RU2319505C2 - Очищенные оболочечные белки вируса гепатита с для диагностического и терапевтического применения - Google Patents
Очищенные оболочечные белки вируса гепатита с для диагностического и терапевтического применения Download PDFInfo
- Publication number
- RU2319505C2 RU2319505C2 RU2004116914/15A RU2004116914A RU2319505C2 RU 2319505 C2 RU2319505 C2 RU 2319505C2 RU 2004116914/15 A RU2004116914/15 A RU 2004116914/15A RU 2004116914 A RU2004116914 A RU 2004116914A RU 2319505 C2 RU2319505 C2 RU 2319505C2
- Authority
- RU
- Russia
- Prior art keywords
- virus
- hepatitis
- vaccine composition
- antigen
- composition against
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title claims abstract 29
- 230000001225 therapeutic effect Effects 0.000 title claims abstract 6
- 101710132601 Capsid protein Proteins 0.000 title abstract 2
- 101710094648 Coat protein Proteins 0.000 title abstract 2
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 title abstract 2
- 101710125418 Major capsid protein Proteins 0.000 title abstract 2
- 101710141454 Nucleoprotein Proteins 0.000 title abstract 2
- 101710083689 Probable capsid protein Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 18
- 241000124008 Mammalia Species 0.000 claims abstract 10
- 230000002163 immunogen Effects 0.000 claims abstract 8
- 102000004169 proteins and genes Human genes 0.000 claims abstract 3
- 108090000623 proteins and genes Proteins 0.000 claims abstract 3
- 230000000694 effects Effects 0.000 claims abstract 2
- 230000007863 steatosis Effects 0.000 claims abstract 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims abstract 2
- 229940021747 therapeutic vaccine Drugs 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 239000002671 adjuvant Substances 0.000 claims 6
- 208000019425 cirrhosis of liver Diseases 0.000 claims 6
- 108700008783 Hepatitis C virus E1 Proteins 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 238000000034 method Methods 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 238000002255 vaccination Methods 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 229940037003 alum Drugs 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 150000001945 cysteines Chemical class 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
- 206010019668 Hepatic fibrosis Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/18—Togaviridae; Flaviviridae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2051001A | 2001-12-18 | 2001-12-18 | |
US10/020,510 | 2001-12-18 | ||
US41835802P | 2002-10-16 | 2002-10-16 | |
US60/418,358 | 2002-10-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2004116914A RU2004116914A (ru) | 2005-04-20 |
RU2319505C2 true RU2319505C2 (ru) | 2008-03-20 |
Family
ID=26693530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2004116914/15A RU2319505C2 (ru) | 2001-12-18 | 2002-12-18 | Очищенные оболочечные белки вируса гепатита с для диагностического и терапевтического применения |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1461080A2 (fr) |
JP (1) | JP2005516939A (fr) |
KR (1) | KR20040076869A (fr) |
CN (1) | CN1622828A (fr) |
AU (1) | AU2002361160B2 (fr) |
BR (1) | BR0215081A (fr) |
CA (1) | CA2468690A1 (fr) |
IL (1) | IL162236A0 (fr) |
MX (1) | MXPA04005891A (fr) |
NZ (1) | NZ533396A (fr) |
RU (1) | RU2319505C2 (fr) |
WO (1) | WO2003051912A2 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7108855B2 (en) | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
US7101561B2 (en) | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
WO2002085932A2 (fr) | 2001-04-24 | 2002-10-31 | Innogenetics N.V. | Constructions et methodes relatives a l'expression de proteines d'enveloppe recombinantes du vhc |
FR2859221B1 (fr) * | 2003-08-28 | 2005-10-14 | Centre Nat Rech Scient | Vecteur de co-expression de domaines membranaires de proteines d'enveloppe d'un virus et utilisations |
EP1574517A1 (fr) | 2004-03-09 | 2005-09-14 | Innogenetics N.V. | HCV E1 contenant les ponts disulfure spécifiques |
EP1809773B1 (fr) * | 2004-10-18 | 2014-07-16 | Globeimmune, Inc. | Moyens therapeutiques a base de levure contre l'infection par hepatite c chronique |
CN100365124C (zh) * | 2005-10-27 | 2008-01-30 | 云南大学 | 一段丙型肝炎病毒特异性cDNA序列的应用 |
WO2009030872A1 (fr) * | 2007-09-07 | 2009-03-12 | Mats Axel Atterdag Persson | Matériaux et procédés pour le traitement de l'hépatite c |
SI2285408T1 (sl) | 2008-06-05 | 2019-02-28 | Ablynx N.V. | Aminokislinska zaporedja usmerjena proti proteinom ovojnicam virusa in polipeptidi, ki zaporedja vsebujejo za zdravljenje virusnih bolezni |
NZ597314A (en) | 2009-06-05 | 2013-07-26 | Ablynx Nv | Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections |
EP2507262A1 (fr) | 2009-11-30 | 2012-10-10 | Ablynx N.V. | Séquences d'acides aminés améliorées dirigées contre le virus syncytial respiratoire humain (hrsv) et polypeptides comprenant celles-ci pour la prévention et/ou le traitement d'infections du tractus respiratoire |
EP2720716B1 (fr) | 2011-06-14 | 2018-03-21 | Globeimmune, Inc. | Compositions immunotherapeutiques pour le traitement ou prévention d'une infection par le virus delta de l'hépatite |
RU2570553C2 (ru) * | 2013-11-20 | 2015-12-10 | Федеральное бюджетное учреждение "Всероссийский научно-исследовательский институт лесоводства и механизации лесного хозяйства (ФБУ ВНИИЛМ) | Способ очистки вирусных полиэдров |
CN104327170A (zh) * | 2014-05-16 | 2015-02-04 | 中国疾病预防控制中心病毒病预防控制所 | 丙型肝炎病毒(hcv)细胞进入抑制肽zte1序列及应用 |
CN107002079A (zh) | 2014-09-17 | 2017-08-01 | 衣阿华大学研究基金会 | 作为免疫调节剂和疫苗组分的病毒rna区段 |
US20190284230A1 (en) * | 2016-09-29 | 2019-09-19 | Macfarlane Burnet Institute For Medical Research And Public Health Limited | Assembled glycoproteins |
WO2020117760A1 (fr) * | 2018-12-03 | 2020-06-11 | Duke University | Procédé de purification de nanoparticules et de protéines recombinantes |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0992580T3 (da) * | 1993-11-04 | 2005-07-11 | Innogenetics Nv | Epitoper på human T-celler, som er immundominante for hepatitis C-virus |
NZ508797A (en) * | 1998-06-24 | 2004-02-27 | Innogenetics N | Particles of HCV envelope proteins: use for vaccination |
-
2002
- 2002-12-18 RU RU2004116914/15A patent/RU2319505C2/ru not_active IP Right Cessation
- 2002-12-18 KR KR10-2004-7009720A patent/KR20040076869A/ko not_active Application Discontinuation
- 2002-12-18 CN CNA028282027A patent/CN1622828A/zh active Pending
- 2002-12-18 EP EP02796675A patent/EP1461080A2/fr not_active Withdrawn
- 2002-12-18 WO PCT/EP2002/014480 patent/WO2003051912A2/fr active IP Right Grant
- 2002-12-18 CA CA002468690A patent/CA2468690A1/fr not_active Abandoned
- 2002-12-18 AU AU2002361160A patent/AU2002361160B2/en not_active Expired - Fee Related
- 2002-12-18 NZ NZ533396A patent/NZ533396A/en unknown
- 2002-12-18 JP JP2003552792A patent/JP2005516939A/ja active Pending
- 2002-12-18 BR BR0215081-6A patent/BR0215081A/pt not_active IP Right Cessation
- 2002-12-18 IL IL16223602A patent/IL162236A0/xx unknown
-
2004
- 2004-06-16 MX MXPA04005891A patent/MXPA04005891A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1622828A (zh) | 2005-06-01 |
KR20040076869A (ko) | 2004-09-03 |
NZ533396A (en) | 2005-04-29 |
AU2002361160B2 (en) | 2008-07-03 |
EP1461080A2 (fr) | 2004-09-29 |
BR0215081A (pt) | 2004-10-19 |
WO2003051912A9 (fr) | 2004-07-15 |
WO2003051912A3 (fr) | 2004-03-04 |
JP2005516939A (ja) | 2005-06-09 |
CA2468690A1 (fr) | 2003-06-26 |
MXPA04005891A (es) | 2004-09-13 |
AU2002361160A1 (en) | 2003-06-30 |
WO2003051912A2 (fr) | 2003-06-26 |
IL162236A0 (en) | 2005-11-20 |
RU2004116914A (ru) | 2005-04-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20081219 |