CN109091497A - A kind of cleaning solution and preparation method thereof for antibacterial reparation - Google Patents
A kind of cleaning solution and preparation method thereof for antibacterial reparation Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A61P11/00—Drugs for disorders of the respiratory system
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P31/02—Local antiseptics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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Abstract
The invention belongs to nasal nursing fields, more particularly to a kind of cleaning solution and preparation method thereof for antibacterial reparation, the cleaning solution is by sodium chloride 15~25%, magnesium chloride hexahydrate 8~12%, calcium chloride 0.5~1%, potassium chloride 0.1~0.5%, six water strontium chlorides 0.01~0.05%, anhydrous sodium sulfate 0.5~3%, sodium bicarbonate 0.05~0.2%, xylitol 0.002~0.2%, alum 0.1~0.5%, hyaluronic acid 0.01~0.3%, menthol 0.005~0.1% and excess water are made, cleaning solution of the present invention has significant bacteriostasis, the nasal obstruction of patients with rhinitis can be significantly improved, rhiocnesmus, inflammation and mycteroxerosis symptom, and its is highly-safe, suitable for vast patients with rhinitis.
Description
Technical field
The invention belongs to nasal nursing fields, and in particular to a kind of cleaning solution and preparation method thereof for antibacterial reparation.
Background technique
With the propulsion of process of industrialization, the development of traffic, atmosphere pollution is got worse, and the dust that suspends in air has
The virulence factors such as chemical particle, virus, bacterium, mould, the anaphylactogen of poison also increase significantly.After these substances are inhaled into nasal cavity,
Most of substance can be blocked in nasal cavity by mechanism such as fibre swing, mucous secretions, but as removed in nasal cavity not in time
These harmful substances, these harmful substances can be deposited in nasal mucosal surface, stimulate schneiderian membrane, caused to have a running nose, be sneezed, nose
The discomforts such as plug, inflammation are also possible to lead to the diseases such as various acute and chronic rhinitis, nasosinusitis, allergic rhinitis, flu over time
Occur, threatens human health.Therefore, there is an urgent need to a kind of suitable nasal cavity cleaning liquid, the dirt that can will have both assembled in nasal cavity
Or harmful substance is removed completely, moreover it is possible to be reached bacteriostasis, be given nasal cavity to provide a clean salubrious environment, restore nasal cavity
Self functions of expelling toxin reduces the incidence of rhinitis and other disease.
If Chinese invention application CN106389810A discloses a kind of nasal cavity health care cleaning solution, the cleaning solution is by gold and silver
Flower, Radix Astragali, Flos Magnoliae Liliflorae, the stem pith of the rice-paper plant, pueraria lobata, cape jasmine, Radix Angelicae Sinensis, radix scrophulariae, radix bupleuri, tendril-leaved fritillary bulb, Rhizoma Chuanxiong and peppermint are made, suitable for nasal cavity
Daily nursing, the impaired daily health caring nursing of antipruritic, nasal obstruction, rhiocnesmus, runny nose, schneiderian membrane function, safely and effectively.But the cleaning solution
For Chinese materia medica preparation, it is easy microbial contamination and occurs to go bad, influence drug effect, it is also possible to secondary pollution can be brought to nasal cavity.
If Chinese invention patent CN106074717A discloses a kind of nasal cavity anti-inflammatory conditioning liquid, the conditioning liquid by activity from
Sub- calcium, sea salt, borneol, olive face cream, lithium magnesium silicate, myrrh essential oils, tea tree quintessence oil, kudzu-vine root powder, allantoin and citric acid system
At.The conditioning liquid can improve nasal cavity microcirculation, and quick anti-inflammatory anti-itch makes Rhinitis Symptoms rapid regression, without any irritation, but should
It nurses and essential oils is added in aqueous solution, without surfactant or emulsifier, be not easy to form a balanced system, and protect
Reason liquid antibacterial effect is undesirable, and need to increase the frequency used just can make nasal cavity keep clean salubrious environment for a long time.
Therefore, there is an urgent need to a kind of cleaning solutions for antibacterial reparation, have significant bacteriostasis, can significantly improve
Nasal obstruction, rhiocnesmus, inflammation and the mycteroxerosis symptom of patients with rhinitis, it is highly-safe, suitable for vast patients with rhinitis.
Summary of the invention
The present invention is intended to provide a kind of cleaning solution and preparation method thereof for antibacterial reparation, the cleaning solution has significant
Bacteriostasis, nasal obstruction, rhiocnesmus, inflammation and the mycteroxerosis symptom of patients with rhinitis can be significantly improved, it is highly-safe, be suitable for
Vast patients with rhinitis.
In order to achieve the above object, the invention adopts the following technical scheme:
A kind of cleaning solution for antibacterial reparation, is made of following raw material and its weight percent: sodium chloride 15~25%,
It is magnesium chloride hexahydrate 8~12%, calcium chloride 0.5~1%, potassium chloride 0.1~0.5%, six water strontium chlorides 0.01~0.05%, anhydrous
Sodium sulphate 0.5~3%, sodium bicarbonate 0.05~0.2%, xylitol 0.002~0.2%, alum 0.1~0.5%, hyaluronic acid
0.01~0.3%, menthol 0.005~0.1% and excess water.
Further, the cleaning solution is made of following raw material and its weight percent: sodium chloride 20~25%, six water chlorine
Change magnesium 10~12%, calcium chloride 0.7~1%, potassium chloride 0.3~0.5%, six water strontium chlorides 0.02~0.05%, anhydrous slufuric acid
Sodium 1~3%, sodium bicarbonate 0.1~0.2%, xylitol 0.05~0.2%, alum 0.3~0.5%, hyaluronic acid 0.1~
0.3%, menthol 0.05~0.1% and excess water.
Further, the cleaning solution is made of following raw material and its weight percent: sodium chloride 20%, six water chlorinations
Magnesium 10%, calcium chloride 0.8%, potassium chloride 0.2%, six water strontium chlorides 0.02%, anhydrous sodium sulfate 1%, sodium bicarbonate 0.05%,
Xylitol 0.1%, alum 0.4%, hyaluronic acid 0.1%, menthol 0.05% and excess water.
Further, the cleaning solution preparation method the following steps are included:
S1, it takes corresponding amount sodium chloride, magnesium chloride hexahydrate, calcium chloride, potassium chloride, six water strontium chlorides to be dissolved with water, obtains solution
A；
S2, it takes corresponding amount anhydrous sodium sulfate and sodium bicarbonate to be dissolved with water, obtains solution B；
S3, step S2 acquired solution B is added in step S1 acquired solution A while stirring, adjusting pH is 6~8,
Sequentially add xylitol, alum, hyaluronic acid and the menthol of corresponding amount, stirring to dissolving, filtering to get.
Further, the dosage of water is the 10~90% of corresponding amount in the step S1, the use of water in the step S2
Amount is the surplus of corresponding amount.
Further, solution water-bath is heated to 40~50 DEG C if any muddiness before the step S3 filtering, it is cooling after dissolution
It is refiltered to room temperature.
Further, the step S3 filtering is filtered using 0.22 μm of miillpore filter.
In addition, the present invention also provides the preparation method of the cleaning solution, the preparation method comprises the following steps:
I, it takes corresponding amount sodium chloride, magnesium chloride hexahydrate, calcium chloride, potassium chloride, six water strontium chlorides to be dissolved with water, obtains solution A；
II, it takes corresponding amount anhydrous sodium sulfate and sodium bicarbonate to be dissolved with water, obtains solution B；
III, step II acquired solution B is added in step I acquired solution A while stirring, adjusting pH is 6~8,
Sequentially add xylitol, alum, hyaluronic acid and the menthol of corresponding amount, stirring to dissolving, filtering to get.
Further, the dosage of water is the 10~90% of corresponding amount in the step I, and the dosage of water is in the step II
The surplus of corresponding amount；If any muddiness before the step III filtering, solution water-bath is heated to 40~50 DEG C, is cooled to after dissolution
Room temperature refilters；The step III filtering is filtered using 0.22 μm of miillpore filter.
In addition, the present invention also provides a kind of noses of cleaning solution prepared containing the cleaning solution or the preparation method
Chamber cleaning agent.
Alum of the invention has significant antibacterial action, to a variety of Gram-negative bacterias, gram-positive cocci and bar
Bacterium has inhibiting effect, can significantly inhibit the growth of bacterium in nasal cavity.Applicant is found surprisingly that in practice, by xylose
Alcohol is used in conjunction with alum, can significantly improve cleaning solution to the inhibiting effect of bacterium in nasal cavity, is equipped with moisturizing, is repaired function
The components such as the hyaluronic acid of energy can significantly improve nasal obstruction, rhiocnesmus, inflammation and the mycteroxerosis symptom of patients with rhinitis.Test example 2
As can be seen that cleaning solution prepared by the embodiment of the present invention 1 has significant bacteriostasis in 10min, and comparative example 1 (is removed
Alum) and comparative example 2 (removing xylitol) preparation cleaning solution it is little without bacteriostasis or bacteriostasis within 10min；Examination
Example 3 is tested as can be seen that cleaning solution prepared by the embodiment of the present invention 1 is up to 80% or more to the rate that significantly improves of Rhinitis Symptoms, and
The therapeutic effect of cleaning solution prepared by comparative example 1 (removing alum) and comparative example 2 (removing xylitol) to nasal obstruction, rhiocnesmus and rhinitis
It generally, is inefficient there are also 16~31% effect.
In addition, the alum in the present invention contains Al3+, largely remain in nasal cavity as being used for a long time to have, be easy by respiratory tract
It into alimentary canal, puts aside in human body, causes the symptoms such as general under senile dementia, the decline of memory force, intelligence.But applicant is in reality
Pleasantly surprised discovery in trampling can substantially reduce Al by adding hyaluronic acid3+Residual quantity in nasal cavity.It can be with by test example 3
Find out, cleaning solution Al prepared by the embodiment of the present invention 13+Residual quantity is only 0.01%, and comparative example 3 (removing hyaluronic acid)
Al3+Residual quantity is increased significantly to 5.10%.Its mechanism is still not clear, it may be possible to Al3+It depends on hyaluronic acid and enters nasal cavity, rise
To significant fungistatic effect, and the relative molecular mass of hyaluronic acid is larger, cannot penetrate nasal membrane layer, can be with cleaning solution
Outflow take away extra Al3+, to significantly reduce Al3+Residual in nasal cavity.
The invention has the following advantages that
(1) cleaning solution prepared by the present invention for antibacterial reparation has significant bacteriostasis, can significantly improve nose
Nasal obstruction, rhiocnesmus, inflammation and the mycteroxerosis symptom of scorching patient, and Al3+Residual quantity is low, highly-safe, suitable for vast rhinitis
Patient.
(2) cleaning solution prepared by the present invention for antibacterial reparation has broad-spectrum antibacterial effect by addition alum, is equipped with
Xylitol is remarkably improved the bacteriostasis of alum, while hyaluronic acid can significantly reduce in alum while moisturizing, reparation
Al3+Residual quantity improves safety.
Specific embodiment
The specific embodiment of form by the following examples makees further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.
Wherein agents useful for same is common agents, can be bought in reagent production and sales company.
A kind of cleaning solution for antibacterial reparation of embodiment 1
It is made of following raw material and its weight percent: sodium chloride 20%, magnesium chloride hexahydrate 10%, calcium chloride 0.8%, chlorine
Change potassium 0.2%, six water strontium chlorides 0.02%, anhydrous sodium sulfate 1%, sodium bicarbonate 0.05%, xylitol 0.1%, alum
0.4%, hyaluronic acid 0.1%, menthol 0.05% and excess water.
Preparation method:
I, take corresponding amount sodium chloride, magnesium chloride hexahydrate, calcium chloride, potassium chloride, six water strontium chloride corresponding amounts 50% water
Dissolution, obtains solution A；
II, it takes corresponding amount anhydrous sodium sulfate and the water of sodium bicarbonate corresponding amount surplus to dissolve, obtains solution B；
III, step II acquired solution B is added in step I acquired solution A while stirring, adjusting pH is 6~8,
Xylitol, alum, hyaluronic acid and the menthol of corresponding amount are sequentially added, stirring is to dissolving, if any muddiness, by solution water-bath
Be heated to 40~50 DEG C, be cooled to room temperature after dissolution again, using 0.22 μm of miillpore filter be filtered to get.
A kind of cleaning solution for antibacterial reparation of embodiment 2
It is made of following raw material and its weight percent: sodium chloride 15%, magnesium chloride hexahydrate 8%, calcium chloride 0.5%, chlorine
Change potassium 0.1%, six water strontium chlorides 0.01%, anhydrous sodium sulfate 0.5%, sodium bicarbonate 0.05%, xylitol 0.002%, alum
0.1%, hyaluronic acid 0.01%, menthol 0.005% and excess water, preparation method reference implementation example 1.
A kind of cleaning solution for antibacterial reparation of embodiment 3
It is made of following raw material and its weight percent: sodium chloride 25%, magnesium chloride hexahydrate 12%, calcium chloride 1%, chlorination
Potassium 0.5%, six water strontium chlorides 0.05%, anhydrous sodium sulfate 3%, sodium bicarbonate 0.2%, xylitol 0.2%, alum 0.5%, thoroughly
Bright matter acid 0.3%, menthol 0.1% and excess water, preparation method reference implementation example 1.
A kind of cleaning solution of comparative example 1
Difference from Example 1 is that comparative example 1 removes alum, increases the dosage of water, remaining component and preparation method
Reference implementation example 1.
A kind of cleaning solution of comparative example 2
Difference from Example 1 is that comparative example 2 removes xylitol, increases the dosage of water, remaining component and preparation side
Method reference implementation example 1.
A kind of cleaning solution of comparative example 3
Difference from Example 1 is that comparative example 3 removes hyaluronic acid, increases the dosage of water, remaining component and preparation
Method reference implementation example 1.
Test example 1 is physical and chemical and biology performance detects
The every physical and chemical, biology performance of the cleaning solution of Examples 1 to 3 preparation is detected, the results are shown in Table 1.
1 physics and chemistry of table, Biological Detection result
As shown in Table 1, cleaning solution pH prepared by the present invention, heavy metal total content, halide content, Sterility testing, cell
Toxicity test, delayed allergy experiment and oral stimulation experiment meet index request, safe and non-stimulating.
The detection of 2 bacteriostasis property of test example
With reference to GB15979-2002 to cleaning solution prepared by embodiment 1 and comparative example 1~2 carry out 2min, 5min and
The bacteriostasis property of 10min detects, and the results are shown in Table 2.
2 bacteriostasis property testing result of table
Note: 50%≤bacteriostasis rate < 90%, to there is bacteriostasis, bacteriostasis rate < 90% is to have stronger bacteriostasis.
As shown in Table 2, cleaning solution prepared by the present invention has bacteriostasis, has stronger bacteriostasis in 10min,
And comparative example 1 (removing alum) then cleaning solution within 10min all without bacteriostasis, bacterial growth can not be inhibited；Comparative example 2
(removing xylitol) without bacteriostasis in 5min, bacteriostasis is little in 5~10min.
3 clinical test of test example
Clinical test is carried out to 200 patients with rhinitis, is divided into four groups, it is early, middle and late daily to use the embodiment of the present invention 1
Whether the cleaning solution prepared with comparative example 1~3, record patient disease symptom make moderate progress and collect the cleaning solution after patient's use
Aluminum ions content is measured, the Al with former cleaning solution3+Comparision contents calculate Al3+Residual quantity.
3 clinical test results of table
Note: it is significant that 1~4 day symptom, which has clear improvement,；It is general that 5~11 days symptoms, which have clear improvement,；Have after 12 days
It is inefficient for being obviously improved.
As shown in Table 3, the cleaning solution that prepared by the embodiment of the present invention 1 has significantly nasal obstruction, rhiocnesmus, inflammation and mycteroxerosis
Therapeutic effect, and Al3+Residual quantity is only 0.01%, highly-safe；And comparative example 1 (removing alum) and comparative example 2 (are removed
Xylitol) Al3+Residual quantity is lower, significant to the therapeutic effect of mycteroxerosis, but to the therapeutic effect of nasal obstruction, rhiocnesmus and inflammation one
As, it is inefficient there are also 16~31% effect；Therapeutic effect of the comparative example 3 (removing hyaluronic acid) to nasal obstruction, rhiocnesmus and inflammation
It is more significant but general to the therapeutic effect of mycteroxerosis, and Al3+Residual quantity dramatically increases.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of cleaning solution for antibacterial reparation, which is characterized in that be made of following raw material and its weight percent: sodium chloride
15~25%, magnesium chloride hexahydrate 8~12%, calcium chloride 0.5~1%, potassium chloride 0.1~0.5%, six water strontium chlorides 0.01~
0.05%, anhydrous sodium sulfate 0.5~3%, sodium bicarbonate 0.05~0.2%, xylitol 0.002~0.2%, alum 0.1~
0.5%, hyaluronic acid 0.01~0.3%, menthol 0.005~0.1% and excess water.
2. cleaning solution as described in claim 1, which is characterized in that be made of following raw material and its weight percent: sodium chloride 20
~25%, magnesium chloride hexahydrate 10~12%, calcium chloride 0.7~1%, potassium chloride 0.3~0.5%, six water strontium chlorides 0.02~
0.05%, anhydrous sodium sulfate 1~3%, sodium bicarbonate 0.1~0.2%, xylitol 0.05~0.2%, alum 0.3~0.5%,
Hyaluronic acid 0.1~0.3%, menthol 0.05~0.1% and excess water.
3. cleaning solution as claimed in claim 2, which is characterized in that be made of following raw material and its weight percent: sodium chloride
20%, magnesium chloride hexahydrate 10%, calcium chloride 0.8%, potassium chloride 0.2%, six water strontium chlorides 0.02%, anhydrous sodium sulfate 1%, carbon
Sour hydrogen sodium 0.05%, xylitol 0.1%, alum 0.4%, hyaluronic acid 0.1%, menthol 0.05% and excess water.
4. the cleaning solution as described in claims 1 to 3 is any, which is characterized in that the preparation method of the cleaning solution includes following step
It is rapid:
S1, it takes corresponding amount sodium chloride, magnesium chloride hexahydrate, calcium chloride, potassium chloride, six water strontium chlorides to be dissolved with water, obtains solution A；
S2, it takes corresponding amount anhydrous sodium sulfate and sodium bicarbonate to be dissolved with water, obtains solution B；
S3, step S2 acquired solution B is added in step S1 acquired solution A while stirring, adjusting pH is 6~8, then according to
It is secondary be added corresponding amount xylitol, alum, hyaluronic acid and menthol, stirring to dissolve, filtering to get.
5. cleaning solution as claimed in claim 4, which is characterized in that in the step S1 dosage of water be corresponding amount 10~
The dosage of water is the surplus of corresponding amount in 90%, the step S2.
6. cleaning solution as claimed in claim 4, which is characterized in that if any muddiness before the step S3 filtering, solution water-bath is added
Heat is cooled to room temperature after dissolution and refilters to 40~50 DEG C.
7. cleaning solution as claimed in claim 4, which is characterized in that the step S3 filtering is carried out using 0.22 μm of miillpore filter
Filtering.
8. the preparation method of cleaning solution as described in claims 1 to 3 is any, which is characterized in that the preparation method includes following
Step:
I, it takes corresponding amount sodium chloride, magnesium chloride hexahydrate, calcium chloride, potassium chloride, six water strontium chlorides to be dissolved with water, obtains solution A；
II, it takes corresponding amount anhydrous sodium sulfate and sodium bicarbonate to be dissolved with water, obtains solution B；
III, step II acquired solution B is added in step I acquired solution A while stirring, adjusting pH is 6~8, then according to
It is secondary be added corresponding amount xylitol, alum, hyaluronic acid and menthol, stirring to dissolve, filtering to get.
9. preparation method as claimed in claim 8, which is characterized in that in the step I dosage of water be corresponding amount 10~
The dosage of water is the surplus of corresponding amount in 90%, the step II；If any muddiness before the step III filtering, by solution water-bath
40~50 DEG C are heated to, is cooled to room temperature and refilters after dissolution；The step III filtering is carried out using 0.22 μm of miillpore filter
Filtering.
10. prepared by a kind of preparation method containing the cleaning solution as described in claim 1~7 is any or as described in by claim 8 or 9
The nasal cavity cleaning preparation of cleaning solution.
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