RU2371194C2 - 'anastasia' herbal mixture - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention concerns chemical and pharmaceutical industry, particularly production of natural media with anti-inflammatory and anti-microbe effect. Mixture includes European pyrola, sidebells wintergreen and prairieweed at 2:2:6 ratio.

EFFECT: enhanced efficiency of treatment, reduced inflammatory changes, reduced duration and intensity of painful sensations, extended range of herbal medicines.

Description

The present invention relates to medicine, namely to the creation of agents of natural origin, exhibiting anti-inflammatory and antimicrobial effects.

Various charges are known that exhibit anti-inflammatory and antimicrobial effects.

So known collection that has anti-inflammatory effect, which contains chamomile pharmacy, dioica nettle, red clover, Ural licorice, Siberian istoda, medicinal marshmallow, Kuril tea, speckled meadowsweet, Polygonaceous meadowsweet, Birdman's highlander, Siberian penny (see RF Patent No. 16, No. 16, No. 16, No. 22, No. 22, RF22 No. 22, 2003).

Known medicinal plant collection "Phytomax" containing marshmallow roots, rosemary shoots, immortelle flowers, hawthorn fruits, valerian roots, snake highlander roots, bird highlander grass, elecampane roots, sweet clover grass, St. John's wort grass, marigold flowers, corn stigmas, linden flowers peppermint grass, black nightshade grass, tansy inflorescences, licorice leaves, licorice roots, marsh cinnamon grass, tricolor violet flowers, field horsetail grass, three-part string grass, large celandine grass, sage leaves, rose hips, which are about Determines the anti-inflammatory, immunostimulant and choleretic effect (see. RF patent №2190419, 2002). However, the known collection contains mutually opposing substances, for example, hemostatic and preventing blood coagulation, tannins included in the composition can bind to other active substances and reduce the therapeutic effect of the collection, in addition, the multicomponent composition of the collection makes it industrially difficult to reproduce, which also reduces it therapeutic activity.

The closest is the collection of "Aphrodite" medicinal plants, which has an antimicrobial, anti-inflammatory and wound healing effect, which contains pharmacy chamomile flowers and calendula, oak bark, motherwort, sage, plantain and eucalyptus (see RF Patent No. 2125884, 1999).

However, the proposed collection is preferably used for external use, as it contains oak bark. When used inside preparations containing oak bark, vomiting is possible due to the irritating effect of ballast substances (resins).

The technical result of the proposed collection is to increase the effectiveness of treatment and expand the arsenal of drugs of natural origin, the ability to apply the proposed collection for external use and orally without side effects.

New to the achievement of the technical result is that the collection contains pear grass, Orthilium one-sided and Kuril tea in the following ratio of components 2: 2: 6.

The drug collection was called "Anastasia."

The proposed ratio of medicinal plants included in the collection is selected empirically and represents the most appropriate quantitative ratio of the components.

Five-leaved shrub (Kuril tea) (Pentaphylloides fruticosa L.) fam. Rosaceae (Rosaceae) in its composition contains flavonoids, tannins, triterpenoids, phenolcarboxylic acids, vitamins. It is used in medicine for diseases of the gastrointestinal tract, colitis, enterocolitis, peptic ulcer of the stomach and duodenum, dysbiosis, diarrhea. It has a strong anti-inflammatory effect, hemostatic, choleretic, thromboplastic effect.

Grushanka round-leaved (Pyrola rotundifolia L.) sem. Grushanky (Pyrolaceae). The main biological active substances of the Grushanka genus are polyphenolic compounds. The leaves of grushanki contain tannins, arbutin, sucrose, invertine, a little emulsin, flavonoids, hydroquinone, ascorbic acid. In the grass of the round-leaved pear, the naphthaquinone compound chymafilin, urson, thaksin, quercetin, kempferol, p-coumaric acid were found; in the leaves - methylarbutin, essential oil, mucus and resins.

In folk medicine, the leaves of pear leaves are used for headaches, rheumatism, fever, pain in the stomach, bleeding, purulent diseases of the kidneys, and for female diseases associated with inflammatory processes. Outwardly, an infusion of leaves is used to wash festering wounds. In the past, plants were used as anti-inflammatory drugs for diseases of the oral cavity and pharynx in the form of rinses with decoction. In Tibetan medicine, winter wheat is used for liver diseases, and in Western European - for dropsy, diabetes and chronic inflammation of the bladder. The northern peoples use dry powder for the bites of snakes and wolves as an antidote.

Ortilia one-sided (Ortylia secunda L.) sem. Grushanka (Pyrolaceae) contains polyphenolic compounds, in particular, arbutin, tannins, ascorbic acid, resins, anthocyanins, flavonoids, coumarins, saponins, and bitter substances. Orthilia one-sided has a wide range of anti-inflammatory effects, it is used for infertility, uterine bleeding, cervical erosion, for menstrual irregularities, for heavy menstruation, for adhesions and tube obstruction, for endometritis and salpingo-oophoritis, for inflammation of the prostate gland, low potency.

The proposed combination of medicinal herbs in the collection provides anti-inflammatory and antimicrobial effects.

Comparative analysis with the prototype shows that the proposed collection differs from the known one in that it contains round-leaved pear, one-sided orthilia and Kuril tea with the following ratio of components 2: 2: 6, which meets the criterion of "novelty."

The proposed collection "Anastasia" increases the effectiveness of treatment due to anti-inflammatory and antimicrobial effects, expands the arsenal of herbal remedies.

The proposed collection "Anastasia" is used in the form of infusion, which is prepared as follows. The infusion is prepared in a ratio of 1:20. To do this, pour 1 tablespoon of the collection with 200 ml of hot boiled water and insist on a boiling water bath with frequent stirring for 15 minutes, then cool at room temperature for at least 45 minutes, filter and add boiled water to 200 ml. The finished infusion is stored closed for no more than 2 days in the refrigerator. Shake before use.

The study of the anti-inflammatory effect of the infusion prepared from the proposed collection of "Anastasia" was carried out in mice. 180 outbred white mice weighing 20-22 g were taken, divided into experimental and control groups of 10 animals each. Within 10 days, the animals of the experimental groups were given 0.2 ml per mouse of decoctions of the proposed collection, respectively, the control groups of mice were given 0.2 ml of 70% ethyl alcohol and water. After 10 days, the mice were induced an inflammatory reaction using sterile turpentine. For this purpose, a drop of turpentine was applied to the skin of the plantar surface of the right hind foot treated with alcohol and punctured through it to a depth of 1.5 mm. After 24 hours, the intensity of the inflammatory response was evaluated. The animals were sacrificed, the hind feet were cut off, they were weighed, and the masses of the right and left feet of each animal were determined. The severity of the reaction was evaluated by the difference in masses of the right and left feet of the animal. The weight of the feet in mice of the control group is 33% greater than the weight in mice of the experimental group, the reliability is P <0.01.

The study of the effectiveness of the anti-inflammatory and antimicrobial therapeutic effect of the Anastasia herbal collection was carried out by intranasal use of decoction in patients after septoplasty (submucous correction of the nasal septum), performed on the deformation of the nasal septum with nasal breathing insufficiency. Objectively, the degree of nasal breathing disturbance was assessed by determining the Brunings index, mucociliary transport-MCT (saccharin time), and peripheral blood parameters were studied.

The experimental group included 30 patients with nasal septum deformity (23 men and 7 women) aged 12 to 39 years; 13 people from them for a long time (up to 6 years) were constantly using vasoconstrictors. All patients had a pronounced deformation of the nasal septum (Art.), 6 of them had hypertrophy of the posterior ends of the lower nasal concha.

The control group consisted of 31 people with deformation of the nasal septum 3 degrees (22 men and 9 women) aged 14 to 42 years; of these, 14 people suffered from medical rhinitis, 9 people had hypertrophy of the posterior ends of the lower nasal concha.

The use of the Anastasia collection infusion in the experimental group began 2 days after the surgery (after removing the tampons) by washing both halves of the nasal cavity with 40 ml of decoction 3 times a day for 10 days. In the postoperative period, a "nasal douche" was carried out for patients with a control group using an isotonic sodium chloride solution.

The results were evaluated at 5 and 10 days after surgery.

Before surgery, obstructed nasal breathing was noted by all patients in both groups (14% - distinct and 86% - pronounced), in 42% of the experimental and 45% of the control groups - moderate mucous discharge from the nose. In all the studied patients, nasal septum deformity of various types of 3 degrees, OAK values were normal, Brunings index from 2.2 to 3.0, slowing of the MCT (from 18 to 26 minutes) was recorded in 57% of the experimental patients and in 46% of the control group.

On the 5th day of the postoperative period, a significant improvement in nasal breathing was subjectively noted by 13 people (43.3%) of the experimental and 9 (29%) control groups, which was confirmed by a decrease in the Brunings index to 1.5-1.7 and an objective decrease in the severity of reactive edematous-infiltrative phenomena from the mucous membrane of the nasal cavity.

On day 10, nasal breathing was assessed as “good” by 26 patients (86.75) in the experimental group and 19 (61.3%) in the control group.

The severity of rhinorrhea progressively decreased in both groups, but by 10 days no nasal discharge was noted by 22 (73.3%) and the minimum - 6 (20%) people in the experimental group, while in the control group rhinorrhea was absent in 14 (45.2 %), the minimum was manifested in 10 (32.34%).

The dynamics of MCT improvement was also different in the groups: by 10 days of the postoperative period, saccharin time decreased to 10 minutes in the experimental group in 18 (60%), in the control group - in 12 (38.7%).

Of the peripheral blood parameters in the postoperative period, ESR underwent significantly significant changes. On the 10th day of the postoperative ESR period less than 10 mm / hour - in 11 (36.6%) people of the experimental group and 15 (48.4%) of the control; up to 15 mm / hour in 19 people (63.3%) of the experimental and 13 people (42%) of the control group; 3 people (9.7%) of the control group of ESR remained above 20 mm / hour.

The use of the Anastasia collection infusion in patients after surgical correction of the nasal septum provides a dynamic restoration of the respiratory and protective functions of the nose, thereby confirming the high anti-inflammatory and antimicrobial activity of the proposed collection.

Claims (1)

Vegetable collection, which has anti-inflammatory and antimicrobial effects, containing Kuril tea, characterized in that it additionally contains pear leaves and one-sided orthilium in the following ratio of 6: 2: 2.