RU2339695C2 - Растительные тимидинкиназы и их применение - Google Patents

Растительные тимидинкиназы и их применение Download PDF

Info

Publication number
RU2339695C2
RU2339695C2 RU2004133390/13A RU2004133390A RU2339695C2 RU 2339695 C2 RU2339695 C2 RU 2339695C2 RU 2004133390/13 A RU2004133390/13 A RU 2004133390/13A RU 2004133390 A RU2004133390 A RU 2004133390A RU 2339695 C2 RU2339695 C2 RU 2339695C2
Authority
RU
Russia
Prior art keywords
seq
thymidine kinase
amino acid
identity
pharmaceutical composition
Prior art date
Application number
RU2004133390/13A
Other languages
English (en)
Russian (ru)
Other versions
RU2004133390A (ru
Inventor
Вольфганг КНЕХТ (SE)
Вольфганг КНЕХТ
Биргитте МУНК-ПЕТЕРСЕН (DK)
Биргитте МУНК-ПЕТЕРСЕН
Юре ПИСКУР (DK)
Юре ПИСКУР
Original Assignee
Вольфганг КНЕХТ
Биргитте МУНК-ПЕТЕРСЕН
Юре ПИСКУР
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вольфганг КНЕХТ, Биргитте МУНК-ПЕТЕРСЕН, Юре ПИСКУР filed Critical Вольфганг КНЕХТ
Publication of RU2004133390A publication Critical patent/RU2004133390A/ru
Application granted granted Critical
Publication of RU2339695C2 publication Critical patent/RU2339695C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C12N9/1211—Thymidine kinase (2.7.1.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01076—Deoxyadenosine kinase (2.7.1.76)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
RU2004133390/13A 2002-05-23 2003-05-21 Растительные тимидинкиназы и их применение RU2339695C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200200794 2002-05-23
DKPA200200794 2002-05-23
DKPA200300178 2003-02-07
DKPA200300178 2003-02-07

Publications (2)

Publication Number Publication Date
RU2004133390A RU2004133390A (ru) 2005-08-10
RU2339695C2 true RU2339695C2 (ru) 2008-11-27

Family

ID=29585606

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004133390/13A RU2339695C2 (ru) 2002-05-23 2003-05-21 Растительные тимидинкиназы и их применение

Country Status (15)

Country Link
US (1) US7928206B2 (enExample)
EP (1) EP1509600B1 (enExample)
JP (1) JP2006504403A (enExample)
CN (1) CN1662647A (enExample)
AT (1) ATE419337T1 (enExample)
AU (1) AU2003229543B2 (enExample)
CA (1) CA2485182A1 (enExample)
DE (1) DE60325587D1 (enExample)
DK (1) DK1509600T3 (enExample)
ES (1) ES2320434T3 (enExample)
MX (1) MXPA04011572A (enExample)
NZ (1) NZ536623A (enExample)
PT (1) PT1509600E (enExample)
RU (1) RU2339695C2 (enExample)
SI (1) SI1509600T1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112007002378T5 (de) 2006-10-24 2009-09-03 Bradley Fixtures Corp., Menomonee Falls Kapazitive Messung für Waschraum-Armaturen
JP5211303B2 (ja) * 2007-10-25 2013-06-12 独立行政法人産業技術総合研究所 蛋白質の製造方法
CN114107339B (zh) * 2021-12-09 2024-06-07 菏泽学院 泡桐丛枝植原体胸苷激酶基因引物、基因、融合蛋白、多克隆抗体及其应用
CN117016549B (zh) * 2023-03-13 2024-02-27 山东蓬勃生物科技有限公司 核苷类化合物及其组合物在促进植物生长中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU99112189A (ru) * 1996-11-07 2001-05-20 Зенека Лимитед Резистентные к гербицидам растения

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0758387B1 (en) * 1994-05-02 2001-12-19 University of Washington Thymidine kinase mutants
US6197743B1 (en) * 1996-07-26 2001-03-06 The Trustees Of Boston University Compositions and methods for the treatment of viral disorders
JP2002516061A (ja) 1997-10-14 2002-06-04 ダーウィン モレキュラー コーポレイション チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質
AU4582899A (en) 1998-06-22 2000-01-10 Board Of Trustees Of The University Of Arkansas, The Mutated herpes simplex virus type 1 thymidine kinases and uses thereof
GB0008966D0 (en) 2000-04-13 2000-05-31 Imp College Innovations Ltd Vectors for gene therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU99112189A (ru) * 1996-11-07 2001-05-20 Зенека Лимитед Резистентные к гербицидам растения

Also Published As

Publication number Publication date
PT1509600E (pt) 2009-03-26
US20060035850A1 (en) 2006-02-16
MXPA04011572A (es) 2005-07-05
DK1509600T3 (da) 2009-04-27
NZ536623A (en) 2006-05-26
DE60325587D1 (de) 2009-02-12
JP2006504403A (ja) 2006-02-09
EP1509600B1 (en) 2008-12-31
CN1662647A (zh) 2005-08-31
SI1509600T1 (sl) 2009-06-30
AU2003229543A1 (en) 2003-12-12
RU2004133390A (ru) 2005-08-10
ES2320434T3 (es) 2009-05-22
EP1509600A1 (en) 2005-03-02
AU2003229543B2 (en) 2008-03-20
CA2485182A1 (en) 2003-12-04
ATE419337T1 (de) 2009-01-15
US7928206B2 (en) 2011-04-19

Similar Documents

Publication Publication Date Title
Bargmann et al. The neu oncogene encodes an epidermal growth factor receptor-related protein
Shuman et al. RNA capping enzyme and DNA ligase: a superfamily of covalent nucleotidyl transferases
RU2013129678A (ru) Поксвирусные онколитические векторы
CA2705869A1 (en) Poxviral oncolytic vectors
EP0879288A1 (fr) Variants de la thymidine kinase, sequences d'acides nucleiques correspondantes et leur utilisation en therapie genique
AU783845B2 (en) Novel deoxynucleoside kinase enzyme variants
HUE026630T2 (hu) Eljárás L-triptofán elõállítására javított, Enterobacteriaceae családba tartozó baktériumtörzsek alkalmazásával
RU2339695C2 (ru) Растительные тимидинкиназы и их применение
Song et al. High conservation of subunit composition of RNA polymerase I (A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40.
EP1183371A2 (fr) Composition destinee a la mise en oeuvre d'un traitement antitumoral ou antiviral chez un mammifere
KR101744763B1 (ko) Bmp 유래 펩타이드 및 이의 용도
JPH04275229A (ja) ヘルペス感染治療用医薬組成物
JP2006504403A5 (enExample)
AU777860B2 (en) Nitroreductase enzymes
CN107868119B (zh) 用于抑制cd279相互作用的组合物和方法
JP2005520866A (ja) 哺乳動物の悪性細胞および形質転換細胞に対する選択的致死性ペプチド
CN110857315A (zh) 一种治疗肿瘤的多肽药物、衍生物及其使用方法
Noguchi et al. Molecular cloning and identification of two types of hamster cyclin-dependent kinases: cdk2 and cdk2L
JP4273234B2 (ja) チオレドキシン改変体
Luo et al. Direct cDNA cloning of novel conotoxins of the T-superfamily from Conus textile
KR101399077B1 (ko) 아데닐레이트 싸이클라제 활성화 폴리펩타이드 1 (뇌하수체)의 유전자를 함유하는 자궁경부암세포의 증식 억제용 재조합벡터 및 자궁경부암 치료용 약학 조성물
US5972648A (en) Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
JP2001103979A (ja) 新規タキキニンペプチドおよびその前駆体ポリペプチドならびにこれらをコードする遺伝子
CN107759673A (zh) 可对hbv的dna进行表观甲基化修饰的蛋白分子及其应用
US20030207830A1 (en) Mutant NDP kinases for antiviral nucleotide analog activation and therapeutic uses thereof

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20120522