CN100384435C - Saline solution for treating nasal cavity disease and its application device - Google Patents
Saline solution for treating nasal cavity disease and its application device Download PDFInfo
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- CN100384435C CN100384435C CNB2005101005304A CN200510100530A CN100384435C CN 100384435 C CN100384435 C CN 100384435C CN B2005101005304 A CNB2005101005304 A CN B2005101005304A CN 200510100530 A CN200510100530 A CN 200510100530A CN 100384435 C CN100384435 C CN 100384435C
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Abstract
The present invention relates to salt water physic liquor for treating nasal cavity diseases and an applying device, which belongs to a medicine and appliance field and is particularly to suitable for allergic rhinitis. The present invention provides a new medicine for treating nasal cavity diseases and aims to improve a treatment effect without side effect; the pain of a patient with a rhinitis symptom is reduced, treatment expenses are decreased, and device making and use is simple and convenient. The salt water physic liquor is composed of 0.002 to 6% of sodium chloride, 0.002 to 1% of calcium chloride, 0.002 to 1% of potassium chloride, 0.002 to 0.2% of xylitol (1, 2, 3, 4, 5-pentitol) and distilled water as the rest. Practice proofs that the salt water physic liquor in long term application has no side effect, the price is low, the present invention is welcome by patients, and the medical effect of applying a spray method is obvious.
Description
Technical field:
The present invention relates to a kind of saline solution and application apparatus for the treatment of nose diseases, belong to medicine and instrument field, be suitable for medication especially allergic rhinitis.
Background technology:
Allergic rhinitis is a kind of common and multiple disease, and men and women, old and young got this disease, makes troubles for work, studying and living, and influence is physically and mentally healthy.This sick being difficult to is effected a radical cure, and take medicine or the medication collunarium in the time of can only sickly sending out.The present Therapeutic Method of allergic rhinitis is a lot, mainly contains three kinds:
(1): the antihistaminic medicine, as: clarityne and the quick spit of fland of letter etc.
(2): the corticosteroids medicine, as: Rhinocort nasal cavity medicine or the like.
(3): desensitization treatment: find corresponding anaphylactogen earlier, carry out subcutaneous multiple low dose desensitization treatment at corresponding anaphylactogen again.
The desensitization treatment of allergic rhinitis is a kind of very effective method theoretically, but facts have proved, its real effective percentage is also only about 30%.
There is following shortcoming in the treatment of above medicine:
One, antihistaminic medicine and corticosteroids medicine can only be controlled the symptom of allergic rhinitis, and a lot of case symptoms of allergic rhinitis after drug withdrawal recur at once;
Two, prolonged application antihistamine drug and 17-hydroxy-11-dehydrocorticosterone can bring certain side effect, can cause headache, drowsiness, tired, the xerostomia dimness of vision, blood pressure reduction or rising, cardiopalmus as using the antihistaminic medicine, faint, hyperkinesis, liver function change, jaundice, hepatitis, hepatic necrosis, alopecia, epilepsy, breast swelling, erythema multiforme and systemic anaphylaxis; Use 17-hydroxy-11-dehydrocorticosterone and can may cause that dryness in the nasal cavity, sneeze, slight courageous and upright secretions or epistaxis, dermoreaction (urticaria, erythra, dermatitis, angioedema) only a few patient have ulcer and perforation of nasal septum after nasal cavity gives glucocorticoid.
Three, the time of desensitization therapy long, expense height, each desensitization about 4000 circle course of treatment, and often a desensitization is not prove effective the course of treatment.Desensitization treatment patient suffered misery in therapeutic process is many, will arrive hospital weekly and carry out subcutaneous injection desensitization antigen one time, more than lasting at least half a year.
Summary of the invention:
The invention provides the novel drugs of treatment nose diseases, its objective is and improve curative effect and patient is had no side effect; Reduce rhinitis symptomatic recurrence and the suffered misery of patient, reduce medical expense, preparation and operative installations are simple, convenient.
A kind of saline solution for the treatment of nose diseases is characterized in that saline solution is made up of water, sodium chloride, calcium chloride, potassium chloride and xylitol.
Saline solution component concentration percentage by weight is: sodium chloride 0.002%---6%, and calcium chloride 0.002%---1%, potassium chloride 0.002%---1%, xylitol (1,2,3,4, the 5-pentite)) 0.002%--0.2%, all the other are distilled water.
The pH value of saline solution acid-base value preferably 7.0.
Saline solution has the lavation effect to nasal cavity.Airborne anaphylactogen lives in concentrated communities at nasal membrane and just can excite when reaching finite concentration nasal membrane to produce anaphylaxis, thereby corresponding symptom occurs as symptoms such as rhinocnesmus, sneeze, snivel, nasal obstructions.Moisture content in this saline solution can be cleared up attached to the anaphylactogen on the nasal membrane, thereby avoids anaphylactoid generation.Sodium chloride in the saline solution, calcium chloride, potassium chloride are inorganic salt, can alleviate the edema of nasal membrane, and these three kinds of salts have increased the osmotic pressure of medicinal liquid together simultaneously, and the hyperosmosis environment can suppress the growth of antibacterial.Xylitol also has bactericidal action.
The compound method of saline solution is: being ready to distilled water and each component by component concentration, distilled water is put into through the disinfectant container, all the other components are added in the aquae destillata again, through stirring each component is dissolved fully, promptly is saline solution; In addition, send out the acid-base value that detects saline solution, and the pH value that adds micro-individual components control saline solution acid-base value is about 7.0 by the side of acid base titration.
When using saline solution, the saline solution storage is contained in the spray bottle, use the have gentle hands light press, then bottle the saline in is evenly distributed on nasal cavity by shower nozzle with the form of vaporific microgranule.Like this, can reach best lavation effect and medical effect.
The sodium chloride of above-mentioned saline solution, calcium chloride, potassium chloride and xylitol are pharmaceutical products.
The saline solution of above-mentioned saline solution is through the curative effect of spraying treatment of allergic rhinitis: through clinical observation, use this saline solution nasal spray is washed, every day 3-5 time, after January, the symptom of about 60% Allergic Rhinitis is controlled; In addition, if use Claritin and saline solution treatment of allergic rhinitis, there is the consumption of 40% left and right sides patient's Claritin obviously to reduce.The advantage of brine spray treatment: really effectively, and prolonged application has no side effect in process of clinical application, low price, and the patient takes like a shot.
The specific embodiment:
Now with this programme being described with several examples.
Example one
Open XX, male, July 12 1956 date of birth.Go to a doctor because of rhinocnesmus, snivel, the slight nasal obstruction of sneeze companion May calendar year 2001.Have a medical check-up: ordinary circumstance is good, the cardiopulmonary no abnormality seen.External nose is no abnormal, bilateral concha nasalis inferior silght enlargement, and nasal septum does not have inclined to one side song, and the nasal membrane color is white, and nasal cavity is not seen neoplasm.The anaphylactogen test is to dust, mycete allergy.Give clarityne 10mg, oral every day 3 times, the back symptom control of 1 week.Allergic symptom shows effect repeatedly later on, uses the clarityne controlling symptoms at every turn.
12 parts of calendar year 2001s begin nasal cavity is carried out saline solution spraying treatment, and every day 3 to 5 times, the allergic rhinitis symptom is recurrence again.Spent cost is 50 circle RMB only
The saline solution component concentration proportioning for the treatment of this case is: the agent of every 500ml brine spray contains: sodium chloride 15 grams, and calcium chloride 4 grams, the xylitol (1,2,3,4, the 5-pentite) of potassium chloride 5 grams and 0.5 gram, remaining is a distilled water.The pH value of saline solution acid-base value is 7.0.
Example two,
Lee XX, male, 1970 dates of birth JIUYUE 19 days.Go to a doctor because of rhinocnesmus, snivel, sneeze in June, 1999.Have a medical check-up: ordinary circumstance is good, the cardiopulmonary no abnormality seen.External nose is no abnormal, and the bilateral concha nasalis inferior does not have enlargement, and nasal septum does not have inclined to one side song, and the nasal membrane color is white, and nasal cavity is not seen neoplasm.The anaphylactogen test is to dust allergy.Give clarityne 10mg oral every day 3 times, use Rhinocort, every day 2 times, symptom control after 3 days.Allergic symptom shows effect repeatedly later on, uses clarityne and Rhinocort controlling symptoms at every turn.
2002 5 parts open nasal cavity carried out saline solution spraying treatment, every day 3 to 5 times, the allergic rhinitis symptom is recurrence more so far, spent cost is 60 circle RMB only.
The saline solution component concentration proportioning for the treatment of this case is: the agent of every 500ml brine spray contains: sodium chloride 13 grams, and calcium chloride 5 grams, potassium chloride 4 grams and 0.6 gram xylitol (1,2,3,4, the 5-pentite), remaining is a distilled water.The pH value of saline solution acid-base value is 7.0.
Example three, king XX, women, October 12 1978 date of birth.Go to a doctor because of rhinocnesmus, snivel, sneeze companion tinnitus in July, 2003.Have a medical check-up: ordinary circumstance is good, the cardiopulmonary no abnormality seen.External nose is no abnormal, and the bilateral concha nasalis inferior does not have enlargement, and nasal septum does not have inclined to one side song, and the nasal membrane color is white, and nasal cavity is not seen neoplasm.The anaphylactogen test is to dust allergy.Give clarityne 10mg oral every day 3 times, symptom control after 3 days.Allergic symptom shows effect repeatedly later on, uses the clarityne controlling symptoms at every turn.
2004 5 parts begin nasal cavity is carried out saline solution spraying treatment every day 3 to 5 times, the allergic rhinitis symptom is recurrence more so far.Spent cost is 40 circle RMB only.
The saline solution component concentration proportioning for the treatment of this case is: the agent of every 500ml brine spray contains: sodium chloride 17 grams, and calcium chloride 5 grams, the xylitol (1,2,3,4, the 5-pentite) of potassium chloride 5 grams and 0.4 gram, remaining is a distilled water.The pH value of saline solution acid-base value is 7.0.
Facts have proved that the medical effect of saline solution spraying is remarkable, through the rhinitis symptom not recurrence more so far of treatment.
Claims (3)
1. saline solution for the treatment of nose diseases is characterized in that saline solution is made up of water, sodium chloride, calcium chloride, potassium chloride and xylitol; The component concentration proportioning is that every 500ml saline solution contains: sodium chloride 15 grams, and calcium chloride 4 grams, the xylitol (1,2,3,4, the 5-pentite) of potassium chloride 5 grams and 0.5 gram, remaining is a distilled water.
2. a kind of saline solution for the treatment of nose diseases according to claim 1 is characterized in that the component concentration proportioning is, every 500ml saline solution contains: sodium chloride 13 grams, calcium chloride 5 grams, potassium chloride 4 grams and 0.6 gram xylitol (1,2,3,4, the 5-pentite), remaining is a distilled water.
3. a kind of saline solution for the treatment of nose diseases according to claim 1 is characterized in that the component concentration proportioning is, every 500ml saline solution contains: sodium chloride 17 grams, calcium chloride 5 grams, the xylitol (1,2,3 of potassium chloride 5 grams and 0.4 gram, 4, the 5-pentite), remaining is a distilled water.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005101005304A CN100384435C (en) | 2005-10-25 | 2005-10-25 | Saline solution for treating nasal cavity disease and its application device |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005101005304A CN100384435C (en) | 2005-10-25 | 2005-10-25 | Saline solution for treating nasal cavity disease and its application device |
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| CN1775222A CN1775222A (en) | 2006-05-24 |
| CN100384435C true CN100384435C (en) | 2008-04-30 |
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| CN109091497A (en) * | 2018-10-16 | 2018-12-28 | 广州润虹医药科技股份有限公司 | A kind of cleaning solution and preparation method thereof for antibacterial reparation |
| FR3088193B1 (en) | 2018-11-13 | 2021-01-22 | Andrea Fox | AQUEOUS COMPOSITION, ITS MANUFACTURING PROCESS, AND NASAL ADMINISTRATION DEVICE |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325680A (en) * | 2000-05-25 | 2001-12-12 | 穆英惠 | Lotion for cleaning nasal and nasopharyngeal cavities |
| CN1583172A (en) * | 2004-05-31 | 2005-02-23 | 刘近周 | Multifunctional liquid for clean therapy of nasal cavity and sinuses |
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- 2005-10-25 CN CNB2005101005304A patent/CN100384435C/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325680A (en) * | 2000-05-25 | 2001-12-12 | 穆英惠 | Lotion for cleaning nasal and nasopharyngeal cavities |
| CN1583172A (en) * | 2004-05-31 | 2005-02-23 | 刘近周 | Multifunctional liquid for clean therapy of nasal cavity and sinuses |
Non-Patent Citations (4)
| Title |
|---|
| 中西药合剂在鼻窦术后鼻腔冲洗中的应用. 李丽明等.吉林中医药，第24卷第12期. 2004 |
| 中西药合剂在鼻窦术后鼻腔冲洗中的应用. 李丽明等.吉林中医药，第24卷第12期. 2004 * |
| 用洗鼻壶冲洗鼻腔治疗鼻炎42例. 刘解先.人民军医，第1995年卷第5期. 1995 |
| 用洗鼻壶冲洗鼻腔治疗鼻炎42例. 刘解先.人民军医，第1995年卷第5期. 1995 * |
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| CN1775222A (en) | 2006-05-24 |
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Effective date of registration: 20161115 Address after: Huadu District, Guangdong city of Guangzhou province 510000 Flower Town Pingshan Private Industrial Park No. 16 south 5 Patentee after: GUANGZHOU YUNDUAN BAIYAN BIOTECHNOLOGY CO., LTD. Address before: Guangzhou City, Guangdong province 510100 Liuhua Road No. 111 building 109 Patentee before: Lu Yuhua |