing treatment time and does not guarantee the exclusion of the possibility of re-illness.

The objective of the invention is to address the issue of effective prevention and treatment of pustular diseases caused by bacterial skin lesions, with optimal treatment time.

This is achieved by the fact that in the known method for the prevention and treatment of pustular diseases caused by bacterial skin lesions, according to which the antiseptic drug "Likvatsid" obtained by the above-described method according to patent RU 2089185 is applied to the affected and adjacent skin areas, the antiseptic agent is applied by lubricating the affected and the skin areas adjacent to them with a cotton swab with a frequency of application of 2-3 times a day, with a duration of therapy of at least 17 days and until the affected surface heals.

In addition, in the method for the prevention and treatment of pustular diseases caused by bacterial skin lesions, according to which the antiseptic drug “Likvatsid" obtained and as described above according to the patent RU 2089185 is applied and additionally taken inside the skin, as follows:

- by lubricating the affected and adjacent skin areas with a cotton swab with a frequency of 2-3 times a day, with a duration of therapy of at least 10 days,

- and additionally by ingesting an alcohol-based mixture orally 3 times a day for no more than 10 days in doses:

- young people under 18 years of age - 5-10 ml per reception;

- adults - 11-16 ml per reception.

The combined use of the drug for the treatment of pustular diseases by its external use and oral administration orally allows to increase the effectiveness of treatment in terms of shortening the duration of therapy and reducing the likelihood of recurrence of the disease. Moreover, depending on the age of the person, the dose of taking the drug inside should be different.

However, taking the drug only orally, a reduction in the duration of therapy is not achieved.

Below are tables with the results of a study of the treatment of pustular diseases in adults and young people under 18 years of age for various uses of the antiseptic drug “Likvatsid”. The results of studies of the external use of the indicated agent by applying it to the affected and adjacent areas of the skin 2-3 times a day for at least 17 days are shown in Table 1, and with the additional intake of the same drug in the form of an alcohol-based mixture, orally are given orally table 2. From the data of table 1 it follows that for the treatment of various types of pustular diseases, cure is achieved with different duration of therapy and, in addition, depends on the frequency of application of the drug to the affected areas of the skin. So, in the treatment of acne by external use of the drug when applied to the affected areas of the skin 2 times a day, healing takes place after 17-19 days, and with a frequency of applying the drug 3 times a day after 17 days. Moreover, the more severe of pustular diseases, such as erysipelas, can be cured only after 19-20 days of therapy. With complex treatment, with the administration of the drug additionally orally (see Table 2), the curing effect is achieved faster. However, the cure of each disease is achieved with the appropriate amount of the drug. At the same time, the process of curing erysipelas remains the same as with external therapy, longer than the diseases listed in the table. In young people under 18 years of age, cure is achieved when taking the drug inside less than in adults.

Moreover, as observations of patients have shown, in the complex treatment of pustular diseases, the period of remission is at least 7 years. This is due to the fact that with repeated use of the drug, the pathological flora of the body does not adapt to the drug "Likvatsid" and the effectiveness of the effect on the drug does not decrease. Since the drug "Likvatsid" is not an antibiotic, it does not cause fungal lesions, which are characteristic of antibiotics, and does not destroy healthy microflora.

table 2 A method for the prevention and treatment of pustular diseases No. p / p FULL NAME. Date, month, year of birth Floor Disease Type of therapy. Dosage of medication Treatment period one 2 3 four 5 6 7 one Rusan Maria Pavlovna 05/08/1984 F Acne Apply to the skin 2 times a day. + Ingestion 3 times a day for 16 ml 12 days + 6 days 2 Ratner Taisiya Zakharovna 12/08/1939 well Furunculosis Skin application + Ingestion 3 times a day, 13 ml each 11-12 days + 8 days 3 Sokolova Olga Vladimirovna 10/27/1955 well Erysipelas of the right foot Skin application + Ingestion 3 times a day, 16 ml each 15 days +10 days four Ignatieva Tatyana Ivanovna 10/14/1964 well Streptoderma Application to the scalp 3 times a day + Ingestion 3 times a day, 10 ml 10-11 days + 9 days 5 Chushina Anna Nikolaevna 10/01/1995 well Acne Apply to the skin 3 times a day. + Ingestion 3 times a day for 10 ml 10 days + 7 days 6 Fedorov Petr Pavlovich 09/22/1991 m Acne Apply to the skin 3 times a day. + Ingestion 3 times a day for 10 ml 10 days + 8 days

Claims (2)

1. A method for the prevention and treatment of pustular diseases caused by bacterial skin lesions, characterized in that the antiseptic Likvatsid is obtained on the affected and adjacent skin areas, obtained using trinitrotoluene by preliminary dissolving it in dimethyl sulfoxide in a ratio of 1 wt.h. to 0.9 parts by weight respectively, at a temperature not lower than room temperature until the dark blue color of the mixture appears and then mix with an alcohol-based filler with glycerol added and then filter the resulting mixture, using an acid solution in ethanol as a filler with its initial concentration taken from conditions that it should be at least 70% in the final product, and with the choice of all ingredients in the following ratios, wt.: trinitrotoluene - 0.25-1.5, dimethyl sulfoxide - 1.0-10.0, acid - 0.5 -1.0, glycerol - 17.5-23.0, ethyl alcohol - the rest, by lubricating them with a cotton swab with a frequency of 2-3 times a day, with a duration of therapy of at least 17 days and until the affected surface heals. 2. A method for the prevention and treatment of pustular diseases caused by bacterial skin lesions, characterized in that the antiseptic Likvatsid obtained using trinitrotoluene by its preliminary dissolution in dimethyl sulfoxide in the ratio 1 parts by weight to 0.9 parts by weight respectively, at a temperature not lower than room temperature until the dark blue color of the mixture appears and then mix with an alcohol-based filler with glycerol added and then filter the resulting mixture, using an acid solution in ethanol as a filler with its initial concentration taken from conditions that it should be at least 70% in the final product, and with the choice of all ingredients in the following ratios, wt.: trinitrotoluene - 0.25-1.5, dimethyl sulfoxide - 1.0-10.0, acid - 0.5 - 1.0, glycerol - 17.5-23.0, ethyl alcohol - the rest, as follows:
- by lubricating the affected and adjacent skin areas with a cotton swab with a frequency of 2-3 times a day, with a duration of therapy of at least 10 days;
- and additionally by ingesting an alcohol-based mixture orally orally 2-3 times a day for no more than 10 days in doses:
- adults - 11-16 ml per reception,
- Young people under 18 years of age - 5-10 ml per reception.