RU2390558C2 - Гемопоэтическая клетка cd34+ и ее применение - Google Patents

Гемопоэтическая клетка cd34+ и ее применение Download PDF

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RU2390558C2
RU2390558C2 RU2007107369/13A RU2007107369A RU2390558C2 RU 2390558 C2 RU2390558 C2 RU 2390558C2 RU 2007107369/13 A RU2007107369/13 A RU 2007107369/13A RU 2007107369 A RU2007107369 A RU 2007107369A RU 2390558 C2 RU2390558 C2 RU 2390558C2
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cells
trail
cell
tumor
apoptosis
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RU2007107369/13A
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Russian (ru)
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RU2007107369A (ru
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Алессандро М. ДЖАННИ (IT)
Алессандро М. ДЖАННИ
Кармело КАРЛО-СТЕЛЛА (IT)
Кармело КАРЛО-СТЕЛЛА
Франческо КОЛОТТА (IT)
Франческо Колотта
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ДОМПЕ ФА.Р.МА С.п.А.
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4231—Cytokines
    • A61K40/4232—Tumor necrosis factors [TNF] or CD70
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/49—Breast
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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RU2007107369/13A 2004-07-29 2005-07-21 Гемопоэтическая клетка cd34+ и ее применение RU2390558C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04017907.9 2004-07-29
EP04017907A EP1621550A1 (en) 2004-07-29 2004-07-29 Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Publications (2)

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RU2007107369A RU2007107369A (ru) 2008-09-10
RU2390558C2 true RU2390558C2 (ru) 2010-05-27

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US (1) US20070264231A1 (OSRAM)
EP (2) EP1621550A1 (OSRAM)
JP (1) JP5042826B2 (OSRAM)
KR (1) KR20070047757A (OSRAM)
CN (1) CN101076540B (OSRAM)
AT (1) ATE455847T1 (OSRAM)
AU (1) AU2005266543B2 (OSRAM)
BR (1) BRPI0513855A (OSRAM)
CA (1) CA2571426A1 (OSRAM)
DE (1) DE602005019050D1 (OSRAM)
DK (1) DK1771468T3 (OSRAM)
ES (1) ES2340400T3 (OSRAM)
HR (1) HRP20100227T1 (OSRAM)
IL (1) IL180233A (OSRAM)
MX (1) MX2007001152A (OSRAM)
NO (1) NO20070956L (OSRAM)
NZ (1) NZ552223A (OSRAM)
PL (1) PL1771468T3 (OSRAM)
PT (1) PT1771468E (OSRAM)
RS (1) RS51381B (OSRAM)
RU (1) RU2390558C2 (OSRAM)
SI (1) SI1771468T1 (OSRAM)
WO (1) WO2006010558A1 (OSRAM)
ZA (1) ZA200701231B (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008503468A (ja) * 2004-06-18 2008-02-07 ジェネンテック・インコーポレーテッド Apo2lレセプターアゴニストおよびnk細胞活性化因子の使用方法
DE102006020307A1 (de) * 2006-05-03 2007-11-08 Martin-Luther-Universität Halle-Wittenberg TNF-related apoptosis-including (TRAIL)stabil transgen exprimierende mesenchymale Stammzellen, Verfahren zu ihrer Herstellung und zu ihrer Verwendung
WO2008142862A1 (ja) * 2007-05-18 2008-11-27 National University Corporation Asahikawa Medical College 血管内皮前駆細胞の移植による抗がん療法
CN102154213B (zh) * 2011-01-19 2012-07-25 郑骏年 一种运载荷载细胞因子的双调控溶瘤腺病毒的新型cik细胞
CN104160027B (zh) * 2012-02-01 2016-06-22 浦项工科大学校产学协力团 同时表达十二聚体trail及hsv-tk自杀基因的载体及利用其的抗癌干细胞治疗剂
CN103288966B (zh) * 2013-05-17 2015-01-21 华侨大学 一种融合受体及其用于治疗大肠癌的基因药物
RU2552609C1 (ru) * 2013-10-28 2015-06-10 Федеральное государственное бюджетное учреждение науки Институт молекулярной биотехнологии им. В.А. Энгельгардта Российской академии наук (ИМБ РАН) Способ получения системы направленной доставки белковых молекул (онколитических белков) в опухолевые ткани на основе активированных лимфоцитов
WO2016065330A1 (en) 2014-10-24 2016-04-28 Aladar Szalay Combination immunotherapy approach for treatment of cancer
CN116064401A (zh) * 2015-07-29 2023-05-05 昂克医疗有限公司 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系
US10906951B2 (en) * 2015-07-29 2021-02-02 Onk Therapeutics Limited Modified natural killer cells and natural killer cell lines having increased cytotoxicity
WO2019232631A1 (en) * 2018-06-06 2019-12-12 Stemcell Technologies Canada Inc. Kits, compositions and methods for myeloid-derived suppressor cell enrichment
US12220465B2 (en) 2018-11-28 2025-02-11 Washington University Compositions and methods for targeted treatment and imaging of cancer or tumors
EP3712257A1 (en) 2019-03-21 2020-09-23 ONK Therapeutics Limited Modified natural killer cells with increased resistance to cell death
CN113677791B (zh) * 2019-03-21 2024-12-03 昂克医疗有限公司 对细胞死亡具有增加的抗性的经修饰的免疫效应细胞
WO2021209625A1 (en) 2020-04-17 2021-10-21 Onk Therapeutics Limited High potency natural killer cells

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RU2232812C2 (ru) * 1994-10-07 2004-07-20 Ридженерон Фармасьютикалз, Инк. Выделенная молекула нуклеиновой кислоты, кодирующая tie-2 лиганд, tie-2 лиганд и способ получения, плазмида (варианты), антитело, конъюгат, лигандное тело, фармацевтическая композиция, способ стимулирования неоваскуляризации, способ поддержания клетки, способ идентификации антагониста tie-2 рецептора

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RU2232812C2 (ru) * 1994-10-07 2004-07-20 Ридженерон Фармасьютикалз, Инк. Выделенная молекула нуклеиновой кислоты, кодирующая tie-2 лиганд, tie-2 лиганд и способ получения, плазмида (варианты), антитело, конъюгат, лигандное тело, фармацевтическая композиция, способ стимулирования неоваскуляризации, способ поддержания клетки, способ идентификации антагониста tie-2 рецептора

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AU2005266543B2 (en) 2012-02-02
EP1771468B1 (en) 2010-01-20
EP1621550A1 (en) 2006-02-01
ZA200701231B (en) 2008-08-27
PL1771468T3 (pl) 2010-07-30
NZ552223A (en) 2009-01-31
RS51381B (sr) 2011-02-28
EP1771468A1 (en) 2007-04-11
PT1771468E (pt) 2010-04-20
ATE455847T1 (de) 2010-02-15
CA2571426A1 (en) 2006-02-02
HK1110874A1 (en) 2008-07-25
WO2006010558A1 (en) 2006-02-02
RU2007107369A (ru) 2008-09-10
WO2006010558A8 (en) 2006-08-24
JP2008507961A (ja) 2008-03-21
DK1771468T3 (da) 2010-05-25
KR20070047757A (ko) 2007-05-07
CN101076540B (zh) 2012-10-24
IL180233A0 (en) 2007-07-04
US20070264231A1 (en) 2007-11-15
CN101076540A (zh) 2007-11-21
HRP20100227T1 (hr) 2010-07-31
MX2007001152A (es) 2007-04-18
NO20070956L (no) 2007-02-20
AU2005266543A1 (en) 2006-02-02
DE602005019050D1 (de) 2010-03-11
BRPI0513855A (pt) 2008-05-20
SI1771468T1 (sl) 2010-07-30
JP5042826B2 (ja) 2012-10-03
ES2340400T3 (es) 2010-06-02
IL180233A (en) 2010-12-30

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