RU2394583C1 - Agent for prevention of metabolic derangement - Google Patents

Abstract

FIELD: food industry.

SUBSTANCE: invention relates to food industry and may be used in practice to correct metabolic derangement in a person. Agent for prevention of metabolic derangement contains vitamin B1, vitamin B2, vitamin B3, vitamin B12, vitamin Bc, vitamin B5, vitamin B6, vitamin C, vitamin E liposomal, hepa-zinc, ferric sulfate, magnesium sulfate, chromium picolinate, glycine, arginine L, glutamate, taurine, organic selenium, liposomal betacarotin, grape skin extract, billbery extract, succinic acid, L-carnitine, creatine monohydrate, riboxinum, oligofructose, inulin and purified water, g/l.

EFFECT: method application makes it possible to provide for prevention of metabolic derangement in organism.

4 tbl

Description

In the 90s, after analyzing the causes of the sharp increase in the incidence rate in the country, the “Concept of state policy in the field of healthy nutrition of the population of the Russian Federation for the period until 2005” was developed [1]. It would seem that an extremely important task has been set - with the help of food and a number of drinks, to compensate for the existing deficiency of vitamins. I must say that the problem of deficiency of trace elements (with the exception of iodine) went unnoticed. However, practice has shown the viability of this idea. The proposed method could not provide the necessary concentration of vitamins in food, because It is known that the temperature treatment of bakery products destroys most of the vitamins.

Currently, you can find drinks, sour-milk products or milk with the presence of, for example, vitamins of groups B, E and C. We are convinced that, given the pH of the medium, the amount of seeds or the presence of lactic acid bacteria, it is difficult to talk about the presence of this kind of foods declared concentrations of vitamins. After 15 years, the problem posed worsened even more. There are several reasons for this. First of all, this is a serious deterioration in human living conditions - polluted air, water, soil. Through grain, vegetables, livestock and poultry products, people receive huge doses of toxins and heavy metals. In addition, the carbohydrate and fatty component of the human diet has increased even more. For high-income sectors of the population - due to overeating, for the poor - due to monotonous nutrition. However, if the first group has vitamin and mineral supplements, consuming a large number of fruits and expensive synthetic vitamins, then most of the population does not have such an opportunity. One way or another, the combination of such powerful impact factors as ecology and nutrition leads to the appearance of a number of metabolic disorders, which are the cause of many serious diseases. The mechanism of their occurrence is established - first of all, as a result of disorders of carbohydrate and fat metabolism, a sharp violation of the liver function, its obesity. As a result, a violation of cholesterol metabolism, a decrease in hormonal functions, depression of the immune system. All these metabolic disorders cause serious human diseases.

It is known that every year the number of cardiovascular, oncological, gastrointestinal diseases, hepatoses and cirrhosis of the liver increases. Naturally, ever-increasing pathologies of everyday life — alcoholism, smoking, drugs — contribute to this.

Recently, the number of so-called “opportunistic” infections, lesions by pathogenic fungi has significantly increased as a result of weakened immunity in cancer, AIDS, tuberculosis, etc. What is the role of vitamins and minerals? It turned out that an increase in the share of metabolic reactions aimed at the forced elimination of excess carbohydrate oxidation products entering the body requires additional administration of vitamins, which are known to be cofactors of most enzymes. In addition, for the same reasons, the need for trace elements is increasing, many of which are part of the enzyme molecule.

A rapid increase in the amount of products of incomplete oxidation of carbohydrates and fats leads to an even greater increase in the concentration of so-called free radicals, the neutralization of which requires the introduction of additional amounts of antioxidants. Thus, at present it is not a question of simply removing the deficiency of vitamins in food, but of developing a special strategy for the prevention and elimination of metabolic disorders. For this purpose, dietary supplements for metabolic disturbances, which are compositions of substances that have regulatory properties with respect to various sides of metabolism, are widely used in world practice. These food additives include enzymes, nucleosides, antioxidants, phospholipids and other naturally occurring substances. There is every reason to believe that with the correct use of dietary supplements, the need for vitamins and minerals can be reduced. However, there is no system in the application of dietary supplements. People can’t figure out what they should buy for various metabolic disorders. In addition, in most cases, dietary supplements can no longer turn the tide - medicines are needed. The weak bioavailability of vitamins and minerals should also be considered. One way or another, the need for additional administration of vitamins and minerals, as well as a number of antioxidants, exists, because no matter what the level of their intake with food, no matter how much their excess is compensated by using dietary supplements-correctors of exchange, the current situation needs to be constantly maintained at a certain concentration in the human body.

We propose combining the functions of metabolic correctors with vitamin and mineral supplements in a constant, daily regimen of use. For this purpose, drinking water is best suited. What are the benefits here? First, vitamins and minerals in an aqueous solution quickly enter the bloodstream, before they break down in the stomach and undergo destruction by intestinal microflora. Secondly, in the same water, you can create the necessary part of the corrector substances. Thirdly, all components can be performed in liposomal form (nanoparticles), thereby reducing the calculated concentration by 5-10 times due to a sharp increase in bioavailability. This will significantly reduce the price of water and increase its accessibility to the population. The task is facilitated by the fact that people are used to drinking purified or artesian water. The only thing that gives the use of such water is its quality compared to tap water. We can take water from a well as a basis, study its mineral composition. It should be minimal (table water). An important part of trace elements we will strengthen. We introduce antioxidants, the most important vitamins, and metabolic correctors in the form of liposomes. A person should drink 2 glasses of water per day (out of 8 glasses of the required rate of drinking). With water, he receives the prevention of metabolic disorders, the necessary doses of vitamins and minerals (taking into account their content in the diet), protects the liver from toxins (including alcohol), supports the body's immunity and energy.

Currently, we have not found any analogues in the composition and effect of the composition of drinking water we offer for humans. Basically, this nomenclature of drinking water, which has a certain composition, sometimes with increased doses of special micro and macro elements (Se ⁺⁺ , Mg ⁺ , Ca ⁺⁺ , etc.). Recently, BonAqva-Viva water appeared on the market, which contains phosphates (K ⁺ , Na ⁺ , Ca ⁺⁺ ) with the addition of citric acid and sodium citrate. Such water cannot prevent anything, although it tastes good and is probably useful as a substitute for tap water. Among the drinks, the category of so-called “energy” drinks for young people should be noted. These drinks are known to include a number of anabolics, including ginseng, eleutherococcus, L-carnitine, taurine, caffeine, and are aimed at sharply stimulating hormonal activity. Naturally, they are contraindicated in the elderly.

The composition of the water we offer is aimed at normalizing all aspects of metabolism and preventing pathologies of vital organs - the liver, heart, lungs, blood system, and immunity.

In addition, this regulatory complex has a pronounced antioxidant and antihypoxic activity. Water is essential for people older than 40-50 years, as it ensures the maintenance of the level of metabolic processes and thus slows down the aging process.

Based on the foregoing, we proposed the following composition of drinking water with a content of components in g / l.

Table 1. Drinking water for the prevention of metabolic disorders

Name of components G / l Vitamin B1 0.002 Vitamin B2 0.002 Vitamin B3 0.02 Vitamin B12 0.00002 Vitamin sun 0,0002 Vitamin B5 0.10 Vitamin B6 0.02 Vitamin C 0.20 Vitamin E Liposomal 0.02 Hepatzinc (Zn ⁺⁺ ) 0.01 Iron (sulfate) (Fe ⁺⁺ ) 0.015 Magnesium (sulfate) (Mg ⁺⁺ ) 0.20 Chromium Picolinate (Cr ⁺⁺ ) 0,0002 Glycine 0.20 Arginine L 0.40 Glutamate 0.15 Taurine 1,0 Organic Selenium 0.00005 Beta-carotene liposomal 0.01 Grape Skin Extract (Aqueous) 1.00 Blueberry Extract (Aqueous) 10.00 succinic acid 0,200 L-carnitine 1,000 Creatine Monohydrate 0,200 Riboxin 0.400 Oligofructose 3.0 Inulin 7.0 Purified water Up to 1 liter

The following is an example implementation of the method.

Example 1

Tap water was subjected to preliminary purification using Geyser filters, after which the components were dissolved in water in accordance with our composition.

After mixing, water was passed through a filter of the Vladipor system (manufacturer - NPP Tekhnofiltr LLC) using a pump to release it from extraneous microflora. The obtained sterile water containing the above proposed composition (Table 1) of biologically active substances was tested in mice. For this purpose, 2 groups of white mice were taken, 10 animals in each experiment and control. In both groups, animals were fed grain containing vitamins and minerals. In the control group, the mice were given purified tap water as a drink, and in the experiment, water of the composition proposed by us was given. The duration of the experiment is 90 days. In the course of the experiment, animals were regularly examined, weighed, fertilized, and at autopsy, the state of internal organs. The experimental data are shown in table 2.

From the data of Table 2 it can be seen that the mice in the experiment received higher growth energy, the survival rate in this group was higher. Towards the end of the experiment, the group of animals that received the water composition that we proposed was significantly more active, had better fertility results than in the control, and better feed conversion.

Example 2

As a comparison, the drinking water prepared by the proposed method was used as control drinking mineralized water taken from the well at the address: Pskov region, Porkhovskaya district, the village of "Holomki", the mineral composition of which is shown in table 3.

Table 3 Mineral composition of water from a well No. p / p Indicators Units measured. Measurement results one pH Units pH 7.52 2 Lithium mg / dm ³ 0.003 3 Ammonia and NH ₄ mg / dm ³ 0.25 four Sodium mg / dm ³ 3.0 5 Potassium mg / dm ³ 4.1 6 Magnesium mg / dm ³ 14.6 7 Calcium mg / dm ³ 84.2 8 Strontium mg / dm ³ 0.22 9 Barium mg / dm ³ 0.10 10 Iron ²⁺ mg / dm ³ <0.05 eleven Iron ³⁺ mg / dm ³ 1.41 12 Aluminum mg / dm ³ 0.13 13 Manganese mg / dm ³ 0.06 fourteen Zinc mg / dm ³ 0.004 fifteen Copper mg / dm ³ 0.003 16 Cobalt mg / dm ³ <0.001 17 Nickel mg / dm ³ 0.003 eighteen Lead mg / dm ³ 0.002 19 Fluorine mg / dm ³ <0.02 twenty Chlorides mg / dm ³ 5.5 21 Bromine mg / dm ³ <0.1 22 Iodine mg / dm ³ <0.001 23 Sulphates mg / dm ³ 13.0 24 Sulphides and hydrogen sulfide (according to Н ₂ S) mg / dm ³ <0.002 25 Hydrocarbonate mg / dm ³ 317.3 26 Carbonates mg / dm ³ <1.5 27 Silicon (by Si) mg / dm ³ 10.7 28 Phosphates (poly) mg / dm ³ 0,07 29th Nitrates mg / dm ³ 0.37 thirty Nitrite mg / dm ³ <0.003 31 Orthoboric acid (boron) mg / dm ³ <0.05 32 Total mineralization (solids) mgO / dm ³ 454.0 33 Mercury mg / dm ³ <0.00005 34 Chromium mg / dm ³ 0.002 35 Selenium mg / dm ³ <0.005 36 Arsenic mg / dm ³ <0.005

For testing, 2 groups of white mice were taken, 10 animals per experiment and in control. In both groups of animals were fed, as in example 1, grain containing vitamins and minerals.

As a drink, the mice were given drinking water prepared in accordance with the proposed method in the experimental group, and drinking water from the well in the control group. The duration of the experiment is 90 days.

In the course of the experiment, animals were regularly examined, as in example 1: they were weighed, fertility was determined, and at autopsy, the state of internal organs was determined.

The experience data are shown in table 4.

From table 4, as in example 1, it is seen that the mice in the experiment received higher growth energy, higher survival rates, better results in terms of fertility and better results in feed conversion than in the control.

Thus, the drinking water we offer has the ability to maintain growth and provides high vitality. At autopsy of experimental mice, it was found that all organs had no pathology, whereas in the control group the liver of mice showed signs of hepatosis, which indicates the presence of metabolic disorders in the body of mice. It has been established that water is completely harmless to the body with prolonged use and provides prophylaxis and correction of metabolic disorders.

The obtained results confirm the correctness of the chosen path, as well as the effectiveness of the proposed combination in the recipe of regulatory substances that ensure the prevention of metabolic disorders in the body.

List of references

1. Decree of the Government of the Russian Federation No. 917 of 08/10/98.

2. FGU Health "Center for Hygiene and Epidemiology in the City of St. Petersburg", Protocol of laboratory studies No. 2893 / 174-3 of 04/28/2009. Drinking water from a well. Pskov region, Porkhov region, the village of "Kholomki".

Claims (1)

An agent for the prevention of metabolic disorders containing vitamin B1, vitamin B2, vitamin B3, vitamin B12, vitamin B, vitamin B5, vitamin B6, vitamin C, vitamin E liposomal, hepatzinc, iron sulfate, magnesium sulfate, chromium picolinate, glycine, arginine L , glutamate, taurine, organic selenium, beta-carotene liposomal, grape skin extract, blueberry extract, succinic acid, L-carnitine, creatine monohydrate, riboxin, oligofructose, inulin and purified water with the following components, g / l:
Vitamin B1 0.002 Vitamin B2 0.002 Vitamin B3 0.02 Vitamin B12 0.00002 Vitamin sun 0,0002 Vitamin B5 0.10 Vitamin B6 0.02 Vitamin C 0.20 Vitamin E Liposomal 0.02 Hepatzinc (Zn ⁺⁺ ) 0.01 Iron (sulfate) (Fe ⁺⁺ ) 0.015 Magnesium (sulfate) (Mg ⁺⁺ ) 0.20 Chromium Picolinate (Cr ⁺⁺ ) 0,0002 Glycine 0.20 Arginine L 0.40 Glutamate 0.15 Taurine 1,0 Organic Selenium 0.00005 Beta-carotene liposomal 0.01 Grape Skin Extract (Aqueous) 1.00 Blueberry Extract (Aqueous) 10.00 succinic acid 0,200 L-carnitine 1,000 Creatine Monohydrate 0,200 Riboxin 0.400 Oligofructose 3.0 Inulin 7.0 Purified water Up to 1.0 l