RU2352245C2 - Method of diagnostics of oral cavity mucosa reaction on stomatologic material - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention concerns medicine and can be used in orthopedic practice. Not removing tooth prostheses, controllable parameter is measured in didymous points of symmetry on surface of red border of lips of the patient; to do that the lips are visually divided by vertical line on two symmetric parts, using index of bioelectromagnetic reactance (BEMRI) as controllable parameter which is preliminary measured in controllable points, and measured values are fixed. Then the patient is offered to moisten the sample of investigated stomatologic material with saliva; then it is placed between lips of the patient symmetrically concerning vertical line of symmetry; the BEMRI index is measured again in the same controllable points on a surface of the red border of the lips and the measured value is fixed. K - factor of functional vertical asymmetry is calculated, thus investigated sample is inserted between the teeth of the patient so that its forward part is placed down between the lips and densely adjoined to the mucosa of internal surface of the lips, and the back part is densely adjoined to the mucosa of palatal surface of tongue; after that measurement of BEMRI indexes is carried out repeatedly in investigated points on surface of the red border of lips, the received results of measurement are fixed, then the results of initial measurements of indexes are compared by difference calculation in each controllable BEMRI point to the results of measurements received with the investigated sample. Then the received value of differences are compared in symmetric points according to vertical symmetry, then K - factor of functional vertical asymmetry is calculated under the formula: K={|[(B₂-T₂)-(B₁-T₁)]|:6}×100%, where B₁, T₁ - value of BEMRI indexes measured in the investigated pair of symmetric points on surface of the red border of lips without the investigated sample; B₂, T₂ - value of BEMRI indexes measured in the same investigated pair of symmetric points on surface of the red border of lips with the investigated sample; 6 - constant accepted for convenience of representation of the end result. However, diagnostics is carried out on three received values of functional vertical asymmetry, thus if at least one K value is equal or exceeds 10%, positive reaction of mucosa of oral cavity to investigated stomatologic material is diagnosed.

EFFECT: method provides simplification of the method without decrease of reliability of results of diagnostics, expansion of arsenal of agents for diagnostics of reaction of mucosa of oral cavity on stomatologic material.

2 cl, 1 dwg, 4 ex

Description

The invention relates to medicine and can be used in orthopedic practice.

There is a method of functional diagnosis of dental diseases, which is based on a potentiometric method for determining the redox potential in tissues ("The use of polarography and potentiometry for the functional diagnosis of dental diseases. Methodical recommendations, M .: Ministry of Health of the USSR, 1980, S.4-18) . The method allows to diagnose the effect of materials of dentures on the condition of the oral mucosa by its functional and morphological state, i.e. diagnoses the reaction of the oral mucosa to dental material. In accordance with the method, two test points are selected on the oral mucosa, a measuring electrode and a reference electrode are installed on them, a voltage potential is formed on the reference electrode, which is kept constant by monitoring, the voltage potential at the measuring electrode is measured, the measurement results are compared, and the comparison result is obtained by measuring the EMF between the electrodes, the value of which is determined by the potential difference at the electrodes. The magnitude of the EMF is used to diagnose the functional state of the oral mucosa in the region of the studied points and conclude that there is an effect of the material of the dentures on it. To increase the reliability, several pairs of points are selected for the study.

The disadvantage of this method when using it to diagnose the reaction of the oral mucosa to the dental material is as follows. When the measuring electrode is in direct contact with tissue or with tissue fluid, its sensitivity decreases due to the deposition of insoluble salts, proteins, sulfhydryl complexes, etc. that are part of the fabric on the electrode working surface, which leads to contamination of the electrode surface. In this case, a reliable, uniform and tight contact of the passive electrode (reference electrode) is required, since the smallest changes in the contact area affect the diagnostic results and reduce its reliability. In addition, the method removes a controlled signal directly from the surface of the mucous membrane of the oral cavity (the current flows along the surface of the mucous membrane), which is subject to external factors: microtrauma, saliva (the surface of the mucous membrane must be dried under the reference electrode), etc., which reduces the reliability of the diagnosis. It is known that a violation of the functional and morphological state of the oral mucosa can be caused by other reasons that are not dependent on the presence of dentures. The known diagnostic method only allows us to state the fact of a deviation from the normal state of the oral cavity, which to increase the reliability requires the removal of dentures to exclude or confirm their pathological effect. This reduces its information content, and, therefore, reduces the reliability of the diagnosis. In addition, the known method is time-consuming, since it requires careful implementation of all measurement conditions, and in the future, decryption and analysis of the measurement results, which complicates it.

Closest to the proposed is a method for diagnosing the pathological effect of structural materials for prosthetics on the state of the oral cavity (RF Patent No. 2146506, 20.03.2000, A61C 13/00, A61 B 5/04), in which the reaction of the oral mucosa to dental material. In the known method, without removing dentures, a controlled parameter is measured at pair symmetry points on the surface of the red border of the patient’s lips, for which the lips are divided into two symmetrical parts by a visual vertical line, and the bioelectromagnetic reactivity index (BEMR) is used as a controlled parameter, which is previously measured at controlled points and recorded the measured values, then offer the patient to moisten the studied structural material for prosthetics with saliva, which is then placed between the lips of the patient symmetrically with respect to the vertical axis of symmetry, the BEMR index is measured a second time at the same controlled points on the red border of the lips and the measured values are fixed, K is calculated - the coefficient of functional vertical asymmetry according to the mathematical formula, the source and the material to be studied, by calculating the difference, compare the obtained the results, in case of exceeding the initial or equality of results, diagnose the presence of pathological effects of the studied structural material of dental products tezov the state of the patient's mouth, otherwise no diagnosed pathologic effect.

The disadvantage of this method is the complexity of the mathematical formula for calculating the coefficient of functional vertical asymmetry, which accordingly complicates the method itself. This is because the study uses only the mucous membrane of the inner surface of the lips, which reduces the information content of the obtained BEMR index measurements and complicates the calculation formula. The calculated mathematical formula ensures the reliability of the diagnostic results, however, the method itself complicates.

Thus, the methods of diagnosing the reaction of the oral mucosa to the dental material as a result of a patent search do not ensure the achievement of a technical result, which consists in simplifying the method without reducing the reliability of the diagnostic results.

The present invention solves the problem of creating a method for diagnosing the reaction of the oral mucosa to dental material, the implementation of which provides the achievement of a technical result consisting in simplifying the method without reducing the reliability of the diagnostic results, as well as expanding the arsenal of tools for diagnosing the reaction of the oral mucosa to dental material .

где Б₁, T₁ - значения индексов БЭМР, измеренные в исследуемой паре симметричных точек на поверхности красной каймы губ без исследуемого образца; Б₂, T₂ - значения индексов БЭМР, измеренные в той же исследуемой паре симметричных точек на поверхности красной каймы губ с исследуемым образцом; 6 - константа, принятая для удобства представления конечного результата, причем диагностику осуществляют по трем полученным значениям функциональной вертикальной асимметрии, при этом, если хотя бы одно значение К равно или превышает 10%, то диагностируют положительную реакцию слизистой оболочки полости рта на исследуемый стоматологический материал. Контактную поверхность образца выполняют шероховатой.The essence of the invention lies in the fact that in the method for diagnosing the reaction of the oral mucosa to the dental material, according to which, without removing the dentures, a controlled parameter is measured at the pair of symmetry points on the surface of the red border of the patient’s lips, for which the lips are divided visually by a vertical line into two symmetrical parts, and as a controlled parameter use the bioelectromagnetic reactivity index (BEMR), which is pre-measured at controlled points and recorded measured e values, then offer the patient to moisten a sample of the studied dental material with saliva, then place it between the patient’s lips symmetrically with respect to the vertical line of symmetry, measure the BEMR index again at the same controlled points on the surface of the red border of the lips and fix the measured values, calculate K - coefficient of functional vertical asymmetry, it is new that the test sample is inserted between the patient’s teeth so that its front is located between the lip mi and tightly adhered to the mucous membrane of the inner surface of the lips, and the back was tightly adhered to the mucous membrane of the palatine surface of the tongue, after which the BEMR indices were measured again at the test points on the surface of the red border of the lips, the measurement results were recorded, after which the difference was calculated by calculating the difference at each controlled point, the results of the initial measurements of the BEMR indices with the measurement results obtained with the test sample, and then the obtained values of the differences ayut at symmetrical points in accordance with the vertical symmetry, then calculating K - coefficient functional vertical asymmetry of the formula:

where B ₁ , T ₁ are the values of the BEMR indices measured in the studied pair of symmetrical points on the surface of the red border of the lips without the test sample; B ₂ , T ₂ - the values of the BEMR indices measured in the same pair of symmetrical points on the surface of the red border of the lips with the sample; 6 is a constant adopted for the convenience of presenting the final result, and diagnostics are carried out according to the three obtained functional vertical asymmetry values, and if at least one K value is equal to or greater than 10%, then a positive reaction of the oral mucosa to the dental material under investigation is diagnosed. The contact surface of the sample is roughened.

The technical result is achieved as follows.

In the inventive method, as a controlled parameter, the bioelectromagnetic reactivity index is used, which is measured at control points on the surface of the red border of the lips.

Using a bioelectromagnetic reactivity index as a controlled parameter provides the ability to control changes in the functional and morphological state of the tissue in the zone of controlled points, which allows you to diagnose the presence or absence of a negative reaction of the oral mucosa to the dental material. This is because the measurement of the BEMR index is based on the property of living tissue to convert electromagnetic waves induced in it by external magnetic fields, namely geo- and heliomagnetic fields, which are low-frequency pulsed complex-modulated fields that are most appropriate for a living organism. As a result of the bioelectric activity of living tissues, when a living organism (organ) is exposed to external electromagnetic fields, a low-frequency pulsed complex-modulated EMF is induced in the tissues in the form of electromagnetic oscillatory processes in living tissue, but its spectral composition differs from the spectral composition of the acting EMF (V.I. Bankov et al. "Low-frequency pulsed complex-modulated electromagnetic fields in medicine and biology", Ekaterinburg: Ural State University Publishing House, 1992, p.33 ... 43). In addition, their own oscillatory processes in living tissue (organ) are due to metabolic processes and microcirculation, which is based on certain parameters of homeostasis, i.e. all layers of tissue participate in the formation of parameters of electromagnetic waves. Therefore, the parameters of electromagnetic oscillatory processes in living tissue correspond to a well-defined functional and morphological state of living tissue (Sent-Dieri A. "Bioenergy". Theory of energy transfer, M .: Publishing house FIZMAT, 1960, S.3 ... 14). All this made it possible to diagnose the functional and morphological state of the tissue by analyzing the appearance or disappearance of a harmonic interacting with the tissue. This phenomenon is called the definition of the bioelectromagnetic reactivity index of living tissues - the BEMR index (V.I. Bankov et al. "Low-frequency pulsed complex-modulated electromagnetic fields in medicine and biology", Ekaterinburg: Ural State University, 1992, p. 38; Using the properties of a pulsed complex-modulated field for physiological studies of the central nervous system. "Abstract for the degree of Doctor of Biological Sciences, Moscow: USSR Academy of Sciences, Institute of Higher Nervous Activity and Neurophysiology, 198 8, p.12 ... 14).

As a result, in the proposed method, the values of the BEMR indices measured at controlled points on the surface of the red border of the lips correspond to the functional and morphological state of the tissues in the area of these points, which allows us to diagnose changes in the functional and morphological conditions in the areas of the oral mucosa in contact with the material of the test sample, and according to the value of the measured values of the BEMP indices, to ascertain the nature of the reaction of the oral mucosa to the dental material.

The nervous system plays a dominant role in human life. Receptor systems on the surface of organs, skin, and mucous membranes, which are highly reactive, are converted into nerve impulses by exposure to them from both positive and negative factors, which reaches the central nervous system and serves as the basis for the formation of the body's response, in particular, forms a protective adaptive reaction by changing the functional and morphological state of tissues in the zone of exposure to a negative factor. In the proposed method, this property of the body made it possible to diagnose a reaction to the dental material of the mucous membrane of the inner surface of the lips and the mucous membrane of the palatine surface of the tongue, which is formed as a result of their interaction with the material and manifests itself in the form of a change in the functional and morphological state of the mucous membrane at the point of contact with the studied material. Using to obtain diagnostic results the properties of the body to form a protective and adaptive reaction in the zone of exposure to a negative factor by changing the functional and morphological state of tissues in this zone ensures the reliability of the diagnostic results.

In the claimed method, the test sample is inserted between the patient’s teeth so that the front part is located between the lips and fits snugly on the mucous membrane of the inner surface of the lips, and the back part is snugly on the mucous membrane of the palatine surface of the tongue. As a result, in the claimed method, in contrast to the prototype, in order to obtain information about the reaction of the oral mucosa to the studied dental material, two contact areas with the studied material are used in the oral cavity: the mucous membrane of the inner surface of the lips and the mucous membrane of the palatine surface of the tongue, which increases the information content of the measured parameter measurements. Moreover, since there are many receptors (taste, heat, tactile, etc.) on the surface of the tongue, then, in comparison with the prototype, this allows you to get additional information about the reaction of the oral mucosa to the material of the test sample, which ensures the reliability of the diagnosis. In addition, compared with the prototype, the placement of the test sample on the surface of the mucous membrane of the tongue provides the ability to introduce an additional organ to generate information about the effect of the test sample on the state of the oral cavity, which also increases the information content of the measurement results and ensures the reliability of the diagnosis. The tight fit of the test sample to the surface of the mucous membrane ensures reliable contact of their surfaces, which enhances the effect on the receptor systems of the contact surfaces of their mucosa and thereby activates the process of formation of the body's response in the form of a short-term protective and adaptive reaction by changing the functional and morphological state of tissues in the zone exposure to a negative factor. This increases the information content of the measurement results and ensures the reliability of the diagnosis.

Moreover, since the patient is first offered to moisten the sample with saliva, the entire sample is in the real environment of the oral cavity and the interaction of the material of the test sample with the mucous membrane occurs through saliva. It is known that for each person the chemical composition of the oral cavity is individual. As a result of the contact of the sample (metal, plastic, ceramics) with the real environment of the oral cavity, conditions may be favorable for a chemical microreaction, expressed to a greater or lesser extent depending on the contacted material. This leads to a change in the chemical composition of the oral cavity at the interface between the surface of the sample and the adjacent mucous membrane of the inner surface of the lips and the contact surface of the mucous membrane of the palatine part of the tongue. The appearance of components, the qualitative and quantitative composition of which is not adequate to the chemical composition of the oral cavity, namely, the test sample, has an irritating effect on the receptors of the mucous surface of the lips and the surface of the tongue in the zone of interaction with the test sample. As a consequence of this, a protective-adaptive reaction of the body is formed, namely, a short-term adaptation of the body is formed, as a response to a short-term exposure. As a result, the functional and morphological state of the oral mucosa, and, consequently, the mucous membrane of the inner surface of the lips, changes in the projection of controlled points on the red border of the lips for a short time. The latter is recorded by repeated measurement of the BEMR indices. In the claimed method, due to the proposed placement in the oral cavity of the test sample, short-term adaptation of the body is formed not only to the reaction of the mucous membrane of the red border of the lips and tongue, but also to the nature of the secret, which is formed by contact with the tongue of the test sample, which increases the information content of the method, and therefore , and provides reliability of diagnosis. Moreover, due to the fact that the contact surface of the sample is roughened, a reliable fit of the surface of the sample to the mucous membrane is ensured and, in addition, both salivation and the amount of secretion formed upon contact of the material of the test sample with the mucous membrane of the tongue increase. This activates the process of formation of the adaptive reaction of the body to the influence of the sample material, which also increases the information content of the obtained measurement results and ensures the reliability of the diagnosis.

It is known that the upper layers of the tissue have a short relaxation time, and, consequently, a short adaptation time to external influences. Since in the proposed method, the sample material interacts with the mucous membrane of the lips and the surface of the tongue, i.e. with the upper layers of tissue, this determines the speed of the reaction of the body in the formation of a short-term protective and adaptive reaction. This allows almost immediately after placing a sample of the studied material in the oral cavity to re-measure the BEMR indices at the studied points on the surface of the red border of the lips, which ensures the reliability of the diagnosis. As experience shows, for the formation of a stable response of the body to the result of the interaction of the mucosa of the lips and tongue with a sample of the studied dental material, 30 seconds is enough.

In the claimed method, the studied structural material for prosthetics is placed between the lips of the patient symmetrically with respect to the vertical line of symmetry, which makes it possible to use paired points of symmetry on the surface of the red border of the lips as controlled ones. Orientation to bilateral symmetry, namely, vertical symmetry: the choice for the study of paired points of symmetry on the surface of the red border of the patient’s lips, for which the lips are divided into two symmetrical parts by a visual vertical line, allows you to increase the information content of the measurements containing information about the reaction the oral mucosa on the dental material, and, therefore, increase the reliability of the method. This is explained by the following.

Bilateral symmetry is determined by the duplication of the anatomical structures of the body and increases the reliability of its functioning under extreme environmental conditions ("Skin Extra-receptors" / Some issues of local diagnosis and therapy / E.S. Velhover, G.V. Kushnir, Chisinau: STIINCA, 1984, p. .28 ... 40). Bilateral symmetry is closely related to functional (physiological) asymmetry, due to the predominance of the regulatory functions of the cerebral hemispheres and parts of the autonomic system (parasympathetic or sympathetic). Ideally, the functional asymmetry should be close to zero. However, due to the different neurotrophic (regulatory) functions of the central nervous system, living tissues of symmetrical organs (or symmetrical parts of the organ) have a different level of metabolic processes, microcirculation (blood supply). The analysis of the specialized literature, as well as the results of the analysis of statistical data on the results of the study of the functional and morphological state of the pair symmetry points of symmetric healthy organs or symmetric parts of healthy organs, showed that the functional norm is a symmetry violation for the skin surface by 25 ± 5%, and for the mucous surface shells of symmetrical organs of the oral cavity by 15 ± 5% (Bognev B.V. "Asymmetry of the human vascular and nervous system, their theoretical and practical significance", Weight Tnik AMS: USSR, 1948, No. 4, p. 264. Skobsky IL "Humoral asymmetry in the body of the development of diseases", M .: 1969, p. 35 ... 60; Piransky BC "Symmetry and asymmetry of the anatomical structure", proceedings Saratov Medical Institute, 1968, t.56, issue 73, p.125; E.S. Velhover, U.V. Kushnir. “Skin extra-receptors” / Some issues of local diagnosis and therapy, Chisinau: STIINCA, 1984, p. 28 ... 40).

Thus, the orientation toward bilateral symmetry when choosing controlled points allows using the property of a living organism, which consists in the ability to form functional asymmetric zones of paired (symmetric) analytical structures formed as a result of the adaptive activity of a whole living organism. This ensures the information content and reliability of the diagnosis, since, firstly, in this case, the measurements of the monitored parameter are duplicated. Secondly, the entire surface of the red border of the patient’s lips is controlled, since by calculating the difference, at each controlled point, the results of the initial measurements of the BEMP indices are compared with the measurements obtained with the test sample, and then, using the functional asymmetry, the obtained differences are compared at symmetric points in accordance with vertical symmetry, after which the coefficient of functional vertical asymmetry is calculated and the fact of presence or absence is ascertained by its magnitude I have a negative reaction of the oral mucosa to the dental material.

Since the values of the BEMR indices correspond to the functional and morphological state of the tissues in the area of a particular studied point, this leads to differentiation in the results of measurements of the BEMR indices and provides the ability to compare the initial measurements with the measurement results obtained with the studied sample by calculating the difference. Comparison by calculating the difference at each controlled point of the results of initial measurements of BEMR indices with the results of measurements obtained with the test sample allows us to detect the presence of morphological and functional changes in the tissues of the control point due to contact with the material of the test sample located in the projection of the mucous membrane on it. Comparison of the difference values obtained from the first comparison at symmetrical points in accordance with vertical symmetry allows you to compare the reaction to the material of the test sample on the left and right sides of the red border of the lips and identify the most sensitive to the material zones of control points.

Calculation of the K - coefficient of functional vertical asymmetry allows you to use the property of a living organism, which consists in the ability to form functional asymmetric zones of paired (symmetric) analytical structures formed as a result of the adaptive activity of a whole living organism to diagnose the nature of the reaction of the oral mucosa to dental material.

где Б₁, T₁ - значения индексов БЭМР, измеренные в исследуемой паре симметричных точек на поверхности красной каймы губ без исследуемого образца; Б₂, Т₂ - значения индексов БЭМР, измеренные в той же исследуемой паре симметричных точек на поверхности красной каймы губ с исследуемым образцом; 6 - константа, принятая для удобства представления конечного результата. Поскольку значение разности, полученной в квадратных скобках, может быть отрицательным, то берут ее абсолютное значение. Диагностику осуществляют по трем полученным значениям функциональной вертикальной асимметрии, при этом, если хотя бы одно значение К равно или превышает 10%, то диагностируют положительную реакцию слизистой оболочки полости рта на исследуемый стоматологический материал. Количественный критерий оценки коэффициента функциональной вертикальной асимметрии 10% получен в результате набора статистических данных, полученных эмпирическим путем.In the claimed method, the coefficient of functional vertical asymmetry is calculated by the formula:

where B ₁ , T ₁ are the values of the BEMR indices measured in the studied pair of symmetrical points on the surface of the red border of the lips without the test sample; B ₂ , T ₂ - the values of the BEMR indices measured in the same pair of symmetrical points on the surface of the red border of the lips with the sample; 6 is a constant adopted for the convenience of presenting the final result. Since the value of the difference obtained in square brackets can be negative, then its absolute value is taken. Diagnostics is carried out according to the three obtained values of functional vertical asymmetry, and if at least one K value is equal to or greater than 10%, then a positive reaction of the oral mucosa to the dental material under investigation is diagnosed. A quantitative criterion for assessing the coefficient of functional vertical asymmetry of 10% was obtained as a result of a set of statistical data obtained empirically.

As can be seen from the above, in comparison with the prototype, the claimed method simplified the calculation formula of the coefficient of functional vertical asymmetry, which, in turn, simplified the implementation of the method. This became possible due to the introduction of the second investigated organ into the claimed method, which is an additional source of information, namely, the mucous membrane of the palatine surface of the tongue. In addition, in the claimed method, the simplification of the mathematical formula became possible due to the fact that, in contrast to the prototype, in the claimed method for obtaining information about the reaction of the oral mucosa to the studied dental material, two contact zones of the studied material with the oral mucosa are formed: the mucous membrane of the inner surface of the lips and on the mucous membrane of the palatine surface of the tongue. To do this, the test sample is inserted between the patient’s teeth in such a way that its front part is located between the lips and fits snugly on the mucous membrane of the inner surface of the lips, and the back part is snugly on the mucous membrane of the palatine surface of the tongue. All this increases the information content of the measurement results of the controlled parameter, ensures the reliability of the diagnostic results and allows you to simplify the calculated mathematical formula.

Moreover, the proposed method, like the prototype, allows you to diagnose without removing dentures from the oral cavity, which does not complicate the method.

As shown by a set of statistical data, increasing the information content of measurements by introducing an additional source of information into the claimed method, namely: the mucous membrane of the tongue, as well as the use of two contact areas of the test material with the oral mucosa, made it possible to reduce the quantitative indicator for assessing functional asymmetry up to 10% (from literary sources for the mucous membrane of 15%). The latter reduces the likelihood of errors in the diagnosis, which ensures the reliability of the diagnostic results and allows us to simplify the calculation formula for the coefficient of functional vertical asymmetry, and, therefore, to simplify the claimed method itself, compared with the prototype, without reducing the reliability of the diagnostic results.

In addition, it follows from the foregoing that the claimed method for diagnosing the reaction of the oral mucosa to dental material realizes its purpose, and, therefore, will expand the arsenal for appropriate diagnosis.

Thus, from the foregoing, it follows that the claimed method for diagnosing the reaction of the oral mucosa to the dental material in the implementation provides the technical result, which consists in simplifying the method without reducing the reliability of the diagnostic results, as well as expanding the arsenal of tools for diagnosing the reaction of the oral mucosa on dental material.

The drawing shows a diagram of the measurement of the BEMR indices on the outer surface of the lips. The serial number of points corresponds to the studied symmetry points.

где Б₁, T₁ - значения индексов БЭМР, измеренные в исследуемой паре симметричных точек на поверхности красной каймы губ без исследуемого образца; Б₂, Т₂ - значения индексов БЭМР, измеренные в той же исследуемой паре симметричных точек на поверхности красной каймы губ с исследуемым образцом; 6 - константа, принятая для удобства представления конечного результата. Диагностику осуществляют по трем полученным значениям функциональной вертикальной асимметрии, при этом, если хотя бы одно значение К равно или превышает 10%, то диагностируют положительную реакцию слизистой оболочки полости рта на исследуемый стоматологический материал.A method for diagnosing the reaction of the oral mucosa to the dental material is as follows. Dentures are not removed. On the surface of the red border of the lips, several paired points of symmetry are chosen for research, for which the lips are divided into two symmetrical parts by a visually vertical line. As a controlled parameter, the bioelectromagnetic reactivity index (BEMR) is used, which is previously measured at controlled points and the measured values are recorded. Then the patient is offered to moisten the dental material under study with saliva and insert it between the patient’s teeth so that the front part is located between the lips and fits snugly on the mucous membrane of the inner surface of the lips, and the back is snugly on the mucous membrane of the palatine surface of the tongue. After that, the BEMR indices are measured again at the studied points on the surface of the red border of the lips. The obtained measurement results are recorded. Then, by calculating the difference, at each controlled point, the results of the initial measurements of the BEMR indices are compared with the measurements obtained with the test sample, and the obtained differences are compared at symmetric points in accordance with vertical symmetry. The coefficient K of the functional vertical asymmetry is calculated by the formula:

where B ₁ , T ₁ are the values of the BEMR indices measured in the studied pair of symmetrical points on the surface of the red border of the lips without the test sample; B ₂ , T ₂ - the values of the BEMR indices measured in the same pair of symmetrical points on the surface of the red border of the lips with the sample; 6 is a constant adopted for the convenience of presenting the final result. Diagnostics is carried out according to the three obtained values of functional vertical asymmetry, and if at least one K value is equal to or greater than 10%, then a positive reaction of the oral mucosa to the dental material under investigation is diagnosed.

The time interval after which the BEMR indices are measured a second time is chosen sufficient to form a stable response of the body to the result of the interaction of the lip mucosa with the sample of denture material, namely at least 30 seconds.

Samples of structural materials of dentures should be made in compliance with the exact technology and polymerization time (for plastics). The thickness of the sample is chosen no more than 1.5 mm in order to ensure tight contact with the mucous membrane, so that the mucous membrane envelops the sample at the points of contact. The minimum surface area of the sample is determined by the ability of the receptors to respond to the test material. The working size of the area of each sample is chosen empirically by a value at which changes in the morphological and functional state of the mucous membrane of the inner surface of the lips from contact with the test sample are already recorded. In examples of the method, the samples had the following dimensions: 30x10x1.5 mm The contact surface of the sample is performed by a rough mechanical method.

The method can be implemented by means of a device based on a device for determining the bioelectromagnetic reactivity of living organ tissues, a block diagram of which is described in the literature: V.I. Bankov and others. "Low-frequency pulsed complex-modulated fields in medicine and biology", Yekaterinburg: Ural University Press, 1992, p. 39, Fig. 8. The device contains a sensor that is applied to the surface of the tissue under study, a balanced demodulator, a pulsed complex modulated electromagnetic field generator (ISM EMF), a corrector, a detector, an amplifier, an analog-to-digital converter, and an indicating device. As a sensor, the device uses a miniature loop antenna, which is part of the measuring open oscillatory circuit, tuned to a pulsed complex-modulated mode of operation. In addition to the sensor, the measuring oscillatory circuit includes an ISM EMF generator, a balanced demodulator, a detector, and a corrector. The vibrational circuit is excited at the moment the sensor touches the surface of living tissue.

Currently, the device is implemented in the expert-diagnostic device "Lira-100", developed and manufactured in the department of medical cybernetics of the central scientific research laboratory of the Ural State Academy. The device was demonstrated in 1997 at the All-Russian Exhibition of Manufacturers of Medical Equipment and Medical Devices and was awarded the I Degree Diploma by the Ministry of Health. The device is protected by patents of the Russian Federation: patent N 2107964, priority 28.04.95; N 96121429/07 (028062), priority 04/28/95; patent N 2080820, priority 01.08.94. Currently, the device has been improved and is completing state certification.

The device contains a sensor, a converter, an amplifier-filter, a microprocessor, an analog-to-digital converter, and a recorder-indicator. The sensor is made in the form of a miniature loop antenna and provides registration of the IMS EMF of living tissues in the form of relative values of the BEMR indices that are displayed on the indicator screen.

The sensor on the surface of the fabric is installed tightly, but without strong pressure.

When implementing the method in the above measurement examples

carried out at controlled points on the surface of the red border of the lips in accordance with the scheme shown in the drawing. According to the measurement results, the values of the coefficient K - functional vertical asymmetry was calculated by the mathematical formula given in the claims. Diagnostics was carried out according to the three obtained values of functional vertical asymmetry. Moreover, if at least one K value is equal to or exceeds 10%, then a positive reaction of the oral mucosa to the dental material under investigation is diagnosed.

Example 1. Patient G., 62 years old. After orthopedic treatment, she applied to restore the dentition of the upper and lower jaw with stamped metal crowns and stamped-soldered bridge prostheses with TIN spraying. Dental formula:

0 TO AND and AND TO AND TO TO AND TO AND AND AND TO 0 8 7 6 5 four 3 2 one one 2 3 four 5 6 7 8 0 0 0 lkshv TO AND TO TO TO AND AND TO AND 0 0 0

K is the crown;

And - an artificial tooth;

lkshv - cast cult pin tab;

O - missing tooth.

One month after the prosthetics, discomfort appeared in the oral cavity - dryness, burning of the oral mucosa, and a change in taste sensitivity.

A visual examination of pathological changes in the state of the mucous membrane of the tongue, cheeks, lips, hard and soft palate was not detected. Congestive hyperemia of marginal periodontium is noted in the area of adjoining of artificial crowns. An increase in the small salivary glands of the upper and lower lips. The saliva is thick, foamy.

The condition of the prosthesis is unsatisfactory, mechanical damage in the form of deep furrows with removal of the deposition layer is noted on the chewing surface of artificial teeth, the soldering area is porous with a color change to dark brown.

A patient, in accordance with the claimed method, was diagnosed with a reaction of the oral mucosa to dental materials, including those present in prostheses. Diagnosis was carried out in accordance with the claimed claims.

The research results are given below.

The sample material of the investigated structural material is stainless steel.

The initial values of the BEMR index.

B ₁ : point 1 - 2.965; point 3 - 2,988; point 5 - 3,529.

T ₁ : point 2 - 2.165; point 4 - 2,706; point 6 - 3.341.

The values of the BEMR index with a sample of the studied structural material. B ₂ : point 1 - 3.224; point 3 - 3.929; point 5 - 3.624.

T ₂ : point 2 - 2.965; point 4 - 3.12; point 6 - 3,529.

The value of functional asymmetry at points 1-2:

The value of functional asymmetry at points 3-4:

The value of functional asymmetry at points 5-6:

The value of functional asymmetry at points 1-2 was 9.02%. The value of functional asymmetry at points 3-4 was 8.78%. The value of functional asymmetry at points 5-6 was 1.55%.

Conclusion: the nature of the reaction of the oral mucosa to the sample material of the studied structural material stainless steel can be considered borderline, since one of the values of K is close to 10%.

The sample material of the investigated structural material is TiN-coated stainless steel.

The initial values of the BEMR index.

B ₁ : point 1 - 2.965; point 3 - 2,988; point 5 - 3,529.

T ₁ : point 2 - 2,165, point 4 - 2,706; point 6 - 3.341.

The values of the BEMR index with a sample of the studied structural material. B ₂ : point 1 - 2.729; point 3 - 3,741; point 5 - 2,682.

T ₂ : point 2 - 2.824; point 4 - 2,988; point 6 - 3.035.

The value of functional asymmetry at points 1-2:

The value of functional asymmetry at points 3-4:

The value of functional asymmetry at points 5-6:

The value of functional asymmetry at points 1-2 was 14.92%,> 10%.

The value of functional asymmetry at points 3-4 was 7.85%. The value of functional asymmetry at points 5-6 was 9.02%.

Conclusion: the reaction of the oral mucosa to the sample material stainless steel with TiN sputtering is positive, since the value of one of the coefficients of the functional vertical asymmetry exceeds 10%.

Further, mathematical calculations were performed similarly to the above.

Sample material of the studied structural material DENTAL NSA vac "DINA & WEST" (Nickel-chromium-molybdenum, a dental alloy of vacuum smelting for cermet work).

The initial values of the BEMR index: point 1 - 2.965; point 2 - 2.165; point 3 - 2,988; point 4 - 2,706; point 5 - 3,529; point 6 - 3.341.

The values of the BEMR index with a sample of the studied structural material: point 1 - 3,059; point 2 - 3,059; point 3 - 2,659; point 4 -2.894; point 5-3.153; point 6 - 2,941.

The value of functional asymmetry at points 1-2 was 13.33%. The value of functional asymmetry at points 3-4 was 8.62%. The value of functional asymmetry at points 5-6 was 0.40%.

Conclusion: the reaction of the oral mucosa to the material of the DENTAL NSA vac "DINA & WEST" sample (Nickel-chromium-molybdenum, a dental alloy for vacuum smelting for cermet works) is positive, since one of the functional vertical asymmetry coefficients exceeds 10%.

The sample material of the studied structural material is an alloy of gold (ZlPlPdSr 87.2-8.8-1.3-0.4) for the manufacture of M / K structures.

The initial values of the BEMR index: point 1 - 2.965; point 2 - 2.165; point 3 - 2,988; point 4 - 2,706; point 5 is 3.529, point 6 is 3.341.

The values of the BEMR index with a sample of the studied structural material: point 1 - 2.659; point 2 - 2,894; point 3 - 3.106; point 4 - 3.388; point 5 - 3,529; point 6 - 2.659.

The value of functional asymmetry at points 1-2 was 17.25%. The value of functional asymmetry at points 3-4 was 9.40%. The value of functional asymmetry at points 5-6 was 11.38%.

Conclusion: the reaction of the oral mucosa to the material of the sample is a gold alloy (ZlPlPdSr 87.2-8.8-1.3-0.4) for the manufacture of M / K designs, since the value of one of the coefficients of the functional vertical asymmetry exceeds 10% .

The sample material of the structural material under study is a titanium alloy — OROTIG (VERONA) ITALIA (CP Titanium Grade 4, ASTM Standard Lot No. 2611; for the manufacture of cermet structures).

The initial values of the BEMR index: point 1 - 2.965; point 2 - 2.165; point 3 - 2,988; point 4 - 2,706; point 5 - 3,529; point 6 - 3.341. Values of the BEMR index with a sample of the studied structural material: point 1 - 3.176; point 2 - 3.224; point 3 - 3,788; point 4 - 3.388; point 5 - 3,529; point 6 - 2,682.

The value of functional asymmetry at points 1-2 was 14.13%.

The value of functional asymmetry at points 3-4 was 1.97%.

The value of functional asymmetry at points 5-6 was 10.98%.

Conclusion: the reaction of the oral mucosa to the material of the sample is titanium alloy — OROTIG (VERONA) ITALIA (CP Titanium Grade 4, ASTM Standard Lot No. 2611; for the manufacture of cermet structures) is positive, since one of the coefficients of the functional vertical asymmetry exceeds 10%. The material of the sample of the studied structural material is Sinma-74, Stoma Ukraine (for fixed prostheses). The initial values of the BEMR index: point 1 - 2.965; point 2 - 2.165; point 3 - 2,988; point 4 - 2,706; point 5 - 3,529; point 6 - 3.341. The values of the BEMR index with a sample of the studied structural material: point 1 - 1,882; point 2 - 2,894; point 3 - 3.388; point 4 - 3.271; point 5 - 3.082; point 6 - 2,776.

The value of functional asymmetry at points 1-2 was 30.3%.

The value of functional asymmetry at points 3-4 was 2.75%.

The value of functional asymmetry at points 5-6 was 1.97.

Conclusion: the reaction of the oral mucosa to the material of the Sinma-74, Stoma sample Ukraine (for fixed prostheses) is positive, since the value of one of the coefficients of the functional vertical asymmetry exceeds 10%.

According to OPTG (orthopantomograms), foci of destruction of preapical tissues were identified due to insufficiency of obstruction of the root canals after endodontic treatment. It was proposed to remove the entire orthopedic design and conduct a complete rehabilitation of the oral cavity.

A complete examination was conducted with the involvement of other specialists - a gastroenterologist, endocrinologist, where the patient was diagnosed with exacerbation of chronic gastritis and appropriate treatment was prescribed.

After treatment, the patient re-checked the reaction of the oral mucosa to dental materials in accordance with the claimed claims.

The research results are given below.

The sample material of the investigated structural material is stainless steel.

The initial values of the BEMR index: point 1 - 1.765; point 2 - 1.694; point 3 - 1.976; point 4 - 1,788; point 5 - 2.141; point 6 - 2,141.

The values of the BEMR index with a sample of the studied structural material: point 1 - 1,741; point 2 - 1,788; point 3 - 1,647; point 4 - 1,671; point 5 - 2.024; point 6 - 1,976.

The value of functional asymmetry at points 1-2 was 1.967%.

The value of functional asymmetry at points 3-4 was 3.533%.

The value of functional asymmetry at points 5-6 was 0.800%.

Conclusion: the reaction of the oral mucosa to the sample material stainless steel is negative.

The sample material of the investigated structural material is TiN-coated stainless steel.

The initial values of the BEMR index: point 1 - 1.765; point 2 - 1,694, point 3 - 1,976; point 4 - 1,788; point 5 - 2.141; point 6 - 2,141.

The values of the BEMR index with a sample of the studied structural material: point 1 - 1,647; point 2 - 1.694; point 3 - 1.718; point 4 - 1.741; point 5 - 1.859; point 6 - 2,000.

The value of functional asymmetry at points 1-2 was 1.967%.

The value of functional asymmetry at points 3-4 was 3.517%.

The value of functional asymmetry at points 5-6 was 2.350%.

Conclusion: the reaction of the oral mucosa to the sample material is stainless steel with a TiN coating negative.

Sample material of the studied structural material DENTAL NSA vac "DINA & WEST" (Nickel-chromium-molybdenum, a dental alloy of vacuum smelting for cermet work).

The initial values of the BEMR index: point 1 - 1.765; point 2 - 1.694; point 3 - 1.976; point 4 - 1,788; point 5 - 2.141; point 6 - 2,141.

The values of the BEMR index with a sample of the studied structural material: point 1 - 1.835; point 2 - 1,788; point 3 - 1.835; point 4 - 1.718; point 5 - 2.071; point 6 - 2.024.

The value of functional asymmetry at points 1-2 was 0.4%. The value of functional asymmetry at points 3-4 was 1.183%. The value of functional asymmetry at points 5-6 was 0.783%.

Conclusion: the reaction of the oral mucosa to the material of the DENTAL NSA vac "DINA & WEST" sample (Nickel-chromium-molybdenum, a dental alloy for vacuum smelting for cermet work) is negative.

The sample material of the studied structural material is an alloy of gold (ZlPlPdSr 87.2-8.8-1.3-0.4) for the manufacture of M / K structures.

The initial values of the BEMR index: point 1 - 1.765; point 2 - 1.694; point 3 - 0.71; point 4 - 1,788; point 5 - 2,141, point 6 - 2,141.

The values of the BEMR index with a sample of the studied structural material: point 1 - 1.835; point 2 - 1.812; point 3 -1.835; point 4 - 1.835; point 5 - 2.047; point 6 - 2.047.

The value of functional asymmetry at points 1-2 was 0.800%.

The value of functional asymmetry at points 3-4 was 3.133%.

The value of functional asymmetry at points 5-6 was 0,000%.

Conclusion: the reaction of the oral mucosa to the sample material is gold alloy (ZlPlPdSr 87.2-8.8-1.3-0.4) for the manufacture of M / K structures is negative.

The sample material of the structural material under study is an alloy of titanium - OROTIG (VERONA) ITALIA (CP Titanium Grade 4.ASTM Standard Lot No. 2611; for the manufacture of cermet structures).

The initial values of the BEMR index: point 1 - 1.765; point 2 - 1.694; point 3 - 1.976; point 4 - 1,788; point 5 - 2.141; point 6 - 2,141.

The values of the BEMR index with a sample of the studied structural material: point 1 - 1.765; point 2 - 1.835; point 3 - 1,788; point 4 - 1.765; point 5 - 1,953; point 6 - 2.047.

The value of functional asymmetry at points 1-2 was 2.35%.

The value of functional asymmetry at points 3-4 was 2.75%.

The value of functional asymmetry at points 5-6 was 1.567%.

Conclusion: the reaction of the oral mucosa to the sample material is titanium alloy - OROTIG (VERONA) ITALIA (CP Titanium Grade 4, ASTM Standard Lot No. 2611; for the manufacture of ceramic-metal structures) is negative.

The sample material of the studied structural material is Sinma-74, Stoma Ukraine (for fixed prostheses). The initial values of the BEMR index: point 1 - 1.765; point 2 - 1.694; point 3 - 1.976; point 4 - 1,788; point 5 - 2.141; point 6 - 2,141.

Values of the BEMR index with a sample of the studied structural material: point 1 - 1.835; point 2 - 1.1835; point 3 - 1.859; point 4 - 1.859; point 5 - 1.929; point 6 - 2.094.

The value of functional asymmetry at points 1-2 was 1.183%. The value of functional asymmetry at points 3-4 was 3.133%. The value of functional asymmetry at points 5-6 was 2.750%.

Conclusion: the reaction of the oral mucosa to the material of the sample "Sinma-74", "Stoma" Ukraine (for fixed prostheses) is negative.

From the foregoing, it follows that after the treatment, all the structural materials for prosthetics taken for research do not have a pathological effect on the condition of the patient’s oral mucosa, since the asymmetry coefficient measured with the prosthesis material is much lower than the initial one.

After oral cavity sanitation and professional hygiene, the stumps of the remaining teeth were restored using Luxacore double-cured composite cement and the teeth were reinforced with fiberglass pins. Cast stump pin-inlays for teeth 1.3 and 1.5 were made of DENTAL NSA vac "DINA & WEST" structural material (Nickel-chromium-molybdenum, a dental alloy for vacuum smelting for ceramic-metal work). Metal-ceramic bridges made of DENTAL NSA vac "DINA & WEST" alloy (Nickel-chromium-molybdenum, dental alloy of vacuum smelting for metal-ceramic work) and "Ducera +" ceramics were made.

After the treatment, the patient's condition improved, there were no complaints from the oral mucosa.

Example 2. Patient I. Complaints about a change in the mucous membrane of the hard palate.

History: chronic gastritis. An allergic history is calm. According to the patient, the changes on the mucous membrane of the hard palate were discovered three years ago. It was prosthetized with a ceramic-metal bridge with a support of 1.7, 1.5, 1.4, 1.2 teeth and a plate prosthesis with fixation on spherical locks, on the lower jaw - ceramic-metal crowns for 3.4, 3.3 and 4.2, 4.3 teeth and a clasp prosthesis with fixation on spherical locks. The prosthesis condition is satisfactory.

A visual examination of pathological changes in the state of the mucous membrane of the tongue, cheeks, lips, soft palate was not detected. There is hyperemia and a change in the relief of the mucous membrane of the hard palate, corresponding to the boundaries of the prosthesis. On the inner surface adjacent to the mucous membrane, there are deepenings and irregularities corresponding to the papillomatous growth of the mucous membrane of the hard palate.

0 TO AND TO TO AND TO AND AND AND AND AND AND AND AND 0 8 7 6 5 four 3 2 one one 2 3 four 5 6 7 8 0 AND AND AND AND TO TO TO TO AND AND AND 0

K is the crown;

And - an artificial tooth;

O - missing tooth.

A patient, in accordance with the claimed method, was diagnosed with a reaction of the oral mucosa to dental materials, including those present in prostheses. Diagnosis was carried out in accordance with the claimed claims.

The research results are given below.

The sample material of the investigated structural material is stainless steel. The initial values of the BEMR index: point 1 - 3,765; point 2 - 4.329; point 3 - 3,741; point 4 - 3.929; point 5 - 4.047; point 6-4.188. The values of the BEMR index with a sample of the studied structural material: point 1 - 3.412; point 2 - 3,576; point 3 - 3.365; point 4 - 3.318; point 5 - 3,529; point 6 - 3.882.

The value of functional asymmetry at points 1-2 was 6.67%. The value of functional asymmetry at points 3-4 was 3.92%. The value of functional asymmetry at points 5-6 was 3.53%.

Conclusion: the reaction of the oral mucosa to the sample material of the studied structural material stainless steel is negative.

The sample material of the investigated structural material is TiN-coated stainless steel.

The initial values of the BEMR index: point 1 - 3,765; point 2 - 4,329, point 3 - 3,741; point 4 - 3.929; point 5 - 4.047; point 6 - 4.188. The values of the BEMR index with a sample of the studied structural material: point 1 - 2,729; point 2 - 3.106; point 3 - 2,988; point 4 - 3.176; point 5 - 3.624; point 6 - 2,000.

The value of functional asymmetry at points 1-2 was 3.12%, the value of functional asymmetry at points 3-4 was 0%. The value of functional asymmetry at points 5-6 was 3.93%.

Conclusion: the reaction of the oral mucosa to the dental material is stainless steel with a TiN coating negative.

Sample material of the studied structural material DENTAL NSA vac "DINA & WEST" (Nickel-chromium-molybdenum, a dental alloy of vacuum smelting for cermet work).

The initial values of the BEMR index: point 1 - 3,765; point 2 - 4.329; point 3 - 3,741; point 4 - 3.929; point 5 - 4.047; point 6 - 4.188. The values of the BEMR index with a sample of the studied structural material: point 1 - 3,082; point 2 - 3.624; point 3 - 3,200; point 4 - 3.224; point 5 - 3.129; point 6 - 3,506. The value of functional asymmetry at points 1-2 was 0.37%. The value of functional asymmetry at points 3-4 was 2.73%. The value of functional asymmetry at points 5-6 was 3.93%.

Conclusion: the reaction of the oral mucosa to the dental material DENTAL NSA vac "DINA & WEST" (Nickel-chromium-molybdenum, a dental alloy of vacuum smelting for cermet work) is negative.

The sample material of the studied structural material is an alloy of gold (ZlPlPdSr 87.2-8.8-1.3-0.4) for the manufacture of M / K structures. The initial values of the BEMR index: point 1 - 3.765; point 2 - 4.329; point 3 - 3,741; point 4 - 3.929; point 5 - 4.047, point 6 - 4.188. The values of the BEMR index with a sample of the studied structural material: point 1 - 2.98; point 2 - 2.729; point 3 - 3,082; point 4 - 2.918; point 5 - 3.106; point 6 - 3.435. The value of functional asymmetry at points 1-2 was 13.72%. The value of functional asymmetry at points 3-4 was 5.86%. The value of functional asymmetry at points 5-6 was 3.13%.

Conclusion: the reaction of the mucous membrane of the cavity to a gold alloy (ZlPlPdSr 87.2-8.8-1.3-0.4) for the manufacture of M / K structures is positive, since the value of the functional asymmetry at points 1-2 was 13.72% that exceeds 10%.

The sample material of the structural material under study is a titanium alloy — OROTIG (VERONA) ITALIA (CP Titanium Grade 4, ASTM Standard Lot No. 2611; for the manufacture of cermet structures).

The initial values of the BEMR index: point 1 - 3,765; point 2 - 4,329, point 3 - 3,741; point 4 - 3.929; point 5 - 4.047; point 6 - 4.188. The values of the BEMR index with a sample of the studied structural material: point 1 - 2,800; point 2 - 3.294; point 3 - 3,200; point 4 - 3.176; point 5 - 3.247; point 6 - 3,553.

The value of functional asymmetry at points 1-2 was 1.17%.

The value of functional asymmetry at points 3-4 was 3.53%.

The value of functional asymmetry at points 5-6 was 2.75%.

Conclusion: the reaction of the oral mucosa to the dental material titanium alloy - OROTIG (VERONA) ITALIA (CP Titanium Grade 4, ASTM Standard Lot No. 2611; for the manufacture of ceramic-metal structures) is negative.

The sample material of the studied structural material is DUCERA + ceramics.

The initial values of the BEMR index: point 1 - 3,765; point 2 - 4.329; point 3 - 3,741; point 4 - 3.929; point 5 - 4.047; point 6 - 4.188.

Values of the BEMR index with a sample of the studied structural material: point 1 - 2.918; point 2 - 3.718; point 3 - 3.035; point 4 - 3.012; point 5 - 3.224; point 6 - 3,506.

The value of functional asymmetry at points 1-2 was 3.93%.

The value of functional asymmetry at points 3-4 was 3.52%.

The value of functional asymmetry at points 5-6 was 2.35%.

Conclusion: the reaction of the oral mucosa to the dental material ceramics "DUCERA +" is negative.

The results of the study showed that prosthetic materials located in the patient’s oral cavity are not the cause of changes in the oral mucosa.

Example 3. Patient C. Complaints about a change in the mucous membrane in the form of edema.

In the anamnesis: Hypertension II tbsp., Allergic reaction to drugs in the form of skin rash, itching.

The development of this disease: 1.5 months ago, crowns with TIN deposition were recorded. After 12 hours, swelling of the oral mucosa appeared. To alleviate the condition, she took Suprastin in tablets, the next day the swelling went away, she went to the dentist in order to identify the cause of her condition and was sent to diagnose the biocompatibility of dental materials.

Dental formula:

0 0 0 to 0 0 0 0 0 0 0 0 0 0 8 7 6 5 four 3 2 one one 2 3 four 5 6 7 8 0 0 0 TO 0 TO 0

K is the crown;

And - an artificial tooth;

O - missing tooth.

The patient in accordance with the claimed method was diagnosed with a reaction of the oral mucosa to dental materials, including those present in prostheses. Diagnosis was carried out in accordance with the claimed claims.

The research results are given below.

The sample material of the investigated structural material is stainless steel.

The initial values of the BEMR index: point 1 - 2.918; point 2 - 3.082; point 3 - 3.318; point 4 - 3.882; point 5 - 3.765; point 6 - 3.929. The values of the BEMR index with a sample of the studied structural material: point 1 - 2.071; point 2 - 2.047; point 3 - 2,376; point 4 - 2,988; point 5 - 2.918; point 6 - 3,200.

The value of functional asymmetry at points 1-2 was 3.13%.

The value of functional asymmetry at points 3-4 was 0.8%.

The value of functional asymmetry at points 5-6 was 1.97%.

Conclusion: the reaction of the oral mucosa to the dental material stainless steel is negative.

The sample material of the studied structural material is stainless steel with a TiN coating.

The initial values of the BEMR index: point 1 - 2.918; point 2 - 3,082, point 3 - 3,318; point 4 - 3.882; point 5 - 3.765; point 6 - 3.929.

The values of the BEMR index with a sample of the studied structural material: point 1 - 2,447; point 2 - 2.118; point 3 - 2,988; point 4 - 2,988; point 5 - 3.318; point 6 - 3.224.

The value of functional asymmetry at points 1-2 was 8.22%.

The value of functional asymmetry at points 3-4 was 9.4%.

The value of functional asymmetry at points 5-6 was 4.3%.

Conclusion: the nature of the reaction of the oral mucosa to the material of the sample of the studied dental material stainless steel with TiN deposition can be considered borderline, since one of the K values is close to 10%.

The sample material of the structural material under study is the base plastic of hot curing with dye and "veins" "VERTEX-CASTAPRESS".

The initial values of the BEMR index: point 1 - 2.918; point 2 - 3.082; point 3 - 3.318; point 4 - 3.882; point 5 - 3.765; point 6 - 3.929.

The values of the BEMR index with a sample of the studied structural material: point 1 - 3.318; point 2 - 3.153; point 3 - 3.647; point 4 - 3.624; point 5 - 3.718; point 6 - 4.21.

The value of functional asymmetry at points 1-2 was 5.48%.

The value of functional asymmetry at points 3-4 was 9.78%.

The value of functional asymmetry at points 5-6 was 5.5%.

Conclusion: the nature of the reaction of the oral mucosa to the studied dental material — hot curing base plastic with dye and “VERTEX-CASTAPRESS” dye — can be considered borderline, since one of the K values is close to 10%.

The sample material of the investigated structural material is colorless plastic "VERTEX-CASTAPRESS".

The initial values of the BEMR index: point 1 - 2.918; point 2 - 3.082; point 3 - 3.318; point 4 - 3.882; point 5 - 3,765, point 6 - 3,929.

The values of the BEMR index with a sample of the studied structural material: point 1 - 2,329; point 2 - 2.047; point 3 - 2.729; point 4 - 2.8; point 5 - 2,800; point 6 - 3.176.

The value of functional asymmetry at points 1-2 was 7.43%.

The value of functional asymmetry at points 3-4 was 8.22%.

The value of functional asymmetry at points 5-6 was 3.53%.

Conclusion: the reaction of the oral mucosa to the dental material is colorless plastic "VERTEX-CASTAPRESS" negative.

The material of the sample of the studied structural material is the base plastic of hot curing with the dye "Ftoraks". The initial values of the BEMR index: point 1 - 2.918; point 2 - 3.082; point 3 - 3.318; point 4 - 3.882; point 5 - 3.765; point 6 - 3.929. The values of the BEMR index with a sample of the studied structural material: point 1 - 2,753; point 2 - 2.871; point 3 - 2,894; point 4 - 3.106; point 5 - 3,529; point 6 - 3.647.

The value of functional asymmetry at points 1-2 was 0.77%.

The value of functional asymmetry at points 3-4 was 5.87%.

The value of functional asymmetry at points 5-6 was 0.77%.

Conclusion: the reaction of the mucous membrane of the oral cavity to the dental material, the base plastic of hot curing with the dye "Ftoraks" is negative.

The sample material of the studied structural material is Sinma-74, Stoma Ukraine (for fixed prostheses). The initial values of the BEMR index: point 1 - 2.918; point 2 - 3.082; point 3 - 3.318; point 4 - 3.882; point 5 - 3.765; point 6 - 3.929.

The values of the BEMR index with a sample of the studied structural material: point 1 - 2,800; point 2 - 2,471; point 3 - 3.012; point 4 - 2,894; point 5 - 3.765; point 6 - 3,788.

The value of functional asymmetry at points 1-2 was 8.22%.

The value of functional asymmetry at points 3-4 was 11.37%.

The value of functional asymmetry at points 5-6 was 2.35%.

Conclusion: the reaction of the oral mucosa to the dental material Sinma-74, Stoma Ukraine (for fixed prostheses) is positive, since one of the K values exceeds 10%.

From the obtained results it follows that since the nature of the reaction of the oral mucosa to the material of the sample stainless steel with TiN deposition can be considered borderline, since one of the K values is close to 10%, we can conclude that the reason for the change in the oral mucosa in the form edema 12 hours after prosthetics was caused by this dental material.

In addition, the dental material Sinma-74, Stoma Ukraine (for fixed prostheses) is contraindicated during prosthetics and the base plastic of hot curing with dye and veins "VERTEX-CASTAPRESS" is undesirable for use.

Example 4. Patient K. Complaints of dryness and burning of the oral mucosa.

History: chronic gastritis. An allergic history is calm.

The development of this disease: according to the patient, dryness and burning in the oral cavity appeared as a result of her orthopedic treatment. She was made on the upper jaw - a ceramic-metal bridge and clasp prosthesis with fixation on friction pins, on the lower jaw - metal-ceramic crowns on 3.4, 3.3 and 4.2, 4.3 teeth and a clasp prosthesis fixed on friction pins.

On visual examination, the presence on the apparently unchanged mucous membrane of the merged small whitish papules (up to 2 mm in diameter), slightly rising above the level of the mucous membrane, in the retromal region and the mucous membrane of the cheeks.

The prosthesis condition is satisfactory. On tooth 3.7, a gold stamped crown does not meet the requirements. The crown is wide, short with exposure of the neck of the tooth, with its edge injures the mucous membrane of the cheek, according to the patient, the crown was made about 7 years ago. 4.7 tooth restored restoration material according to class II according to Black, with an unsatisfactory marginal fit and changed in color. The sharp edges of the tooth injure the mucous membrane of the cheek. Diagnosis: lichen planus, typical form.

The patient in accordance with the claimed method was diagnosed with a reaction of the oral mucosa to dental materials, including those present in prostheses. Diagnosis was carried out in accordance with the claimed claims.

The research results are given below.

The sample material of the investigated structural material is stainless steel. The initial values of the BEMR index: point 1 - 2.141; point 2 - 2.094; point 3 - 2,447; point 4 - 2,447; point 5 - 2,988; point 6 - 3.365. Values of the BEMR index with a sample of the studied structural material: point 1 - 2.918; point 2 - 2,447; point 3 - 3.318; point 4 - 3,553; point 5 - 4.188; point 6 - 4,588.

The value of functional asymmetry at points 1-2 was 7.07%.

The value of functional asymmetry at points 3-4 was 3.92%.

The value of functional asymmetry at points 5-6 was 0.38%.

Conclusion: the reaction of the oral mucosa to the dental material stainless steel is negative.

The sample material of the investigated structural material is TiN-coated stainless steel.

The initial values of the BEMR index: point 1 - 2.141; point 2 - 2,094, point 3 - 2,447; point 4 - 2,447; point 5 - 2,988; point 6 - 3.365. The values of the BEMR index with a sample of the studied structural material: point 1 - 3,906; point 2 - 3.271; point 3 - 3.412; point 4 - 3.365; point 5 - 3.882; point 6 - 4.165.

The value of functional asymmetry at points 1-2 was 9.8%.

The value of functional asymmetry at points 3-4 was 0.78%.

The value of functional asymmetry at points 5-6 was 1.57%.

Conclusion: the nature of the reaction of the oral mucosa to the dental material stainless steel with TiN spraying can be considered borderline, since one of the K values is close to 10%.

Sample material of the studied structural material DENTAL NSA vac "DINA & WEST" (Nickel-chromium-molybdenum, a dental alloy of vacuum smelting for cermet work). The initial values of the BEMR index: point 1 - 2.141; point 2 - 2.094; point 3 - 2,447; point 4 - 2,447; point 5 - 2,988; point 6 - 3.365.

The values of the BEMR index with a sample of the studied structural material: point 1 - 3.247; point 2 - 2.824; point 3 - 3.318; point 4 - 3.129; point 5 - 3.929; point 6 - 4,706.

The value of functional asymmetry at points 1-2 was 6.27%.

The value of functional asymmetry at points 3-4 was 3.15%.

The value of functional asymmetry at points 5-6 was 6.67%.

Conclusion: the reaction of the oral mucosa to the dental material DENTAL NSA vac "DINA & WEST" (Nickel-chromium-molybdenum, a dental alloy of vacuum smelting for cermet work) is negative.

The sample material of the studied structural material is an alloy of gold (ZlPlPdSr 87.2-8.8-1.3-0.4) for the manufacture of M / K structures. The initial values of the BEMR index: point 1 - 2.141; point 2 - 2.094; point 3 - 2,447; point 4 - 2,447; point 5 - 2,988, point 6 - 3,365. The values of the BEMR index with a sample of the studied structural material: point 1 - 2.965; point 2 - 2.753; point 3 - 2,847; point 4 - 2,800; point 5 - 3.247; point 6 - 3,482.

The value of functional asymmetry at points 1-2 was 2.75%.

The value of functional asymmetry at points 3-4 was 0.78%.

The value of functional asymmetry at points 5-6 was 2.37%.

Conclusion: the reaction of the oral mucosa to the dental material is an alloy of gold (ZlPlPdSr 87.2-8.8-1.3-0.4) for the manufacture of M / K is negative.

The sample material of the structural material under study is a titanium alloy — OROTIG (VERONA) ITALIA (CP Titanium Grade 4, ASTM Standard Lot No. 2611; for the manufacture of cermet structures). The initial values of the BEMR index: point 1 - 2.141; point 2 - 2.094; point 3 - 2,447; point 4 - 2,447; point 5 - 2,988; point 6 - 3.365.

The values of the BEMR index with a sample of the studied structural material: point 1 - 3.082; point 2 - 3.482; point 3 - 3.647; point 4 - 3.153; point 5 - 4.047; point 6 - 4.188.

The value of functional asymmetry at points 1-2 was 7.45%.

The value of functional asymmetry at points 3-4 was 8.23%.

The value of functional asymmetry at points 5-6 was 3.93%.

Conclusion: the reaction of the oral mucosa to the dental material titanium alloy - OROTIG (VERONA) ITALIA (CP Titanium Grade 4, ASTM Standard Lot No. 2611; for the manufacture of ceramic-metal structures) is negative.

The sample material of the studied structural material is ceramic "DUCERA +". The initial values of the BEMR index: point 1 - 2.14; point 2 - 2.094; point 3 - 2,447; point 4 - 2,447; point 5 - 2,988; point 6 - 3.365. The values of the BEMR index with a sample of the studied structural material: point 1 - 3,529; point 2 - 3.176; point 3 - 3,529; point 4 - 3,812; point 5 - 4.21; point 6 - 4.494.

The value of functional asymmetry at points 1-2 was 5.1%.

The value of functional asymmetry at points 3-4 was 4.72%.

The value of functional asymmetry at points 5-6 was 1.58%.

Conclusion: the reaction of the oral mucosa to the dental material ceramics "DUCERA +" is negative. The patient was recommended: replacement of a gold crown with an all-ceramic with preliminary treatment of 3.7 teeth; replacement of an old filling with a ceramic insert with preliminary treatment of 4.7 teeth; examination by a gastroenterologist, endocrinologist, immunologist.

Claims (2)

1. A method for diagnosing the reaction of the oral mucosa to the dental material, according to which, without removing the dentures, a controlled parameter is measured at the pair of symmetry points on the surface of the red border of the patient’s lips, for which the lips are divided into two symmetrical parts by a visually vertical line, and as a controlled parameter, the bioelectromagnetic reactivity index (BEMR) is used, which is pre-measured at controlled points and the measured values are recorded, then the patient is offered to see to saliva a sample of the studied dental material, then place it between the patient’s lips symmetrically with respect to the vertical line of symmetry, measure the BEMP index a second time at the same controlled points on the surface of the red border of the lips and fix the measured values, calculate K - coefficient of functional vertical asymmetry, characterized in that the test sample is inserted between the patient’s teeth in such a way that its front part is located between the lips and fits snugly against the mucous membrane e of the inner surface of the lips, and the back part is tightly attached to the mucous membrane of the palatine surface of the tongue, after which the BEMP indices are repeatedly measured at the points on the surface of the red border of the lips, the measurement results are recorded, after which, by calculating the difference, the results of the initial measuring the BEMR indices with the measurement results obtained with the test sample, and then the obtained values of the differences are compared at symmetric points in accordance with vertical symmetry, then calculate the K - coefficient of functional vertical asymmetry according to the formula: K = {| [(B ₂ -T ₂ ) - (B ₁ -T ₁ )] |: 6} × 100%, where B ₁ , T ₁ - the values of the BEMR indices measured in the studied pair of symmetrical points on the surface of the red border of the lips without the test sample; B ₂ , T ₂ - the values of the BEMR indices measured in the same pair of symmetrical points on the surface of the red border of the lips with the sample; 6 is a constant adopted for the convenience of presenting the final result, moreover, the diagnosis is carried out according to the three obtained values of the functional vertical asymmetry, while if at least one K value is equal to or greater than 10%, then a positive reaction of the oral mucosa to the dental material under investigation is diagnosed. 2. The method according to claim 1, characterized in that the contact surface of the sample is roughened.

Images