RU2391969C2 - Method of plague treatment - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention belongs to medicine, notably to biguanid compounds, namely Siofor 500, Delagil and 0.5 acetylsalicylic acid administration 1 tablet 3 times a day for plague treatment.

EFFECT: there is offered plague treatment method.

1 ex

Description

The invention relates to medicine: to infectious diseases, namely to means for treating plague.

Known drugs used to treat plague (see Big Medical Encyclopedia, 1986, Volume 27, p. 355, MD Mashkovsky "Medicines". M., 2008).

The disadvantage of these drugs in the treatment of plague is the reduced sensitivity to these drugs due to the adaptation of the pathogen to them.

The present invention is the creation of an effective tool for specific treatment of plague.

The essence of the claimed technical solution lies in the fact that for the treatment of plague, an agent is proposed consisting of a combination of biguanide, delagil and acetylsalicylic acid in the usual therapeutic doses authorized by the pharmaceutical committee.

This combination of previously known agents of biguanide, delagil and acetylsalicylic acid, used for a new purpose, allows, in contrast to previously known agents, treatment of plague, affecting the following links of etiopathogenesis:

- suppression of the plague-causing infection of Y. Pestis, which spreads and propagates with the help of protozoa (Y. Pestis does not have mobility organelles);

- conditions conducive to the development of infection are eliminated;

- insulin reception and insulin supply, protein, fat, carbohydrate, mineral metabolism, immunity, oxygen transfer to tissues, blood rheology of the cerebrospinal fluid, bile are restored;

- eliminates cramping, thrombosis in the vessels, serous hemorrhagic lymphadenitis, intoxication.

The proposed tool uses biguanide from a number of metformin compounds, in combination with delagil and acetylsalicylic acid.

Reception is carried out at a time on an empty stomach:

for metformin compounds 0.5 g

for delagil 0.25 g

for acetylsalicylic acid 0.5 g

(M.D. Mashkovsky. Medicines. M., 2008, p. 164, 562, 898).

Example

Patient Z., 29 years old, suddenly developed chills, fever up to 39 °, headache, pain in the muscles of the extremities, slurred speech, confusion (the patient is in the endemic region of the plague, was in contact with rodents). The face is purplish-cyanotic, features are sharpened, eyes with red sclera. The pulse is arrhythmic, 120 in 1 minute, blood pressure 90/60 mm Hg, heart sounds are deaf, the tongue is covered with a thick white coating, periadenitis of the inguinal lymph nodes. In an. blood hemoglobin 110, red blood cells 3.2, sigma 86, wand. 12, soe - 60 mm / hour. In general, an. urine beats weight 1035, acid reaction, protein 4%, erythro. 20, lake. 15 in point of view. Biochemical an. blood cholesterol 9, triglycerides 3.8, sugar 8, urea 8.1, creatinine 68, AlAT - 50, AcAT - 58, total. bilirubin 7.

Bacteriological examination (from inguinal nodes) - gram-negative ovoid bipolar-stained bacilli were found. An accelerated luminescence-serological test is a positive reaction.

Treatment has begun with a combination of glibutide 0.5, delagil 0.25, acetylsalicylic acid 0.5 at a time three times a day on an empty stomach.

Improvement was noted after 1 day: headache and muscle pain decreased, temperature reached 37.8 °, weakness decreased, pulse rate 100 in 1 minute, AD 100/70 mm Hg. After 4 days, the clinical manifestations of the disease disappeared and did not resume thereafter. The course of treatment was carried out for 3 weeks. On day 20, hemoglobin 130, erythra, in blood tests. 5.0, lake. 4,5, sigma 67, stick. 7, ESR - 26 mm / hour. Total urinalysis: beats. weight 1022, acidic reaction, protein - traces, lake. 10 in sight, units red blood cells.

Biochemical blood test: total. protein 68, cholesterol 5.7, triglycerides 1.9, AlAT - 26, AcAT - 30, urea 7.1 creatinine 57, total. bilirubin 7.

Claims (1)

The use of siofor 500, delagil and acetylsalicylic acid 0.5 for the treatment of plague.