RU2436568C2 - Самоконсервирующиеся водные фармацевтические композиции - Google Patents

Самоконсервирующиеся водные фармацевтические композиции Download PDF

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Publication number
RU2436568C2
RU2436568C2 RU2009114849/15A RU2009114849A RU2436568C2 RU 2436568 C2 RU2436568 C2 RU 2436568C2 RU 2009114849/15 A RU2009114849/15 A RU 2009114849/15A RU 2009114849 A RU2009114849 A RU 2009114849A RU 2436568 C2 RU2436568 C2 RU 2436568C2
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Russia
Prior art keywords
composition
concentration
days
compositions
polyol
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RU2009114849/15A
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English (en)
Russian (ru)
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RU2009114849A (ru
Inventor
Бхагвати П. КАБРА (US)
Бхагвати П. КАБРА
Масуд А. ЧОВХАН (US)
Масуд А. ЧОВХАН
Л. Уэйн ШНЕЙДЕР (US)
Л. Уэйн ШНЕЙДЕР
Уэсли Вехсин ХАН (US)
Уэсли Вехсин ХАН
Original Assignee
Алькон Рисерч, Лтд.
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Application filed by Алькон Рисерч, Лтд. filed Critical Алькон Рисерч, Лтд.
Publication of RU2009114849A publication Critical patent/RU2009114849A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
RU2009114849/15A 2006-09-21 2007-09-20 Самоконсервирующиеся водные фармацевтические композиции RU2436568C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82652906P 2006-09-21 2006-09-21
US60/826,529 2006-09-21
US82741106P 2006-09-28 2006-09-28
US60/827,411 2006-09-28

Publications (2)

Publication Number Publication Date
RU2009114849A RU2009114849A (ru) 2010-10-27
RU2436568C2 true RU2436568C2 (ru) 2011-12-20

Family

ID=39156274

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009114849/15A RU2436568C2 (ru) 2006-09-21 2007-09-20 Самоконсервирующиеся водные фармацевтические композиции

Country Status (21)

Country Link
US (3) US8268299B2 (https=)
EP (1) EP2068822B2 (https=)
JP (2) JP4785970B2 (https=)
KR (1) KR101021933B1 (https=)
AR (1) AR062929A1 (https=)
AT (1) ATE531358T1 (https=)
AU (1) AU2007299727B2 (https=)
BR (1) BRPI0717067A2 (https=)
CA (1) CA2606370C (https=)
CL (1) CL2007002705A1 (https=)
CY (1) CY1112138T1 (https=)
DK (1) DK2068822T4 (https=)
ES (1) ES2374444T5 (https=)
MX (1) MX2009002221A (https=)
PL (1) PL2068822T5 (https=)
PT (1) PT2068822E (https=)
RU (1) RU2436568C2 (https=)
SI (1) SI2068822T2 (https=)
TW (1) TWI394564B (https=)
UY (1) UY30605A1 (https=)
WO (1) WO2008036847A2 (https=)

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TW200904485A (en) * 2007-05-18 2009-02-01 Alcon Res Ltd Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions
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JP2009256281A (ja) * 2008-04-21 2009-11-05 Teika Seiyaku Kk イソプロピルウノプロストン含有点眼剤組成物
TW201010727A (en) * 2008-09-03 2010-03-16 Alcon Res Ltd Pharmaceutical composition having relatively low ionic strength
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EP2228058A1 (en) 2009-03-04 2010-09-15 Novagali Pharma S.A. Anionic oil-in-water emulsion containing prostaglandins and uses thereof
TWI489997B (zh) * 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸－多元醇錯合物之水性藥學組成物
EP2389939A1 (en) 2010-05-28 2011-11-30 Novagali Pharma S.A. Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions
TWI618539B (zh) * 2009-12-15 2018-03-21 遠景生物製藥股份有限公司 無刺激性眼用聚乙烯吡咯啶酮-碘組成物
TW201127423A (en) * 2009-12-17 2011-08-16 Alcon Res Ltd Ophthalmic solutions with improved disinfection profiles
KR101946790B1 (ko) 2011-03-04 2019-02-13 그뤼넨탈 게엠베하 경구 투여를 위한 타펜타돌의 수성 약제학적 제형
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US20150374820A1 (en) * 2013-02-15 2015-12-31 Senju Pharmaceutical Co., Ltd. Difluprednate emulsion composition containing zinc
CN105263476A (zh) 2013-03-13 2016-01-20 库尔制药开发公司 用于治疗炎症的免疫修饰性颗粒
EP3037094A1 (en) 2014-12-23 2016-06-29 Poifa Warszawa SA Ophthalmic pharmaceutical composition
EP3273953B1 (en) 2015-03-27 2019-01-02 Grünenthal GmbH Stable formulation for parenteral administration of tapentadol
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
US10632202B2 (en) 2016-03-04 2020-04-28 Johnson & Johnson Consumer Inc. Preservative containing compositions
CN109996533A (zh) 2016-09-23 2019-07-09 格吕伦塔尔有限公司 用于肠胃外施用他喷他多的稳定制剂
WO2019123266A1 (en) 2017-12-20 2019-06-27 Novartis Ag Ophthalmic composition having a prostaglandin and a beta-blocker
CA3166738A1 (en) 2020-02-06 2021-08-12 Charles D. Blizzard Travoprost compositions and methods for treating ocular diseases
WO2021222117A1 (en) 2020-04-27 2021-11-04 Ocular Therapeutix, Inc. Methods of treating allergic conjunctivitis
US20220031739A1 (en) * 2020-07-31 2022-02-03 Eye Therapies Llc Anti-viral compositions and methods of use thereof
EP4393510A4 (en) 2021-09-30 2025-08-06 Rohto Pharma OPHTHALMOLOGICAL COMPOSITION
EP4543456A1 (en) * 2022-06-27 2025-04-30 Zaklady Farmaceutyczne "Polpharma" Spolka Akcyjna Preservative-free ophthalmic composition comprising a prostaglandin analogue
KR20250034105A (ko) 2022-07-06 2025-03-10 로토 세이야쿠 가부시키가이샤 안과 조성물
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Also Published As

Publication number Publication date
DK2068822T3 (da) 2012-01-23
US8323630B2 (en) 2012-12-04
US20110195132A1 (en) 2011-08-11
EP2068822A2 (en) 2009-06-17
BRPI0717067A2 (pt) 2013-09-24
JP2011246476A (ja) 2011-12-08
TW200820962A (en) 2008-05-16
AR062929A1 (es) 2008-12-17
AU2007299727A1 (en) 2008-03-27
DK2068822T4 (da) 2022-10-31
JP2010504358A (ja) 2010-02-12
SI2068822T2 (sl) 2022-10-28
JP5411897B2 (ja) 2014-02-12
EP2068822B2 (en) 2022-07-27
EP2068822B1 (en) 2011-11-02
CL2007002705A1 (es) 2008-05-16
CA2606370C (en) 2012-03-27
SI2068822T1 (sl) 2012-02-29
WO2008036847A3 (en) 2008-05-29
CY1112138T1 (el) 2015-11-04
AU2007299727B2 (en) 2011-10-06
UY30605A1 (es) 2008-03-31
PL2068822T5 (pl) 2022-11-14
CA2606370A1 (en) 2008-03-21
ES2374444T3 (es) 2012-02-16
ATE531358T1 (de) 2011-11-15
ES2374444T5 (es) 2022-11-21
JP4785970B2 (ja) 2011-10-05
US20130053440A1 (en) 2013-02-28
US8268299B2 (en) 2012-09-18
PT2068822E (pt) 2012-01-10
US20080075790A1 (en) 2008-03-27
KR101021933B1 (ko) 2011-03-16
TWI394564B (zh) 2013-05-01
RU2009114849A (ru) 2010-10-27
KR20090058567A (ko) 2009-06-09
PL2068822T3 (pl) 2012-03-30
WO2008036847A2 (en) 2008-03-27
HK1126667A1 (en) 2009-09-11
AU2007299727A8 (en) 2009-04-09
MX2009002221A (es) 2009-03-13

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