RU2297229C2 - Фармацевтическое применение бисфосфонатов - Google Patents
Фармацевтическое применение бисфосфонатов Download PDFInfo
- Publication number
- RU2297229C2 RU2297229C2 RU2003133773/14A RU2003133773A RU2297229C2 RU 2297229 C2 RU2297229 C2 RU 2297229C2 RU 2003133773/14 A RU2003133773/14 A RU 2003133773/14A RU 2003133773 A RU2003133773 A RU 2003133773A RU 2297229 C2 RU2297229 C2 RU 2297229C2
- Authority
- RU
- Russia
- Prior art keywords
- acid
- diphosphonic acid
- bisphosphonate
- study
- prostate cancer
- Prior art date
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010036140A1 (ru) * | 2008-09-29 | 2010-04-01 | Закрытое Акционерное Общество "Фарм-Синтез" | Металлокомплексы, способ их получения, радиофармацевтические средства на их основе |
| RU2609871C1 (ru) * | 2015-08-10 | 2017-02-06 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Противоопухолевое средство |
| RU2697873C2 (ru) * | 2014-07-04 | 2019-08-21 | Остео-Фарма Б.В. | Композиции и продукты для применения в лечении переломов и дефектов кости |
Families Citing this family (80)
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| US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
| US8119159B2 (en) * | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| CA2525929A1 (en) | 2003-05-13 | 2004-11-25 | Chiron Corporation | Methods of modulating metastasis and skeletal related events resulting from metastases |
| GB0320806D0 (en) * | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Therapeutic treatment |
| MXPA06003063A (es) * | 2003-09-19 | 2006-05-31 | Pfizer Prod Inc | Composiciones farmaceuticas y metodos que comprenden combinaciones de derivados de 2-alquiliden-19-nor-vitamina- d y un bisfosfonato. |
| BRPI0710503A2 (pt) * | 2006-04-07 | 2011-08-16 | Merrion Res Iii Ltd | uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral |
| US20090280169A1 (en) * | 2008-05-07 | 2009-11-12 | Merrion Research Iii Limited | Compositions of peptides and processes of preparation thereof |
| TWI480286B (zh) * | 2009-02-25 | 2015-04-11 | Merrion Res Iii Ltd | 雙膦酸鹽類組合物及藥物遞送 |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| KR101813728B1 (ko) | 2009-07-31 | 2017-12-29 | 그뤼넨탈 게엠베하 | 결정화 방법 및 생체이용률 |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| EP2289900A1 (en) * | 2009-08-26 | 2011-03-02 | Humboldt Universität zu Berlin | Bisphosphonates as inhibitors of acid sphingomyelinase |
| EP2473172B1 (en) * | 2009-09-01 | 2015-04-08 | Duke University | Bisphosphonate compositions and methods for treating heart failure |
| US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
| WO2011120033A1 (en) * | 2010-03-26 | 2011-09-29 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor xa inhibitors for oral administration |
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| CN107003298B (zh) * | 2014-11-27 | 2020-04-14 | 皇家飞利浦有限公司 | 尿液和粪便蒸汽的化学分析 |
| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
| CN108514645B (zh) * | 2018-04-08 | 2021-07-20 | 西南医科大学附属医院 | 一种兼具骨显像和骨转移瘤治疗的制剂及其制备和应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000041725A2 (en) * | 1999-01-15 | 2000-07-20 | Light Sciences Corporation | Therapeutic compositions for metabolic bone disorders or bone metastases |
| RU2153358C1 (ru) * | 1999-11-10 | 2000-07-27 | Центральный научно-исследовательский рентгенорадиологический институт МЗ России | Способ лечения остеолитических метастазов |
| WO2000059485A2 (en) * | 1999-04-07 | 2000-10-12 | Novartis Ag | Pharmaceutical compositions comprising in combination a bisphosphonate and a matrix metalloproteinase inhibitor |
| WO2000071104A2 (en) * | 1999-05-21 | 2000-11-30 | Novartis Ag | Use of bisphosphonic acids for treating angiogenesis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634691A (en) * | 1980-10-07 | 1987-01-06 | The Procter & Gamble Company | Method for inhibiting tumor metastasis |
| FI89364C (fi) * | 1990-12-20 | 1993-09-27 | Leiras Oy | Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat |
| WO1996012467A1 (en) * | 1994-10-20 | 1996-05-02 | The Procter & Gamble Company | Personal treatment compositions and/or cosmetic compositions containing enduring perfume |
| US6572874B1 (en) * | 1998-05-15 | 2003-06-03 | Umd, Inc. | Vaginal delivery of bisphosphonates |
| US6015801A (en) * | 1997-07-22 | 2000-01-18 | Merck & Co., Inc. | Method for inhibiting bone resorption |
| US6142383A (en) * | 1998-04-08 | 2000-11-07 | Hinsilblon Laboratories | Method of waterless large scale dispersion of essential oils and apparatus therefor |
-
2002
- 2002-04-30 RU RU2003133773/14A patent/RU2297229C2/ru not_active IP Right Cessation
- 2002-04-30 WO PCT/EP2002/004771 patent/WO2002087555A2/en not_active Ceased
- 2002-04-30 CA CA002443625A patent/CA2443625A1/en not_active Abandoned
- 2002-04-30 IL IL15827302A patent/IL158273A0/xx unknown
- 2002-04-30 SK SK1351-2003A patent/SK13512003A3/sk not_active Application Discontinuation
- 2002-04-30 JP JP2002584901A patent/JP2004528340A/ja active Pending
- 2002-04-30 KR KR10-2003-7014244A patent/KR20040015230A/ko not_active Abandoned
- 2002-04-30 MX MXPA03010007A patent/MXPA03010007A/es not_active Application Discontinuation
- 2002-04-30 US US10/476,365 patent/US20040157799A1/en not_active Abandoned
- 2002-04-30 CZ CZ20032950A patent/CZ20032950A3/cs unknown
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- 2002-04-30 CN CNB028092236A patent/CN1277545C/zh not_active Expired - Fee Related
- 2002-04-30 AR ARP020101586A patent/AR033175A1/es not_active Application Discontinuation
- 2002-04-30 BR BR0209365-0A patent/BR0209365A/pt not_active IP Right Cessation
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- 2002-05-02 MY MYPI20021606A patent/MY141584A/en unknown
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2003
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000041725A2 (en) * | 1999-01-15 | 2000-07-20 | Light Sciences Corporation | Therapeutic compositions for metabolic bone disorders or bone metastases |
| WO2000059485A2 (en) * | 1999-04-07 | 2000-10-12 | Novartis Ag | Pharmaceutical compositions comprising in combination a bisphosphonate and a matrix metalloproteinase inhibitor |
| WO2000071104A2 (en) * | 1999-05-21 | 2000-11-30 | Novartis Ag | Use of bisphosphonic acids for treating angiogenesis |
| RU2153358C1 (ru) * | 1999-11-10 | 2000-07-27 | Центральный научно-исследовательский рентгенорадиологический институт МЗ России | Способ лечения остеолитических метастазов |
Non-Patent Citations (1)
| Title |
|---|
| Stearns M.E. et al. Effects of alendronate and taxol on PC-3 ML cell bone metastases in SCID mice // Invasion Metastasis. 1996; 16(3): 116-31, реферат. Pollard M. et al. Effects of diphosphonate and x-rays on bone lesions induced in rats by prostate cancer cells// Cancer. 1988 May 15;61(10):2027-32, реферат. Clezardin P. et al. Mechanisms of action of bisphosphonates on tumor cells and prospects for use in the treatment of malignant osteolysis // Joint Bone Spine. 2000 Jan;67(l):22-9, реферат. * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010036140A1 (ru) * | 2008-09-29 | 2010-04-01 | Закрытое Акционерное Общество "Фарм-Синтез" | Металлокомплексы, способ их получения, радиофармацевтические средства на их основе |
| RU2697873C2 (ru) * | 2014-07-04 | 2019-08-21 | Остео-Фарма Б.В. | Композиции и продукты для применения в лечении переломов и дефектов кости |
| RU2609871C1 (ru) * | 2015-08-10 | 2017-02-06 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Противоопухолевое средство |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0209365A (pt) | 2004-06-08 |
| AU2002257802B2 (en) | 2006-02-16 |
| WO2002087555A3 (en) | 2004-02-05 |
| SK13512003A3 (sk) | 2004-08-03 |
| NO20034877D0 (no) | 2003-10-31 |
| PL363507A1 (en) | 2004-11-29 |
| MY141584A (en) | 2010-05-14 |
| NO20034877L (no) | 2003-12-19 |
| CZ20032950A3 (cs) | 2004-06-16 |
| HK1080711A1 (en) | 2006-05-04 |
| US20040157799A1 (en) | 2004-08-12 |
| HUP0400096A2 (hu) | 2004-04-28 |
| EP1418897A2 (en) | 2004-05-19 |
| JP2004528340A (ja) | 2004-09-16 |
| MXPA03010007A (es) | 2004-02-12 |
| CN1277545C (zh) | 2006-10-04 |
| AR033175A1 (es) | 2003-12-03 |
| CN1638778A (zh) | 2005-07-13 |
| RU2003133773A (ru) | 2005-02-10 |
| IL158273A0 (en) | 2004-05-12 |
| KR20040015230A (ko) | 2004-02-18 |
| CA2443625A1 (en) | 2002-11-07 |
| NZ528676A (en) | 2006-03-31 |
| WO2002087555A2 (en) | 2002-11-07 |
| ZA200307666B (en) | 2004-05-05 |
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Legal Events
| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20080501 |