RU2407743C2 - Фармацевтические соединения - Google Patents
Фармацевтические соединения Download PDFInfo
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- RU2407743C2 RU2407743C2 RU2008108623/04A RU2008108623A RU2407743C2 RU 2407743 C2 RU2407743 C2 RU 2407743C2 RU 2008108623/04 A RU2008108623/04 A RU 2008108623/04A RU 2008108623 A RU2008108623 A RU 2008108623A RU 2407743 C2 RU2407743 C2 RU 2407743C2
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- Prior art keywords
- dihydrotetrabenazine
- psychosis
- cis
- compound
- isomer
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| AU2007317242B2 (en) | 2006-11-08 | 2013-08-01 | Neurocrine Biosciences, Inc. | Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto |
| US8008500B2 (en) | 2007-06-08 | 2011-08-30 | General Electric Company | Intermediates useful for making tetrabenazine compounds |
| US8053578B2 (en) | 2007-11-29 | 2011-11-08 | General Electric Company | Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| GB2463451A (en) | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| JP2013527237A (ja) | 2010-06-01 | 2013-06-27 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | ベンゾキノロン系ｖｍａｔ２阻害剤 |
| US9658363B2 (en) | 2011-04-01 | 2017-05-23 | 3M Innovative Properties Company | Films including triazine-based ultraviolet absorbers |
| EP3099299A4 (en) | 2014-01-27 | 2017-10-04 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| US9782398B2 (en) * | 2014-02-07 | 2017-10-10 | Neurocrine Biosciences, Inc. | Pharmaceutical compositions comprising an antipsychotic drug and a VMAT2 inhibitor and uses thereof |
| US10065952B2 (en) | 2015-10-30 | 2018-09-04 | Neurocrine Biosciences, Inc. | Valbenazine salts and polymorphs thereof |
| CN108925135B (zh) | 2015-12-23 | 2025-09-19 | 纽罗克里生物科学有限公司 | 制备(S)-(2R,3R,11bR)-3-异丁基-9,10-二甲氧基-2,3,4,6,7,11b-六氢-1H-吡啶并[2,1-a]异喹啉-2-基2-氨基-3-甲基丁酸酯二(4-甲基苯磺酸盐)的合成方法 |
| EP3548027A1 (en) * | 2016-12-02 | 2019-10-09 | Neurocrine Biosciences, Inc. | Use of valbenazine for treating schizophrenia or schizoaffective disorder |
| EA202090676A1 (ru) | 2017-01-27 | 2021-10-08 | Нейрокрин Байосайенсиз, Инк. | Способы введения некоторых vmat2-ингибиторов |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705302D0 (en) * | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| IL273300B2 (en) | 2017-09-21 | 2024-06-01 | Neurocrine Biosciences Inc | High dose valbenazine formulation and related preparations, methods and kits |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| KR20200066661A (ko) | 2017-10-10 | 2020-06-10 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| GB201808464D0 (en) | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
| KR20210044817A (ko) | 2018-08-15 | 2021-04-23 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2073678C1 (ru) * | 1991-01-25 | 1997-02-20 | Ф.Хоффманн-Ля Рош Аг | (s)-1-[(10-хлор-6,7-дигидро-4-оксо-3-фенил-4h-бензо/а/хинолизин-1-ил)карбонил]-3-этоксипирролидин, (s)-1-[(10-хлор-6,7-дигидро-4-оксо-3-фенил-4h-бензо/а/хинолизин-1-ил)карбонил]-3-оксипирролидин в качестве промежуточного продукта, композиция, обладающая гипнотическим неседативным действием |
| WO1999021856A1 (fr) * | 1997-10-28 | 1999-05-06 | Pierre Fabre Medicament | Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives |
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| US2843591A (en) | 1958-07-15 | Method for preparing same | ||
| US2830993A (en) | 1958-04-15 | Quinolizine derivatives | ||
| US6087376A (en) * | 1997-02-05 | 2000-07-11 | University Of Kentucky Research Foundation | Use of lobeline compounds in the treatment of central nervous system diseases and pathologies |
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
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Patent Citations (2)
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| RU2073678C1 (ru) * | 1991-01-25 | 1997-02-20 | Ф.Хоффманн-Ля Рош Аг | (s)-1-[(10-хлор-6,7-дигидро-4-оксо-3-фенил-4h-бензо/а/хинолизин-1-ил)карбонил]-3-этоксипирролидин, (s)-1-[(10-хлор-6,7-дигидро-4-оксо-3-фенил-4h-бензо/а/хинолизин-1-ил)карбонил]-3-оксипирролидин в качестве промежуточного продукта, композиция, обладающая гипнотическим неседативным действием |
| WO1999021856A1 (fr) * | 1997-10-28 | 1999-05-06 | Pierre Fabre Medicament | Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives |
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Cited By (1)
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|---|---|---|---|---|
| RU2783865C2 (ru) * | 2017-04-01 | 2022-11-21 | Адептио Фармасьютикалз Лимитед | Фармацевтические композиции |
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| SI1855677T1 (sl) | 2009-04-30 |
| ATE534391T1 (de) | 2011-12-15 |
| AU2006277753A1 (en) | 2007-02-15 |
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| DE602006004009D1 (de) | 2009-01-15 |
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| HK1111083A1 (en) | 2008-08-01 |
| US20110257220A1 (en) | 2011-10-20 |
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| EP1855677B1 (en) | 2008-12-03 |
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| DK1855677T3 (da) | 2009-02-09 |
| CA2620960A1 (en) | 2007-02-15 |
| EP2050451A1 (en) | 2009-04-22 |
| CY1108843T1 (el) | 2014-07-02 |
| WO2007017654A1 (en) | 2007-02-15 |
| RU2008108623A (ru) | 2009-09-20 |
| PL1855677T3 (pl) | 2009-07-31 |
| EP1855677A1 (en) | 2007-11-21 |
| RS50807B (sr) | 2010-08-31 |
| AU2006277753B2 (en) | 2011-11-10 |
| HRP20090074T3 (en) | 2009-04-30 |
| NZ566011A (en) | 2011-01-28 |
| MX2008001549A (es) | 2008-04-04 |
| ES2318771T3 (es) | 2009-05-01 |
| EP2050451B1 (en) | 2011-11-23 |
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