RU2292878C2 - Способ приготовления микрочастиц, содержащих метопролол - Google Patents

Способ приготовления микрочастиц, содержащих метопролол Download PDF

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Publication number
RU2292878C2
RU2292878C2 RU2003127739/15A RU2003127739A RU2292878C2 RU 2292878 C2 RU2292878 C2 RU 2292878C2 RU 2003127739/15 A RU2003127739/15 A RU 2003127739/15A RU 2003127739 A RU2003127739 A RU 2003127739A RU 2292878 C2 RU2292878 C2 RU 2292878C2
Authority
RU
Russia
Prior art keywords
metoprolol
microparticle
microparticles
microns
polymer
Prior art date
Application number
RU2003127739/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2003127739A (ru
Inventor
Альф ДЬЮРЛЕ (SE)
Альф ДЬЮРЛЕ
Микаэль ХАНССОН (SE)
Микаэль ХАНССОН
Малин СЕДЕРБОМ (SE)
Малин СЕДЕРБОМ
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of RU2003127739A publication Critical patent/RU2003127739A/ru
Application granted granted Critical
Publication of RU2292878C2 publication Critical patent/RU2292878C2/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
RU2003127739/15A 2001-03-09 2002-03-06 Способ приготовления микрочастиц, содержащих метопролол RU2292878C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0100824-2 2001-03-09
SE0100824A SE0100824D0 (sv) 2001-03-09 2001-03-09 Method III to obtain microparticles

Publications (2)

Publication Number Publication Date
RU2003127739A RU2003127739A (ru) 2005-03-10
RU2292878C2 true RU2292878C2 (ru) 2007-02-10

Family

ID=20283295

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003127739/15A RU2292878C2 (ru) 2001-03-09 2002-03-06 Способ приготовления микрочастиц, содержащих метопролол

Country Status (24)

Country Link
US (1) US20040116392A1 (enExample)
EP (1) EP1370245B1 (enExample)
JP (1) JP2004522798A (enExample)
KR (1) KR20030081507A (enExample)
CN (1) CN1236761C (enExample)
AT (1) ATE295153T1 (enExample)
AU (1) AU2002235102B2 (enExample)
BR (1) BR0207919A (enExample)
CA (1) CA2440167A1 (enExample)
DE (1) DE60204125T2 (enExample)
ES (1) ES2240691T3 (enExample)
HU (1) HUP0303450A2 (enExample)
IL (1) IL157777A0 (enExample)
IS (1) IS6937A (enExample)
MX (1) MXPA03008088A (enExample)
NO (1) NO20033967L (enExample)
NZ (1) NZ528168A (enExample)
PL (1) PL363972A1 (enExample)
PT (1) PT1370245E (enExample)
RU (1) RU2292878C2 (enExample)
SE (1) SE0100824D0 (enExample)
UA (1) UA75909C2 (enExample)
WO (1) WO2002072074A1 (enExample)
ZA (1) ZA200306880B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2585023C1 (ru) * 2014-12-18 2016-05-27 Общество с ограниченной ответственностью "Нанолек" Способ гранулирования

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* Cited by examiner, † Cited by third party
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SE0100823D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method I to obtain microparticles
US20060159756A1 (en) * 1999-09-10 2006-07-20 Brita Sjoblom Method to obtain microparticles containing an H+,K+-ATP-ASE inhibitor
SE0100822D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method II to obtain microparticles
US8006685B2 (en) * 2002-07-05 2011-08-30 Turbochef Technologies, Inc. Re-circulating oven with gas clean-up
EP1915137B8 (de) 2005-08-10 2013-09-11 ADD Advanced Drug Delivery Technologies, Ltd. Orales präparat mit kontrollierter freisetzung
US20070053983A1 (en) * 2005-09-06 2007-03-08 Girish Jain Extended release compositions of metoprolol succinate
NZ574427A (en) * 2006-07-28 2011-11-25 Zaklady Farmaceutyczne Polpharma S A Extended release pharmaceutical formulation of metoprolol and process for its preparation
ES2753148T3 (es) * 2007-02-23 2020-04-07 Glatt Air Techniques Inc Método para determinar el peso del recubrimiento que va a ser aplicado para formar una forma de dosificación de liberación controlada
CN101269056B (zh) * 2007-03-19 2010-05-19 天津药物研究院 一种美托洛尔盐类口服脉冲微丸制剂
NZ584521A (en) * 2007-10-10 2011-03-31 Avantor Performance Mat Inc Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
CN102641257A (zh) * 2012-03-31 2012-08-22 内蒙古医学院 阿替洛尔缓释微囊及其制备方法
CN104739805B (zh) * 2015-04-09 2017-12-19 邸蓉 制备琥珀酸美托洛尔缓释微丸的复相乳液法
WO2019183470A2 (en) 2018-03-22 2019-09-26 Incarda Therapeutics, Inc. A novel method to slow ventricular rate
CN115252913A (zh) * 2022-08-02 2022-11-01 赛诺神畅医疗科技有限公司 一种血管给药涂层及其制备方法和应用

Citations (4)

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Publication number Priority date Publication date Assignee Title
SU1326180A3 (ru) * 1975-11-17 1987-07-23 Аб Хессле (Фирма) Способ получени препарата продленного действи
US4946654A (en) * 1984-04-07 1990-08-07 Bayer Aktiengesellschaft Process for preparing granulates
SU1706373A3 (ru) * 1985-10-11 1992-01-15 Актиеболагет Хессле (Фирма) Способ получени средства с регулируемым высвобождением активного соединени
SU1760969A3 (ru) * 1985-10-11 1992-09-07 Актиеболагет Хессле (Фирма) Способ получени твердой лекарственной формы метопролола с регулируемым его высвобождением

Family Cites Families (17)

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US653014A (en) * 1899-10-06 1900-07-03 Ashley & Bailey Company Process of silkifying cotton.
SE354851B (enExample) * 1970-02-18 1973-03-26 Haessle Ab
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
DE3909455A1 (de) * 1989-03-22 1990-09-27 Hoechst Ag Verfahren zur herstellung von wasserdispergierbaren granulaten
FR2725623A1 (fr) * 1994-10-18 1996-04-19 Flamel Tech Sa Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
AU6824996A (en) * 1995-08-17 1997-03-12 Dyer, Alison Margaret Controlled release products
DE19613395A1 (de) * 1996-04-03 1997-10-09 Basf Ag Granulate hygroskopischer, wasserlöslicher Produkte
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
US5891474A (en) * 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
DE19733094A1 (de) * 1997-07-31 1999-02-04 Merck Patent Gmbh Formulierung auf der Basis von Ascorbinsäure mit verbesserter Farbstabilität
WO1999018935A1 (de) * 1997-10-15 1999-04-22 Merck Patent Gmbh Herstellung eines direkt verpressbaren tablettierhilfsstoffes
EP0987020A1 (en) * 1998-09-04 2000-03-22 Pharma Pass LLC Metoprolol composition and processes for manufacturing the same
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US20060159756A1 (en) * 1999-09-10 2006-07-20 Brita Sjoblom Method to obtain microparticles containing an H+,K+-ATP-ASE inhibitor
SE0100823D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method I to obtain microparticles
TWI354568B (en) * 2000-09-20 2011-12-21 Jagotec Ag Insoluble drug particle compositions with improved
SE0100822D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method II to obtain microparticles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1326180A3 (ru) * 1975-11-17 1987-07-23 Аб Хессле (Фирма) Способ получени препарата продленного действи
US4946654A (en) * 1984-04-07 1990-08-07 Bayer Aktiengesellschaft Process for preparing granulates
SU1706373A3 (ru) * 1985-10-11 1992-01-15 Актиеболагет Хессле (Фирма) Способ получени средства с регулируемым высвобождением активного соединени
SU1760969A3 (ru) * 1985-10-11 1992-09-07 Актиеболагет Хессле (Фирма) Способ получени твердой лекарственной формы метопролола с регулируемым его высвобождением

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2585023C1 (ru) * 2014-12-18 2016-05-27 Общество с ограниченной ответственностью "Нанолек" Способ гранулирования

Also Published As

Publication number Publication date
DE60204125T2 (de) 2006-01-19
ATE295153T1 (de) 2005-05-15
ZA200306880B (en) 2004-12-03
JP2004522798A (ja) 2004-07-29
PT1370245E (pt) 2005-08-31
EP1370245A1 (en) 2003-12-17
ES2240691T3 (es) 2005-10-16
IS6937A (is) 2003-09-03
NO20033967L (no) 2003-10-28
IL157777A0 (en) 2004-03-28
EP1370245B1 (en) 2005-05-11
NO20033967D0 (no) 2003-09-08
NZ528168A (en) 2005-01-28
DE60204125D1 (de) 2005-06-16
BR0207919A (pt) 2004-04-27
UA75909C2 (en) 2006-06-15
US20040116392A1 (en) 2004-06-17
MXPA03008088A (es) 2003-12-12
HK1059737A1 (en) 2004-07-16
CN1507345A (zh) 2004-06-23
SE0100824D0 (sv) 2001-03-09
PL363972A1 (en) 2004-11-29
HUP0303450A2 (hu) 2004-01-28
CA2440167A1 (en) 2002-09-19
AU2002235102B2 (en) 2006-08-31
RU2003127739A (ru) 2005-03-10
KR20030081507A (ko) 2003-10-17
WO2002072074A1 (en) 2002-09-19
CN1236761C (zh) 2006-01-18

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20090307