KR20110056459A - Composition for prevention and improvement of periodontal disease - Google Patents
Composition for prevention and improvement of periodontal disease Download PDFInfo
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- KR20110056459A KR20110056459A KR1020110030581A KR20110030581A KR20110056459A KR 20110056459 A KR20110056459 A KR 20110056459A KR 1020110030581 A KR1020110030581 A KR 1020110030581A KR 20110030581 A KR20110030581 A KR 20110030581A KR 20110056459 A KR20110056459 A KR 20110056459A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A23V2200/00—Function of food ingredients
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- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
Description
본 발명은 생약재를 유효성분으로 하는 치주질환의 예방 및 개선용 조성물에 관한 것이다.
The present invention relates to a composition for the prevention and improvement of periodontal disease using the herbal medicine as an active ingredient.
치주질환(periodontal disease)은 치주조직에 발병하는 병변의 총칭이다. 치주질환의 원인은 일반적으로 치구 내의 여러 가지 세균이지만 흡연, 스트레스, 영양불균형, 운동 부족, 당뇨병, 혈액질환 등에 의한 면역력 저하도 원인이 된다. 치주조직에 염증이 생기는 치주염은, 치석이 붙은 잇몸부분에 염증이 있는 초기의 치육염(치은염) 상태에서는 치석을 제거하면 염증이 없어지고 건강한 치육으로 돌아갈 수 있다. 그러나 중기에는 치석 내의 세균에 의해 염증이 치육에서 치조골로 전파하여 골이 녹아들게 되며, 후기에는 치조골의 대부분이 녹아버려 치육에서 농이 흘러나오면서 치아가 움직이거나 빠지게 되는 경우도 있다. 치주염은 초기에는 동통이 없고 만성적으로 진행하기 때문에 발견이 늦어지는데, 현재 치주염에 대해서는 염증 자체를 치료하거나 개선하는 방법은 거의 없으며, 염증조직을 수술로 제거하는 것이 유일한 치료방법이다. 그러나 수술적인 제거는 통증을 수반하고, 치주조직의 물리적인 손실을 초래하며, 심한 경우 치아의 손실까지 초래하게 된다.
Periodontal disease (periodontal disease) is a general term for lesions that occur in the periodontal tissue. Periodontal disease is generally caused by various bacteria in the plaque, but also caused by decreased immunity due to smoking, stress, malnutrition, lack of exercise, diabetes and blood diseases. Periodontitis, which is inflamed in the periodontal tissue, in the early stages of gingivitis (gingivitis), which is inflamed on the gum part with the tartar, when the calculus is removed, the inflammation disappears and can be returned to the healthy tooth. However, in the mid-term, inflammation in the tartar spreads from the dental plaque to the alveolar bone, and the bone melts. In the latter period, most of the alveolar bone melts, and the pus flow out of the tooth, causing teeth to move or fall out. Periodontitis is delayed because it is initially painless and progresses chronically. Currently, for periodontitis, there is little to cure or ameliorate the inflammation itself, and surgical removal of inflammatory tissue is the only treatment. Surgical removal, however, involves pain, physical loss of periodontal tissue, and even severe tooth loss.
본 발명은, 종래 특별한 예방법이나 치료방법이 없던 치주질환을 예방 및 개선할 수 있는 조성물을 제공하는 것을 목적으로 한다. 특히, 본 발명은 안전한 생약재를 유효성분하는 치주질환 예방 및 개선용 조성물을 제공하는 것을 목적으로 한다. An object of the present invention is to provide a composition capable of preventing and improving periodontal disease, which has not been provided with any special preventive method or treatment. In particular, it is an object of the present invention to provide a composition for preventing and improving periodontal disease effective ingredients for safe herbal medicine.
본 발명에서는,In the present invention,
유효성분으로 망초잎 100 중량부와 시호 4~12 중량부를 포함하는 치주질환 예방 및 개선용 조성물이 제공된다. 상기 망초잎은 바람직하게는, 6월 전에 채취된 어린잎을 사용한다. As an active ingredient, there is provided a composition for preventing and improving periodontal disease, including 100 parts by weight of forget-me-not leaves and 4 to 12 parts by weight of Siho. The forget-me-not leaves preferably use young leaves collected before June.
본 발명의 조성물은 바람직하게는, 성인의 1회 복용량으로 망초잎 0.4~1.5g 및 시호 0.02~0.18g을 포함하며, 1일 2~3회 복용한다. 상기 조성물은 본 발명의 일 실시예에서 약제학적으로 허용 가능한 부형제를 더 포함하며 바람직하게는 환제 형태로 제제화될 수 있다. The composition of the present invention preferably contains 0.4 to 1.5 g of forget-me-not leaves and 0.02 to 0.18 g of Shiho in a single dose of an adult, and is taken 2-3 times a day. The composition further comprises a pharmaceutically acceptable excipient in one embodiment of the present invention and may be preferably formulated in pill form.
본 발명의 치주질환 예방 및 개선용 조성물은 종래에 특별한 예방법이나 치료방법이 없던 치주질환을 예방은 물론 거의 완치에 가깝게 치료할 수 있으며, 부작용이 없는 안전한 조성물로서 의약품이나 건강식품으로 이용될 수 있다. 이밖에도 본 발명의 조성물은 위염, 위장장애, 대장염, 변비, 설사, 복부팽만감 등의 위장관 질환, 축농증, 비염, 두통, 편두통 등에도 뛰어난 효과가 있어, 치주질환 개선과 함께 이들 증상의 개선도 가져올 수 있다.
The composition for preventing and improving periodontal disease of the present invention can prevent periodontal disease, which has not been particularly prevented or treated in the past, as well as almost cure, and can be used as a safe composition without side effects as a medicine or health food. In addition, the composition of the present invention has excellent effects on gastrointestinal diseases such as gastritis, gastrointestinal disorders, colitis, constipation, diarrhea, bloating, sinusitis, rhinitis, headache, migraine headaches, and can also improve the symptoms of periodontal disease. have.
본 발명의 치주질환 예방 및 개선용 조성물을 상세히 설명한다. It describes the composition for preventing and improving periodontal disease of the present invention in detail.
본 발명의 치주질환 예방 및 개선용 조성물은 유효성분으로 망초잎 100 중량부와 시호 4~12 중량부를 포함한다.The composition for preventing and improving periodontal disease of the present invention comprises 100 parts by weight of the forget-me-not leaves and 4-12 parts by weight of seaweed as an active ingredient.
본 발명에서 "치주질환"은, 치주조직에 발병하는 병변을 총칭하는 것으로, 치은염, 치근막염, 치조골염 등을 포함하는 치주염, 풍치를 모두 포함하는 의미이다.In the present invention, "periodontal disease" is a generic term for lesions occurring on the periodontal tissue, it is meant to include all the periodontitis, flavor, including gingivitis, periodontitis, alveolar inflammation.
망초(Erigeron canadensis)는 국화과의 두해살이풀로 잔꽃풀이라고도 하는데, 꽃은 7~9월에 핀다. 잎을 식용이나 약재로 사용하는데, 약재로는 꽃이 피기 전이나 후에 채취한 잎이 모두 사용 가능하며, 식용으로는 꽃이 피기 전의 어린잎을 사용하고 있다. 한방에서 망초는 성질이 차서 몸안의 열을 내리고 죽은 피를 몰아내는 작용이 있다고 하며, 폐와 위의 열을 내려주는 효능이 있어 외감 열병에 활용하고, 각종 종기를 없애는 데도 사용한다. 본 발명에서 사용하는 망초잎은 식용으로 사용 가능한 어린잎으로, 바람직하게는 6월 전에 채취된 어린잎을 사용하며, 더욱 좋기로는 5월 중순에서 5월 말 사이에 채취한 어린 순을 사용한다. 망초는 약재는 물론 식용 나물로도 사용되고 있어 안전성이 확인된 생약재이다. Forget-me-not ( Erigeron canadensis ) is a biennial herb of the Asteraceae, also called hyacinth. Flowers bloom in July-September. The leaves are used as food or medicinal herbs. The medicinal herbs can be used both before and after flowering, and young leaves before flowering. In one shot, the forget-me-not has the effect of lowering the heat in the body and driving dead blood, and it has the effect of lowering the heat of the lungs and stomach, which is used for external fever, and is also used to remove various boils. The forget-me-not leaves used in the present invention are young leaves that can be used for food, preferably, young leaves collected before June, and more preferably, young shoots collected between mid-May and late May. . Forget-me-not is used as a medicinal herb as well as medicinal herbs is a safe herbal medicine.
시호(Bupleurum falcatum L.)는 미나리과의 여러해살이풀로, 북시호, 묏미나리라고도 한다. 시호의 뿌리는 자색이며, 뿌리에 사포닌과 지방유 등이 들어 있어 한방에서 약재로 쓴다. "시호"라고 하면 한방에서 그 뿌리를 의미하는데, 본 발명에서도 "시호"는 시호 뿌리를 의미한다. 한방에서 시호는 나쁜 기운이 몸 안에 있는 것도 아니고 피부 부위에 있지도 않고 그 사이에 있어 오한과 신열이 번갈아 있는 병증에 쓰며, 해열, 발한, 가슴과 옆구리통증, 유방통증, 생리불순, 생리통, 탈항, 자궁하수 등에 사용한다. 약리작용으로 해열, 진정, 진통, 진해, 항염증, 담즙분비촉진, 지질대사활성화, 면역증가, 억균작용 등이 보고되어있다. 본 발명의 조성물에서 시호는 망초잎 100 중량부에 대해 4~12 중량부로 사용되며, 더욱 바람직하게는 5~7 중량부로 사용된다. 중국에서는 시호를 북시호라고 하는데, 본 발명의 조성물에 보다 바람직하게는 중국산의 시호(북시호)가 사용될 수 있다. 산지에 따라 효과에 다소 차이가 있는데, 이는 토양, 기후 등 생약의 재배환경에 따른 차이로 생각된다. Shiple ( Bupleurum falcatum L.) is a perennial herb of the Apiaceae family , also known as the North Siho and 묏 Minari. Shiho's root is purple, and its root contains saponin and fatty oil. "Shiho" means the root in one shot, but in the present invention "siho" refers to the root of Shiho. In oriental medicine, Shiho is used for a condition in which chills are not in the body, not on the skin, and between the chills and the fever, and fever, sweating, chest and flank pain, breast pain, menstrual disorder, menstrual pain, breakout, Used for sewage. As a pharmacological action, antipyretic, soothing, analgesic, antitussive, anti-inflammatory, bile secretion promotion, lipid metabolism activation, increase of immunity, fungal action has been reported. Shiho in the composition of the present invention is used in 4 to 12 parts by weight, more preferably 5 to 7 parts by weight based on 100 parts by weight of the forget-me-not leaves. In China, Shiho is called North Shiho, and more preferably, Chinese Shiho (North Shiho) may be used in the composition of the present invention. The effect is somewhat different depending on the region, which is thought to be due to the growing environment of herbal medicines such as soil and climate.
망초잎이나 시호는 각각 단독으로는 뚜렷한 치주질환 예방이나 개선효과를 나타내지 못하나, 이 둘을 일정 비율로 배합한 본 발명의 조성물은 치주질환 예방과 개선에 분명한 효과를 나타낸다. 본 발명의 치주질환 예방 및 개선용 조성물은, 보다 바람직하게는, 성인의 1회 복용량으로 망초잎 0.4~1.5g 및 시호 0.02~0.18g을 포함하며, 1일 2~3회 복용한다. 본 발명의 조성물은 탕제, 환제, 과립제, 산제 등 공지된 다양한 제형으로 제제화 될 수 있으며, 필요에 따라 약제학적으로 허용 가능한 부형제를 더 포함할 수 있다. 본 발명의 일 실시예에서는, 찹쌀가루, 밀가루 등을 부형제로 사용하여 본 발명의 조성물을 환제로 만들었다. 그러나 가능한 제형이 이에 한정되지는 않으며, 본 발명의 조성물은 한방제제와 같은 제형 외에도 정제, 캡슐제 등의 다양한 제형으로도 제제화가 가능하다. Each of the forget-me-not leaves and shiho alone do not show a clear periodontal disease prevention or amelioration effect, but the composition of the present invention in combination of the two in a certain ratio has a clear effect on the prevention and improvement of periodontal disease. More preferably, the composition for preventing and improving periodontal disease of the present invention comprises 0.4-1.5 g of forget-me-not leaves and 0.02-0.18 g of Shiho in a single dose of an adult, and is taken 2-3 times a day. The composition of the present invention may be formulated into a variety of known formulations, such as powders, pills, granules, powders, etc., may further comprise a pharmaceutically acceptable excipient as needed. In one embodiment of the present invention, the composition of the present invention was made into pills using glutinous rice flour, flour or the like as an excipient. However, the possible formulations are not limited thereto, and the compositions of the present invention may be formulated into various formulations, such as tablets and capsules, in addition to formulations such as herbal preparations.
본 발명의 치주질환 예방 및 개선용 조성물은 종래에 특별한 예방법이나 치료방법이 없던 치주질환에 뛰어난 효능이 있어, 예방은 물론 진행 중인 증상을 거의 완치에 가깝게 치료할 수 있다. 또한, 망초잎과 시호는 한방에서 오래 전부터 약재로 사용하고 있어 안전성이 확인된 생약재이므로, 이들을 유효성분으로 하는 본 발명의 조성물은 부작용이 없는 안전한 조성물로서 의약품이나 건강식품으로 이용될 수 있다. 이밖에도 본 발명의 조성물은 위염, 위장장애, 대장염, 변비, 설사, 복부팽만감 등의 위장관 질환, 축농증, 비염, 두통, 편두통 등에도 뛰어난 효과가 있어, 앞으로 다른 용도로의 개발도 가능하다.
The composition for preventing and improving periodontal disease of the present invention has an excellent effect on periodontal disease, which has not had any special preventive methods or treatments in the prior art, and can prevent and cure the symptoms in progress as close to cure as possible. In addition, the forage leaf and Shiho has been used as a herbal medicine for a long time in herbal medicine, so the safety of the herbal medicine has been confirmed, the composition of the present invention using them as an active ingredient can be used as a safe composition without side effects as a medicine or health food. In addition, the composition of the present invention has excellent effects on gastrointestinal diseases such as gastritis, gastrointestinal disorders, colitis, constipation, diarrhea, bloating, sinusitis, rhinitis, headaches, migraine headaches, and the like.
[실시예][Example]
이하 구체적인 실시예를 통해 본 발명을 보다 상세히 설명한다. 그러나 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 범위가 이들 실시예에 의해 한정되는 것은 아니다.
Hereinafter, the present invention will be described in more detail with reference to specific examples. However, these examples are only for illustrating the present invention in more detail, the scope of the present invention is not limited by these examples.
실시예 1Example 1
5월 중순에 채취하여 말린 망초의 어린 잎 100g과, 시호 10g을 각각 분말화한 후 혼합하고, 여기에 밀가루를 40g 정도 부가하고 가습하여 1환이 0.04g 정도가 되도록 환제로 만들었다.
In the middle of May, 100 g of young leaves of dried forget-me-not and 10 g of Siho were powdered and mixed, and about 40 g of flour was added and humidified to make a pill about 0.04 g.
실시예 2Example 2
5월 중순에 채취하여 말린 망초의 어린 잎 150g과 시호 8g에 20배 정도의 물을 가하고 가열하여 10봉지 분량의 탕제로 만들었다. Collected in mid-May, 150g of young leaves of dried forget-me-not and 8g of Siho were added with about 20 times of water, and heated to make 10 bags of tangerine.
실시예 3Example 3
복용사례Case of taking
상기 실시예 1과 같은 방법으로 만든 환제를 5명의 성인에게 1회 25~30환씩 1일 2 내지 3회 복용시켰다. 복용기간은 개인별로 차이가 있었다. 복용기간 및 결과를 다음 표 1에 정리하였다. 5명 모두에서 복용 후 치주질환이 거의 증상이 없어질 정도로 완치에 가깝게 호전되는 효과를 확인할 수 있었다. 이밖에도 위염, 위장장애, 대장염, 변비, 설사, 비염, 축농증, 두통 등의 증상도 함께 개선되는 효과가 확인되었다. 그리고 모든 복용례에서 부작용은 전혀 발견되지 않았다.Pills made in the same manner as in Example 1 were administered to 5 adults 2 to 3 times a day 25 to 30 pills once. Duration of administration varied from individual to individual. Dosing period and results are summarized in Table 1 below. In all five patients, the periodontal disease was almost as symptomatic as the symptoms, and the effect was improved. In addition, the effects of gastritis, gastrointestinal disorders, colitis, constipation, diarrhea, rhinitis, sinusitis, headache, etc. were also improved. And no adverse effects were found in all doses.
본 발명의 치주질환 예방 및 개선용 조성물은 치주질환에 대해 뛰어난 예방 및 치료 효과가 있으면서 부작용은 없는 안전한 조성물로서 의약품 및/또는 건강식품으로 이용될 수 있다. 이밖에도 본 발명의 조성물은 위염, 위장장애, 대장염, 변비, 설사, 복부팽만감 등의 위장관계 질환, 축농증, 비염, 두통, 편두통 등에도 뛰어난 효과가 있어, 다양한 용도로의 개발이 가능하다. The composition for preventing and improving periodontal disease of the present invention can be used as a pharmaceutical and / or health food as a safe composition having excellent preventive and therapeutic effects against periodontal disease and no side effects. In addition, the composition of the present invention has excellent effects on gastroenteritis, gastrointestinal disorders, colitis, constipation, diarrhea, gastrointestinal disorders such as bloating, sinusitis, rhinitis, headache, migraine headaches, and the like.
Claims (4)
The composition for preventing and improving periodontal disease according to any one of claims 1 to 3, further comprising a pharmaceutically acceptable excipient and formulated in a pill form.
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| KR1020110030581A KR20110056459A (en) | 2011-04-04 | 2011-04-04 | Composition for prevention and improvement of periodontal disease |
| KR1020110112329A KR20120113170A (en) | 2011-04-04 | 2011-10-31 | Composition for prevention and improvement of periodontal disease |
| PCT/KR2011/008268 WO2012138024A1 (en) | 2011-04-04 | 2011-11-02 | Composition for preventing and improving periodontal disease |
| PCT/KR2012/002281 WO2012138076A2 (en) | 2011-04-04 | 2012-03-28 | Composition containing herbal extract mixture for prevention or treatment of gastrointestinal diseases |
| KR1020120031495A KR101606773B1 (en) | 2011-04-04 | 2012-03-28 | Composition comprising oriental herbal extract for preventing or treating gastrointestinal disorder |
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| KR1020110112329A KR20120113170A (en) | 2011-04-04 | 2011-10-31 | Composition for prevention and improvement of periodontal disease |
| KR1020120031495A KR101606773B1 (en) | 2011-04-04 | 2012-03-28 | Composition comprising oriental herbal extract for preventing or treating gastrointestinal disorder |
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| KR1020120031495A KR101606773B1 (en) | 2011-04-04 | 2012-03-28 | Composition comprising oriental herbal extract for preventing or treating gastrointestinal disorder |
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| CN104491633A (en) * | 2014-12-31 | 2015-04-08 | 李玉宾 | Pharmaceutical composition for treating anaphylactic rhinitis and preparation method thereof |
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| KR102588372B1 (en) | 2021-06-23 | 2023-10-13 | (주)비엔텍 | Composition comprising natural complex extract for prenenting, improving or treating gastritis and peptic ulcer |
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| KR100899377B1 (en) | 2007-06-27 | 2009-05-26 | 인제대학교 산학협력단 | A composition comprising an extract of Erigeron canadensis L. for preventing and treating lipid metabolism disorder |
| KR101099004B1 (en) | 2009-03-13 | 2011-12-28 | 주식회사 사이그린 | A composition for preventing or treating a gastrointestinal disease |
| KR20110061883A (en) | 2009-12-02 | 2011-06-10 | 한국생명공학연구원 | Pharmaceutical composition for treatment and prevention of inflammatory disease comprising triterpenoid saponin compounds |
| KR101762353B1 (en) | 2010-01-06 | 2017-08-04 | (주)아모레퍼시픽 | Health food composition for immune enhancement and antioxidant containing extract of red ginseng and fermented extract of herbs |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104491633A (en) * | 2014-12-31 | 2015-04-08 | 李玉宾 | Pharmaceutical composition for treating anaphylactic rhinitis and preparation method thereof |
| CN108619436A (en) * | 2014-12-31 | 2018-10-09 | 李德兰 | A kind of preparation method of pharmaceutical composition that treating allergic rhinitis |
| CN108704091A (en) * | 2014-12-31 | 2018-10-26 | 李德兰 | A kind of pharmaceutical composition and preparation method thereof for treating allergic rhinitis |
| CN108704090A (en) * | 2014-12-31 | 2018-10-26 | 李德兰 | Treat the preparation method of the pharmaceutical composition of allergic rhinitis |
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