RU2412944C2 - Иммуногены для вакцин против менингита а - Google Patents

Иммуногены для вакцин против менингита а Download PDF

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Publication number
RU2412944C2
RU2412944C2 RU2007145219/05A RU2007145219A RU2412944C2 RU 2412944 C2 RU2412944 C2 RU 2412944C2 RU 2007145219/05 A RU2007145219/05 A RU 2007145219/05A RU 2007145219 A RU2007145219 A RU 2007145219A RU 2412944 C2 RU2412944 C2 RU 2412944C2
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Russia
Prior art keywords
oligosaccharide
mannose
unit
mannose unit
protein
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RU2007145219/05A
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English (en)
Russian (ru)
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RU2007145219A (ru
Inventor
Стефан ОСКАРСОН (SE)
Стефан ОСКАРСОН
Питер ТЕОДОРОВИЧ (SE)
Питер ТЕОДОРОВИЧ
Паоло КОНСТАНТИНО (IT)
Паоло КОНСТАНТИНО
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Новартис Вэксинз Энд Дайагностикс Срл
Стефан ОСКАРСОН
Питер ТЕОДОРОВИЧ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2007145219/05A 2005-05-06 2006-05-08 Иммуногены для вакцин против менингита а RU2412944C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67828905P 2005-05-06 2005-05-06
US60/678,289 2005-05-06

Publications (2)

Publication Number Publication Date
RU2007145219A RU2007145219A (ru) 2009-06-20
RU2412944C2 true RU2412944C2 (ru) 2011-02-27

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ID=36942242

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RU2007145219/05A RU2412944C2 (ru) 2005-05-06 2006-05-08 Иммуногены для вакцин против менингита а

Country Status (15)

Country Link
US (1) US8062641B2 (cg-RX-API-DMAC10.html)
EP (1) EP1885734B1 (cg-RX-API-DMAC10.html)
JP (2) JP2008540398A (cg-RX-API-DMAC10.html)
CN (1) CN101282984B (cg-RX-API-DMAC10.html)
AU (1) AU2006245440B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0611447A2 (cg-RX-API-DMAC10.html)
CA (1) CA2606890C (cg-RX-API-DMAC10.html)
ES (1) ES2533248T3 (cg-RX-API-DMAC10.html)
MX (1) MX2007013881A (cg-RX-API-DMAC10.html)
NZ (1) NZ563940A (cg-RX-API-DMAC10.html)
PL (1) PL1885734T3 (cg-RX-API-DMAC10.html)
PT (1) PT1885734E (cg-RX-API-DMAC10.html)
RU (1) RU2412944C2 (cg-RX-API-DMAC10.html)
WO (1) WO2006120576A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200710558B (cg-RX-API-DMAC10.html)

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WO2013009826A1 (en) * 2011-07-12 2013-01-17 The General Hospital Corporation Conjugating amines

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HUE045482T2 (hu) 2005-06-27 2019-12-30 Glaxosmithkline Biologicals Sa Immunogén készítmény
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
AU2014200640B2 (en) * 2007-01-11 2016-06-16 Glaxosmithkline Biologicals Sa Modified saccharides
GB0700562D0 (en) * 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
ES2584927T7 (es) 2007-10-16 2020-11-05 Progen Pg500 Series Pty Ltd Derivados de oligosacáridos sulfatados novedosos
CA2808975C (en) 2010-08-23 2018-10-30 Wyeth Llc Stable formulations of neisseria meningitidis rlp2086 antigens
EP2612148B1 (en) 2010-09-04 2019-06-12 GlaxoSmithKline Biologicals SA Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines
KR101584871B1 (ko) 2010-09-10 2016-01-22 와이어쓰 엘엘씨 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체
CN102417521B (zh) * 2010-09-28 2014-05-07 中国医学科学院医药生物技术研究所 一种非环核苷类抗病毒药物磷酸单酯化合物的制备方法
US10010616B2 (en) 2011-01-28 2018-07-03 Purdue Research Foundation Immunogenic compositions and reagents for preparing
RU2476444C1 (ru) * 2011-07-15 2013-02-27 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) СПОСОБ ПОЛУЧЕНИЯ КОНЪЮГАТА НОНА-β-(1→3)-ГЛЮКОЗИДА С БЫЧЬИМ СЫВОРОТОЧНЫМ АЛЬБУМИНОМ СКВАРАТНЫМ МЕТОДОМ
CA2865745C (en) 2012-03-09 2018-01-09 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
EP2958905B1 (en) 2013-02-22 2017-03-29 Amgen Inc. Carbohydrate phosphonate derivatives as modulators of glycosylation
CA2903716C (en) 2013-03-08 2019-04-09 Pfizer Inc. Immunogenic fusion polypeptides
JP6416249B2 (ja) * 2013-07-07 2018-10-31 マックス プランク ゲゼルシャフト ツゥアー フェデルゥン デル ヴィッセンシャフテン エー フォー ストレプトコッカス ニューモニエ１型に対する合成ワクチン
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
KR20160124802A (ko) * 2014-02-25 2016-10-28 엠에스디 웰컴 트러스트 힐레맨 랩스 피브이티. 리미티드 네이세리아 메닝기티디스 혈청군 x의 신규한 합성 올리고머 및 이의 제조 방법
TN2017000126A1 (en) * 2014-10-09 2018-10-19 Msd Wellcome Trust Hilleman Laboratories Pvt Ltd An improved process of conjugation and novel synthetic oligosaccharide- protein conjugates obtained thereof
KR20190049940A (ko) 2015-02-19 2019-05-09 화이자 인코포레이티드 나이세리아 메닌지티디스 조성물 및 그의 방법
CN109890413B (zh) 2016-09-02 2024-04-16 赛诺菲巴斯德股份有限公司 脑膜炎奈瑟氏菌疫苗
SG11201906519RA (en) 2017-01-31 2019-08-27 Pfizer Neisseria meningitidis compositions and methods thereof
WO2018173068A1 (en) * 2017-03-21 2018-09-27 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. A novel synthetic neisseria meningitidis serogroup a oligomer and process for synthesizing thereof
MX2021005949A (es) 2018-11-22 2021-07-06 Idorsia Pharmaceuticals Ltd Vacuna estable contra clostridium difficile.
CA3155669A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN118178643B (zh) * 2024-04-28 2024-11-29 亚培烯科技(上海)有限公司 饱和α烯烃低聚物作为佐剂在动物疫苗中的应用

Citations (1)

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RU2250113C2 (ru) * 2003-06-04 2005-04-20 Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова Российской академии наук Способ приготовления бивалентной вакцины для профилактики менингококковой инфекции

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ES2616180T3 (es) * 2002-03-26 2017-06-09 Glaxosmithkline Biologicals Sa Sacáridos modificados con estabilidad mejorada en agua para su uso como medicamento
GB0220198D0 (en) 2002-08-30 2002-10-09 Chiron Spa Modified saccharides,conjugates thereof and their manufacture
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SLATTEGARD RIKARD ET AL:" Synthesis of structures corresponding to the capsular polysaccharide of Neisseria meningitides group A." ORGANIC & BIOMOLECULAR CHEMISTPY. 21 ОСТ 2005, vol.3, №20, p.3782-3787. POPELOVA A ET AL: " A concise synthesis of 4-nitrophenyl 2-azido-2-deoxy- and 2-acetaamido-2-deoxy-d-mannopyranosides" CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol.340, №1, 17.01.2005, p.161-166. CASERO F ET AL: Stereoselective synthesis of the isosteric phosphono analogues of N-acetyl-[alpha]-D-glucosamine 1-phosphate and N-acetyl-[alpha]-D-mannosamine 1-phosphate" JOURNAL OF ORGANIC CHEMISTRY 1996 UNITED STATES, vol.61, №10, 1996, p.3428-3432. *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013009826A1 (en) * 2011-07-12 2013-01-17 The General Hospital Corporation Conjugating amines
US9616139B2 (en) 2011-07-12 2017-04-11 The General Hospital Corporation Conjugating amines

Also Published As

Publication number Publication date
BRPI0611447A2 (pt) 2010-09-08
JP2008540398A (ja) 2008-11-20
NZ563940A (en) 2010-11-26
JP2013136639A (ja) 2013-07-11
WO2006120576A2 (en) 2006-11-16
ZA200710558B (en) 2010-04-28
AU2006245440A1 (en) 2006-11-16
CA2606890C (en) 2014-02-04
EP1885734A2 (en) 2008-02-13
ES2533248T3 (es) 2015-04-08
CN101282984B (zh) 2013-05-08
AU2006245440B2 (en) 2012-04-19
PT1885734E (pt) 2015-03-04
MX2007013881A (es) 2008-10-22
US8062641B2 (en) 2011-11-22
CN101282984A (zh) 2008-10-08
WO2006120576A3 (en) 2007-07-12
JP5699174B2 (ja) 2015-04-08
PL1885734T3 (pl) 2015-08-31
EP1885734B1 (en) 2015-01-14
US20090304734A1 (en) 2009-12-10
RU2007145219A (ru) 2009-06-20
CA2606890A1 (en) 2006-11-16

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