CA2468690A1 - Proteines purifiees du virus de l'hepatite c utilisables en diagnostic et therapie - Google Patents
Proteines purifiees du virus de l'hepatite c utilisables en diagnostic et therapie Download PDFInfo
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- CA2468690A1 CA2468690A1 CA002468690A CA2468690A CA2468690A1 CA 2468690 A1 CA2468690 A1 CA 2468690A1 CA 002468690 A CA002468690 A CA 002468690A CA 2468690 A CA2468690 A CA 2468690A CA 2468690 A1 CA2468690 A1 CA 2468690A1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/18—Togaviridae; Flaviviridae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne un procédé permettant de purifier des protéines d'enveloppe simple ou d'oligomères spécifiques du VHC (virus de l'hépatite C) recombinant. Ces protéines sont choisies dans le groupe constitué des E1 et/ou E2 et/ou E1/E2. La caractéristique du procédé est qu'au moment de la lyse des cellules transformées, pour isoler la protéine exprimée par recombinaison, on utilise un agent de clivage de la liaison bisulfure de façon à réaliser une réduction ou un clivage de la liaison bisulfure. L'invention concerne également, d'une part une composition isolée par un tel procédé, d'autre part l'application diagnostic et thérapeutique de ces compositions, et enfin l'utilisation des peptides et de la protéine E1 du VHC pour établir un pronostic ou pour surveiller l'efficacité clinique et/ou l'avantage clinique du traitement contre le VHC.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2051001A | 2001-12-18 | 2001-12-18 | |
| US10/020,510 | 2001-12-18 | ||
| US41835802P | 2002-10-16 | 2002-10-16 | |
| US60/418,358 | 2002-10-16 | ||
| PCT/EP2002/014480 WO2003051912A2 (fr) | 2001-12-18 | 2002-12-18 | Proteines purifiees du virus de l'hepatite c utilisables en diagnostic et therapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2468690A1 true CA2468690A1 (fr) | 2003-06-26 |
Family
ID=26693530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002468690A Abandoned CA2468690A1 (fr) | 2001-12-18 | 2002-12-18 | Proteines purifiees du virus de l'hepatite c utilisables en diagnostic et therapie |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1461080A2 (fr) |
| JP (1) | JP2005516939A (fr) |
| KR (1) | KR20040076869A (fr) |
| CN (1) | CN1622828A (fr) |
| AU (1) | AU2002361160B2 (fr) |
| BR (1) | BR0215081A (fr) |
| CA (1) | CA2468690A1 (fr) |
| IL (1) | IL162236A0 (fr) |
| MX (1) | MXPA04005891A (fr) |
| NZ (1) | NZ533396A (fr) |
| RU (1) | RU2319505C2 (fr) |
| WO (1) | WO2003051912A2 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7108855B2 (en) | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| US7101561B2 (en) | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| WO2002085932A2 (fr) | 2001-04-24 | 2002-10-31 | Innogenetics N.V. | Constructions et methodes relatives a l'expression de proteines d'enveloppe recombinantes du vhc |
| FR2859221B1 (fr) * | 2003-08-28 | 2005-10-14 | Centre Nat Rech Scient | Vecteur de co-expression de domaines membranaires de proteines d'enveloppe d'un virus et utilisations |
| EP1574517A1 (fr) | 2004-03-09 | 2005-09-14 | Innogenetics N.V. | HCV E1 contenant les ponts disulfure spécifiques |
| EP1809773B1 (fr) * | 2004-10-18 | 2014-07-16 | Globeimmune, Inc. | Moyens therapeutiques a base de levure contre l'infection par hepatite c chronique |
| CN100365124C (zh) * | 2005-10-27 | 2008-01-30 | 云南大学 | 一段丙型肝炎病毒特异性cDNA序列的应用 |
| WO2009030872A1 (fr) * | 2007-09-07 | 2009-03-12 | Mats Axel Atterdag Persson | Matériaux et procédés pour le traitement de l'hépatite c |
| SI2285408T1 (sl) | 2008-06-05 | 2019-02-28 | Ablynx N.V. | Aminokislinska zaporedja usmerjena proti proteinom ovojnicam virusa in polipeptidi, ki zaporedja vsebujejo za zdravljenje virusnih bolezni |
| NZ597314A (en) | 2009-06-05 | 2013-07-26 | Ablynx Nv | Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections |
| EP2507262A1 (fr) | 2009-11-30 | 2012-10-10 | Ablynx N.V. | Séquences d'acides aminés améliorées dirigées contre le virus syncytial respiratoire humain (hrsv) et polypeptides comprenant celles-ci pour la prévention et/ou le traitement d'infections du tractus respiratoire |
| EP2720716B1 (fr) | 2011-06-14 | 2018-03-21 | Globeimmune, Inc. | Compositions immunotherapeutiques pour le traitement ou prévention d'une infection par le virus delta de l'hépatite |
| RU2570553C2 (ru) * | 2013-11-20 | 2015-12-10 | Федеральное бюджетное учреждение "Всероссийский научно-исследовательский институт лесоводства и механизации лесного хозяйства (ФБУ ВНИИЛМ) | Способ очистки вирусных полиэдров |
| CN104327170A (zh) * | 2014-05-16 | 2015-02-04 | 中国疾病预防控制中心病毒病预防控制所 | 丙型肝炎病毒(hcv)细胞进入抑制肽zte1序列及应用 |
| CN107002079A (zh) | 2014-09-17 | 2017-08-01 | 衣阿华大学研究基金会 | 作为免疫调节剂和疫苗组分的病毒rna区段 |
| US20190284230A1 (en) * | 2016-09-29 | 2019-09-19 | Macfarlane Burnet Institute For Medical Research And Public Health Limited | Assembled glycoproteins |
| WO2020117760A1 (fr) * | 2018-12-03 | 2020-06-11 | Duke University | Procédé de purification de nanoparticules et de protéines recombinantes |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0992580T3 (da) * | 1993-11-04 | 2005-07-11 | Innogenetics Nv | Epitoper på human T-celler, som er immundominante for hepatitis C-virus |
| NZ508797A (en) * | 1998-06-24 | 2004-02-27 | Innogenetics N | Particles of HCV envelope proteins: use for vaccination |
-
2002
- 2002-12-18 RU RU2004116914/15A patent/RU2319505C2/ru not_active IP Right Cessation
- 2002-12-18 KR KR10-2004-7009720A patent/KR20040076869A/ko not_active Application Discontinuation
- 2002-12-18 CN CNA028282027A patent/CN1622828A/zh active Pending
- 2002-12-18 EP EP02796675A patent/EP1461080A2/fr not_active Withdrawn
- 2002-12-18 WO PCT/EP2002/014480 patent/WO2003051912A2/fr active IP Right Grant
- 2002-12-18 CA CA002468690A patent/CA2468690A1/fr not_active Abandoned
- 2002-12-18 AU AU2002361160A patent/AU2002361160B2/en not_active Expired - Fee Related
- 2002-12-18 NZ NZ533396A patent/NZ533396A/en unknown
- 2002-12-18 JP JP2003552792A patent/JP2005516939A/ja active Pending
- 2002-12-18 BR BR0215081-6A patent/BR0215081A/pt not_active IP Right Cessation
- 2002-12-18 IL IL16223602A patent/IL162236A0/xx unknown
-
2004
- 2004-06-16 MX MXPA04005891A patent/MXPA04005891A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1622828A (zh) | 2005-06-01 |
| KR20040076869A (ko) | 2004-09-03 |
| NZ533396A (en) | 2005-04-29 |
| AU2002361160B2 (en) | 2008-07-03 |
| EP1461080A2 (fr) | 2004-09-29 |
| BR0215081A (pt) | 2004-10-19 |
| RU2319505C2 (ru) | 2008-03-20 |
| WO2003051912A9 (fr) | 2004-07-15 |
| WO2003051912A3 (fr) | 2004-03-04 |
| JP2005516939A (ja) | 2005-06-09 |
| MXPA04005891A (es) | 2004-09-13 |
| AU2002361160A1 (en) | 2003-06-30 |
| WO2003051912A2 (fr) | 2003-06-26 |
| IL162236A0 (en) | 2005-11-20 |
| RU2004116914A (ru) | 2005-04-20 |
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| FZDE | Discontinued |